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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPIL4
Full Name:
Peptidyl-prolyl cis-trans isomerase-like 4
Alias:
Cyclophilin-like protein PPIL4; HDCME13P; Peptidylprolyl isomerase (cyclophilin)-like 4; PPIase; Rotamase
Type:
Isomerase; Cyclophilin; EC 5.2.1.8
Mass (Da):
57225
Number AA:
492
UniProt ID:
Q8WUA2
International Prot ID:
IPI00642862
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0000166
GO:0003755
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y17
G
D
V
V
I
D
L
Y
T
E
E
R
P
R
A
Site 2
T18
D
V
V
I
D
L
Y
T
E
E
R
P
R
A
C
Site 3
Y39
C
K
I
K
Y
Y
N
Y
C
L
I
H
N
V
Q
Site 4
T53
Q
R
D
F
I
I
Q
T
G
D
P
T
G
T
G
Site 5
T57
I
I
Q
T
G
D
P
T
G
T
G
R
G
G
E
Site 6
T59
Q
T
G
D
P
T
G
T
G
R
G
G
E
S
I
Site 7
S65
G
T
G
R
G
G
E
S
I
F
G
Q
L
Y
G
Site 8
Y71
E
S
I
F
G
Q
L
Y
G
D
Q
A
S
F
F
Site 9
S76
Q
L
Y
G
D
Q
A
S
F
F
E
A
E
K
V
Site 10
S95
H
K
K
K
G
T
V
S
M
V
N
N
G
S
D
Site 11
S106
N
G
S
D
Q
H
G
S
Q
F
L
I
T
T
G
Site 12
Y118
T
T
G
E
N
L
D
Y
L
D
G
V
H
T
V
Site 13
T124
D
Y
L
D
G
V
H
T
V
F
G
E
V
T
E
Site 14
T159
Q
D
I
R
I
N
H
T
V
I
L
D
D
P
F
Site 15
S178
D
L
L
I
P
D
R
S
P
E
P
T
R
E
Q
Site 16
T182
P
D
R
S
P
E
P
T
R
E
Q
L
D
S
G
Site 17
S188
P
T
R
E
Q
L
D
S
G
R
I
G
A
D
E
Site 18
S204
I
D
D
F
K
G
R
S
A
E
E
V
E
E
I
Site 19
T219
K
A
E
K
E
A
K
T
Q
A
I
L
L
E
M
Site 20
S261
E
D
L
E
I
I
F
S
R
F
G
P
I
R
S
Site 21
S268
S
R
F
G
P
I
R
S
C
E
V
I
R
D
W
Site 22
T277
E
V
I
R
D
W
K
T
G
E
S
L
C
Y
A
Site 23
Y283
K
T
G
E
S
L
C
Y
A
F
I
E
F
E
K
Site 24
S316
R
R
I
H
V
D
F
S
Q
S
V
A
K
V
K
Site 25
T332
K
G
K
G
G
K
Y
T
K
S
D
F
K
E
Y
Site 26
S334
K
G
G
K
Y
T
K
S
D
F
K
E
Y
E
K
Site 27
Y363
K
P
K
Q
D
T
K
Y
D
L
I
L
D
E
Q
Site 28
S374
L
D
E
Q
A
E
D
S
K
S
S
H
S
H
T
Site 29
S376
E
Q
A
E
D
S
K
S
S
H
S
H
T
S
K
Site 30
S379
E
D
S
K
S
S
H
S
H
T
S
K
K
H
K
Site 31
T381
S
K
S
S
H
S
H
T
S
K
K
H
K
K
K
Site 32
T389
S
K
K
H
K
K
K
T
H
H
C
S
E
E
K
Site 33
S393
K
K
K
T
H
H
C
S
E
E
K
E
D
E
D
Site 34
Y401
E
E
K
E
D
E
D
Y
M
P
I
K
N
T
N
Site 35
Y412
K
N
T
N
Q
D
I
Y
R
E
M
G
F
G
H
Site 36
Y420
R
E
M
G
F
G
H
Y
E
E
E
E
S
C
W
Site 37
S432
S
C
W
E
K
Q
K
S
E
K
R
D
R
T
Q
Site 38
T438
K
S
E
K
R
D
R
T
Q
N
R
S
R
S
R
Site 39
S442
R
D
R
T
Q
N
R
S
R
S
R
S
R
E
R
Site 40
S444
R
T
Q
N
R
S
R
S
R
S
R
E
R
D
G
Site 41
S446
Q
N
R
S
R
S
R
S
R
E
R
D
G
H
Y
Site 42
Y453
S
R
E
R
D
G
H
Y
S
N
S
H
K
S
K
Site 43
S454
R
E
R
D
G
H
Y
S
N
S
H
K
S
K
Y
Site 44
S456
R
D
G
H
Y
S
N
S
H
K
S
K
Y
Q
T
Site 45
Y461
S
N
S
H
K
S
K
Y
Q
T
D
L
Y
E
R
Site 46
T463
S
H
K
S
K
Y
Q
T
D
L
Y
E
R
E
R
Site 47
Y466
S
K
Y
Q
T
D
L
Y
E
R
E
R
S
K
K
Site 48
S471
D
L
Y
E
R
E
R
S
K
K
R
D
R
S
R
Site 49
S477
R
S
K
K
R
D
R
S
R
S
P
K
K
S
K
Site 50
S479
K
K
R
D
R
S
R
S
P
K
K
S
K
D
K
Site 51
S483
R
S
R
S
P
K
K
S
K
D
K
E
K
S
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation