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Updated November 2019
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Protein Info
Short Name:
TSPEAR
Full Name:
Protein TSPEAR
Alias:
Type:
Mass (Da):
74924
Number AA:
669
UniProt ID:
Q8WU66
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
T
Q
G
W
E
P
C
T
D
L
R
P
L
D
I
Site 2
T68
L
S
V
A
A
P
R
T
M
S
F
P
A
S
R
Site 3
S74
R
T
M
S
F
P
A
S
R
I
F
S
Q
C
D
Site 4
S78
F
P
A
S
R
I
F
S
Q
C
D
L
F
P
E
Site 5
Y105
L
P
P
K
R
N
E
Y
L
L
T
V
V
A
E
Site 6
T108
K
R
N
E
Y
L
L
T
V
V
A
E
E
S
D
Site 7
T137
F
L
F
L
R
E
D
T
A
G
A
W
Q
T
R
Site 8
S146
G
A
W
Q
T
R
V
S
F
R
S
P
A
L
V
Site 9
S149
Q
T
R
V
S
F
R
S
P
A
L
V
D
G
R
Site 10
T172
S
A
G
V
F
S
L
T
T
D
C
G
L
P
V
Site 11
S202
G
A
R
F
F
V
G
S
R
R
R
A
K
G
L
Site 12
T226
L
L
P
G
S
D
A
T
P
R
L
C
P
S
R
Site 13
S232
A
T
P
R
L
C
P
S
R
N
A
P
L
A
V
Site 14
T250
P
R
V
L
Q
A
L
T
G
K
P
E
D
N
E
Site 15
Y261
E
D
N
E
V
L
K
Y
P
Y
E
T
N
I
R
Site 16
T270
Y
E
T
N
I
R
V
T
L
G
P
Q
P
P
C
Site 17
T278
L
G
P
Q
P
P
C
T
E
V
E
D
A
Q
F
Site 18
Y295
D
A
S
R
K
G
L
Y
L
C
V
G
N
E
W
Site 19
Y314
A
A
K
E
R
L
D
Y
V
E
E
H
Q
N
L
Site 20
S322
V
E
E
H
Q
N
L
S
T
N
S
E
T
L
G
Site 21
T350
A
T
A
N
R
K
A
T
S
A
V
Y
K
W
T
Site 22
Y364
T
E
E
K
F
V
S
Y
Q
N
I
P
T
H
Q
Site 23
T414
S
H
R
K
L
K
F
T
P
Y
Q
S
I
A
T
Site 24
Y416
R
K
L
K
F
T
P
Y
Q
S
I
A
T
H
S
Site 25
S418
L
K
F
T
P
Y
Q
S
I
A
T
H
S
A
R
Site 26
T470
R
L
F
E
A
N
Q
T
I
A
T
S
G
A
Y
Site 27
S500
A
N
T
F
N
G
T
S
T
K
V
H
S
H
L
Site 28
T501
N
T
F
N
G
T
S
T
K
V
H
S
H
L
Y
Site 29
S547
L
A
V
A
N
S
H
S
Y
D
V
E
M
Q
V
Site 30
Y559
M
Q
V
Q
N
D
S
Y
V
I
N
S
V
I
Y
Site 31
T610
A
N
S
F
D
G
R
T
F
S
V
N
S
I
I
Site 32
S612
S
F
D
G
R
T
F
S
V
N
S
I
I
Y
R
Site 33
T645
R
D
W
E
A
F
S
T
T
A
G
A
Y
L
I
Site 34
S655
G
A
Y
L
I
Y
S
S
A
K
E
P
L
S
R
Site 35
S661
S
S
A
K
E
P
L
S
R
V
L
R
L
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation