KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
MICAL1
Full Name:
NEDD9-interacting protein with calponin homology and LIM domains
Alias:
CasL interacting molecule; DKFZp434B1517; FLJ11937; FLJ21739; MICA1; MICAL; MICAL-1; Microtubule associated monoxygenase, calponin and LIM domain containing 1; NEDD9 interacting protein with calponin homology and LIM domains; NICAL
Type:
Adaptor/scaffold
Mass (Da):
117875
Number AA:
1067
UniProt ID:
Q8TDZ2
International Prot ID:
IPI00157757
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005882
Uniprot
OncoNet
Molecular Function:
GO:0017124
GO:0004497
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007010
GO:0055114
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
A
S
P
T
S
T
N
P
A
H
A
H
F
Site 2
Y48
P
G
G
G
L
P
Q
Y
H
K
I
K
D
Q
L
Site 3
Y57
K
I
K
D
Q
L
N
Y
W
S
A
K
S
L
W
Site 4
Y76
K
R
A
G
Q
P
V
Y
Q
Q
G
R
A
C
T
Site 5
T83
Y
Q
Q
G
R
A
C
T
S
T
K
C
L
V
V
Site 6
Y144
A
L
G
A
K
K
F
Y
G
R
F
C
T
G
T
Site 7
T149
K
F
Y
G
R
F
C
T
G
T
L
D
H
I
S
Site 8
T151
Y
G
R
F
C
T
G
T
L
D
H
I
S
I
R
Site 9
S192
Q
P
P
P
R
K
G
S
G
W
R
A
Q
L
Q
Site 10
T241
G
K
L
A
I
G
I
T
A
N
F
V
N
G
R
Site 11
T253
N
G
R
T
V
E
E
T
Q
V
P
E
I
S
G
Site 12
Y265
I
S
G
V
A
R
I
Y
N
Q
S
F
F
Q
S
Site 13
S268
V
A
R
I
Y
N
Q
S
F
F
Q
S
L
L
K
Site 14
S272
Y
N
Q
S
F
F
Q
S
L
L
K
A
T
G
I
Site 15
T277
F
Q
S
L
L
K
A
T
G
I
D
L
E
N
I
Site 16
Y286
I
D
L
E
N
I
V
Y
Y
K
D
D
T
H
Y
Site 17
Y287
D
L
E
N
I
V
Y
Y
K
D
D
T
H
Y
F
Site 18
Y293
Y
Y
K
D
D
T
H
Y
F
V
M
T
A
K
K
Site 19
T316
L
R
Q
D
W
P
D
T
N
R
L
L
G
S
A
Site 20
T334
P
E
A
L
Q
R
F
T
R
A
A
A
D
F
A
Site 21
T342
R
A
A
A
D
F
A
T
H
G
K
L
G
K
L
Site 22
S362
A
H
G
Q
P
D
V
S
A
F
D
F
T
S
M
Site 23
S368
V
S
A
F
D
F
T
S
M
M
R
A
E
S
S
Site 24
S374
T
S
M
M
R
A
E
S
S
A
R
V
Q
E
K
Site 25
S375
S
M
M
R
A
E
S
S
A
R
V
Q
E
K
H
Site 26
S429
R
W
A
E
G
A
E
S
L
E
V
L
A
E
R
Site 27
S438
E
V
L
A
E
R
E
S
L
Y
Q
L
L
S
Q
Site 28
Y440
L
A
E
R
E
S
L
Y
Q
L
L
S
Q
T
S
Site 29
S444
E
S
L
Y
Q
L
L
S
Q
T
S
P
E
N
M
Site 30
T446
L
Y
Q
L
L
S
Q
T
S
P
E
N
M
H
R
Site 31
S447
Y
Q
L
L
S
Q
T
S
P
E
N
M
H
R
N
Site 32
T464
Q
Y
G
L
D
P
A
T
R
Y
P
N
L
N
L
Site 33
Y466
G
L
D
P
A
T
R
Y
P
N
L
N
L
R
A
Site 34
T475
N
L
N
L
R
A
V
T
P
N
Q
V
R
D
L
Site 35
Y483
P
N
Q
V
R
D
L
Y
D
V
L
A
K
E
P
Site 36
T498
V
Q
R
N
N
D
K
T
D
T
G
M
P
A
T
Site 37
T500
R
N
N
D
K
T
D
T
G
M
P
A
T
G
S
Site 38
S507
T
G
M
P
A
T
G
S
A
G
T
Q
E
E
L
Site 39
Y525
C
Q
E
Q
T
A
G
Y
P
G
V
H
V
S
D
Site 40
S531
G
Y
P
G
V
H
V
S
D
L
S
S
S
W
A
Site 41
S534
G
V
H
V
S
D
L
S
S
S
W
A
D
G
L
Site 42
S558
Q
P
G
L
L
E
P
S
E
L
Q
G
L
G
A
Site 43
S613
H
F
H
S
A
F
K
S
M
A
H
S
P
G
P
Site 44
S617
A
F
K
S
M
A
H
S
P
G
P
V
S
Q
A
Site 45
S622
A
H
S
P
G
P
V
S
Q
A
S
P
G
T
S
Site 46
S625
P
G
P
V
S
Q
A
S
P
G
T
S
S
A
V
Site 47
S629
S
Q
A
S
P
G
T
S
S
A
V
L
F
L
S
Site 48
S636
S
S
A
V
L
F
L
S
K
L
Q
R
T
L
Q
Site 49
T641
F
L
S
K
L
Q
R
T
L
Q
R
S
R
A
K
Site 50
S645
L
Q
R
T
L
Q
R
S
R
A
K
E
N
A
E
Site 51
T667
R
L
E
M
E
A
E
T
P
S
T
E
V
P
P
Site 52
S669
E
M
E
A
E
T
P
S
T
E
V
P
P
D
P
Site 53
T670
M
E
A
E
T
P
S
T
E
V
P
P
D
P
E
Site 54
T683
P
E
P
G
V
P
L
T
P
P
S
Q
H
Q
E
Site 55
S686
G
V
P
L
T
P
P
S
Q
H
Q
E
A
G
A
Site 56
Y736
A
T
L
W
P
G
G
Y
E
Q
H
P
G
D
G
Site 57
Y746
H
P
G
D
G
H
F
Y
C
L
Q
H
L
P
Q
Site 58
S761
T
D
H
K
A
E
G
S
D
R
G
P
E
S
P
Site 59
S767
G
S
D
R
G
P
E
S
P
E
L
P
T
P
S
Site 60
T772
P
E
S
P
E
L
P
T
P
S
E
N
S
M
P
Site 61
S774
S
P
E
L
P
T
P
S
E
N
S
M
P
P
G
Site 62
S777
L
P
T
P
S
E
N
S
M
P
P
G
L
S
T
Site 63
S783
N
S
M
P
P
G
L
S
T
P
T
A
S
Q
E
Site 64
T784
S
M
P
P
G
L
S
T
P
T
A
S
Q
E
G
Site 65
S788
G
L
S
T
P
T
A
S
Q
E
G
A
G
P
V
Site 66
S799
A
G
P
V
P
D
P
S
Q
P
T
R
R
Q
I
Site 67
S809
T
R
R
Q
I
R
L
S
S
P
E
R
Q
R
L
Site 68
S810
R
R
Q
I
R
L
S
S
P
E
R
Q
R
L
S
Site 69
S817
S
P
E
R
Q
R
L
S
S
L
N
L
T
P
D
Site 70
S818
P
E
R
Q
R
L
S
S
L
N
L
T
P
D
P
Site 71
T822
R
L
S
S
L
N
L
T
P
D
P
E
M
E
P
Site 72
S836
P
P
P
K
P
P
R
S
C
S
A
L
A
R
H
Site 73
S838
P
K
P
P
R
S
C
S
A
L
A
R
H
A
L
Site 74
S848
A
R
H
A
L
E
S
S
F
V
G
W
G
L
P
Site 75
S858
G
W
G
L
P
V
Q
S
P
Q
A
L
V
A
M
Site 76
S872
M
E
K
E
E
K
E
S
P
F
S
S
E
E
E
Site 77
S875
E
E
K
E
S
P
F
S
S
E
E
E
E
E
D
Site 78
S876
E
K
E
S
P
F
S
S
E
E
E
E
E
D
V
Site 79
S887
E
E
D
V
P
L
D
S
D
V
E
Q
A
L
Q
Site 80
T895
D
V
E
Q
A
L
Q
T
F
A
K
T
S
G
T
Site 81
Y906
T
S
G
T
M
N
N
Y
P
T
W
R
R
T
L
Site 82
T908
G
T
M
N
N
Y
P
T
W
R
R
T
L
L
R
Site 83
T912
N
Y
P
T
W
R
R
T
L
L
R
R
A
K
E
Site 84
T930
K
R
F
C
K
A
Q
T
I
Q
R
R
L
N
E
Site 85
S960
E
L
A
L
R
R
Q
S
S
S
P
E
Q
Q
K
Site 86
S961
L
A
L
R
R
Q
S
S
S
P
E
Q
Q
K
K
Site 87
S962
A
L
R
R
Q
S
S
S
P
E
Q
Q
K
K
L
Site 88
S983
Q
L
V
D
K
K
N
S
L
V
A
E
E
A
E
Site 89
T994
E
E
A
E
L
M
I
T
V
Q
E
L
N
L
E
Site 90
Y1014
L
D
Q
E
L
R
G
Y
M
N
R
E
E
N
L
Site 91
T1023
N
R
E
E
N
L
K
T
A
A
D
R
Q
A
E
Site 92
S1057
F
Q
E
E
R
R
L
S
E
L
A
L
G
T
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation