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Updated November 2019
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Protein Info
Short Name:
RAPGEF6
Full Name:
Rap guanine nucleotide exchange factor 6
Alias:
PDZ domain containing guanine nucleotide exchange factor 2; PDZGEF2; PDZ-GEF2; RA-GEF-2; Rap guanine nucleotide exchange factor (GEF) 6; RGE6; RPGF6
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
179407
Number AA:
1601
UniProt ID:
Q8TEU7
International Prot ID:
IPI00337694
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0030742
GO:0017016
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0043087
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T21
R
K
K
P
P
E
R
T
P
E
D
L
N
T
I
Site 2
T27
R
T
P
E
D
L
N
T
I
Y
S
Y
L
H
G
Site 3
Y29
P
E
D
L
N
T
I
Y
S
Y
L
H
G
M
E
Site 4
S30
E
D
L
N
T
I
Y
S
Y
L
H
G
M
E
I
Site 5
S39
L
H
G
M
E
I
L
S
N
L
R
E
H
Q
L
Site 6
S50
E
H
Q
L
R
L
M
S
A
R
A
R
Y
E
R
Site 7
Y55
L
M
S
A
R
A
R
Y
E
R
Y
S
G
N
Q
Site 8
Y58
A
R
A
R
Y
E
R
Y
S
G
N
Q
V
L
F
Site 9
S59
R
A
R
Y
E
R
Y
S
G
N
Q
V
L
F
C
Site 10
S138
R
E
I
P
A
R
Q
S
R
R
R
F
R
K
I
Site 11
Y147
R
R
F
R
K
I
N
Y
K
G
E
R
Q
T
I
Site 12
T153
N
Y
K
G
E
R
Q
T
I
T
D
D
V
E
V
Site 13
T155
K
G
E
R
Q
T
I
T
D
D
V
E
V
N
S
Site 14
Y163
D
D
V
E
V
N
S
Y
L
S
L
P
A
D
L
Site 15
S165
V
E
V
N
S
Y
L
S
L
P
A
D
L
T
K
Site 16
T171
L
S
L
P
A
D
L
T
K
M
H
L
T
E
N
Site 17
T176
D
L
T
K
M
H
L
T
E
N
P
H
P
Q
V
Site 18
T184
E
N
P
H
P
Q
V
T
H
V
S
S
S
Q
S
Site 19
S187
H
P
Q
V
T
H
V
S
S
S
Q
S
G
C
S
Site 20
S189
Q
V
T
H
V
S
S
S
Q
S
G
C
S
I
A
Site 21
S191
T
H
V
S
S
S
Q
S
G
C
S
I
A
S
D
Site 22
S194
S
S
S
Q
S
G
C
S
I
A
S
D
S
G
S
Site 23
S197
Q
S
G
C
S
I
A
S
D
S
G
S
S
S
L
Site 24
S199
G
C
S
I
A
S
D
S
G
S
S
S
L
S
D
Site 25
S201
S
I
A
S
D
S
G
S
S
S
L
S
D
I
Y
Site 26
S203
A
S
D
S
G
S
S
S
L
S
D
I
Y
Q
A
Site 27
S205
D
S
G
S
S
S
L
S
D
I
Y
Q
A
T
E
Site 28
Y208
S
S
S
L
S
D
I
Y
Q
A
T
E
S
E
V
Site 29
S213
D
I
Y
Q
A
T
E
S
E
V
G
D
V
D
L
Site 30
T221
E
V
G
D
V
D
L
T
R
L
P
E
G
P
V
Site 31
S230
L
P
E
G
P
V
D
S
E
D
D
E
E
E
D
Site 32
T243
E
D
E
E
I
D
R
T
D
P
L
Q
G
R
D
Site 33
T264
E
K
E
P
A
D
K
T
D
D
D
I
E
Q
L
Site 34
S317
E
D
G
Q
E
L
D
S
W
Y
V
I
L
N
G
Site 35
T347
M
G
N
S
F
G
I
T
P
T
L
D
K
Q
Y
Site 36
T349
N
S
F
G
I
T
P
T
L
D
K
Q
Y
M
H
Site 37
Y354
T
P
T
L
D
K
Q
Y
M
H
G
I
V
R
T
Site 38
S408
E
H
R
E
L
D
R
S
G
T
R
K
G
H
I
Site 39
T410
R
E
L
D
R
S
G
T
R
K
G
H
I
V
I
Site 40
T449
D
F
L
L
T
Y
R
T
F
L
E
S
P
L
D
Site 41
S453
T
Y
R
T
F
L
E
S
P
L
D
V
G
I
K
Site 42
S469
L
E
W
F
K
I
D
S
L
R
D
K
V
T
R
Site 43
T496
F
E
G
D
P
A
M
T
R
F
L
E
E
F
E
Site 44
S540
L
Q
K
A
S
R
E
S
P
L
Q
F
S
L
N
Site 45
S545
R
E
S
P
L
Q
F
S
L
N
G
G
S
E
K
Site 46
S550
Q
F
S
L
N
G
G
S
E
K
G
F
G
I
F
Site 47
S565
V
E
G
V
E
P
G
S
E
A
A
D
S
G
L
Site 48
S570
P
G
S
E
A
A
D
S
G
L
K
R
G
D
Q
Site 49
S627
F
R
T
E
Q
E
K
S
G
V
P
H
I
P
K
Site 50
S640
P
K
I
A
K
K
K
S
N
R
H
S
I
Q
H
Site 51
S644
K
K
K
S
N
R
H
S
I
Q
H
V
P
G
D
Site 52
S656
P
G
D
I
E
Q
T
S
Q
E
K
G
S
K
K
Site 53
S670
K
V
K
A
N
T
A
S
G
G
R
N
K
I
R
Site 54
T683
I
R
K
I
L
D
K
T
R
F
S
I
L
P
P
Site 55
S694
I
L
P
P
K
L
F
S
D
G
G
L
S
Q
S
Site 56
S699
L
F
S
D
G
G
L
S
Q
S
Q
D
D
S
I
Site 57
S701
S
D
G
G
L
S
Q
S
Q
D
D
S
I
V
G
Site 58
S705
L
S
Q
S
Q
D
D
S
I
V
G
T
R
H
C
Site 59
T709
Q
D
D
S
I
V
G
T
R
H
C
R
H
S
L
Site 60
S715
G
T
R
H
C
R
H
S
L
A
I
M
P
I
P
Site 61
S726
M
P
I
P
G
T
L
S
S
S
S
P
D
L
L
Site 62
S727
P
I
P
G
T
L
S
S
S
S
P
D
L
L
Q
Site 63
S728
I
P
G
T
L
S
S
S
S
P
D
L
L
Q
P
Site 64
S729
P
G
T
L
S
S
S
S
P
D
L
L
Q
P
T
Site 65
T736
S
P
D
L
L
Q
P
T
T
S
M
L
D
F
S
Site 66
T737
P
D
L
L
Q
P
T
T
S
M
L
D
F
S
N
Site 67
S738
D
L
L
Q
P
T
T
S
M
L
D
F
S
N
P
Site 68
S743
T
T
S
M
L
D
F
S
N
P
S
D
I
P
D
Site 69
S746
M
L
D
F
S
N
P
S
D
I
P
D
Q
V
I
Site 70
Y764
K
V
D
Q
Q
S
C
Y
I
I
I
S
K
D
T
Site 71
T787
A
V
H
E
F
G
L
T
G
A
S
D
T
Y
S
Site 72
S790
E
F
G
L
T
G
A
S
D
T
Y
S
L
C
E
Site 73
S816
R
R
L
P
D
Q
F
S
K
L
A
D
R
I
Q
Site 74
Y829
I
Q
L
N
G
R
Y
Y
L
K
N
N
M
E
T
Site 75
S841
M
E
T
E
T
L
C
S
D
E
D
A
Q
E
L
Site 76
S852
A
Q
E
L
V
K
E
S
Q
L
S
M
L
Q
L
Site 77
T882
L
F
R
N
I
E
P
T
E
Y
I
D
D
L
F
Site 78
Y884
R
N
I
E
P
T
E
Y
I
D
D
L
F
K
L
Site 79
S893
D
D
L
F
K
L
N
S
K
T
G
N
T
H
L
Site 80
T895
L
F
K
L
N
S
K
T
G
N
T
H
L
K
R
Site 81
T920
W
V
A
S
E
I
L
T
E
A
N
Q
L
K
R
Site 82
T968
S
V
A
R
L
R
G
T
W
E
K
L
P
S
K
Site 83
S974
G
T
W
E
K
L
P
S
K
Y
E
K
H
L
Q
Site 84
Y976
W
E
K
L
P
S
K
Y
E
K
H
L
Q
D
L
Site 85
Y996
P
S
R
N
M
A
K
Y
R
N
I
L
S
S
Q
Site 86
S1001
A
K
Y
R
N
I
L
S
S
Q
S
M
Q
P
P
Site 87
S1002
K
Y
R
N
I
L
S
S
Q
S
M
Q
P
P
I
Site 88
S1004
R
N
I
L
S
S
Q
S
M
Q
P
P
I
I
P
Site 89
T1021
P
V
V
K
K
D
M
T
F
L
H
E
G
N
D
Site 90
S1029
F
L
H
E
G
N
D
S
K
V
D
G
L
V
N
Site 91
S1044
F
E
K
L
R
M
I
S
K
E
I
R
Q
V
V
Site 92
T1054
I
R
Q
V
V
R
M
T
S
A
N
M
D
P
A
Site 93
S1055
R
Q
V
V
R
M
T
S
A
N
M
D
P
A
M
Site 94
S1068
A
M
M
F
R
Q
R
S
L
S
Q
G
S
T
N
Site 95
S1070
M
F
R
Q
R
S
L
S
Q
G
S
T
N
S
N
Site 96
S1073
Q
R
S
L
S
Q
G
S
T
N
S
N
M
L
D
Site 97
T1074
R
S
L
S
Q
G
S
T
N
S
N
M
L
D
V
Site 98
S1076
L
S
Q
G
S
T
N
S
N
M
L
D
V
Q
G
Site 99
S1093
H
K
K
R
A
R
R
S
S
L
L
N
A
K
K
Site 100
S1094
K
K
R
A
R
R
S
S
L
L
N
A
K
K
L
Site 101
Y1102
L
L
N
A
K
K
L
Y
E
D
A
Q
M
A
R
Site 102
Y1114
M
A
R
K
V
K
Q
Y
L
S
S
L
D
V
E
Site 103
S1116
R
K
V
K
Q
Y
L
S
S
L
D
V
E
T
D
Site 104
Y1138
S
L
Q
W
E
P
A
Y
G
T
L
T
K
N
L
Site 105
T1142
E
P
A
Y
G
T
L
T
K
N
L
S
E
K
R
Site 106
S1146
G
T
L
T
K
N
L
S
E
K
R
S
A
K
S
Site 107
S1150
K
N
L
S
E
K
R
S
A
K
S
S
E
M
S
Site 108
S1153
S
E
K
R
S
A
K
S
S
E
M
S
P
V
P
Site 109
S1154
E
K
R
S
A
K
S
S
E
M
S
P
V
P
M
Site 110
S1157
S
A
K
S
S
E
M
S
P
V
P
M
R
S
A
Site 111
S1163
M
S
P
V
P
M
R
S
A
G
Q
T
T
K
A
Site 112
T1167
P
M
R
S
A
G
Q
T
T
K
A
H
L
H
Q
Site 113
T1168
M
R
S
A
G
Q
T
T
K
A
H
L
H
Q
P
Site 114
S1179
L
H
Q
P
H
R
V
S
Q
V
L
Q
V
P
A
Site 115
T1198
P
I
R
K
K
G
Q
T
K
D
P
A
L
N
T
Site 116
S1206
K
D
P
A
L
N
T
S
L
P
Q
K
V
L
G
Site 117
T1227
G
K
K
H
T
E
D
T
I
S
V
A
S
S
L
Site 118
S1229
K
H
T
E
D
T
I
S
V
A
S
S
L
H
S
Site 119
S1232
E
D
T
I
S
V
A
S
S
L
H
S
S
P
P
Site 120
S1233
D
T
I
S
V
A
S
S
L
H
S
S
P
P
A
Site 121
S1236
S
V
A
S
S
L
H
S
S
P
P
A
S
P
Q
Site 122
S1237
V
A
S
S
L
H
S
S
P
P
A
S
P
Q
G
Site 123
S1241
L
H
S
S
P
P
A
S
P
Q
G
S
P
H
K
Site 124
S1245
P
P
A
S
P
Q
G
S
P
H
K
G
Y
T
L
Site 125
Y1250
Q
G
S
P
H
K
G
Y
T
L
I
P
S
A
K
Site 126
T1251
G
S
P
H
K
G
Y
T
L
I
P
S
A
K
S
Site 127
S1258
T
L
I
P
S
A
K
S
D
N
L
S
D
S
S
Site 128
S1262
S
A
K
S
D
N
L
S
D
S
S
H
S
E
I
Site 129
S1264
K
S
D
N
L
S
D
S
S
H
S
E
I
S
S
Site 130
S1265
S
D
N
L
S
D
S
S
H
S
E
I
S
S
R
Site 131
S1267
N
L
S
D
S
S
H
S
E
I
S
S
R
S
S
Site 132
S1270
D
S
S
H
S
E
I
S
S
R
S
S
I
V
S
Site 133
S1271
S
S
H
S
E
I
S
S
R
S
S
I
V
S
N
Site 134
S1273
H
S
E
I
S
S
R
S
S
I
V
S
N
C
S
Site 135
S1274
S
E
I
S
S
R
S
S
I
V
S
N
C
S
V
Site 136
S1277
S
S
R
S
S
I
V
S
N
C
S
V
D
S
M
Site 137
S1283
V
S
N
C
S
V
D
S
M
S
A
A
L
Q
D
Site 138
S1285
N
C
S
V
D
S
M
S
A
A
L
Q
D
E
R
Site 139
S1294
A
L
Q
D
E
R
C
S
S
Q
A
L
A
V
P
Site 140
S1295
L
Q
D
E
R
C
S
S
Q
A
L
A
V
P
E
Site 141
T1310
S
T
G
A
L
E
K
T
E
H
A
S
G
I
G
Site 142
S1320
A
S
G
I
G
D
H
S
Q
H
G
P
G
W
T
Site 143
T1327
S
Q
H
G
P
G
W
T
L
L
K
P
S
L
I
Site 144
S1342
K
C
L
A
V
S
S
S
V
S
N
E
E
I
S
Site 145
S1344
L
A
V
S
S
S
V
S
N
E
E
I
S
Q
E
Site 146
S1349
S
V
S
N
E
E
I
S
Q
E
H
I
I
I
E
Site 147
S1360
I
I
I
E
A
A
D
S
G
R
G
S
W
T
S
Site 148
S1364
A
A
D
S
G
R
G
S
W
T
S
C
S
S
S
Site 149
T1366
D
S
G
R
G
S
W
T
S
C
S
S
S
S
H
Site 150
S1367
S
G
R
G
S
W
T
S
C
S
S
S
S
H
D
Site 151
S1369
R
G
S
W
T
S
C
S
S
S
S
H
D
N
F
Site 152
S1370
G
S
W
T
S
C
S
S
S
S
H
D
N
F
Q
Site 153
S1371
S
W
T
S
C
S
S
S
S
H
D
N
F
Q
S
Site 154
S1372
W
T
S
C
S
S
S
S
H
D
N
F
Q
S
L
Site 155
S1378
S
S
H
D
N
F
Q
S
L
P
N
P
K
S
W
Site 156
S1384
Q
S
L
P
N
P
K
S
W
D
F
L
N
S
Y
Site 157
Y1391
S
W
D
F
L
N
S
Y
R
H
T
H
L
D
D
Site 158
T1394
F
L
N
S
Y
R
H
T
H
L
D
D
P
I
A
Site 159
T1406
P
I
A
E
V
E
P
T
D
S
E
P
Y
S
C
Site 160
S1408
A
E
V
E
P
T
D
S
E
P
Y
S
C
S
K
Site 161
Y1411
E
P
T
D
S
E
P
Y
S
C
S
K
S
C
S
Site 162
S1412
P
T
D
S
E
P
Y
S
C
S
K
S
C
S
R
Site 163
S1414
D
S
E
P
Y
S
C
S
K
S
C
S
R
T
C
Site 164
S1416
E
P
Y
S
C
S
K
S
C
S
R
T
C
G
Q
Site 165
T1420
C
S
K
S
C
S
R
T
C
G
Q
C
K
G
S
Site 166
S1427
T
C
G
Q
C
K
G
S
L
E
R
K
S
W
T
Site 167
S1432
K
G
S
L
E
R
K
S
W
T
S
S
S
S
L
Site 168
T1434
S
L
E
R
K
S
W
T
S
S
S
S
L
S
D
Site 169
S1435
L
E
R
K
S
W
T
S
S
S
S
L
S
D
T
Site 170
S1436
E
R
K
S
W
T
S
S
S
S
L
S
D
T
Y
Site 171
S1437
R
K
S
W
T
S
S
S
S
L
S
D
T
Y
E
Site 172
S1438
K
S
W
T
S
S
S
S
L
S
D
T
Y
E
P
Site 173
S1440
W
T
S
S
S
S
L
S
D
T
Y
E
P
N
Y
Site 174
T1442
S
S
S
S
L
S
D
T
Y
E
P
N
Y
G
T
Site 175
Y1443
S
S
S
L
S
D
T
Y
E
P
N
Y
G
T
V
Site 176
Y1447
S
D
T
Y
E
P
N
Y
G
T
V
K
R
R
V
Site 177
T1449
T
Y
E
P
N
Y
G
T
V
K
R
R
V
L
E
Site 178
S1457
V
K
R
R
V
L
E
S
T
P
A
E
S
S
E
Site 179
T1458
K
R
R
V
L
E
S
T
P
A
E
S
S
E
G
Site 180
T1472
G
L
D
P
K
D
A
T
D
P
V
Y
K
T
V
Site 181
Y1476
K
D
A
T
D
P
V
Y
K
T
V
T
S
S
T
Site 182
T1478
A
T
D
P
V
Y
K
T
V
T
S
S
T
E
K
Site 183
Y1490
T
E
K
G
L
I
V
Y
C
V
T
S
P
K
K
Site 184
S1494
L
I
V
Y
C
V
T
S
P
K
K
D
D
R
Y
Site 185
Y1501
S
P
K
K
D
D
R
Y
R
E
P
P
P
T
P
Site 186
T1507
R
Y
R
E
P
P
P
T
P
P
G
Y
L
G
I
Site 187
Y1511
P
P
P
T
P
P
G
Y
L
G
I
S
L
A
D
Site 188
S1515
P
P
G
Y
L
G
I
S
L
A
D
L
K
E
G
Site 189
T1525
D
L
K
E
G
P
H
T
H
L
K
P
P
D
Y
Site 190
Y1532
T
H
L
K
P
P
D
Y
S
V
A
V
Q
R
S
Site 191
S1533
H
L
K
P
P
D
Y
S
V
A
V
Q
R
S
K
Site 192
S1545
R
S
K
M
M
H
N
S
L
S
R
L
P
P
A
Site 193
S1547
K
M
M
H
N
S
L
S
R
L
P
P
A
S
L
Site 194
T1568
C
V
P
S
K
I
V
T
Q
P
Q
R
H
N
L
Site 195
T1586
H
P
K
L
G
D
V
T
D
A
D
S
E
A
D
Site 196
S1590
G
D
V
T
D
A
D
S
E
A
D
E
N
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation