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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
COG1
Full Name:
Conserved oligomeric Golgi complex subunit 1
Alias:
Component of oligomeric golgi complex 1; conserved oligomeric Golgi complex protein 1; LDLB; low density lipoprotein receptor defect B complementing
Type:
Vesicle protein
Mass (Da):
108978
Number AA:
980
UniProt ID:
Q8WTW3
International Prot ID:
IPI00141561
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0017119
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007030
GO:0006891
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
A
T
A
A
T
S
P
A
L
Site 2
T6
_
_
M
A
T
A
A
T
S
P
A
L
K
R
L
Site 3
S7
_
M
A
T
A
A
T
S
P
A
L
K
R
L
D
Site 4
T65
D
L
I
E
A
A
D
T
I
G
Q
M
R
R
C
Site 5
Y86
A
V
K
A
T
D
Q
Y
C
A
R
L
R
Q
A
Site 6
S95
A
R
L
R
Q
A
G
S
A
A
P
R
P
P
R
Site 7
S110
A
Q
Q
P
Q
Q
P
S
Q
E
K
F
Y
S
M
Site 8
S116
P
S
Q
E
K
F
Y
S
M
A
A
Q
I
K
L
Site 9
S133
E
I
P
E
K
I
W
S
S
M
E
A
S
Q
C
Site 10
S134
I
P
E
K
I
W
S
S
M
E
A
S
Q
C
L
Site 11
S161
H
S
L
L
Q
L
D
S
S
S
S
R
Y
S
P
Site 12
S162
S
L
L
Q
L
D
S
S
S
S
R
Y
S
P
V
Site 13
S163
L
L
Q
L
D
S
S
S
S
R
Y
S
P
V
L
Site 14
S164
L
Q
L
D
S
S
S
S
R
Y
S
P
V
L
S
Site 15
Y166
L
D
S
S
S
S
R
Y
S
P
V
L
S
R
F
Site 16
S167
D
S
S
S
S
R
Y
S
P
V
L
S
R
F
P
Site 17
S171
S
R
Y
S
P
V
L
S
R
F
P
I
L
I
R
Site 18
S188
A
A
A
S
H
F
R
S
T
I
L
H
E
S
K
Site 19
T189
A
A
S
H
F
R
S
T
I
L
H
E
S
K
M
Site 20
S222
I
M
L
L
E
E
S
S
P
R
Q
A
L
T
D
Site 21
T228
S
S
P
R
Q
A
L
T
D
F
L
L
A
R
K
Site 22
T334
S
I
V
E
F
Q
P
T
L
R
T
L
A
H
P
Site 23
S343
R
T
L
A
H
P
I
S
Q
E
Y
L
K
D
T
Site 24
Y346
A
H
P
I
S
Q
E
Y
L
K
D
T
L
Q
K
Site 25
T391
D
A
M
W
E
L
L
T
N
E
S
T
N
H
S
Site 26
S398
T
N
E
S
T
N
H
S
W
D
V
L
C
R
R
Site 27
T428
L
F
L
D
R
L
Q
T
L
T
K
E
G
F
D
Site 28
T430
L
D
R
L
Q
T
L
T
K
E
G
F
D
S
I
Site 29
S436
L
T
K
E
G
F
D
S
I
S
S
S
S
K
E
Site 30
S438
K
E
G
F
D
S
I
S
S
S
S
K
E
L
L
Site 31
S439
E
G
F
D
S
I
S
S
S
S
K
E
L
L
V
Site 32
S440
G
F
D
S
I
S
S
S
S
K
E
L
L
V
S
Site 33
S447
S
S
K
E
L
L
V
S
A
L
Q
E
L
E
S
Site 34
S454
S
A
L
Q
E
L
E
S
S
T
S
N
S
P
S
Site 35
S455
A
L
Q
E
L
E
S
S
T
S
N
S
P
S
N
Site 36
S457
Q
E
L
E
S
S
T
S
N
S
P
S
N
K
H
Site 37
S459
L
E
S
S
T
S
N
S
P
S
N
K
H
I
H
Site 38
S461
S
S
T
S
N
S
P
S
N
K
H
I
H
F
E
Site 39
S477
N
M
S
L
F
L
W
S
E
S
P
N
D
L
P
Site 40
S479
S
L
F
L
W
S
E
S
P
N
D
L
P
S
D
Site 41
S485
E
S
P
N
D
L
P
S
D
A
A
W
V
S
V
Site 42
S491
P
S
D
A
A
W
V
S
V
A
N
R
G
Q
F
Site 43
S500
A
N
R
G
Q
F
A
S
S
G
L
S
M
K
A
Site 44
S519
P
C
V
Q
N
F
C
S
A
L
D
S
K
L
K
Site 45
S523
N
F
C
S
A
L
D
S
K
L
K
V
K
L
D
Site 46
Y535
K
L
D
D
L
L
A
Y
L
P
S
D
D
S
S
Site 47
S538
D
L
L
A
Y
L
P
S
D
D
S
S
L
P
K
Site 48
S541
A
Y
L
P
S
D
D
S
S
L
P
K
D
V
S
Site 49
S542
Y
L
P
S
D
D
S
S
L
P
K
D
V
S
P
Site 50
S548
S
S
L
P
K
D
V
S
P
T
Q
A
K
S
S
Site 51
T550
L
P
K
D
V
S
P
T
Q
A
K
S
S
A
F
Site 52
S554
V
S
P
T
Q
A
K
S
S
A
F
D
R
Y
A
Site 53
Y560
K
S
S
A
F
D
R
Y
A
D
A
G
T
V
Q
Site 54
T565
D
R
Y
A
D
A
G
T
V
Q
E
M
L
R
T
Site 55
T572
T
V
Q
E
M
L
R
T
Q
S
V
A
C
I
K
Site 56
S574
Q
E
M
L
R
T
Q
S
V
A
C
I
K
H
I
Site 57
S591
C
I
R
A
E
L
Q
S
I
E
E
G
V
Q
G
Site 58
S636
K
Q
C
I
L
G
K
S
E
S
S
E
K
P
A
Site 59
S638
C
I
L
G
K
S
E
S
S
E
K
P
A
R
E
Site 60
T657
R
K
Q
G
K
V
K
T
Q
E
I
I
P
T
Q
Site 61
T663
K
T
Q
E
I
I
P
T
Q
A
K
W
Q
E
V
Site 62
S715
S
V
L
A
T
A
T
S
W
D
E
L
E
I
Q
Site 63
S727
E
I
Q
E
E
A
E
S
G
S
S
V
T
S
K
Site 64
S730
E
E
A
E
S
G
S
S
V
T
S
K
I
R
L
Site 65
S733
E
S
G
S
S
V
T
S
K
I
R
L
P
A
Q
Site 66
T802
K
E
G
A
F
P
V
T
Q
N
R
A
L
Q
L
Site 67
Y811
N
R
A
L
Q
L
L
Y
D
L
R
Y
L
N
I
Site 68
S829
A
K
G
D
E
V
K
S
G
R
S
K
P
D
S
Site 69
S836
S
G
R
S
K
P
D
S
R
I
E
K
V
T
D
Site 70
T842
D
S
R
I
E
K
V
T
D
H
L
E
A
L
I
Site 71
T858
P
F
D
L
D
V
F
T
P
H
L
N
S
N
L
Site 72
S863
V
F
T
P
H
L
N
S
N
L
H
R
L
V
Q
Site 73
S890
E
N
Q
L
A
P
R
S
S
T
F
N
S
Q
E
Site 74
S891
N
Q
L
A
P
R
S
S
T
F
N
S
Q
E
P
Site 75
T892
Q
L
A
P
R
S
S
T
F
N
S
Q
E
P
H
Site 76
S895
P
R
S
S
T
F
N
S
Q
E
P
H
N
I
L
Site 77
S917
R
F
G
L
L
P
L
S
M
T
S
T
R
K
A
Site 78
T919
G
L
L
P
L
S
M
T
S
T
R
K
A
K
S
Site 79
T921
L
P
L
S
M
T
S
T
R
K
A
K
S
T
R
Site 80
S926
T
S
T
R
K
A
K
S
T
R
N
I
E
T
K
Site 81
T927
S
T
R
K
A
K
S
T
R
N
I
E
T
K
A
Site 82
S942
Q
V
V
P
P
A
R
S
T
A
G
D
P
T
V
Site 83
T943
V
V
P
P
A
R
S
T
A
G
D
P
T
V
P
Site 84
T948
R
S
T
A
G
D
P
T
V
P
G
S
L
F
R
Site 85
S952
G
D
P
T
V
P
G
S
L
F
R
Q
L
V
S
Site 86
S959
S
L
F
R
Q
L
V
S
E
E
D
N
T
S
A
Site 87
T964
L
V
S
E
E
D
N
T
S
A
P
S
L
F
K
Site 88
S965
V
S
E
E
D
N
T
S
A
P
S
L
F
K
L
Site 89
S968
E
D
N
T
S
A
P
S
L
F
K
L
G
W
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation