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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRS2
Full Name:
Fibroblast growth factor receptor substrate 2
Alias:
FGFR signalling adaptor; FGFR signalling adaptor SNT-1; FGFR substrate 2; FRS2A; FRS2alpha; SNT1; SNT-1; SNT2; SUC1-associated neurotrophic factor target; Suc1-associated neurotrophic factor target; Suc1-associated neurotrophic factor target 1
Type:
Adapter/scaffold protein
Mass (Da):
57029
Number AA:
508
UniProt ID:
Q8WU20
International Prot ID:
IPI00107698
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0012505
GO:0005768
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005104
GO:0005158
GO:0019211
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0008543
GO:0007185
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y48
T
D
T
E
L
I
L
Y
T
R
K
R
D
S
V
Site 2
T49
D
T
E
L
I
L
Y
T
R
K
R
D
S
V
K
Site 3
Y59
R
D
S
V
K
W
H
Y
L
C
L
R
R
Y
G
Site 4
Y65
H
Y
L
C
L
R
R
Y
G
Y
D
S
N
L
F
Site 5
Y67
L
C
L
R
R
Y
G
Y
D
S
N
L
F
S
F
Site 6
S69
L
R
R
Y
G
Y
D
S
N
L
F
S
F
E
S
Site 7
S73
G
Y
D
S
N
L
F
S
F
E
S
G
R
R
C
Site 8
S76
S
N
L
F
S
F
E
S
G
R
R
C
Q
T
G
Site 9
T82
E
S
G
R
R
C
Q
T
G
Q
G
I
F
A
F
Site 10
T125
V
E
R
N
N
H
Q
T
E
L
E
V
P
R
T
Site 11
T132
T
E
L
E
V
P
R
T
P
R
T
P
T
T
P
Site 12
T135
E
V
P
R
T
P
R
T
P
T
T
P
G
F
A
Site 13
T137
R
T
P
R
T
P
T
T
P
G
F
A
A
Q
N
Site 14
T138
R
T
P
R
T
P
T
T
P
G
F
A
A
Q
N
Site 15
Y150
A
Q
N
L
P
N
G
Y
P
R
Y
P
S
F
G
Site 16
Y153
L
P
N
G
Y
P
R
Y
P
S
F
G
D
A
S
Site 17
S155
N
G
Y
P
R
Y
P
S
F
G
D
A
S
S
H
Site 18
S160
Y
P
S
F
G
D
A
S
S
H
P
S
S
R
H
Site 19
S161
P
S
F
G
D
A
S
S
H
P
S
S
R
H
P
Site 20
S164
G
D
A
S
S
H
P
S
S
R
H
P
S
V
G
Site 21
S165
D
A
S
S
H
P
S
S
R
H
P
S
V
G
S
Site 22
S169
H
P
S
S
R
H
P
S
V
G
S
A
R
L
P
Site 23
S172
S
R
H
P
S
V
G
S
A
R
L
P
S
V
G
Site 24
S177
V
G
S
A
R
L
P
S
V
G
E
E
S
T
H
Site 25
T195
V
A
E
E
Q
V
H
T
Y
V
N
T
T
G
V
Site 26
Y196
A
E
E
Q
V
H
T
Y
V
N
T
T
G
V
Q
Site 27
S211
E
E
R
K
N
R
T
S
V
H
V
P
L
E
A
Site 28
S221
V
P
L
E
A
R
V
S
N
A
E
S
S
T
P
Site 29
S225
A
R
V
S
N
A
E
S
S
T
P
K
E
E
P
Site 30
S226
R
V
S
N
A
E
S
S
T
P
K
E
E
P
S
Site 31
T227
V
S
N
A
E
S
S
T
P
K
E
E
P
S
S
Site 32
S234
T
P
K
E
E
P
S
S
I
E
D
R
D
P
Q
Site 33
S279
G
R
D
Q
V
S
G
S
G
A
N
N
T
E
W
Site 34
T284
S
G
S
G
A
N
N
T
E
W
D
T
G
Y
D
Site 35
T288
A
N
N
T
E
W
D
T
G
Y
D
S
D
E
R
Site 36
Y290
N
T
E
W
D
T
G
Y
D
S
D
E
R
R
D
Site 37
S292
E
W
D
T
G
Y
D
S
D
E
R
R
D
A
P
Site 38
S300
D
E
R
R
D
A
P
S
V
N
K
L
V
Y
E
Site 39
Y306
P
S
V
N
K
L
V
Y
E
N
I
N
G
L
S
Site 40
S313
Y
E
N
I
N
G
L
S
I
P
S
A
S
G
V
Site 41
S316
I
N
G
L
S
I
P
S
A
S
G
V
R
R
G
Site 42
S318
G
L
S
I
P
S
A
S
G
V
R
R
G
R
L
Site 43
T326
G
V
R
R
G
R
L
T
S
T
S
T
S
D
T
Site 44
S327
V
R
R
G
R
L
T
S
T
S
T
S
D
T
Q
Site 45
T328
R
R
G
R
L
T
S
T
S
T
S
D
T
Q
N
Site 46
S329
R
G
R
L
T
S
T
S
T
S
D
T
Q
N
I
Site 47
S331
R
L
T
S
T
S
T
S
D
T
Q
N
I
N
N
Site 48
T333
T
S
T
S
T
S
D
T
Q
N
I
N
N
S
A
Site 49
S339
D
T
Q
N
I
N
N
S
A
Q
R
R
T
A
L
Site 50
T344
N
N
S
A
Q
R
R
T
A
L
L
N
Y
E
N
Site 51
Y349
R
R
T
A
L
L
N
Y
E
N
L
P
S
L
P
Site 52
S354
L
N
Y
E
N
L
P
S
L
P
P
V
W
E
A
Site 53
S365
V
W
E
A
R
K
L
S
R
D
E
D
D
N
L
Site 54
T376
D
D
N
L
G
P
K
T
P
S
L
N
G
Y
H
Site 55
S378
N
L
G
P
K
T
P
S
L
N
G
Y
H
N
N
Site 56
Y382
K
T
P
S
L
N
G
Y
H
N
N
L
D
P
M
Site 57
Y392
N
L
D
P
M
H
N
Y
V
N
T
E
N
V
T
Site 58
T395
P
M
H
N
Y
V
N
T
E
N
V
T
V
P
A
Site 59
T399
Y
V
N
T
E
N
V
T
V
P
A
S
A
H
K
Site 60
S403
E
N
V
T
V
P
A
S
A
H
K
I
E
Y
S
Site 61
Y409
A
S
A
H
K
I
E
Y
S
R
R
R
D
C
T
Site 62
S410
S
A
H
K
I
E
Y
S
R
R
R
D
C
T
P
Site 63
T416
Y
S
R
R
R
D
C
T
P
T
V
F
N
F
D
Site 64
T418
R
R
R
D
C
T
P
T
V
F
N
F
D
I
R
Site 65
S428
N
F
D
I
R
R
P
S
L
E
H
R
Q
L
N
Site 66
Y436
L
E
H
R
Q
L
N
Y
I
Q
V
D
L
E
G
Site 67
S445
Q
V
D
L
E
G
G
S
D
S
D
N
P
Q
T
Site 68
S447
D
L
E
G
G
S
D
S
D
N
P
Q
T
P
K
Site 69
T452
S
D
S
D
N
P
Q
T
P
K
T
P
T
T
P
Site 70
T455
D
N
P
Q
T
P
K
T
P
T
T
P
L
P
Q
Site 71
T458
Q
T
P
K
T
P
T
T
P
L
P
Q
T
P
T
Site 72
T463
P
T
T
P
L
P
Q
T
P
T
R
R
T
E
L
Site 73
T465
T
P
L
P
Q
T
P
T
R
R
T
E
L
Y
A
Site 74
T468
P
Q
T
P
T
R
R
T
E
L
Y
A
V
I
D
Site 75
Y471
P
T
R
R
T
E
L
Y
A
V
I
D
I
E
R
Site 76
T479
A
V
I
D
I
E
R
T
A
A
M
S
N
L
Q
Site 77
S483
I
E
R
T
A
A
M
S
N
L
Q
K
A
L
P
Site 78
T495
A
L
P
R
D
D
G
T
S
R
K
T
R
H
N
Site 79
S496
L
P
R
D
D
G
T
S
R
K
T
R
H
N
S
Site 80
T499
D
D
G
T
S
R
K
T
R
H
N
S
T
D
L
Site 81
S503
S
R
K
T
R
H
N
S
T
D
L
P
M
_
_
Site 82
T504
R
K
T
R
H
N
S
T
D
L
P
M
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation