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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EPS8L1
Full Name:
Epidermal growth factor receptor kinase substrate 8-like protein 1
Alias:
DRC3; Epidermal growth factor receptor pathway substrate 8-like protein 1; Epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-like 1; EPS8R1; EPS8-related protein 1; ES8L1; FLJ20258; MGC23164; MGC4642; PP10566
Type:
Adaptor/scaffold
Mass (Da):
80309
Number AA:
723
UniProt ID:
Q8TE68
International Prot ID:
IPI00301250
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y19
K
P
S
A
K
S
I
Y
E
Q
R
K
R
Y
S
Site 2
Y25
I
Y
E
Q
R
K
R
Y
S
T
V
V
M
A
D
Site 3
S26
Y
E
Q
R
K
R
Y
S
T
V
V
M
A
D
V
Site 4
T27
E
Q
R
K
R
Y
S
T
V
V
M
A
D
V
S
Site 5
T43
Y
P
V
N
H
L
V
T
F
C
L
G
E
D
D
Site 6
T54
G
E
D
D
G
V
H
T
V
E
D
A
S
R
K
Site 7
S67
R
K
L
A
V
M
D
S
Q
G
R
V
W
A
Q
Site 8
T86
R
V
S
P
D
H
V
T
L
L
D
P
A
S
K
Site 9
S92
V
T
L
L
D
P
A
S
K
E
E
L
E
S
Y
Site 10
Y99
S
K
E
E
L
E
S
Y
P
L
G
A
I
V
R
Site 11
Y158
I
Q
G
A
L
H
N
Y
R
S
G
R
G
E
R
Site 12
S160
G
A
L
H
N
Y
R
S
G
R
G
E
R
R
A
Site 13
T173
R
A
A
A
L
R
A
T
Q
E
E
L
Q
R
D
Site 14
S182
E
E
L
Q
R
D
R
S
P
A
A
E
T
P
P
Site 15
T187
D
R
S
P
A
A
E
T
P
P
L
Q
R
R
P
Site 16
S195
P
P
L
Q
R
R
P
S
V
R
A
V
I
S
T
Site 17
T202
S
V
R
A
V
I
S
T
V
E
R
G
A
G
R
Site 18
T231
Q
R
P
E
P
V
G
T
S
S
N
A
D
S
A
Site 19
S233
P
E
P
V
G
T
S
S
N
A
D
S
A
S
P
Site 20
S237
G
T
S
S
N
A
D
S
A
S
P
D
L
G
P
Site 21
S239
S
S
N
A
D
S
A
S
P
D
L
G
P
R
G
Site 22
S270
H
V
F
D
D
V
E
S
F
V
S
R
L
Q
K
Site 23
S273
D
D
V
E
S
F
V
S
R
L
Q
K
S
A
E
Site 24
S294
H
R
E
R
G
R
R
S
R
R
R
A
A
G
E
Site 25
T305
A
A
G
E
G
L
L
T
L
R
A
K
P
P
S
Site 26
S312
T
L
R
A
K
P
P
S
E
A
E
Y
T
D
V
Site 27
Y316
K
P
P
S
E
A
E
Y
T
D
V
L
Q
K
I
Site 28
T317
P
P
S
E
A
E
Y
T
D
V
L
Q
K
I
K
Site 29
S328
Q
K
I
K
Y
A
F
S
L
L
A
R
L
R
G
Site 30
S341
R
G
N
I
A
D
P
S
S
P
E
L
L
H
F
Site 31
S342
G
N
I
A
D
P
S
S
P
E
L
L
H
F
L
Site 32
S367
S
G
G
P
E
F
A
S
S
V
R
R
P
H
L
Site 33
S368
G
G
P
E
F
A
S
S
V
R
R
P
H
L
T
Site 34
S376
V
R
R
P
H
L
T
S
D
A
V
A
L
L
R
Site 35
T387
A
L
L
R
D
N
V
T
P
R
E
N
E
L
W
Site 36
S396
R
E
N
E
L
W
T
S
L
G
D
S
W
T
R
Site 37
S400
L
W
T
S
L
G
D
S
W
T
R
P
G
L
E
Site 38
T402
T
S
L
G
D
S
W
T
R
P
G
L
E
L
S
Site 39
S409
T
R
P
G
L
E
L
S
P
E
E
G
P
P
Y
Site 40
Y416
S
P
E
E
G
P
P
Y
R
P
E
F
F
S
G
Site 41
S422
P
Y
R
P
E
F
F
S
G
W
E
P
P
V
T
Site 42
T429
S
G
W
E
P
P
V
T
D
P
Q
S
R
A
W
Site 43
S433
P
P
V
T
D
P
Q
S
R
A
W
E
D
P
V
Site 44
S454
E
R
R
R
R
Q
Q
S
A
P
Q
V
A
V
N
Site 45
S470
H
R
D
L
E
P
E
S
E
P
Q
L
E
S
E
Site 46
S476
E
S
E
P
Q
L
E
S
E
T
A
G
K
W
V
Site 47
Y487
G
K
W
V
L
C
N
Y
D
F
Q
A
R
N
S
Site 48
S494
Y
D
F
Q
A
R
N
S
S
E
L
S
V
K
Q
Site 49
S495
D
F
Q
A
R
N
S
S
E
L
S
V
K
Q
R
Site 50
S498
A
R
N
S
S
E
L
S
V
K
Q
R
D
V
L
Site 51
Y526
D
P
A
G
Q
E
G
Y
V
P
Y
N
I
L
T
Site 52
Y529
G
Q
E
G
Y
V
P
Y
N
I
L
T
P
Y
P
Site 53
T533
Y
V
P
Y
N
I
L
T
P
Y
P
G
P
R
L
Site 54
Y535
P
Y
N
I
L
T
P
Y
P
G
P
R
L
H
H
Site 55
S543
P
G
P
R
L
H
H
S
Q
S
P
A
R
S
L
Site 56
S545
P
R
L
H
H
S
Q
S
P
A
R
S
L
N
S
Site 57
S549
H
S
Q
S
P
A
R
S
L
N
S
T
P
P
P
Site 58
S552
S
P
A
R
S
L
N
S
T
P
P
P
P
P
A
Site 59
T553
P
A
R
S
L
N
S
T
P
P
P
P
P
A
P
Site 60
S580
W
D
R
P
R
W
D
S
C
D
S
L
N
G
L
Site 61
S583
P
R
W
D
S
C
D
S
L
N
G
L
D
P
S
Site 62
S590
S
L
N
G
L
D
P
S
E
K
E
K
F
S
Q
Site 63
S596
P
S
E
K
E
K
F
S
Q
M
L
I
V
N
E
Site 64
S617
A
Q
G
R
S
G
P
S
R
A
V
P
G
P
R
Site 65
S631
R
A
P
E
P
Q
L
S
P
G
S
D
A
S
E
Site 66
S634
E
P
Q
L
S
P
G
S
D
A
S
E
V
R
A
Site 67
S637
L
S
P
G
S
D
A
S
E
V
R
A
W
L
Q
Site 68
T660
V
D
A
L
G
V
L
T
G
A
Q
L
F
S
L
Site 69
S666
L
T
G
A
Q
L
F
S
L
Q
R
E
E
L
R
Site 70
S676
R
E
E
L
R
A
V
S
P
E
E
G
A
R
V
Site 71
Y684
P
E
E
G
A
R
V
Y
S
Q
V
T
V
Q
R
Site 72
S685
E
E
G
A
R
V
Y
S
Q
V
T
V
Q
R
S
Site 73
T688
A
R
V
Y
S
Q
V
T
V
Q
R
S
L
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation