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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHROOM3
Full Name:
Protein Shroom3
Alias:
APXL3; KIAA1481; SHRM; SHRM3; ShrmL; Shroom family member 3; Shroom-related protein
Type:
Cytoskeletal protein
Mass (Da):
216661
Number AA:
1995
UniProt ID:
Q8TF72
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005912
GO:0043296
GO:0016324
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0045176
GO:0000902
GO:0043482
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T20
T
L
N
S
N
T
A
T
K
G
R
Y
I
Y
L
Site 2
Y26
A
T
K
G
R
Y
I
Y
L
E
A
F
L
E
G
Site 3
T40
G
G
A
P
W
G
F
T
L
K
G
G
L
E
H
Site 4
S54
H
G
E
P
L
I
I
S
K
V
E
E
G
G
K
Site 5
T64
E
E
G
G
K
A
D
T
L
S
S
K
L
Q
A
Site 6
S66
G
G
K
A
D
T
L
S
S
K
L
Q
A
G
D
Site 7
T82
V
V
H
I
N
E
V
T
L
S
S
S
R
K
E
Site 8
S84
H
I
N
E
V
T
L
S
S
S
R
K
E
A
V
Site 9
S85
I
N
E
V
T
L
S
S
S
R
K
E
A
V
S
Site 10
S92
S
S
R
K
E
A
V
S
L
V
K
G
S
Y
K
Site 11
T100
L
V
K
G
S
Y
K
T
L
R
L
V
V
R
R
Site 12
T111
V
V
R
R
D
V
C
T
D
P
G
H
A
D
T
Site 13
S121
G
H
A
D
T
G
A
S
N
F
V
S
P
E
H
Site 14
S125
T
G
A
S
N
F
V
S
P
E
H
L
T
S
G
Site 15
S131
V
S
P
E
H
L
T
S
G
P
Q
H
R
K
A
Site 16
S141
Q
H
R
K
A
A
W
S
G
G
V
K
L
R
L
Site 17
S152
K
L
R
L
K
H
R
S
S
E
P
A
G
R
P
Site 18
S153
L
R
L
K
H
R
S
S
E
P
A
G
R
P
H
Site 19
S161
E
P
A
G
R
P
H
S
W
H
T
T
K
S
G
Site 20
T165
R
P
H
S
W
H
T
T
K
S
G
E
K
Q
P
Site 21
S167
H
S
W
H
T
T
K
S
G
E
K
Q
P
D
A
Site 22
S175
G
E
K
Q
P
D
A
S
M
M
Q
I
S
Q
G
Site 23
S180
D
A
S
M
M
Q
I
S
Q
G
M
I
G
P
P
Site 24
S191
I
G
P
P
W
H
Q
S
Y
H
S
S
S
S
T
Site 25
Y192
G
P
P
W
H
Q
S
Y
H
S
S
S
S
T
S
Site 26
S194
P
W
H
Q
S
Y
H
S
S
S
S
T
S
D
L
Site 27
S195
W
H
Q
S
Y
H
S
S
S
S
T
S
D
L
S
Site 28
S196
H
Q
S
Y
H
S
S
S
S
T
S
D
L
S
N
Site 29
S197
Q
S
Y
H
S
S
S
S
T
S
D
L
S
N
Y
Site 30
T198
S
Y
H
S
S
S
S
T
S
D
L
S
N
Y
D
Site 31
S199
Y
H
S
S
S
S
T
S
D
L
S
N
Y
D
H
Site 32
S202
S
S
S
T
S
D
L
S
N
Y
D
H
A
Y
L
Site 33
Y204
S
T
S
D
L
S
N
Y
D
H
A
Y
L
R
R
Site 34
Y208
L
S
N
Y
D
H
A
Y
L
R
R
S
P
D
Q
Site 35
S212
D
H
A
Y
L
R
R
S
P
D
Q
C
S
S
Q
Site 36
S217
R
R
S
P
D
Q
C
S
S
Q
G
S
M
E
S
Site 37
S218
R
S
P
D
Q
C
S
S
Q
G
S
M
E
S
L
Site 38
S221
D
Q
C
S
S
Q
G
S
M
E
S
L
E
P
S
Site 39
S224
S
S
Q
G
S
M
E
S
L
E
P
S
G
A
Y
Site 40
S228
S
M
E
S
L
E
P
S
G
A
Y
P
P
C
H
Site 41
Y231
S
L
E
P
S
G
A
Y
P
P
C
H
L
S
P
Site 42
S237
A
Y
P
P
C
H
L
S
P
A
K
S
T
G
S
Site 43
S241
C
H
L
S
P
A
K
S
T
G
S
I
D
Q
L
Site 44
T242
H
L
S
P
A
K
S
T
G
S
I
D
Q
L
S
Site 45
S244
S
P
A
K
S
T
G
S
I
D
Q
L
S
H
F
Site 46
S249
T
G
S
I
D
Q
L
S
H
F
H
N
K
R
D
Site 47
S257
H
F
H
N
K
R
D
S
A
Y
S
S
F
S
T
Site 48
Y259
H
N
K
R
D
S
A
Y
S
S
F
S
T
S
S
Site 49
S260
N
K
R
D
S
A
Y
S
S
F
S
T
S
S
S
Site 50
S261
K
R
D
S
A
Y
S
S
F
S
T
S
S
S
I
Site 51
S263
D
S
A
Y
S
S
F
S
T
S
S
S
I
L
E
Site 52
T264
S
A
Y
S
S
F
S
T
S
S
S
I
L
E
Y
Site 53
S265
A
Y
S
S
F
S
T
S
S
S
I
L
E
Y
P
Site 54
S267
S
S
F
S
T
S
S
S
I
L
E
Y
P
H
P
Site 55
Y271
T
S
S
S
I
L
E
Y
P
H
P
G
I
S
A
Site 56
S277
E
Y
P
H
P
G
I
S
A
R
E
R
S
G
S
Site 57
S282
G
I
S
A
R
E
R
S
G
S
M
D
N
T
S
Site 58
S284
S
A
R
E
R
S
G
S
M
D
N
T
S
A
R
Site 59
T288
R
S
G
S
M
D
N
T
S
A
R
G
G
L
L
Site 60
S289
S
G
S
M
D
N
T
S
A
R
G
G
L
L
E
Site 61
Y305
M
R
Q
A
D
I
R
Y
V
K
T
V
Y
D
T
Site 62
T308
A
D
I
R
Y
V
K
T
V
Y
D
T
R
R
G
Site 63
Y310
I
R
Y
V
K
T
V
Y
D
T
R
R
G
V
S
Site 64
T312
Y
V
K
T
V
Y
D
T
R
R
G
V
S
A
E
Site 65
S317
Y
D
T
R
R
G
V
S
A
E
Y
E
V
N
S
Site 66
Y320
R
R
G
V
S
A
E
Y
E
V
N
S
S
A
L
Site 67
S324
S
A
E
Y
E
V
N
S
S
A
L
L
L
Q
G
Site 68
S325
A
E
Y
E
V
N
S
S
A
L
L
L
Q
G
R
Site 69
S337
Q
G
R
E
A
R
A
S
A
N
G
Q
G
Y
D
Site 70
Y343
A
S
A
N
G
Q
G
Y
D
K
W
S
N
I
P
Site 71
S359
G
K
G
V
P
P
P
S
W
S
Q
Q
C
P
S
Site 72
S361
G
V
P
P
P
S
W
S
Q
Q
C
P
S
S
L
Site 73
S367
W
S
Q
Q
C
P
S
S
L
E
T
A
T
D
N
Site 74
T370
Q
C
P
S
S
L
E
T
A
T
D
N
L
P
P
Site 75
S388
A
P
L
P
P
A
R
S
D
S
Y
A
A
F
R
Site 76
S390
L
P
P
A
R
S
D
S
Y
A
A
F
R
H
R
Site 77
Y391
P
P
A
R
S
D
S
Y
A
A
F
R
H
R
E
Site 78
S401
F
R
H
R
E
R
P
S
S
W
S
S
L
D
Q
Site 79
S402
R
H
R
E
R
P
S
S
W
S
S
L
D
Q
K
Site 80
S404
R
E
R
P
S
S
W
S
S
L
D
Q
K
R
L
Site 81
S405
E
R
P
S
S
W
S
S
L
D
Q
K
R
L
C
Site 82
S418
L
C
R
P
Q
A
N
S
L
G
S
L
K
S
P
Site 83
S421
P
Q
A
N
S
L
G
S
L
K
S
P
F
I
E
Site 84
S424
N
S
L
G
S
L
K
S
P
F
I
E
E
Q
L
Site 85
T433
F
I
E
E
Q
L
H
T
V
L
E
K
S
P
E
Site 86
S438
L
H
T
V
L
E
K
S
P
E
N
S
P
P
V
Site 87
S442
L
E
K
S
P
E
N
S
P
P
V
K
P
K
H
Site 88
S471
T
S
I
Y
A
V
P
S
L
E
P
H
F
A
Q
Site 89
S483
F
A
Q
V
P
Q
P
S
V
S
S
N
G
M
L
Site 90
S485
Q
V
P
Q
P
S
V
S
S
N
G
M
L
Y
P
Site 91
Y491
V
S
S
N
G
M
L
Y
P
A
L
A
K
E
S
Site 92
Y500
A
L
A
K
E
S
G
Y
I
A
P
Q
G
A
C
Site 93
S522
E
N
G
N
Q
N
G
S
G
R
P
G
F
A
F
Site 94
S539
P
L
E
H
D
L
L
S
P
V
E
K
K
P
E
Site 95
Y551
K
P
E
A
T
A
K
Y
V
P
S
K
V
H
F
Site 96
S560
P
S
K
V
H
F
C
S
V
P
E
N
E
E
D
Site 97
S569
P
E
N
E
E
D
A
S
L
K
R
H
L
T
P
Site 98
T575
A
S
L
K
R
H
L
T
P
P
Q
G
N
S
P
Site 99
S581
L
T
P
P
Q
G
N
S
P
H
S
N
E
R
K
Site 100
S584
P
Q
G
N
S
P
H
S
N
E
R
K
S
T
H
Site 101
S589
P
H
S
N
E
R
K
S
T
H
S
N
K
P
S
Site 102
T590
H
S
N
E
R
K
S
T
H
S
N
K
P
S
S
Site 103
S592
N
E
R
K
S
T
H
S
N
K
P
S
S
H
P
Site 104
S596
S
T
H
S
N
K
P
S
S
H
P
H
S
L
K
Site 105
S597
T
H
S
N
K
P
S
S
H
P
H
S
L
K
C
Site 106
S601
K
P
S
S
H
P
H
S
L
K
C
P
Q
A
Q
Site 107
S618
Q
A
G
E
D
K
R
S
S
R
L
S
E
P
W
Site 108
S619
A
G
E
D
K
R
S
S
R
L
S
E
P
W
E
Site 109
S622
D
K
R
S
S
R
L
S
E
P
W
E
G
D
F
Site 110
S649
E
R
E
G
L
G
Q
S
L
S
G
N
F
G
K
Site 111
S651
E
G
L
G
Q
S
L
S
G
N
F
G
K
T
K
Site 112
T657
L
S
G
N
F
G
K
T
K
S
A
F
S
S
L
Site 113
S659
G
N
F
G
K
T
K
S
A
F
S
S
L
Q
N
Site 114
S663
K
T
K
S
A
F
S
S
L
Q
N
I
P
E
S
Site 115
S670
S
L
Q
N
I
P
E
S
L
R
R
H
S
S
L
Site 116
S675
P
E
S
L
R
R
H
S
S
L
E
L
G
R
G
Site 117
S676
E
S
L
R
R
H
S
S
L
E
L
G
R
G
T
Site 118
T683
S
L
E
L
G
R
G
T
Q
E
G
Y
P
G
G
Site 119
Y687
G
R
G
T
Q
E
G
Y
P
G
G
R
P
T
C
Site 120
T693
G
Y
P
G
G
R
P
T
C
A
V
N
T
K
A
Site 121
S720
S
H
L
D
R
Q
V
S
Y
P
R
P
E
G
R
Site 122
Y721
H
L
D
R
Q
V
S
Y
P
R
P
E
G
R
T
Site 123
T728
Y
P
R
P
E
G
R
T
G
A
S
A
S
F
N
Site 124
S733
G
R
T
G
A
S
A
S
F
N
S
T
D
P
S
Site 125
S736
G
A
S
A
S
F
N
S
T
D
P
S
P
E
E
Site 126
T737
A
S
A
S
F
N
S
T
D
P
S
P
E
E
P
Site 127
S740
S
F
N
S
T
D
P
S
P
E
E
P
P
A
P
Site 128
S748
P
E
E
P
P
A
P
S
H
P
H
T
S
S
L
Site 129
T752
P
A
P
S
H
P
H
T
S
S
L
G
R
R
G
Site 130
S754
P
S
H
P
H
T
S
S
L
G
R
R
G
P
G
Site 131
S764
R
R
G
P
G
P
G
S
A
S
A
L
Q
G
F
Site 132
S766
G
P
G
P
G
S
A
S
A
L
Q
G
F
Q
Y
Site 133
Y773
S
A
L
Q
G
F
Q
Y
G
K
P
H
C
S
V
Site 134
S794
F
E
Q
R
E
Q
G
S
Q
R
P
S
V
G
G
Site 135
S798
E
Q
G
S
Q
R
P
S
V
G
G
S
G
F
G
Site 136
S802
Q
R
P
S
V
G
G
S
G
F
G
H
N
Y
R
Site 137
Y808
G
S
G
F
G
H
N
Y
R
P
H
R
T
V
S
Site 138
T813
H
N
Y
R
P
H
R
T
V
S
T
S
S
T
S
Site 139
S815
Y
R
P
H
R
T
V
S
T
S
S
T
S
G
N
Site 140
T816
R
P
H
R
T
V
S
T
S
S
T
S
G
N
D
Site 141
S817
P
H
R
T
V
S
T
S
S
T
S
G
N
D
F
Site 142
S818
H
R
T
V
S
T
S
S
T
S
G
N
D
F
E
Site 143
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Site 152
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K
I
L
A
Site 295
S1913
G
I
L
A
N
Y
L
S
E
E
Q
L
Q
D
Y
Site 296
Y1920
S
E
E
Q
L
Q
D
Y
Q
H
F
V
K
M
K
Site 297
S1928
Q
H
F
V
K
M
K
S
T
L
L
I
E
Q
R
Site 298
T1929
H
F
V
K
M
K
S
T
L
L
I
E
Q
R
K
Site 299
S1974
A
L
P
P
N
L
T
S
E
P
I
P
A
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation