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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP33
Full Name:
Ubiquitin carboxyl-terminal hydrolase 33
Alias:
Deubiquitinating enzyme 33; EC 3.1.2.15; Ubiquitin carboxyl-terminal hydrolase 33; Ubiquitin thioesterase 33; UBP33; VDU1; VHL-interacting deubiquitinating enzyme 1
Type:
Protease, Ubiquitin conjugating system
Mass (Da):
106727
Number AA:
942
UniProt ID:
Q8TEY7
International Prot ID:
IPI00236901
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030891
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0016579
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
K
V
L
P
H
F
E
S
L
G
K
Q
E
K
I
Site 2
S44
N
H
C
P
H
L
D
S
V
G
E
I
T
K
E
Site 3
S57
K
E
D
L
I
Q
K
S
L
G
T
C
Q
D
C
Site 4
S80
A
C
L
E
N
R
C
S
Y
V
G
C
G
E
S
Site 5
Y81
C
L
E
N
R
C
S
Y
V
G
C
G
E
S
Q
Site 6
S87
S
Y
V
G
C
G
E
S
Q
V
D
H
S
T
I
Site 7
S92
G
E
S
Q
V
D
H
S
T
I
H
S
Q
E
T
Site 8
T93
E
S
Q
V
D
H
S
T
I
H
S
Q
E
T
K
Site 9
S96
V
D
H
S
T
I
H
S
Q
E
T
K
H
Y
L
Site 10
Y102
H
S
Q
E
T
K
H
Y
L
T
V
N
L
T
T
Site 11
T104
Q
E
T
K
H
Y
L
T
V
N
L
T
T
L
R
Site 12
T129
F
L
D
R
K
L
G
T
Q
P
S
L
P
H
V
Site 13
S132
R
K
L
G
T
Q
P
S
L
P
H
V
R
Q
P
Site 14
S146
P
H
Q
I
Q
E
N
S
V
Q
D
F
K
I
P
Site 15
T156
D
F
K
I
P
S
N
T
T
L
K
T
P
L
V
Site 16
T185
E
L
R
A
R
G
L
T
G
L
K
N
I
G
N
Site 17
Y195
K
N
I
G
N
T
C
Y
M
N
A
A
L
Q
A
Site 18
S204
N
A
A
L
Q
A
L
S
N
C
P
P
L
T
Q
Site 19
S231
K
K
P
A
I
C
K
S
Y
L
K
L
M
T
E
Site 20
S243
M
T
E
L
W
H
K
S
R
P
G
S
V
V
P
Site 21
S247
W
H
K
S
R
P
G
S
V
V
P
T
T
L
F
Site 22
T259
T
L
F
Q
G
I
K
T
V
N
P
T
F
R
G
Site 23
T263
G
I
K
T
V
N
P
T
F
R
G
Y
S
Q
Q
Site 24
Y267
V
N
P
T
F
R
G
Y
S
Q
Q
D
A
Q
E
Site 25
S268
N
P
T
F
R
G
Y
S
Q
Q
D
A
Q
E
F
Site 26
T300
E
V
E
E
D
P
Q
T
I
T
T
E
E
T
M
Site 27
S312
E
T
M
E
E
D
K
S
Q
S
D
V
D
F
Q
Site 28
S314
M
E
E
D
K
S
Q
S
D
V
D
F
Q
S
C
Site 29
S320
Q
S
D
V
D
F
Q
S
C
E
S
C
S
N
S
Site 30
S323
V
D
F
Q
S
C
E
S
C
S
N
S
D
R
A
Site 31
S327
S
C
E
S
C
S
N
S
D
R
A
E
N
E
N
Site 32
S340
E
N
G
S
R
C
F
S
E
D
N
N
E
T
T
Site 33
S387
E
F
D
K
D
R
D
S
I
S
E
T
V
D
L
Site 34
S389
D
K
D
R
D
S
I
S
E
T
V
D
L
N
N
Site 35
T391
D
R
D
S
I
S
E
T
V
D
L
N
N
Q
E
Site 36
T399
V
D
L
N
N
Q
E
T
V
K
V
Q
I
H
S
Site 37
S409
V
Q
I
H
S
R
A
S
E
Y
I
T
D
V
H
Site 38
T413
S
R
A
S
E
Y
I
T
D
V
H
S
N
D
L
Site 39
S417
E
Y
I
T
D
V
H
S
N
D
L
S
T
P
Q
Site 40
S421
D
V
H
S
N
D
L
S
T
P
Q
I
L
P
S
Site 41
T422
V
H
S
N
D
L
S
T
P
Q
I
L
P
S
N
Site 42
S428
S
T
P
Q
I
L
P
S
N
E
G
V
N
P
R
Site 43
S437
E
G
V
N
P
R
L
S
A
S
P
P
K
S
G
Site 44
S439
V
N
P
R
L
S
A
S
P
P
K
S
G
N
L
Site 45
S443
L
S
A
S
P
P
K
S
G
N
L
W
P
G
L
Site 46
S459
P
P
H
K
K
A
Q
S
A
S
P
K
R
K
K
Site 47
S461
H
K
K
A
Q
S
A
S
P
K
R
K
K
Q
H
Site 48
Y471
R
K
K
Q
H
K
K
Y
R
S
V
I
S
D
I
Site 49
S473
K
Q
H
K
K
Y
R
S
V
I
S
D
I
F
D
Site 50
T498
T
C
D
R
V
S
V
T
L
E
T
F
Q
D
L
Site 51
S506
L
E
T
F
Q
D
L
S
L
P
I
P
G
K
E
Site 52
S520
E
D
L
A
K
L
H
S
S
S
H
P
T
S
I
Site 53
S521
D
L
A
K
L
H
S
S
S
H
P
T
S
I
V
Site 54
S522
L
A
K
L
H
S
S
S
H
P
T
S
I
V
K
Site 55
T525
L
H
S
S
S
H
P
T
S
I
V
K
A
G
S
Site 56
S526
H
S
S
S
H
P
T
S
I
V
K
A
G
S
C
Site 57
Y588
E
L
K
G
D
N
M
Y
S
C
E
K
C
K
K
Site 58
S626
F
R
H
E
L
M
F
S
T
K
I
S
T
H
V
Site 59
S634
T
K
I
S
T
H
V
S
F
P
L
E
G
L
D
Site 60
S650
Q
P
F
L
A
K
D
S
P
A
Q
I
V
T
Y
Site 61
Y674
G
T
A
S
S
G
H
Y
I
A
Y
C
R
N
N
Site 62
Y677
S
S
G
H
Y
I
A
Y
C
R
N
N
L
N
N
Site 63
Y687
N
N
L
N
N
L
W
Y
E
F
D
D
Q
S
V
Site 64
S693
W
Y
E
F
D
D
Q
S
V
T
E
V
S
E
S
Site 65
S698
D
Q
S
V
T
E
V
S
E
S
T
V
Q
N
A
Site 66
Y708
T
V
Q
N
A
E
A
Y
V
L
F
Y
R
K
S
Site 67
S715
Y
V
L
F
Y
R
K
S
S
E
E
A
Q
K
E
Site 68
S716
V
L
F
Y
R
K
S
S
E
E
A
Q
K
E
R
Site 69
S727
Q
K
E
R
R
R
I
S
N
L
L
N
I
M
E
Site 70
Y741
E
P
S
L
L
Q
F
Y
I
S
R
Q
W
L
N
Site 71
T752
Q
W
L
N
K
F
K
T
F
A
E
P
G
P
I
Site 72
Y795
Q
N
I
W
D
N
L
Y
S
R
Y
G
G
G
P
Site 73
T826
K
I
E
K
R
R
K
T
E
L
E
I
F
I
R
Site 74
S843
R
A
F
Q
K
E
D
S
P
A
T
F
Y
C
I
Site 75
T876
P
P
G
P
I
D
N
T
K
I
A
V
T
K
C
Site 76
S894
M
L
R
Q
G
A
D
S
G
Q
I
S
E
E
T
Site 77
S898
G
A
D
S
G
Q
I
S
E
E
T
W
N
F
L
Site 78
T901
S
G
Q
I
S
E
E
T
W
N
F
L
Q
S
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation