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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Sh3rf2
Full Name:
Putative E3 ubiquitin-protein ligase SH3RF2
Alias:
Flj23654; Mgc149788; Mgc149789; Mgc90410; RING finger protein 158; Rnf158; Sh3 domain containing ring finger 2; SH3 domain-containing RING finger protein 2
Type:
EC 6.3.2.-; Ligase
Mass (Da):
79232
Number AA:
729
UniProt ID:
Q8TEC5
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
K
V
L
P
C
Q
H
T
F
C
K
P
C
L
Q
Site 2
T54
L
R
C
P
E
C
R
T
P
V
F
S
N
I
E
Site 3
S78
R
L
L
D
G
V
R
S
G
Q
S
S
G
R
G
Site 4
S81
D
G
V
R
S
G
Q
S
S
G
R
G
G
S
F
Site 5
S82
G
V
R
S
G
Q
S
S
G
R
G
G
S
F
R
Site 6
S87
Q
S
S
G
R
G
G
S
F
R
R
P
G
T
M
Site 7
T93
G
S
F
R
R
P
G
T
M
T
L
Q
D
G
R
Site 8
T95
F
R
R
P
G
T
M
T
L
Q
D
G
R
K
S
Site 9
S102
T
L
Q
D
G
R
K
S
R
T
N
P
R
R
L
Site 10
T104
Q
D
G
R
K
S
R
T
N
P
R
R
L
Q
A
Site 11
S112
N
P
R
R
L
Q
A
S
P
F
R
L
V
P
N
Site 12
Y136
R
A
K
A
L
C
N
Y
R
G
Q
N
P
G
D
Site 13
Y163
R
Q
L
D
E
N
W
Y
Q
G
E
I
N
G
I
Site 14
S171
Q
G
E
I
N
G
I
S
G
N
F
P
A
S
S
Site 15
S178
S
G
N
F
P
A
S
S
V
E
V
I
K
Q
L
Site 16
Y196
P
P
L
C
R
A
L
Y
N
F
D
L
R
G
K
Site 17
S206
D
L
R
G
K
D
K
S
E
N
Q
D
C
L
T
Site 18
T213
S
E
N
Q
D
C
L
T
F
L
K
D
D
I
I
Site 19
T252
L
F
V
E
P
N
L
T
A
R
H
L
L
E
K
Site 20
S265
E
K
N
K
G
R
Q
S
S
C
T
K
N
L
S
Site 21
S266
K
N
K
G
R
Q
S
S
C
T
K
N
L
S
L
Site 22
T268
K
G
R
Q
S
S
C
T
K
N
L
S
L
V
S
Site 23
S272
S
S
C
T
K
N
L
S
L
V
S
S
S
S
R
Site 24
S275
T
K
N
L
S
L
V
S
S
S
S
R
G
N
T
Site 25
S276
K
N
L
S
L
V
S
S
S
S
R
G
N
T
S
Site 26
S277
N
L
S
L
V
S
S
S
S
R
G
N
T
S
T
Site 27
S278
L
S
L
V
S
S
S
S
R
G
N
T
S
T
L
Site 28
T282
S
S
S
S
R
G
N
T
S
T
L
R
R
G
P
Site 29
S283
S
S
S
R
G
N
T
S
T
L
R
R
G
P
G
Site 30
T284
S
S
R
G
N
T
S
T
L
R
R
G
P
G
S
Site 31
S291
T
L
R
R
G
P
G
S
R
R
K
V
P
G
Q
Site 32
T307
S
I
T
T
A
L
N
T
L
N
R
M
V
H
S
Site 33
S314
T
L
N
R
M
V
H
S
P
S
G
R
H
M
V
Site 34
S316
N
R
M
V
H
S
P
S
G
R
H
M
V
E
I
Site 35
S335
L
I
S
S
S
N
P
S
V
I
T
Q
P
M
E
Site 36
S348
M
E
K
A
D
V
P
S
S
C
V
G
Q
V
S
Site 37
S349
E
K
A
D
V
P
S
S
C
V
G
Q
V
S
T
Site 38
S355
S
S
C
V
G
Q
V
S
T
Y
H
P
A
P
V
Site 39
T356
S
C
V
G
Q
V
S
T
Y
H
P
A
P
V
S
Site 40
S363
T
Y
H
P
A
P
V
S
P
G
H
S
T
A
V
Site 41
S372
G
H
S
T
A
V
V
S
L
P
G
S
Q
Q
H
Site 42
S376
A
V
V
S
L
P
G
S
Q
Q
H
L
S
A
N
Site 43
S390
N
M
F
V
A
L
H
S
Y
S
A
H
G
P
D
Site 44
T443
V
I
P
I
F
R
K
T
S
S
F
P
D
S
R
Site 45
S444
I
P
I
F
R
K
T
S
S
F
P
D
S
R
S
Site 46
S445
P
I
F
R
K
T
S
S
F
P
D
S
R
S
P
Site 47
S449
K
T
S
S
F
P
D
S
R
S
P
G
L
Y
T
Site 48
S451
S
S
F
P
D
S
R
S
P
G
L
Y
T
T
W
Site 49
Y455
D
S
R
S
P
G
L
Y
T
T
W
T
L
S
T
Site 50
T456
S
R
S
P
G
L
Y
T
T
W
T
L
S
T
S
Site 51
T457
R
S
P
G
L
Y
T
T
W
T
L
S
T
S
S
Site 52
T459
P
G
L
Y
T
T
W
T
L
S
T
S
S
V
S
Site 53
S461
L
Y
T
T
W
T
L
S
T
S
S
V
S
S
Q
Site 54
T462
Y
T
T
W
T
L
S
T
S
S
V
S
S
Q
G
Site 55
S463
T
T
W
T
L
S
T
S
S
V
S
S
Q
G
S
Site 56
S464
T
W
T
L
S
T
S
S
V
S
S
Q
G
S
I
Site 57
S466
T
L
S
T
S
S
V
S
S
Q
G
S
I
S
E
Site 58
S467
L
S
T
S
S
V
S
S
Q
G
S
I
S
E
G
Site 59
S470
S
S
V
S
S
Q
G
S
I
S
E
G
D
P
R
Site 60
S472
V
S
S
Q
G
S
I
S
E
G
D
P
R
Q
S
Site 61
S479
S
E
G
D
P
R
Q
S
R
P
F
K
S
V
F
Site 62
S484
R
Q
S
R
P
F
K
S
V
F
V
P
T
A
I
Site 63
T503
R
S
T
A
G
P
G
T
L
G
Q
G
S
L
R
Site 64
S508
P
G
T
L
G
Q
G
S
L
R
K
G
R
S
S
Site 65
S514
G
S
L
R
K
G
R
S
S
M
R
K
N
G
S
Site 66
S515
S
L
R
K
G
R
S
S
M
R
K
N
G
S
L
Site 67
S521
S
S
M
R
K
N
G
S
L
Q
R
P
L
Q
S
Site 68
T543
G
S
L
R
R
S
P
T
M
V
L
R
P
Q
Q
Site 69
Y554
R
P
Q
Q
F
Q
F
Y
Q
P
Q
G
I
P
S
Site 70
S562
Q
P
Q
G
I
P
S
S
P
S
A
V
V
V
E
Site 71
T583
L
T
G
E
P
A
L
T
C
I
S
R
G
S
E
Site 72
S589
L
T
C
I
S
R
G
S
E
A
R
I
H
S
A
Site 73
S599
R
I
H
S
A
A
S
S
L
I
M
E
D
K
E
Site 74
S611
D
K
E
I
P
I
K
S
E
P
L
P
K
P
P
Site 75
S624
P
P
A
S
A
P
P
S
I
L
V
K
P
E
N
Site 76
T642
G
I
E
K
Q
V
K
T
V
R
F
Q
N
Y
S
Site 77
Y648
K
T
V
R
F
Q
N
Y
S
P
P
P
T
K
H
Site 78
S649
T
V
R
F
Q
N
Y
S
P
P
P
T
K
H
Y
Site 79
T653
Q
N
Y
S
P
P
P
T
K
H
Y
T
S
H
P
Site 80
Y656
S
P
P
P
T
K
H
Y
T
S
H
P
T
S
G
Site 81
T657
P
P
P
T
K
H
Y
T
S
H
P
T
S
G
K
Site 82
S658
P
P
T
K
H
Y
T
S
H
P
T
S
G
K
P
Site 83
S662
H
Y
T
S
H
P
T
S
G
K
P
E
Q
P
A
Site 84
T670
G
K
P
E
Q
P
A
T
L
K
A
S
Q
P
E
Site 85
S680
A
S
Q
P
E
A
A
S
L
G
P
E
M
T
V
Site 86
S693
T
V
L
F
A
H
R
S
G
C
H
S
G
Q
Q
Site 87
S697
A
H
R
S
G
C
H
S
G
Q
Q
T
D
L
R
Site 88
T701
G
C
H
S
G
Q
Q
T
D
L
R
R
K
S
A
Site 89
S707
Q
T
D
L
R
R
K
S
A
L
A
K
A
T
T
Site 90
S717
A
K
A
T
T
L
V
S
T
A
S
G
T
Q
T
Site 91
T722
L
V
S
T
A
S
G
T
Q
T
V
F
P
S
K
Site 92
T724
S
T
A
S
G
T
Q
T
V
F
P
S
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation