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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SH3TC2
Full Name:
SH3 domain and tetratricopeptide repeats-containing protein 2
Alias:
Type:
Mass (Da):
144777
Number AA:
1288
UniProt ID:
Q8TF17
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
F
C
I
P
R
E
R
S
L
T
R
G
P
G
K
Site 2
T14
I
P
R
E
R
S
L
T
R
G
P
G
K
E
T
Site 3
T21
T
R
G
P
G
K
E
T
P
S
K
D
P
T
V
Site 4
S23
G
P
G
K
E
T
P
S
K
D
P
T
V
S
S
Site 5
T27
E
T
P
S
K
D
P
T
V
S
S
E
C
I
A
Site 6
S29
P
S
K
D
P
T
V
S
S
E
C
I
A
S
S
Site 7
S30
S
K
D
P
T
V
S
S
E
C
I
A
S
S
E
Site 8
S35
V
S
S
E
C
I
A
S
S
E
Y
K
E
K
C
Site 9
S36
S
S
E
C
I
A
S
S
E
Y
K
E
K
C
F
Site 10
T53
Q
N
I
N
P
D
L
T
L
S
F
C
V
K
S
Site 11
S55
I
N
P
D
L
T
L
S
F
C
V
K
S
R
S
Site 12
S60
T
L
S
F
C
V
K
S
R
S
R
R
C
V
N
Site 13
S62
S
F
C
V
K
S
R
S
R
R
C
V
N
G
P
Site 14
S101
D
L
S
A
R
L
V
S
I
Q
S
Q
R
A
Q
Site 15
S104
A
R
L
V
S
I
Q
S
Q
R
A
Q
F
L
I
Site 16
T112
Q
R
A
Q
F
L
I
T
F
K
T
M
E
E
I
Site 17
Y125
E
I
W
K
F
S
T
Y
L
N
L
G
Y
V
S
Site 18
S159
E
D
T
E
I
Q
V
S
V
D
D
K
H
L
E
Site 19
T188
C
R
A
L
C
S
V
T
P
P
A
E
K
E
G
Site 20
T199
E
K
E
G
E
C
L
T
L
C
K
N
E
L
I
Site 21
S221
G
S
E
L
E
G
V
S
L
V
T
G
Q
R
G
Site 22
Y250
H
Q
W
F
L
K
N
Y
P
G
S
C
G
L
S
Site 23
S253
F
L
K
N
Y
P
G
S
C
G
L
S
R
K
R
Site 24
S257
Y
P
G
S
C
G
L
S
R
K
R
D
W
T
G
Site 25
T263
L
S
R
K
R
D
W
T
G
S
Y
Q
I
G
R
Site 26
S265
R
K
R
D
W
T
G
S
Y
Q
I
G
R
G
R
Site 27
Y266
K
R
D
W
T
G
S
Y
Q
I
G
R
G
R
C
Site 28
T277
R
G
R
C
K
A
L
T
G
Y
E
P
G
E
K
Site 29
Y290
E
K
D
E
L
N
F
Y
Q
G
E
S
I
E
I
Site 30
S312
L
Q
W
F
I
G
K
S
T
S
S
G
Q
V
G
Site 31
S330
T
R
N
I
D
P
D
S
Y
S
P
M
S
R
N
Site 32
Y331
R
N
I
D
P
D
S
Y
S
P
M
S
R
N
S
Site 33
S332
N
I
D
P
D
S
Y
S
P
M
S
R
N
S
A
Site 34
S335
P
D
S
Y
S
P
M
S
R
N
S
A
F
L
S
Site 35
S338
Y
S
P
M
S
R
N
S
A
F
L
S
D
E
E
Site 36
S342
S
R
N
S
A
F
L
S
D
E
E
R
C
S
L
Site 37
S348
L
S
D
E
E
R
C
S
L
L
A
L
G
S
D
Site 38
S354
C
S
L
L
A
L
G
S
D
K
Q
T
E
C
S
Site 39
T358
A
L
G
S
D
K
Q
T
E
C
S
S
F
L
H
Site 40
S362
D
K
Q
T
E
C
S
S
F
L
H
T
L
A
R
Site 41
T366
E
C
S
S
F
L
H
T
L
A
R
T
D
I
T
Site 42
T373
T
L
A
R
T
D
I
T
S
V
Y
R
L
S
G
Site 43
Y376
R
T
D
I
T
S
V
Y
R
L
S
G
F
E
S
Site 44
S379
I
T
S
V
Y
R
L
S
G
F
E
S
I
Q
N
Site 45
S383
Y
R
L
S
G
F
E
S
I
Q
N
P
P
N
D
Site 46
S392
Q
N
P
P
N
D
L
S
A
S
Q
P
E
G
F
Site 47
S394
P
P
N
D
L
S
A
S
Q
P
E
G
F
K
E
Site 48
S416
E
E
H
Q
A
V
G
S
R
Q
S
S
S
S
E
Site 49
S419
Q
A
V
G
S
R
Q
S
S
S
S
E
D
S
S
Site 50
S420
A
V
G
S
R
Q
S
S
S
S
E
D
S
S
L
Site 51
S421
V
G
S
R
Q
S
S
S
S
E
D
S
S
L
E
Site 52
S422
G
S
R
Q
S
S
S
S
E
D
S
S
L
E
E
Site 53
S425
Q
S
S
S
S
E
D
S
S
L
E
E
E
L
L
Site 54
S426
S
S
S
S
E
D
S
S
L
E
E
E
L
L
S
Site 55
S433
S
L
E
E
E
L
L
S
A
T
S
D
S
Y
R
Site 56
S436
E
E
L
L
S
A
T
S
D
S
Y
R
L
P
E
Site 57
S438
L
L
S
A
T
S
D
S
Y
R
L
P
E
P
D
Site 58
Y439
L
S
A
T
S
D
S
Y
R
L
P
E
P
D
D
Site 59
S457
P
E
L
L
M
D
L
S
T
G
Q
E
E
E
A
Site 60
Y479
A
F
L
D
H
E
G
Y
A
D
H
F
K
S
L
Site 61
S485
G
Y
A
D
H
F
K
S
L
Y
D
F
S
F
S
Site 62
Y487
A
D
H
F
K
S
L
Y
D
F
S
F
S
F
L
Site 63
S497
S
F
S
F
L
T
S
S
F
Y
S
F
S
E
E
Site 64
S500
F
L
T
S
S
F
Y
S
F
S
E
E
D
E
F
Site 65
S502
T
S
S
F
Y
S
F
S
E
E
D
E
F
V
A
Site 66
Y510
E
E
D
E
F
V
A
Y
L
E
A
S
R
K
W
Site 67
S545
S
I
R
K
V
K
L
S
Q
A
R
V
Y
F
E
Site 68
Y550
K
L
S
Q
A
R
V
Y
F
E
E
A
I
H
I
Site 69
Y579
Y
I
N
L
A
A
I
Y
L
K
Q
R
L
R
H
Site 70
S607
A
C
L
P
D
R
E
S
S
A
K
H
E
L
D
Site 71
S608
C
L
P
D
R
E
S
S
A
K
H
E
L
D
V
Site 72
S663
A
E
R
L
Q
L
L
S
G
H
P
P
A
S
E
Site 73
Y680
A
S
V
L
S
F
L
Y
D
K
K
Y
L
P
H
Site 74
S726
T
K
L
L
G
F
P
S
P
G
W
G
E
V
S
Site 75
S754
C
E
E
L
A
D
R
S
T
Q
R
A
L
C
L
Site 76
T755
E
E
L
A
D
R
S
T
Q
R
A
L
C
L
I
Site 77
S772
K
V
Y
L
E
H
R
S
P
D
G
A
I
H
Y
Site 78
S795
Q
L
L
G
E
Q
E
S
F
E
S
S
L
C
L
Site 79
S798
G
E
Q
E
S
F
E
S
S
L
C
L
A
W
A
Site 80
S799
E
Q
E
S
F
E
S
S
L
C
L
A
W
A
Y
Site 81
T829
L
L
C
S
L
K
E
T
E
S
L
T
Q
R
G
Site 82
S831
C
S
L
K
E
T
E
S
L
T
Q
R
G
V
I
Site 83
T833
L
K
E
T
E
S
L
T
Q
R
G
V
I
Y
N
Site 84
S858
R
V
N
R
A
A
K
S
Y
L
R
A
L
N
R
Site 85
Y859
V
N
R
A
A
K
S
Y
L
R
A
L
N
R
A
Site 86
S886
M
A
N
L
G
H
L
S
L
K
S
W
A
Q
H
Site 87
S889
L
G
H
L
S
L
K
S
W
A
Q
H
P
A
R
Site 88
Y898
A
Q
H
P
A
R
N
Y
L
L
Q
A
V
R
L
Site 89
S912
L
Y
C
E
L
Q
A
S
K
E
T
D
M
E
L
Site 90
S958
L
R
H
R
H
L
K
S
Q
L
Q
A
T
K
S
Site 91
S965
S
Q
L
Q
A
T
K
S
L
C
H
F
Y
S
S
Site 92
Y970
T
K
S
L
C
H
F
Y
S
S
V
S
P
N
P
Site 93
S971
K
S
L
C
H
F
Y
S
S
V
S
P
N
P
E
Site 94
S972
S
L
C
H
F
Y
S
S
V
S
P
N
P
E
A
Site 95
S974
C
H
F
Y
S
S
V
S
P
N
P
E
A
C
I
Site 96
S1019
R
N
L
N
T
A
R
S
L
R
R
S
L
T
C
Site 97
S1023
T
A
R
S
L
R
R
S
L
T
C
I
K
E
S
Site 98
T1025
R
S
L
R
R
S
L
T
C
I
K
E
S
L
R
Site 99
Y1055
L
G
A
G
R
L
H
Y
L
M
Q
E
D
E
L
Site 100
Y1107
H
R
H
H
A
V
E
Y
Y
R
A
G
A
V
P
Site 101
T1124
R
R
L
K
A
V
R
T
E
L
R
I
F
N
K
Site 102
S1138
K
L
T
E
L
Q
I
S
L
E
G
Y
E
K
A
Site 103
S1156
A
T
L
A
A
R
L
S
T
V
T
G
D
Q
R
Site 104
T1157
T
L
A
A
R
L
S
T
V
T
G
D
Q
R
Q
Site 105
Y1176
F
H
R
L
A
T
V
Y
Y
S
L
H
M
Y
E
Site 106
Y1182
V
Y
Y
S
L
H
M
Y
E
M
A
E
D
C
Y
Site 107
T1192
A
E
D
C
Y
L
K
T
L
S
L
C
P
P
W
Site 108
S1202
L
C
P
P
W
L
Q
S
P
K
E
A
L
Y
Y
Site 109
Y1208
Q
S
P
K
E
A
L
Y
Y
A
K
V
Y
Y
R
Site 110
Y1209
S
P
K
E
A
L
Y
Y
A
K
V
Y
Y
R
L
Site 111
Y1213
A
L
Y
Y
A
K
V
Y
Y
R
L
G
R
L
T
Site 112
T1220
Y
Y
R
L
G
R
L
T
F
C
Q
L
K
D
A
Site 113
T1252
G
D
E
E
L
Q
D
T
I
R
S
R
L
D
N
Site 114
S1263
R
L
D
N
I
C
Q
S
P
L
W
H
S
R
P
Site 115
S1268
C
Q
S
P
L
W
H
S
R
P
S
G
C
S
S
Site 116
S1271
P
L
W
H
S
R
P
S
G
C
S
S
E
R
A
Site 117
S1274
H
S
R
P
S
G
C
S
S
E
R
A
R
W
L
Site 118
S1275
S
R
P
S
G
C
S
S
E
R
A
R
W
L
S
Site 119
S1282
S
E
R
A
R
W
L
S
G
G
G
L
A
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation