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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DIS3L
Full Name:
DIS3-like exonuclease 1
Alias:
di3l1; dis3 mitotic control homolog (s. cerevisiae)-like; DIS3 mitotic control-like; dis3l; dis3l protein; flj38088; kiaa1955; kiaa1955 protein; mgc4562
Type:
EC 3.1.13.-; Ribonuclease
Mass (Da):
120790
Number AA:
UniProt ID:
Q8TF46
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0004527
GO:0004540
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T13
E
K
V
L
L
L
R
T
F
Q
G
R
T
L
R
Site 2
T18
L
R
T
F
Q
G
R
T
L
R
I
V
R
E
H
Site 3
S35
R
P
C
V
P
C
H
S
P
L
C
P
Q
P
A
Site 4
S45
C
P
Q
P
A
A
C
S
H
D
G
K
L
L
S
Site 5
S52
S
H
D
G
K
L
L
S
S
D
V
T
H
Y
V
Site 6
S53
H
D
G
K
L
L
S
S
D
V
T
H
Y
V
I
Site 7
T56
K
L
L
S
S
D
V
T
H
Y
V
I
P
D
W
Site 8
Y58
L
S
S
D
V
T
H
Y
V
I
P
D
W
K
V
Site 9
Y69
D
W
K
V
V
Q
D
Y
L
E
I
L
E
F
P
Site 10
Y100
H
Q
R
G
R
R
Q
Y
N
K
L
R
N
L
L
Site 11
Y126
N
E
F
Q
Q
C
C
Y
L
P
R
E
R
G
E
Site 12
S134
L
P
R
E
R
G
E
S
M
E
K
W
Q
T
R
Site 13
S175
E
A
I
Q
Q
Y
G
S
E
T
E
G
V
F
V
Site 14
S205
A
A
H
E
L
C
D
S
I
L
Q
S
R
R
E
Site 15
S209
L
C
D
S
I
L
Q
S
R
R
E
R
E
N
E
Site 16
S217
R
R
E
R
E
N
E
S
Q
E
S
H
G
K
E
Site 17
S220
R
E
N
E
S
Q
E
S
H
G
K
E
Y
P
E
Site 18
Y225
Q
E
S
H
G
K
E
Y
P
E
H
L
P
L
E
Site 19
S267
F
V
R
L
Q
G
A
S
S
K
D
S
D
L
V
Site 20
S268
V
R
L
Q
G
A
S
S
K
D
S
D
L
V
S
Site 21
S271
Q
G
A
S
S
K
D
S
D
L
V
S
D
I
L
Site 22
S275
S
K
D
S
D
L
V
S
D
I
L
I
H
G
M
Site 23
S288
G
M
K
A
R
N
R
S
I
H
G
D
V
V
V
Site 24
T308
K
N
E
W
K
G
R
T
V
A
L
C
E
N
D
Site 25
S321
N
D
C
D
D
K
A
S
G
E
S
P
S
E
P
Site 26
S324
D
D
K
A
S
G
E
S
P
S
E
P
M
P
T
Site 27
S326
K
A
S
G
E
S
P
S
E
P
M
P
T
G
R
Site 28
Y345
L
Q
K
N
W
R
D
Y
V
V
T
F
P
S
K
Site 29
T348
N
W
R
D
Y
V
V
T
F
P
S
K
E
E
V
Site 30
S357
P
S
K
E
E
V
Q
S
Q
G
K
N
A
Q
K
Site 31
T368
N
A
Q
K
I
L
V
T
P
W
D
Y
R
I
P
Site 32
S380
R
I
P
K
I
R
I
S
T
Q
Q
A
E
T
L
Site 33
T381
I
P
K
I
R
I
S
T
Q
Q
A
E
T
L
Q
Site 34
S398
R
V
V
V
R
I
D
S
W
E
S
T
S
V
Y
Site 35
S401
V
R
I
D
S
W
E
S
T
S
V
Y
P
N
G
Site 36
T402
R
I
D
S
W
E
S
T
S
V
Y
P
N
G
H
Site 37
Y405
S
W
E
S
T
S
V
Y
P
N
G
H
F
V
R
Site 38
T450
M
C
E
M
P
V
N
T
P
E
S
P
W
K
V
Site 39
S453
M
P
V
N
T
P
E
S
P
W
K
V
S
P
E
Site 40
S458
P
E
S
P
W
K
V
S
P
E
E
E
Q
K
R
Site 41
S471
K
R
K
D
L
R
K
S
H
L
V
F
S
I
D
Site 42
S476
R
K
S
H
L
V
F
S
I
D
P
K
G
C
E
Site 43
T488
G
C
E
D
V
D
D
T
L
S
V
R
T
L
N
Site 44
S490
E
D
V
D
D
T
L
S
V
R
T
L
N
N
G
Site 45
S516
T
H
F
V
A
P
N
S
Y
I
D
I
E
A
R
Site 46
T527
I
E
A
R
T
R
A
T
T
Y
Y
L
A
D
R
Site 47
T528
E
A
R
T
R
A
T
T
Y
Y
L
A
D
R
R
Site 48
Y530
R
T
R
A
T
T
Y
Y
L
A
D
R
R
Y
D
Site 49
Y536
Y
Y
L
A
D
R
R
Y
D
M
L
P
S
V
L
Site 50
S541
R
R
Y
D
M
L
P
S
V
L
S
A
D
L
C
Site 51
Y570
W
E
L
D
K
A
S
Y
E
I
K
K
V
W
Y
Site 52
Y577
Y
E
I
K
K
V
W
Y
G
R
T
I
I
R
S
Site 53
T580
K
K
V
W
Y
G
R
T
I
I
R
S
A
Y
K
Site 54
Y586
R
T
I
I
R
S
A
Y
K
L
F
Y
E
A
A
Site 55
Y590
R
S
A
Y
K
L
F
Y
E
A
A
Q
E
L
L
Site 56
S602
E
L
L
D
G
N
L
S
V
V
D
D
I
P
E
Site 57
S617
F
K
D
L
D
E
K
S
R
Q
A
K
L
E
E
Site 58
S718
P
P
H
Q
E
F
F
S
E
L
R
E
C
A
K
Site 59
T733
A
K
G
F
F
I
D
T
R
S
N
K
T
L
A
Site 60
S735
G
F
F
I
D
T
R
S
N
K
T
L
A
D
S
Site 61
T738
I
D
T
R
S
N
K
T
L
A
D
S
L
D
N
Site 62
S742
S
N
K
T
L
A
D
S
L
D
N
A
N
D
P
Site 63
S776
A
L
Y
F
S
T
G
S
C
A
E
E
E
F
H
Site 64
Y785
A
E
E
E
F
H
H
Y
G
L
A
L
D
K
Y
Site 65
Y792
Y
G
L
A
L
D
K
Y
T
H
F
T
S
P
I
Site 66
T793
G
L
A
L
D
K
Y
T
H
F
T
S
P
I
R
Site 67
S797
D
K
Y
T
H
F
T
S
P
I
R
R
Y
S
D
Site 68
Y802
F
T
S
P
I
R
R
Y
S
D
I
V
V
H
R
Site 69
S803
T
S
P
I
R
R
Y
S
D
I
V
V
H
R
L
Site 70
S816
R
L
L
M
A
A
I
S
K
D
K
K
M
E
I
Site 71
S829
E
I
K
G
N
L
F
S
N
K
D
L
E
E
L
Site 72
S850
R
N
Q
A
A
Q
H
S
Q
K
Q
S
T
E
L
Site 73
Y862
T
E
L
F
Q
C
M
Y
F
K
D
K
D
P
A
Site 74
T870
F
K
D
K
D
P
A
T
E
E
R
C
I
S
D
Site 75
Y881
C
I
S
D
G
V
I
Y
S
I
R
T
N
G
V
Site 76
Y902
F
G
I
K
G
A
A
Y
L
K
N
K
D
G
L
Site 77
S912
N
K
D
G
L
V
I
S
C
G
P
D
S
C
S
Site 78
S917
V
I
S
C
G
P
D
S
C
S
E
W
K
P
G
Site 79
S919
S
C
G
P
D
S
C
S
E
W
K
P
G
S
L
Site 80
S925
C
S
E
W
K
P
G
S
L
Q
R
F
Q
N
K
Site 81
S942
S
T
T
T
D
G
E
S
V
T
F
H
L
F
D
Site 82
T944
T
T
D
G
E
S
V
T
F
H
L
F
D
H
V
Site 83
S960
V
R
I
S
I
Q
A
S
R
C
H
S
D
T
I
Site 84
S964
I
Q
A
S
R
C
H
S
D
T
I
R
L
E
I
Site 85
T966
A
S
R
C
H
S
D
T
I
R
L
E
I
I
S
Site 86
S973
T
I
R
L
E
I
I
S
N
K
P
Y
K
I
P
Site 87
Y977
E
I
I
S
N
K
P
Y
K
I
P
N
T
E
L
Site 88
T982
K
P
Y
K
I
P
N
T
E
L
I
H
Q
S
S
Site 89
S989
T
E
L
I
H
Q
S
S
P
L
L
K
S
E
L
Site 90
S994
Q
S
S
P
L
L
K
S
E
L
V
K
E
V
T
Site 91
S1003
L
V
K
E
V
T
K
S
V
E
E
A
Q
L
A
Site 92
Y1022
V
N
I
I
Q
E
E
Y
Q
E
Y
R
Q
T
K
Site 93
Y1025
I
Q
E
E
Y
Q
E
Y
R
Q
T
K
G
R
S
Site 94
T1028
E
Y
Q
E
Y
R
Q
T
K
G
R
S
L
Y
T
Site 95
Y1034
Q
T
K
G
R
S
L
Y
T
L
L
E
E
I
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation