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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IPO4
Full Name:
Importin-4
Alias:
Ran-binding protein 4
Type:
Mass (Da):
118715
Number AA:
1081
UniProt ID:
Q8TEX9
International Prot ID:
IPI00156374
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008565
PhosphoSite+
KinaseNET
Biological Process:
GO:0006886
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T18
R
E
L
L
L
P
D
T
E
R
I
R
R
A
T
Site 2
T25
T
E
R
I
R
R
A
T
E
Q
L
Q
I
V
L
Site 3
T61
R
Q
F
A
A
V
L
T
R
R
R
L
N
T
R
Site 4
T67
L
T
R
R
R
L
N
T
R
W
R
R
L
A
A
Site 5
S79
L
A
A
E
Q
R
E
S
L
K
S
L
I
L
T
Site 6
S82
E
Q
R
E
S
L
K
S
L
I
L
T
A
L
Q
Site 7
T86
S
L
K
S
L
I
L
T
A
L
Q
R
E
T
E
Site 8
T92
L
T
A
L
Q
R
E
T
E
H
C
V
S
L
S
Site 9
S97
R
E
T
E
H
C
V
S
L
S
L
A
Q
L
S
Site 10
S126
L
L
Q
L
L
Q
H
S
T
H
S
P
H
S
P
Site 11
T127
L
Q
L
L
Q
H
S
T
H
S
P
H
S
P
E
Site 12
S129
L
L
Q
H
S
T
H
S
P
H
S
P
E
R
E
Site 13
S132
H
S
T
H
S
P
H
S
P
E
R
E
M
G
L
Site 14
T186
Y
S
L
R
T
L
T
T
M
A
P
Y
L
S
T
Site 15
S279
T
F
L
V
K
V
K
S
K
A
L
L
K
N
R
Site 16
S315
L
D
P
E
D
Q
D
S
E
E
E
E
L
E
I
Site 17
T328
E
I
E
L
M
G
E
T
P
K
H
F
A
V
Q
Site 18
S363
M
L
E
E
A
L
R
S
E
S
P
Y
Q
R
K
Site 19
S365
E
E
A
L
R
S
E
S
P
Y
Q
R
K
A
G
Site 20
Y367
A
L
R
S
E
S
P
Y
Q
R
K
A
G
L
L
Site 21
S407
C
K
G
L
E
D
P
S
Q
V
V
R
N
A
A
Site 22
S430
E
N
L
Q
P
H
I
S
S
Y
S
R
E
V
M
Site 23
S431
N
L
Q
P
H
I
S
S
Y
S
R
E
V
M
P
Site 24
Y476
L
G
P
K
V
Q
P
Y
L
P
E
L
M
E
C
Site 25
S492
L
Q
L
L
R
N
P
S
S
P
R
A
K
E
L
Site 26
S493
Q
L
L
R
N
P
S
S
P
R
A
K
E
L
A
Site 27
T532
H
L
R
E
F
L
L
T
G
R
E
D
L
Q
P
Site 28
T586
D
P
D
L
R
R
C
T
Y
S
L
F
A
A
L
Site 29
Y626
T
E
G
I
V
P
Q
Y
D
G
S
S
S
F
L
Site 30
S631
P
Q
Y
D
G
S
S
S
F
L
L
F
D
D
E
Site 31
S639
F
L
L
F
D
D
E
S
D
G
E
E
E
E
E
Site 32
S658
D
V
E
E
E
D
D
S
E
I
S
G
Y
S
V
Site 33
Y663
D
D
S
E
I
S
G
Y
S
V
E
N
A
F
F
Site 34
T676
F
F
D
E
K
E
D
T
C
A
A
V
G
E
I
Site 35
S734
A
L
H
K
A
C
Q
S
C
P
S
E
P
N
T
Site 36
T741
S
C
P
S
E
P
N
T
A
A
L
Q
A
A
L
Site 37
Y755
L
A
R
V
V
P
S
Y
M
Q
A
V
N
R
E
Site 38
T786
L
R
S
C
G
T
L
T
L
K
P
P
G
R
L
Site 39
T808
K
A
V
L
Q
R
K
T
A
C
Q
D
T
D
E
Site 40
Y827
E
D
D
D
Q
A
E
Y
D
A
M
L
L
E
H
Site 41
T871
C
K
T
K
Q
G
C
T
V
A
E
K
S
F
A
Site 42
S917
E
A
D
P
E
V
R
S
N
A
I
F
G
M
G
Site 43
S972
L
A
R
L
L
M
A
S
P
T
R
K
P
E
P
Site 44
T974
R
L
L
M
A
S
P
T
R
K
P
E
P
Q
V
Site 45
T1000
E
D
L
E
E
W
V
T
I
G
R
L
F
S
F
Site 46
Y1009
G
R
L
F
S
F
L
Y
Q
S
S
P
D
Q
V
Site 47
S1011
L
F
S
F
L
Y
Q
S
S
P
D
Q
V
I
D
Site 48
S1058
L
A
K
Q
H
T
D
S
F
Q
A
A
L
G
S
Site 49
S1065
S
F
Q
A
A
L
G
S
L
P
V
D
K
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation