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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3MD4
Full Name:
SH3 domain-containing RING finger protein 3
Alias:
FLJ00204; POSH2; SH3 domain containing ring finger 3; SH3 multiple domains 4
Type:
Mass (Da):
92776
Number AA:
882
UniProt ID:
Q8TEJ3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T38
R
R
R
R
A
A
A
T
A
A
G
A
G
E
D
Site 2
S49
A
G
E
D
M
D
E
S
S
L
L
D
L
L
E
Site 3
S50
G
E
D
M
D
E
S
S
L
L
D
L
L
E
C
Site 4
T67
C
L
E
R
L
D
T
T
A
K
V
L
P
C
Q
Site 5
S88
C
L
E
S
I
V
C
S
R
H
E
L
R
C
P
Site 6
T129
R
Q
R
P
R
A
G
T
S
P
G
G
S
P
P
Site 7
S130
Q
R
P
R
A
G
T
S
P
G
G
S
P
P
A
Site 8
S134
A
G
T
S
P
G
G
S
P
P
A
R
P
I
P
Site 9
S144
A
R
P
I
P
G
Q
S
A
A
P
T
L
A
G
Site 10
T148
P
G
Q
S
A
A
P
T
L
A
G
G
G
G
G
Site 11
S177
A
A
G
S
T
A
G
S
L
R
E
L
A
T
S
Site 12
T183
G
S
L
R
E
L
A
T
S
R
T
A
P
A
A
Site 13
S184
S
L
R
E
L
A
T
S
R
T
A
P
A
A
K
Site 14
Y198
K
N
P
C
L
L
P
Y
G
K
A
L
Y
S
Y
Site 15
S204
P
Y
G
K
A
L
Y
S
Y
E
G
K
E
P
G
Site 16
Y205
Y
G
K
A
L
Y
S
Y
E
G
K
E
P
G
D
Site 17
Y232
R
K
V
D
E
Q
W
Y
H
G
E
L
H
G
T
Site 18
T239
Y
H
G
E
L
H
G
T
Q
G
F
L
P
A
S
Site 19
Y265
P
P
Q
G
K
A
L
Y
D
F
E
M
K
D
K
Site 20
T280
D
Q
D
K
D
C
L
T
F
T
K
D
E
I
L
Site 21
T288
F
T
K
D
E
I
L
T
V
L
R
R
V
D
E
Site 22
S319
L
Y
V
E
L
N
D
S
A
K
Q
L
I
E
M
Site 23
S340
A
A
S
S
C
N
A
S
L
P
S
D
S
G
A
Site 24
S343
S
C
N
A
S
L
P
S
D
S
G
A
V
A
S
Site 25
S360
P
S
P
T
L
S
S
S
G
A
V
S
A
F
Q
Site 26
S364
L
S
S
S
G
A
V
S
A
F
Q
R
R
V
D
Site 27
S381
K
N
T
K
K
R
H
S
F
T
A
L
S
V
T
Site 28
T383
T
K
K
R
H
S
F
T
A
L
S
V
T
H
R
Site 29
S386
R
H
S
F
T
A
L
S
V
T
H
R
S
S
Q
Site 30
T388
S
F
T
A
L
S
V
T
H
R
S
S
Q
A
A
Site 31
S391
A
L
S
V
T
H
R
S
S
Q
A
A
S
H
R
Site 32
S392
L
S
V
T
H
R
S
S
Q
A
A
S
H
R
H
Site 33
S396
H
R
S
S
Q
A
A
S
H
R
H
S
M
E
I
Site 34
S400
Q
A
A
S
H
R
H
S
M
E
I
S
A
P
V
Site 35
S404
H
R
H
S
M
E
I
S
A
P
V
L
I
S
S
Site 36
S412
A
P
V
L
I
S
S
S
D
P
R
A
A
A
R
Site 37
T432
H
L
S
C
A
A
P
T
Q
D
V
S
S
S
A
Site 38
S436
A
A
P
T
Q
D
V
S
S
S
A
G
S
T
P
Site 39
S437
A
P
T
Q
D
V
S
S
S
A
G
S
T
P
T
Site 40
S438
P
T
Q
D
V
S
S
S
A
G
S
T
P
T
A
Site 41
S441
D
V
S
S
S
A
G
S
T
P
T
A
V
P
R
Site 42
T442
V
S
S
S
A
G
S
T
P
T
A
V
P
R
A
Site 43
T444
S
S
A
G
S
T
P
T
A
V
P
R
A
A
S
Site 44
S451
T
A
V
P
R
A
A
S
V
S
G
E
Q
G
T
Site 45
S453
V
P
R
A
A
S
V
S
G
E
Q
G
T
P
P
Site 46
T458
S
V
S
G
E
Q
G
T
P
P
K
V
Q
L
P
Site 47
Y469
V
Q
L
P
L
N
V
Y
L
A
L
Y
A
Y
K
Site 48
Y473
L
N
V
Y
L
A
L
Y
A
Y
K
P
Q
K
S
Site 49
S480
Y
A
Y
K
P
Q
K
S
D
E
L
E
L
H
K
Site 50
S506
D
G
W
F
K
G
A
S
L
R
T
G
V
S
G
Site 51
S524
G
N
Y
V
T
P
V
S
R
V
P
A
G
G
A
Site 52
S542
R
N
N
V
V
G
G
S
P
L
A
K
G
I
T
Site 53
T549
S
P
L
A
K
G
I
T
T
T
M
H
P
G
S
Site 54
T551
L
A
K
G
I
T
T
T
M
H
P
G
S
G
S
Site 55
S556
T
T
T
M
H
P
G
S
G
S
L
S
S
L
A
Site 56
S558
T
M
H
P
G
S
G
S
L
S
S
L
A
T
A
Site 57
S560
H
P
G
S
G
S
L
S
S
L
A
T
A
T
R
Site 58
S561
P
G
S
G
S
L
S
S
L
A
T
A
T
R
P
Site 59
T574
R
P
A
L
P
I
T
T
P
Q
A
H
A
Q
H
Site 60
T583
Q
A
H
A
Q
H
P
T
A
S
P
P
T
G
S
Site 61
S585
H
A
Q
H
P
T
A
S
P
P
T
G
S
C
L
Site 62
S590
T
A
S
P
P
T
G
S
C
L
R
H
S
A
Q
Site 63
S595
T
G
S
C
L
R
H
S
A
Q
P
T
A
S
Q
Site 64
T599
L
R
H
S
A
Q
P
T
A
S
Q
A
R
S
T
Site 65
S601
H
S
A
Q
P
T
A
S
Q
A
R
S
T
I
S
Site 66
S605
P
T
A
S
Q
A
R
S
T
I
S
T
A
A
H
Site 67
T606
T
A
S
Q
A
R
S
T
I
S
T
A
A
H
S
Site 68
S608
S
Q
A
R
S
T
I
S
T
A
A
H
S
A
A
Site 69
T609
Q
A
R
S
T
I
S
T
A
A
H
S
A
A
Q
Site 70
T622
A
Q
A
Q
D
R
P
T
A
T
V
S
P
L
R
Site 71
T624
A
Q
D
R
P
T
A
T
V
S
P
L
R
T
Q
Site 72
S626
D
R
P
T
A
T
V
S
P
L
R
T
Q
N
S
Site 73
T630
A
T
V
S
P
L
R
T
Q
N
S
P
S
R
L
Site 74
S633
S
P
L
R
T
Q
N
S
P
S
R
L
P
A
T
Site 75
S635
L
R
T
Q
N
S
P
S
R
L
P
A
T
S
L
Site 76
T640
S
P
S
R
L
P
A
T
S
L
R
P
H
S
V
Site 77
S641
P
S
R
L
P
A
T
S
L
R
P
H
S
V
V
Site 78
S646
A
T
S
L
R
P
H
S
V
V
S
P
Q
H
S
Site 79
S649
L
R
P
H
S
V
V
S
P
Q
H
S
H
Q
P
Site 80
S653
S
V
V
S
P
Q
H
S
H
Q
P
P
V
Q
M
Site 81
S698
G
G
P
I
G
V
L
S
T
S
S
P
T
N
T
Site 82
T699
G
P
I
G
V
L
S
T
S
S
P
T
N
T
G
Site 83
S701
I
G
V
L
S
T
S
S
P
T
N
T
G
C
K
Site 84
T705
S
T
S
S
P
T
N
T
G
C
K
L
D
E
K
Site 85
S714
C
K
L
D
E
K
K
S
E
K
K
E
K
K
S
Site 86
S721
S
E
K
K
E
K
K
S
G
L
L
K
L
L
A
Site 87
S731
L
K
L
L
A
G
A
S
T
K
K
K
S
R
S
Site 88
T732
K
L
L
A
G
A
S
T
K
K
K
S
R
S
P
Site 89
S736
G
A
S
T
K
K
K
S
R
S
P
P
S
V
S
Site 90
S738
S
T
K
K
K
S
R
S
P
P
S
V
S
P
T
Site 91
S741
K
K
S
R
S
P
P
S
V
S
P
T
H
D
P
Site 92
S743
S
R
S
P
P
S
V
S
P
T
H
D
P
Q
V
Site 93
T745
S
P
P
S
V
S
P
T
H
D
P
Q
V
A
V
Site 94
S768
G
P
E
V
S
S
L
S
I
H
G
R
A
G
S
Site 95
S775
S
I
H
G
R
A
G
S
C
P
I
E
S
E
M
Site 96
S780
A
G
S
C
P
I
E
S
E
M
Q
G
A
M
G
Site 97
S797
P
L
H
R
K
A
G
S
L
D
L
N
F
T
S
Site 98
S804
S
L
D
L
N
F
T
S
P
S
R
Q
A
P
L
Site 99
S806
D
L
N
F
T
S
P
S
R
Q
A
P
L
S
M
Site 100
S812
P
S
R
Q
A
P
L
S
M
A
A
I
R
P
E
Site 101
Y828
K
L
L
P
R
E
R
Y
R
V
V
V
S
Y
P
Site 102
S833
E
R
Y
R
V
V
V
S
Y
P
P
Q
S
E
A
Site 103
Y834
R
Y
R
V
V
V
S
Y
P
P
Q
S
E
A
E
Site 104
S838
V
V
S
Y
P
P
Q
S
E
A
E
I
E
L
K
Site 105
Y861
K
K
R
E
D
G
W
Y
K
G
T
L
Q
R
N
Site 106
T864
E
D
G
W
Y
K
G
T
L
Q
R
N
G
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation