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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GEMIN5
Full Name:
Gem-associated protein 5
Alias:
Gem (nuclear organelle) associated protein 5; GEM5; GEMI5; Gemin 5; Gemin5
Type:
RNA processing; RNA binding protein; Nuclear receptor co-regulator
Mass (Da):
168561
Number AA:
1508
UniProt ID:
Q8TEQ6
International Prot ID:
IPI00291783
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0015030
GO:0005829
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0017069
PhosphoSite+
KinaseNET
Biological Process:
GO:0006461
GO:0000387
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
G
Q
E
P
R
T
L
P
P
S
P
N
W
Site 2
S11
E
P
R
T
L
P
P
S
P
N
W
Y
C
A
R
Site 3
Y15
L
P
P
S
P
N
W
Y
C
A
R
C
S
D
A
Site 4
S48
V
G
P
G
A
G
E
S
P
G
T
P
P
F
R
Site 5
T51
G
A
G
E
S
P
G
T
P
P
F
R
V
I
G
Site 6
S68
V
G
H
T
E
R
V
S
G
F
T
F
S
H
H
Site 7
T71
T
E
R
V
S
G
F
T
F
S
H
H
P
G
Q
Site 8
S86
Y
N
L
C
A
T
S
S
D
D
G
T
V
K
I
Site 9
T90
A
T
S
S
D
D
G
T
V
K
I
W
D
V
E
Site 10
T98
V
K
I
W
D
V
E
T
K
T
V
V
T
E
H
Site 11
T114
L
H
Q
H
T
I
S
T
L
H
W
S
P
R
V
Site 12
S118
T
I
S
T
L
H
W
S
P
R
V
K
D
L
I
Site 13
S127
R
V
K
D
L
I
V
S
G
D
E
K
G
V
V
Site 14
S213
L
P
G
E
D
C
L
S
I
N
Q
E
E
T
S
Site 15
S220
S
I
N
Q
E
E
T
S
E
E
A
E
I
T
N
Site 16
T226
T
S
E
E
A
E
I
T
N
G
N
A
V
A
Q
Site 17
Y241
A
P
V
T
K
G
C
Y
L
A
T
G
S
K
D
Site 18
S246
G
C
Y
L
A
T
G
S
K
D
Q
T
I
R
I
Site 19
T250
A
T
G
S
K
D
Q
T
I
R
I
W
S
C
S
Site 20
S255
D
Q
T
I
R
I
W
S
C
S
R
G
R
G
V
Site 21
T280
R
G
G
G
I
D
P
T
V
K
E
R
L
W
L
Site 22
T288
V
K
E
R
L
W
L
T
L
H
W
P
S
N
Q
Site 23
T297
H
W
P
S
N
Q
P
T
Q
L
V
S
S
C
F
Site 24
S301
N
Q
P
T
Q
L
V
S
S
C
F
G
G
E
L
Site 25
T314
E
L
L
Q
W
D
L
T
Q
S
W
R
R
K
Y
Site 26
Y321
T
Q
S
W
R
R
K
Y
T
L
F
S
A
S
S
Site 27
T322
Q
S
W
R
R
K
Y
T
L
F
S
A
S
S
E
Site 28
S325
R
R
K
Y
T
L
F
S
A
S
S
E
G
Q
N
Site 29
S327
K
Y
T
L
F
S
A
S
S
E
G
Q
N
H
S
Site 30
S334
S
S
E
G
Q
N
H
S
R
I
V
F
N
L
C
Site 31
T345
F
N
L
C
P
L
Q
T
E
D
D
K
Q
L
L
Site 32
S354
D
D
K
Q
L
L
L
S
T
S
M
D
R
D
V
Site 33
S356
K
Q
L
L
L
S
T
S
M
D
R
D
V
K
C
Site 34
Y416
T
L
S
I
K
N
N
Y
D
V
K
N
F
W
Q
Site 35
T437
T
A
L
C
W
H
P
T
K
E
G
C
L
A
F
Site 36
Y454
D
D
G
K
V
G
L
Y
D
T
Y
S
N
K
P
Site 37
T456
G
K
V
G
L
Y
D
T
Y
S
N
K
P
P
Q
Site 38
Y457
K
V
G
L
Y
D
T
Y
S
N
K
P
P
Q
I
Site 39
S458
V
G
L
Y
D
T
Y
S
N
K
P
P
Q
I
S
Site 40
S466
N
K
P
P
Q
I
S
S
T
Y
H
K
K
T
V
Site 41
T467
K
P
P
Q
I
S
S
T
Y
H
K
K
T
V
Y
Site 42
T472
S
S
T
Y
H
K
K
T
V
Y
T
L
A
W
G
Site 43
Y474
T
Y
H
K
K
T
V
Y
T
L
A
W
G
P
P
Site 44
T475
Y
H
K
K
T
V
Y
T
L
A
W
G
P
P
V
Site 45
S486
G
P
P
V
P
P
M
S
L
G
G
E
G
D
R
Site 46
S495
G
G
E
G
D
R
P
S
L
A
L
Y
S
C
G
Site 47
Y499
D
R
P
S
L
A
L
Y
S
C
G
G
E
G
I
Site 48
T529
I
N
K
L
I
R
D
T
N
S
I
K
Y
K
L
Site 49
S531
K
L
I
R
D
T
N
S
I
K
Y
K
L
P
V
Site 50
Y534
R
D
T
N
S
I
K
Y
K
L
P
V
H
T
E
Site 51
S559
A
L
G
N
E
D
G
S
I
E
I
F
Q
I
P
Site 52
T573
P
N
L
K
L
I
C
T
I
Q
Q
H
H
K
L
Site 53
S592
S
W
H
H
E
H
G
S
Q
P
E
L
S
Y
L
Site 54
S597
H
G
S
Q
P
E
L
S
Y
L
M
A
S
G
S
Site 55
Y598
G
S
Q
P
E
L
S
Y
L
M
A
S
G
S
N
Site 56
T616
I
Y
V
H
N
L
K
T
V
I
E
S
S
P
E
Site 57
S620
N
L
K
T
V
I
E
S
S
P
E
S
P
V
T
Site 58
S624
V
I
E
S
S
P
E
S
P
V
T
I
T
E
P
Site 59
T627
S
S
P
E
S
P
V
T
I
T
E
P
Y
R
T
Site 60
Y632
P
V
T
I
T
E
P
Y
R
T
L
S
G
H
T
Site 61
T634
T
I
T
E
P
Y
R
T
L
S
G
H
T
A
K
Site 62
S636
T
E
P
Y
R
T
L
S
G
H
T
A
K
I
T
Site 63
T643
S
G
H
T
A
K
I
T
S
V
A
W
S
P
H
Site 64
S648
K
I
T
S
V
A
W
S
P
H
H
D
G
R
L
Site 65
S657
H
H
D
G
R
L
V
S
A
S
Y
D
G
T
A
Site 66
S659
D
G
R
L
V
S
A
S
Y
D
G
T
A
Q
V
Site 67
Y699
P
L
D
P
D
C
I
Y
S
G
A
D
D
F
C
Site 68
S718
L
T
S
M
Q
D
H
S
R
P
P
Q
G
K
K
Site 69
S726
R
P
P
Q
G
K
K
S
I
E
L
E
K
K
R
Site 70
S735
E
L
E
K
K
R
L
S
Q
P
K
A
K
P
K
Site 71
T748
P
K
K
K
K
K
P
T
L
R
T
P
V
K
L
Site 72
T751
K
K
K
P
T
L
R
T
P
V
K
L
E
S
I
Site 73
S757
R
T
P
V
K
L
E
S
I
D
G
N
E
E
E
Site 74
S765
I
D
G
N
E
E
E
S
M
K
E
N
S
G
P
Site 75
S770
E
E
S
M
K
E
N
S
G
P
V
E
N
G
V
Site 76
S778
G
P
V
E
N
G
V
S
D
Q
E
G
E
E
Q
Site 77
T807
S
R
E
P
V
I
C
T
P
V
S
S
G
F
E
Site 78
S810
P
V
I
C
T
P
V
S
S
G
F
E
K
S
K
Site 79
S816
V
S
S
G
F
E
K
S
K
V
T
I
N
N
K
Site 80
T838
P
P
K
E
K
P
E
T
L
I
K
K
R
K
A
Site 81
S847
I
K
K
R
K
A
R
S
L
L
P
L
S
T
S
Site 82
S852
A
R
S
L
L
P
L
S
T
S
L
D
H
R
S
Site 83
T853
R
S
L
L
P
L
S
T
S
L
D
H
R
S
K
Site 84
S854
S
L
L
P
L
S
T
S
L
D
H
R
S
K
E
Site 85
S859
S
T
S
L
D
H
R
S
K
E
E
L
H
Q
D
Site 86
S884
R
E
L
N
E
D
V
S
A
D
V
E
E
R
F
Site 87
T897
R
F
H
L
G
L
F
T
D
R
A
T
L
Y
R
Site 88
Y903
F
T
D
R
A
T
L
Y
R
M
I
D
I
E
G
Site 89
Y978
Q
L
C
F
Q
D
Q
Y
V
K
A
A
S
H
L
Site 90
S983
D
Q
Y
V
K
A
A
S
H
L
L
S
I
H
K
Site 91
S987
K
A
A
S
H
L
L
S
I
H
K
V
Y
E
A
Site 92
S1000
E
A
V
E
L
L
K
S
N
H
F
Y
R
E
A
Site 93
Y1026
D
P
V
L
K
D
L
Y
L
S
W
G
T
V
L
Site 94
S1028
V
L
K
D
L
Y
L
S
W
G
T
V
L
E
R
Site 95
Y1039
V
L
E
R
D
G
H
Y
A
V
A
A
K
C
Y
Site 96
Y1053
Y
L
G
A
T
C
A
Y
D
A
A
K
V
L
A
Site 97
S1067
A
K
K
G
D
A
A
S
L
R
T
A
A
E
L
Site 98
S1086
G
E
D
E
L
S
A
S
L
A
L
R
C
A
Q
Site 99
S1113
E
A
L
Q
L
H
E
S
L
Q
G
Q
R
L
V
Site 100
S1128
F
C
L
L
E
L
L
S
R
H
L
E
E
K
Q
Site 101
S1137
H
L
E
E
K
Q
L
S
E
G
K
S
S
S
S
Site 102
S1141
K
Q
L
S
E
G
K
S
S
S
S
Y
H
T
W
Site 103
S1142
Q
L
S
E
G
K
S
S
S
S
Y
H
T
W
N
Site 104
S1143
L
S
E
G
K
S
S
S
S
Y
H
T
W
N
T
Site 105
S1144
S
E
G
K
S
S
S
S
Y
H
T
W
N
T
G
Site 106
Y1145
E
G
K
S
S
S
S
Y
H
T
W
N
T
G
T
Site 107
T1147
K
S
S
S
S
Y
H
T
W
N
T
G
T
E
G
Site 108
S1169
A
V
W
K
S
I
F
S
L
D
T
P
E
Q
Y
Site 109
T1172
K
S
I
F
S
L
D
T
P
E
Q
Y
Q
E
A
Site 110
Y1176
S
L
D
T
P
E
Q
Y
Q
E
A
F
Q
K
L
Site 111
Y1188
Q
K
L
Q
N
I
K
Y
P
S
A
T
N
N
T
Site 112
T1195
Y
P
S
A
T
N
N
T
P
A
K
Q
L
L
L
Site 113
S1239
V
R
S
Y
D
S
G
S
F
T
I
M
Q
E
V
Site 114
T1241
S
Y
D
S
G
S
F
T
I
M
Q
E
V
Y
S
Site 115
S1267
D
K
L
G
D
H
Q
S
P
A
T
P
A
F
K
Site 116
T1270
G
D
H
Q
S
P
A
T
P
A
F
K
S
L
E
Site 117
S1299
L
S
R
P
C
P
N
S
S
V
W
V
R
A
G
Site 118
S1300
S
R
P
C
P
N
S
S
V
W
V
R
A
G
H
Site 119
T1309
W
V
R
A
G
H
R
T
L
S
V
E
P
S
Q
Site 120
S1311
R
A
G
H
R
T
L
S
V
E
P
S
Q
Q
L
Site 121
S1315
R
T
L
S
V
E
P
S
Q
Q
L
D
T
A
S
Site 122
T1320
E
P
S
Q
Q
L
D
T
A
S
T
E
E
T
D
Site 123
S1322
S
Q
Q
L
D
T
A
S
T
E
E
T
D
P
E
Site 124
T1326
D
T
A
S
T
E
E
T
D
P
E
T
S
Q
P
Site 125
T1330
T
E
E
T
D
P
E
T
S
Q
P
E
P
N
R
Site 126
S1331
E
E
T
D
P
E
T
S
Q
P
E
P
N
R
P
Site 127
S1339
Q
P
E
P
N
R
P
S
E
L
D
L
R
L
T
Site 128
T1346
S
E
L
D
L
R
L
T
E
E
G
E
R
M
L
Site 129
S1354
E
E
G
E
R
M
L
S
T
F
K
E
L
F
S
Site 130
T1355
E
G
E
R
M
L
S
T
F
K
E
L
F
S
E
Site 131
S1366
L
F
S
E
K
H
A
S
L
Q
N
S
Q
R
T
Site 132
S1370
K
H
A
S
L
Q
N
S
Q
R
T
V
A
E
V
Site 133
T1380
T
V
A
E
V
Q
E
T
L
A
E
M
I
R
Q
Site 134
S1391
M
I
R
Q
H
Q
K
S
Q
L
C
K
S
T
A
Site 135
S1396
Q
K
S
Q
L
C
K
S
T
A
N
G
P
D
K
Site 136
S1416
E
A
E
Q
P
L
C
S
S
Q
S
Q
C
K
E
Site 137
S1417
A
E
Q
P
L
C
S
S
Q
S
Q
C
K
E
E
Site 138
S1419
Q
P
L
C
S
S
Q
S
Q
C
K
E
E
K
N
Site 139
S1430
E
E
K
N
E
P
L
S
L
P
E
L
T
K
R
Site 140
T1439
P
E
L
T
K
R
L
T
E
A
N
Q
R
M
A
Site 141
S1451
R
M
A
K
F
P
E
S
I
K
A
W
P
F
P
Site 142
Y1493
A
Q
E
L
L
Q
K
Y
G
N
T
K
T
Y
R
Site 143
Y1499
K
Y
G
N
T
K
T
Y
R
R
H
C
Q
T
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation