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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPS8L3
Full Name:
Epidermal growth factor receptor kinase substrate 8-like protein 3
Alias:
Epidermal growth factor receptor pathway substrate 8-related protein 3
Type:
Mass (Da):
66861
Number AA:
593
UniProt ID:
Q8TE67
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
S
R
P
S
S
R
A
I
Y
L
H
R
Site 2
Y10
R
P
S
S
R
A
I
Y
L
H
R
K
E
Y
S
Site 3
Y16
I
Y
L
H
R
K
E
Y
S
Q
N
L
T
S
E
Site 4
S17
Y
L
H
R
K
E
Y
S
Q
N
L
T
S
E
P
Site 5
T21
K
E
Y
S
Q
N
L
T
S
E
P
T
L
L
Q
Site 6
T36
H
R
V
E
H
L
M
T
C
K
Q
G
S
Q
R
Site 7
S41
L
M
T
C
K
Q
G
S
Q
R
V
Q
G
P
E
Site 8
S65
D
A
Q
G
R
V
W
S
Q
D
L
I
L
Q
V
Site 9
T84
L
Q
L
L
D
I
E
T
K
E
E
L
D
S
Y
Site 10
S90
E
T
K
E
E
L
D
S
Y
R
L
D
S
I
Q
Site 11
Y91
T
K
E
E
L
D
S
Y
R
L
D
S
I
Q
A
Site 12
S95
L
D
S
Y
R
L
D
S
I
Q
A
M
N
V
A
Site 13
S113
C
S
Y
N
S
I
L
S
I
T
V
Q
E
P
G
Site 14
T126
P
G
L
P
G
T
S
T
L
L
F
Q
C
Q
E
Site 15
T141
V
G
A
E
R
L
K
T
S
L
Q
K
A
L
E
Site 16
Y183
L
P
M
E
Q
A
R
Y
L
E
P
G
I
P
P
Site 17
T197
P
E
Q
P
H
Q
R
T
L
E
H
S
L
P
P
Site 18
S201
H
Q
R
T
L
E
H
S
L
P
P
S
P
R
P
Site 19
S205
L
E
H
S
L
P
P
S
P
R
P
L
P
R
H
Site 20
T213
P
R
P
L
P
R
H
T
S
A
R
E
P
S
A
Site 21
S214
R
P
L
P
R
H
T
S
A
R
E
P
S
A
F
Site 22
S219
H
T
S
A
R
E
P
S
A
F
T
L
P
P
P
Site 23
S229
T
L
P
P
P
R
R
S
S
S
P
E
D
P
E
Site 24
S230
L
P
P
P
R
R
S
S
S
P
E
D
P
E
R
Site 25
S231
P
P
P
R
R
S
S
S
P
E
D
P
E
R
D
Site 26
T263
L
E
K
A
Q
A
K
T
S
R
K
K
K
F
G
Site 27
Y284
G
G
L
T
Q
A
Q
Y
I
D
C
F
Q
K
I
Site 28
T303
N
L
L
G
R
L
A
T
W
L
K
E
T
S
A
Site 29
S352
K
A
I
N
L
L
Q
S
C
L
S
P
P
E
S
Site 30
S355
N
L
L
Q
S
C
L
S
P
P
E
S
N
L
W
Site 31
S359
S
C
L
S
P
P
E
S
N
L
W
M
G
L
G
Site 32
S372
L
G
P
A
W
T
T
S
R
A
D
W
T
G
D
Site 33
T377
T
T
S
R
A
D
W
T
G
D
E
P
L
P
Y
Site 34
Y384
T
G
D
E
P
L
P
Y
Q
P
T
F
S
D
D
Site 35
T387
E
P
L
P
Y
Q
P
T
F
S
D
D
W
Q
L
Site 36
S389
L
P
Y
Q
P
T
F
S
D
D
W
Q
L
P
E
Site 37
S399
W
Q
L
P
E
P
S
S
Q
A
P
L
G
Y
Q
Site 38
Y405
S
S
Q
A
P
L
G
Y
Q
D
P
V
S
L
R
Site 39
S410
L
G
Y
Q
D
P
V
S
L
R
R
G
S
H
R
Site 40
S415
P
V
S
L
R
R
G
S
H
R
L
G
S
T
S
Site 41
S420
R
G
S
H
R
L
G
S
T
S
H
F
P
Q
E
Site 42
S422
S
H
R
L
G
S
T
S
H
F
P
Q
E
K
T
Site 43
T429
S
H
F
P
Q
E
K
T
H
N
H
D
P
Q
P
Site 44
S441
P
Q
P
G
D
P
N
S
R
P
S
S
P
K
P
Site 45
S444
G
D
P
N
S
R
P
S
S
P
K
P
A
Q
P
Site 46
S445
D
P
N
S
R
P
S
S
P
K
P
A
Q
P
A
Site 47
Y459
A
L
K
M
Q
V
L
Y
E
F
E
A
R
N
P
Site 48
T470
A
R
N
P
R
E
L
T
V
V
Q
G
E
K
L
Site 49
S496
V
K
N
E
A
G
R
S
G
Y
I
P
S
N
I
Site 50
Y498
N
E
A
G
R
S
G
Y
I
P
S
N
I
L
E
Site 51
S501
G
R
S
G
Y
I
P
S
N
I
L
E
P
L
Q
Site 52
T511
L
E
P
L
Q
P
G
T
P
G
T
Q
G
Q
S
Site 53
T514
L
Q
P
G
T
P
G
T
Q
G
Q
S
P
S
R
Site 54
S518
T
P
G
T
Q
G
Q
S
P
S
R
V
P
M
L
Site 55
S520
G
T
Q
G
Q
S
P
S
R
V
P
M
L
R
L
Site 56
S528
R
V
P
M
L
R
L
S
S
R
P
E
E
V
T
Site 57
S529
V
P
M
L
R
L
S
S
R
P
E
E
V
T
D
Site 58
T535
S
S
R
P
E
E
V
T
D
W
L
Q
A
E
N
Site 59
T545
L
Q
A
E
N
F
S
T
A
T
V
R
T
L
G
Site 60
S557
T
L
G
S
L
T
G
S
Q
L
L
R
I
R
P
Site 61
S580
Q
E
A
P
R
I
L
S
R
L
E
A
V
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation