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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAR3-beta
Full Name:
Partitioning defective 3 homolog B
Alias:
ALS2CR19; Amyotrophic lateral sclerosis 2 chromosome region candidate gene protein 19; Par-3 partitioning defective 3 B; PAR3B; PAR3beta; PAR3L; PAR3-L protein; Partitioning-defective 3-like protein
Type:
Adapter/scaffold protein
Mass (Da):
132494
Number AA:
1205
UniProt ID:
Q8TEW8
International Prot ID:
IPI00043978
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0012505
GO:0005923
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
Q
L
R
V
G
E
L
T
Q
Q
A
L
Q
R
Y
Site 2
T37
A
L
Q
R
Y
L
K
T
R
E
K
G
P
G
Y
Site 3
Y44
T
R
E
K
G
P
G
Y
W
V
K
I
H
H
L
Site 4
Y53
V
K
I
H
H
L
E
Y
T
D
G
G
I
L
D
Site 5
S90
E
P
L
H
K
I
E
S
P
S
G
N
P
A
D
Site 6
S92
L
H
K
I
E
S
P
S
G
N
P
A
D
R
Q
Site 7
S100
G
N
P
A
D
R
Q
S
P
D
A
F
E
T
E
Site 8
S127
G
E
I
E
V
T
P
S
A
L
K
L
G
T
P
Site 9
T133
P
S
A
L
K
L
G
T
P
L
L
V
R
R
S
Site 10
S140
T
P
L
L
V
R
R
S
S
D
P
V
P
G
P
Site 11
S141
P
L
L
V
R
R
S
S
D
P
V
P
G
P
P
Site 12
T151
V
P
G
P
P
A
D
T
Q
P
S
A
S
H
P
Site 13
S154
P
P
A
D
T
Q
P
S
A
S
H
P
G
G
Q
Site 14
S156
A
D
T
Q
P
S
A
S
H
P
G
G
Q
S
L
Site 15
S162
A
S
H
P
G
G
Q
S
L
K
L
V
V
P
D
Site 16
S170
L
K
L
V
V
P
D
S
T
Q
N
L
E
D
R
Site 17
S190
V
Q
T
E
L
L
T
S
P
R
T
K
D
T
L
Site 18
T193
E
L
L
T
S
P
R
T
K
D
T
L
S
D
M
Site 19
T196
T
S
P
R
T
K
D
T
L
S
D
M
T
R
T
Site 20
S198
P
R
T
K
D
T
L
S
D
M
T
R
T
V
E
Site 21
T201
K
D
T
L
S
D
M
T
R
T
V
E
I
S
G
Site 22
T203
T
L
S
D
M
T
R
T
V
E
I
S
G
E
G
Site 23
S207
M
T
R
T
V
E
I
S
G
E
G
G
P
L
G
Site 24
S240
I
R
G
I
E
D
N
S
R
S
K
R
E
G
L
Site 25
S242
G
I
E
D
N
S
R
S
K
R
E
G
L
F
H
Site 26
T266
N
V
D
L
V
D
K
T
F
A
Q
A
Q
D
V
Site 27
Y296
P
P
Q
N
R
E
Q
Y
E
K
S
V
I
G
S
Site 28
S299
N
R
E
Q
Y
E
K
S
V
I
G
S
L
N
I
Site 29
S303
Y
E
K
S
V
I
G
S
L
N
I
F
G
N
N
Site 30
T316
N
N
D
G
V
L
K
T
K
V
P
P
P
V
H
Site 31
S326
P
P
P
V
H
G
K
S
G
L
K
T
A
N
L
Site 32
T330
H
G
K
S
G
L
K
T
A
N
L
T
G
T
D
Site 33
T334
G
L
K
T
A
N
L
T
G
T
D
S
P
E
T
Site 34
T336
K
T
A
N
L
T
G
T
D
S
P
E
T
D
A
Site 35
S338
A
N
L
T
G
T
D
S
P
E
T
D
A
S
A
Site 36
T341
T
G
T
D
S
P
E
T
D
A
S
A
S
L
Q
Site 37
S344
D
S
P
E
T
D
A
S
A
S
L
Q
Q
N
K
Site 38
S346
P
E
T
D
A
S
A
S
L
Q
Q
N
K
S
P
Site 39
S352
A
S
L
Q
Q
N
K
S
P
R
V
P
R
L
G
Site 40
S363
P
R
L
G
G
K
P
S
S
P
S
L
S
P
L
Site 41
S364
R
L
G
G
K
P
S
S
P
S
L
S
P
L
M
Site 42
S366
G
G
K
P
S
S
P
S
L
S
P
L
M
G
F
Site 43
S368
K
P
S
S
P
S
L
S
P
L
M
G
F
G
S
Site 44
S375
S
P
L
M
G
F
G
S
N
K
N
A
K
K
I
Site 45
T396
G
P
E
G
L
G
F
T
V
V
T
R
D
S
S
Site 46
S402
F
T
V
V
T
R
D
S
S
I
H
G
P
G
P
Site 47
S403
T
V
V
T
R
D
S
S
I
H
G
P
G
P
I
Site 48
S429
I
K
D
G
R
L
Q
S
G
D
R
I
L
E
V
Site 49
T442
E
V
N
G
R
D
V
T
G
R
T
Q
E
E
L
Site 50
T445
G
R
D
V
T
G
R
T
Q
E
E
L
V
A
M
Site 51
T456
L
V
A
M
L
R
S
T
K
Q
G
E
T
A
S
Site 52
S463
T
K
Q
G
E
T
A
S
L
V
I
A
R
Q
E
Site 53
S488
E
P
D
C
C
A
L
S
L
E
T
S
E
Q
L
Site 54
T496
L
E
T
S
E
Q
L
T
F
E
I
P
L
N
D
Site 55
S512
G
S
A
G
L
G
V
S
L
K
G
N
K
S
R
Site 56
S518
V
S
L
K
G
N
K
S
R
E
T
G
T
D
L
Site 57
T521
K
G
N
K
S
R
E
T
G
T
D
L
G
I
F
Site 58
S557
L
I
A
V
N
G
E
S
L
L
G
K
S
N
H
Site 59
S562
G
E
S
L
L
G
K
S
N
H
E
A
M
E
T
Site 60
T569
S
N
H
E
A
M
E
T
L
R
R
S
M
S
M
Site 61
S573
A
M
E
T
L
R
R
S
M
S
M
E
G
N
I
Site 62
S575
E
T
L
R
R
S
M
S
M
E
G
N
I
R
G
Site 63
S620
C
Q
N
A
V
T
T
S
R
R
N
D
N
S
I
Site 64
S626
T
S
R
R
N
D
N
S
I
L
H
P
L
G
T
Site 65
T633
S
I
L
H
P
L
G
T
C
S
P
Q
D
K
Q
Site 66
S635
L
H
P
L
G
T
C
S
P
Q
D
K
Q
K
G
Site 67
S653
P
N
D
G
W
A
E
S
E
V
P
P
S
P
T
Site 68
S658
A
E
S
E
V
P
P
S
P
T
P
H
S
A
L
Site 69
T660
S
E
V
P
P
S
P
T
P
H
S
A
L
G
L
Site 70
S663
P
P
S
P
T
P
H
S
A
L
G
L
G
L
E
Site 71
Y672
L
G
L
G
L
E
D
Y
S
H
S
S
G
V
D
Site 72
S673
G
L
G
L
E
D
Y
S
H
S
S
G
V
D
S
Site 73
S675
G
L
E
D
Y
S
H
S
S
G
V
D
S
A
V
Site 74
S676
L
E
D
Y
S
H
S
S
G
V
D
S
A
V
Y
Site 75
S680
S
H
S
S
G
V
D
S
A
V
Y
F
P
D
Q
Site 76
Y683
S
G
V
D
S
A
V
Y
F
P
D
Q
H
I
N
Site 77
S693
D
Q
H
I
N
F
R
S
V
T
P
A
R
Q
P
Site 78
T695
H
I
N
F
R
S
V
T
P
A
R
Q
P
E
S
Site 79
S702
T
P
A
R
Q
P
E
S
I
N
L
K
A
S
K
Site 80
S708
E
S
I
N
L
K
A
S
K
S
M
D
L
V
P
Site 81
S710
I
N
L
K
A
S
K
S
M
D
L
V
P
D
E
Site 82
S718
M
D
L
V
P
D
E
S
K
V
H
S
L
A
G
Site 83
S722
P
D
E
S
K
V
H
S
L
A
G
Q
K
S
E
Site 84
S728
H
S
L
A
G
Q
K
S
E
S
P
S
K
D
F
Site 85
S730
L
A
G
Q
K
S
E
S
P
S
K
D
F
G
P
Site 86
S732
G
Q
K
S
E
S
P
S
K
D
F
G
P
T
L
Site 87
S744
P
T
L
G
L
K
K
S
S
S
L
E
S
L
Q
Site 88
S745
T
L
G
L
K
K
S
S
S
L
E
S
L
Q
T
Site 89
S746
L
G
L
K
K
S
S
S
L
E
S
L
Q
T
A
Site 90
S749
K
K
S
S
S
L
E
S
L
Q
T
A
V
A
E
Site 91
T752
S
S
L
E
S
L
Q
T
A
V
A
E
V
R
K
Site 92
S780
R
G
R
G
C
N
E
S
F
R
A
A
I
D
K
Site 93
S788
F
R
A
A
I
D
K
S
Y
D
G
P
E
E
I
Site 94
Y789
R
A
A
I
D
K
S
Y
D
G
P
E
E
I
E
Site 95
S801
E
I
E
A
D
G
L
S
D
K
S
S
H
S
G
Site 96
S804
A
D
G
L
S
D
K
S
S
H
S
G
Q
G
A
Site 97
S805
D
G
L
S
D
K
S
S
H
S
G
Q
G
A
L
Site 98
S807
L
S
D
K
S
S
H
S
G
Q
G
A
L
N
C
Site 99
S816
Q
G
A
L
N
C
E
S
A
P
Q
G
N
S
E
Site 100
T837
K
A
R
K
V
K
K
T
K
E
K
E
K
K
K
Site 101
T894
G
K
A
E
Q
K
G
T
L
K
H
G
G
L
R
Site 102
S940
Y
A
T
G
A
I
G
S
V
Y
D
M
D
D
D
Site 103
Y942
T
G
A
I
G
S
V
Y
D
M
D
D
D
E
M
Site 104
Y953
D
D
E
M
D
P
N
Y
A
R
V
N
H
F
R
Site 105
S965
H
F
R
E
P
C
T
S
A
N
V
F
R
S
P
Site 106
S971
T
S
A
N
V
F
R
S
P
S
P
P
R
A
G
Site 107
S973
A
N
V
F
R
S
P
S
P
P
R
A
G
P
F
Site 108
Y982
P
R
A
G
P
F
G
Y
P
R
D
G
H
P
L
Site 109
S990
P
R
D
G
H
P
L
S
P
E
R
D
H
L
E
Site 110
Y1000
R
D
H
L
E
G
L
Y
A
K
V
N
K
P
Y
Site 111
Y1007
Y
A
K
V
N
K
P
Y
H
P
L
V
P
A
D
Site 112
S1015
H
P
L
V
P
A
D
S
G
R
P
T
G
G
S
Site 113
T1019
P
A
D
S
G
R
P
T
G
G
S
T
D
R
I
Site 114
S1022
S
G
R
P
T
G
G
S
T
D
R
I
Q
K
L
Site 115
T1023
G
R
P
T
G
G
S
T
D
R
I
Q
K
L
R
Site 116
Y1033
I
Q
K
L
R
K
E
Y
Y
Q
A
R
R
E
G
Site 117
Y1034
Q
K
L
R
K
E
Y
Y
Q
A
R
R
E
G
F
Site 118
Y1044
R
R
E
G
F
P
L
Y
E
D
D
E
G
R
A
Site 119
S1054
D
E
G
R
A
R
P
S
E
Y
D
L
L
W
V
Site 120
Y1056
G
R
A
R
P
S
E
Y
D
L
L
W
V
P
G
Site 121
Y1082
F
E
G
M
E
R
Q
Y
A
S
L
P
R
G
G
Site 122
S1084
G
M
E
R
Q
Y
A
S
L
P
R
G
G
P
A
Site 123
Y1096
G
P
A
D
P
V
D
Y
L
P
A
A
P
R
G
Site 124
Y1105
P
A
A
P
R
G
L
Y
K
E
R
E
L
P
Y
Site 125
Y1113
K
E
R
E
L
P
Y
Y
P
G
A
H
P
M
H
Site 126
S1125
P
M
H
P
P
K
G
S
Y
P
R
P
T
E
L
Site 127
Y1126
M
H
P
P
K
G
S
Y
P
R
P
T
E
L
R
Site 128
T1130
K
G
S
Y
P
R
P
T
E
L
R
V
A
D
L
Site 129
Y1139
L
R
V
A
D
L
R
Y
P
Q
H
Y
P
P
P
Site 130
Y1143
D
L
R
Y
P
Q
H
Y
P
P
P
P
A
P
Q
Site 131
S1162
F
R
Q
D
V
P
P
S
P
P
Q
H
Q
R
M
Site 132
Y1172
Q
H
Q
R
M
P
A
Y
Q
E
T
G
R
P
G
Site 133
T1175
R
M
P
A
Y
Q
E
T
G
R
P
G
P
R
G
Site 134
S1184
R
P
G
P
R
G
G
S
P
D
Q
Y
P
Y
R
Site 135
Y1188
R
G
G
S
P
D
Q
Y
P
Y
R
T
Q
D
S
Site 136
Y1190
G
S
P
D
Q
Y
P
Y
R
T
Q
D
S
R
Q
Site 137
T1192
P
D
Q
Y
P
Y
R
T
Q
D
S
R
Q
K
N
Site 138
S1195
Y
P
Y
R
T
Q
D
S
R
Q
K
N
P
M
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation