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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DENND1A
Full Name:
DENN domain-containing protein 1A
Alias:
Connecdenn; Protein FAM31A
Type:
Mass (Da):
110577
Number AA:
1009
UniProt ID:
Q8TEH3
International Prot ID:
IPI00170641
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030054
GO:0019898
GO:0045202
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T12
I
K
Q
N
P
E
T
T
F
E
V
Y
V
E
V
Site 2
Y16
P
E
T
T
F
E
V
Y
V
E
V
A
Y
P
R
Site 3
Y21
E
V
Y
V
E
V
A
Y
P
R
T
G
G
T
L
Site 4
S29
P
R
T
G
G
T
L
S
D
P
E
V
Q
R
Q
Site 5
Y41
Q
R
Q
F
P
E
D
Y
S
D
Q
E
V
L
Q
Site 6
S42
R
Q
F
P
E
D
Y
S
D
Q
E
V
L
Q
T
Site 7
T49
S
D
Q
E
V
L
Q
T
L
T
K
F
C
F
P
Site 8
T63
P
F
Y
V
D
S
L
T
V
S
Q
V
G
Q
N
Site 9
S65
Y
V
D
S
L
T
V
S
Q
V
G
Q
N
F
T
Site 10
T76
Q
N
F
T
F
V
L
T
D
I
D
S
K
Q
R
Site 11
S90
R
F
G
F
C
R
L
S
S
G
A
K
S
C
F
Site 12
Y119
L
L
N
I
L
A
D
Y
T
T
K
R
Q
E
N
Site 13
T120
L
N
I
L
A
D
Y
T
T
K
R
Q
E
N
Q
Site 14
T134
Q
W
N
E
L
L
E
T
L
H
K
L
P
I
P
Site 15
Y154
V
H
L
S
V
H
S
Y
F
T
V
P
D
T
R
Site 16
T160
S
Y
F
T
V
P
D
T
R
E
L
P
S
I
P
Site 17
T173
I
P
E
N
R
N
L
T
E
Y
F
V
A
V
D
Site 18
Y175
E
N
R
N
L
T
E
Y
F
V
A
V
D
V
N
Site 19
Y188
V
N
N
M
L
H
L
Y
A
S
M
L
Y
E
R
Site 20
S202
R
R
I
L
I
I
C
S
K
L
S
T
L
T
A
Site 21
T277
V
D
T
N
T
L
E
T
P
F
D
D
L
Q
S
Site 22
S284
T
P
F
D
D
L
Q
S
L
P
N
D
V
I
S
Site 23
S292
L
P
N
D
V
I
S
S
L
K
N
R
L
K
K
Site 24
S301
K
N
R
L
K
K
V
S
T
T
T
G
D
G
V
Site 25
S348
A
F
V
S
H
Y
R
S
G
A
M
R
Q
F
L
Site 26
S377
G
R
L
D
L
L
N
S
G
E
G
F
S
D
V
Site 27
Y394
E
E
I
N
M
G
E
Y
A
G
S
D
K
L
Y
Site 28
Y401
Y
A
G
S
D
K
L
Y
H
Q
W
L
S
T
V
Site 29
S406
K
L
Y
H
Q
W
L
S
T
V
R
K
G
S
G
Site 30
T407
L
Y
H
Q
W
L
S
T
V
R
K
G
S
G
A
Site 31
T418
G
S
G
A
I
L
N
T
V
K
T
K
A
N
P
Site 32
T421
A
I
L
N
T
V
K
T
K
A
N
P
A
M
K
Site 33
T429
K
A
N
P
A
M
K
T
V
Y
K
F
A
K
D
Site 34
T462
A
E
N
G
C
A
P
T
P
E
E
Q
L
P
K
Site 35
T470
P
E
E
Q
L
P
K
T
A
P
S
P
L
V
E
Site 36
S473
Q
L
P
K
T
A
P
S
P
L
V
E
A
K
D
Site 37
T491
R
E
D
R
R
P
I
T
V
H
F
G
Q
V
R
Site 38
S510
H
V
V
K
R
P
K
S
N
I
A
V
E
G
R
Site 39
T519
I
A
V
E
G
R
R
T
S
V
P
S
P
E
Q
Site 40
S520
A
V
E
G
R
R
T
S
V
P
S
P
E
Q
P
Site 41
S523
G
R
R
T
S
V
P
S
P
E
Q
P
Q
P
Y
Site 42
Y530
S
P
E
Q
P
Q
P
Y
R
T
L
R
E
S
D
Site 43
T532
E
Q
P
Q
P
Y
R
T
L
R
E
S
D
S
A
Site 44
S536
P
Y
R
T
L
R
E
S
D
S
A
E
G
D
E
Site 45
S538
R
T
L
R
E
S
D
S
A
E
G
D
E
A
E
Site 46
S546
A
E
G
D
E
A
E
S
P
E
Q
Q
V
R
K
Site 47
S554
P
E
Q
Q
V
R
K
S
T
G
P
V
P
A
P
Site 48
T555
E
Q
Q
V
R
K
S
T
G
P
V
P
A
P
P
Site 49
S567
A
P
P
D
R
A
A
S
I
D
L
L
E
D
V
Site 50
S592
Q
P
L
G
Q
A
K
S
L
E
D
L
R
A
P
Site 51
T608
D
L
R
E
Q
P
G
T
F
D
Y
Q
R
L
D
Site 52
Y611
E
Q
P
G
T
F
D
Y
Q
R
L
D
L
G
G
Site 53
S619
Q
R
L
D
L
G
G
S
E
R
S
R
G
V
T
Site 54
T626
S
E
R
S
R
G
V
T
V
A
L
K
L
T
H
Site 55
S650
Q
D
D
M
A
I
P
S
K
P
P
A
A
S
P
Site 56
S656
P
S
K
P
P
A
A
S
P
E
K
P
S
A
L
Site 57
S667
P
S
A
L
L
G
N
S
L
A
L
P
R
R
P
Site 58
S679
R
R
P
Q
N
R
D
S
I
L
N
P
S
D
K
Site 59
S684
R
D
S
I
L
N
P
S
D
K
E
E
V
P
T
Site 60
T691
S
D
K
E
E
V
P
T
P
T
L
G
S
I
T
Site 61
T707
P
R
P
Q
G
R
K
T
P
E
L
G
I
V
P
Site 62
S735
G
A
A
L
G
D
V
S
E
R
L
Q
T
D
R
Site 63
T740
D
V
S
E
R
L
Q
T
D
R
D
R
R
A
A
Site 64
S749
R
D
R
R
A
A
L
S
P
G
L
L
P
G
V
Site 65
S769
T
E
L
L
Q
P
L
S
P
G
P
G
A
A
G
Site 66
S794
D
P
L
S
T
A
W
S
G
S
T
L
P
S
R
Site 67
S796
L
S
T
A
W
S
G
S
T
L
P
S
R
P
A
Site 68
T797
S
T
A
W
S
G
S
T
L
P
S
R
P
A
T
Site 69
S800
W
S
G
S
T
L
P
S
R
P
A
T
P
N
V
Site 70
T804
T
L
P
S
R
P
A
T
P
N
V
A
T
P
F
Site 71
T809
P
A
T
P
N
V
A
T
P
F
T
P
Q
F
S
Site 72
T812
P
N
V
A
T
P
F
T
P
Q
F
S
F
P
P
Site 73
S816
T
P
F
T
P
Q
F
S
F
P
P
A
G
T
P
Site 74
T822
F
S
F
P
P
A
G
T
P
T
P
F
P
Q
P
Site 75
T824
F
P
P
A
G
T
P
T
P
F
P
Q
P
P
L
Site 76
S883
G
F
C
A
P
H
R
S
Q
P
N
L
S
A
L
Site 77
S888
H
R
S
Q
P
N
L
S
A
L
S
M
P
N
L
Site 78
S891
Q
P
N
L
S
A
L
S
M
P
N
L
F
G
Q
Site 79
S906
M
P
M
G
T
H
T
S
P
L
Q
P
L
G
P
Site 80
T923
V
A
P
S
R
I
R
T
L
P
L
A
R
S
S
Site 81
S929
R
T
L
P
L
A
R
S
S
A
R
A
A
E
T
Site 82
S930
T
L
P
L
A
R
S
S
A
R
A
A
E
T
K
Site 83
T961
P
P
Q
G
L
E
P
T
L
Q
P
S
A
P
Q
Site 84
S965
L
E
P
T
L
Q
P
S
A
P
Q
Q
A
R
D
Site 85
S986
Q
K
T
K
Q
D
V
S
P
S
P
A
L
A
P
Site 86
S988
T
K
Q
D
V
S
P
S
P
A
L
A
P
A
P
Site 87
S997
A
L
A
P
A
P
D
S
V
E
Q
L
R
K
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation