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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AEN
Full Name:
Apoptosis-enhancing nuclease
Alias:
Interferon-stimulated 20 kDa exonuclease-like 1
Type:
Mass (Da):
36350
Number AA:
325
UniProt ID:
Q8WTP8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
V
P
R
E
A
P
E
S
A
Q
C
L
C
P
S
Site 2
S34
R
K
R
H
K
R
R
S
R
Q
H
Q
R
F
M
Site 3
S54
L
Q
E
Q
G
L
L
S
M
P
P
E
P
G
S
Site 4
S61
S
M
P
P
E
P
G
S
S
P
L
P
T
P
F
Site 5
S62
M
P
P
E
P
G
S
S
P
L
P
T
P
F
G
Site 6
T66
P
G
S
S
P
L
P
T
P
F
G
A
A
T
A
Site 7
T74
P
F
G
A
A
T
A
T
E
A
A
S
S
G
K
Site 8
S88
K
Q
C
L
R
A
G
S
G
S
A
P
C
S
R
Site 9
S90
C
L
R
A
G
S
G
S
A
P
C
S
R
R
P
Site 10
S94
G
S
G
S
A
P
C
S
R
R
P
A
P
G
K
Site 11
S103
R
P
A
P
G
K
A
S
G
P
L
P
S
K
C
Site 12
T120
I
D
C
E
M
V
G
T
G
P
R
G
R
V
S
Site 13
S127
T
G
P
R
G
R
V
S
E
L
A
R
C
S
I
Site 14
S133
V
S
E
L
A
R
C
S
I
V
S
Y
H
G
D
Site 15
Y137
A
R
C
S
I
V
S
Y
H
G
D
V
L
Y
D
Site 16
Y143
S
Y
H
G
D
V
L
Y
D
K
Y
I
R
P
E
Site 17
Y146
G
D
V
L
Y
D
K
Y
I
R
P
E
M
P
I
Site 18
Y156
P
E
M
P
I
A
D
Y
R
T
R
W
S
G
I
Site 19
Y204
N
D
F
Q
A
L
K
Y
V
H
P
R
S
Q
T
Site 20
S209
L
K
Y
V
H
P
R
S
Q
T
R
D
T
T
Y
Site 21
T211
Y
V
H
P
R
S
Q
T
R
D
T
T
Y
V
P
Site 22
T214
P
R
S
Q
T
R
D
T
T
Y
V
P
N
F
L
Site 23
T215
R
S
Q
T
R
D
T
T
Y
V
P
N
F
L
S
Site 24
Y216
S
Q
T
R
D
T
T
Y
V
P
N
F
L
S
E
Site 25
S222
T
Y
V
P
N
F
L
S
E
P
G
L
H
T
R
Site 26
S233
L
H
T
R
A
R
V
S
L
K
D
L
A
L
Q
Site 27
S255
V
G
Q
H
G
H
S
S
V
E
D
A
T
T
A
Site 28
T260
H
S
S
V
E
D
A
T
T
A
M
E
L
Y
R
Site 29
T261
S
S
V
E
D
A
T
T
A
M
E
L
Y
R
L
Site 30
S292
P
E
D
R
E
P
D
S
S
T
D
M
E
Q
Y
Site 31
S293
E
D
R
E
P
D
S
S
T
D
M
E
Q
Y
M
Site 32
Y299
S
S
T
D
M
E
Q
Y
M
E
D
Q
Y
W
P
Site 33
Y304
E
Q
Y
M
E
D
Q
Y
W
P
D
D
L
A
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation