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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRPC4AP
Full Name:
Short transient receptor potential channel 4-associated protein
Alias:
C20orf188; DJ756N5.2; DKFZp586C1223; DKFZP727M231; Short transient receptor potential channel 4 associated protein; TAP1; TAP1 protein; TNF-receptor ubiquitous scaffolding/signaling protein; TP4AP; Transient receptor potential cation channel, subfamily C, member 4 associated protein; Trpc4-associated protein; TRRP4AP; TRUSS
Type:
Adaptor/scaffold
Mass (Da):
90852
Number AA:
797
UniProt ID:
Q8TEL6
International Prot ID:
IPI00152769
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005788
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042288
GO:0046978
PhosphoSite+
KinaseNET
Biological Process:
GO:0019885
GO:0046967
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
A
A
P
V
A
A
G
S
G
A
G
R
G
R
R
Site 2
S18
G
A
G
R
G
R
R
S
A
A
T
V
A
A
W
Site 3
T21
R
G
R
R
S
A
A
T
V
A
A
W
G
G
W
Site 4
T47
Q
L
R
Q
G
Q
L
T
G
R
G
L
V
R
A
Site 5
T60
R
A
V
Q
F
T
E
T
F
L
T
E
R
D
K
Site 6
T63
Q
F
T
E
T
F
L
T
E
R
D
K
Q
S
K
Site 7
S69
L
T
E
R
D
K
Q
S
K
W
S
G
I
P
Q
Site 8
T83
Q
L
L
L
K
L
H
T
T
S
H
L
H
S
D
Site 9
T120
V
T
E
E
R
K
L
T
Q
E
T
T
Y
P
N
Site 10
T123
E
R
K
L
T
Q
E
T
T
Y
P
N
T
Y
I
Site 11
Y125
K
L
T
Q
E
T
T
Y
P
N
T
Y
I
F
D
Site 12
T148
V
E
I
L
M
R
P
T
I
S
I
R
G
Q
K
Site 13
S150
I
L
M
R
P
T
I
S
I
R
G
Q
K
L
K
Site 14
S159
R
G
Q
K
L
K
I
S
D
E
M
S
K
D
C
Site 15
S231
L
D
E
V
P
N
L
S
S
L
V
S
N
F
D
Site 16
S232
D
E
V
P
N
L
S
S
L
V
S
N
F
D
Q
Site 17
S235
P
N
L
S
S
L
V
S
N
F
D
Q
Q
Q
L
Site 18
S254
R
I
L
A
V
T
I
S
E
M
D
T
G
N
D
Site 19
T258
V
T
I
S
E
M
D
T
G
N
D
D
K
H
T
Site 20
T265
T
G
N
D
D
K
H
T
L
L
A
K
N
A
Q
Site 21
S276
K
N
A
Q
Q
K
K
S
L
S
L
G
P
S
A
Site 22
S278
A
Q
Q
K
K
S
L
S
L
G
P
S
A
A
E
Site 23
S282
K
S
L
S
L
G
P
S
A
A
E
I
N
Q
A
Site 24
T306
E
R
L
C
K
L
A
T
R
K
V
S
E
S
T
Site 25
S310
K
L
A
T
R
K
V
S
E
S
T
G
T
A
S
Site 26
S312
A
T
R
K
V
S
E
S
T
G
T
A
S
F
L
Site 27
S317
S
E
S
T
G
T
A
S
F
L
Q
E
L
E
E
Site 28
S352
E
S
E
H
N
Q
A
S
I
V
F
P
P
P
G
Site 29
S361
V
F
P
P
P
G
A
S
E
E
N
G
L
P
H
Site 30
S370
E
N
G
L
P
H
T
S
A
R
T
Q
L
P
Q
Site 31
T373
L
P
H
T
S
A
R
T
Q
L
P
Q
S
M
K
Site 32
S435
I
W
R
K
H
S
A
S
A
L
V
L
H
G
H
Site 33
S464
Q
F
L
R
L
L
Q
S
F
S
D
H
H
E
N
Site 34
S466
L
R
L
L
Q
S
F
S
D
H
H
E
N
K
Y
Site 35
Y473
S
D
H
H
E
N
K
Y
L
L
L
N
N
Q
E
Site 36
S485
N
Q
E
L
N
E
L
S
A
I
S
L
K
A
N
Site 37
T502
E
V
E
A
V
L
N
T
D
R
S
L
V
C
D
Site 38
S505
A
V
L
N
T
D
R
S
L
V
C
D
G
K
R
Site 39
S529
M
K
K
E
P
A
E
S
S
F
R
F
W
Q
A
Site 40
S530
K
K
E
P
A
E
S
S
F
R
F
W
Q
A
R
Site 41
S541
W
Q
A
R
A
V
E
S
F
L
R
G
T
T
S
Site 42
T546
V
E
S
F
L
R
G
T
T
S
Y
A
D
Q
M
Site 43
T547
E
S
F
L
R
G
T
T
S
Y
A
D
Q
M
F
Site 44
S548
S
F
L
R
G
T
T
S
Y
A
D
Q
M
F
L
Site 45
S575
I
V
D
S
E
C
K
S
R
D
V
L
Q
S
Y
Site 46
S581
K
S
R
D
V
L
Q
S
Y
F
D
L
L
G
E
Site 47
Y582
S
R
D
V
L
Q
S
Y
F
D
L
L
G
E
L
Site 48
Y603
A
F
K
R
F
N
K
Y
I
N
T
D
A
K
F
Site 49
T606
R
F
N
K
Y
I
N
T
D
A
K
F
Q
V
F
Site 50
S634
L
V
R
C
V
T
L
S
L
D
R
F
E
N
Q
Site 51
Y658
S
E
C
R
L
L
A
Y
I
S
Q
V
P
T
Q
Site 52
Y708
R
K
E
R
L
P
L
Y
L
R
L
L
Q
R
M
Site 53
Y721
R
M
E
H
S
K
K
Y
P
G
F
L
L
N
N
Site 54
S747
Y
L
H
K
D
K
D
S
T
C
L
E
N
S
S
Site 55
T748
L
H
K
D
K
D
S
T
C
L
E
N
S
S
C
Site 56
S753
D
S
T
C
L
E
N
S
S
C
I
S
F
S
Y
Site 57
S757
L
E
N
S
S
C
I
S
F
S
Y
W
K
E
T
Site 58
S759
N
S
S
C
I
S
F
S
Y
W
K
E
T
V
S
Site 59
Y760
S
S
C
I
S
F
S
Y
W
K
E
T
V
S
I
Site 60
T764
S
F
S
Y
W
K
E
T
V
S
I
L
L
N
P
Site 61
S775
L
L
N
P
D
R
Q
S
P
S
A
L
V
S
Y
Site 62
S777
N
P
D
R
Q
S
P
S
A
L
V
S
Y
I
E
Site 63
S781
Q
S
P
S
A
L
V
S
Y
I
E
E
P
Y
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation