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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF139
Full Name:
E3 ubiquitin-protein ligase RNF139
Alias:
HRCA1; Multiple membrane spanning receptor TRC8; Patched related protein translocated in renal cancer; RCA1; RN139; Translocation in renal carcinoma on chromosome 8; TRC8
Type:
Ubiquitin conjugating system
Mass (Da):
75994
Number AA:
664
UniProt ID:
Q8WU17
International Prot ID:
IPI00289584
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0005515
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0019941
GO:0031396
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
I
I
D
A
I
F
N
S
Y
P
D
S
S
Q
S
Site 2
Y41
I
D
A
I
F
N
S
Y
P
D
S
S
Q
S
R
Site 3
S44
I
F
N
S
Y
P
D
S
S
Q
S
R
F
C
I
Site 4
S45
F
N
S
Y
P
D
S
S
Q
S
R
F
C
I
V
Site 5
Y80
Q
R
S
L
F
K
F
Y
T
Y
S
S
A
F
L
Site 6
Y106
A
S
L
H
I
D
F
Y
G
A
Y
N
T
S
A
Site 7
Y202
A
V
K
L
K
W
F
Y
Y
S
T
R
Y
V
Y
Site 8
Y203
V
K
L
K
W
F
Y
Y
S
T
R
Y
V
Y
L
Site 9
Y207
W
F
Y
Y
S
T
R
Y
V
Y
L
L
V
R
H
Site 10
Y209
Y
Y
S
T
R
Y
V
Y
L
L
V
R
H
M
Y
Site 11
T228
L
Q
L
L
M
E
D
T
W
K
R
I
R
F
P
Site 12
S315
G
I
L
A
F
I
G
S
T
E
E
D
D
R
R
Site 13
S341
L
A
L
Q
T
G
L
S
G
L
R
P
E
E
R
Site 14
S384
S
L
S
A
S
H
V
S
S
F
R
R
H
F
P
Site 15
S385
L
S
A
S
H
V
S
S
F
R
R
H
F
P
V
Site 16
Y450
L
F
M
I
D
G
Y
Y
N
V
L
W
E
K
L
Site 17
Y460
L
W
E
K
L
D
D
Y
V
Y
Y
V
R
S
T
Site 18
Y462
E
K
L
D
D
Y
V
Y
Y
V
R
S
T
G
S
Site 19
Y463
K
L
D
D
Y
V
Y
Y
V
R
S
T
G
S
I
Site 20
Y509
L
H
A
Y
F
N
I
Y
L
Q
A
K
N
G
W
Site 21
T524
K
T
F
M
N
R
R
T
A
V
K
K
I
N
S
Site 22
S538
S
L
P
E
I
K
G
S
R
L
Q
E
I
N
D
Site 23
Y566
R
I
T
P
C
N
H
Y
F
H
A
L
C
L
R
Site 24
Y590
P
M
C
H
Q
K
V
Y
I
E
D
D
I
K
D
Site 25
S599
E
D
D
I
K
D
N
S
N
V
S
N
N
N
G
Site 26
T613
G
F
I
P
P
N
E
T
P
E
E
A
V
R
E
Site 27
S625
V
R
E
A
A
A
E
S
D
R
E
L
N
E
D
Site 28
S634
R
E
L
N
E
D
D
S
T
D
C
D
D
D
V
Site 29
T635
E
L
N
E
D
D
S
T
D
C
D
D
D
V
Q
Site 30
T663
A
E
E
F
N
D
D
T
D
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation