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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D22A
Full Name:
TBC1 domain family member 22A
Alias:
C22orf4; TB22A; TBC1 domain family 22A; TBC1 domain family, member 22A
Type:
Mass (Da):
59121
Number AA:
517
UniProt ID:
Q8WUA7
International Prot ID:
IPI00011032
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
R
K
Q
F
W
K
R
S
N
S
K
L
P
G
S
Site 2
S16
Q
F
W
K
R
S
N
S
K
L
P
G
S
I
Q
Site 3
S21
S
N
S
K
L
P
G
S
I
Q
H
V
Y
G
A
Site 4
Y26
P
G
S
I
Q
H
V
Y
G
A
Q
H
P
P
F
Site 5
T40
F
D
P
L
L
H
G
T
L
L
R
S
T
A
K
Site 6
S44
L
H
G
T
L
L
R
S
T
A
K
M
P
T
T
Site 7
T45
H
G
T
L
L
R
S
T
A
K
M
P
T
T
P
Site 8
T50
R
S
T
A
K
M
P
T
T
P
V
K
A
K
R
Site 9
T51
S
T
A
K
M
P
T
T
P
V
K
A
K
R
V
Site 10
S59
P
V
K
A
K
R
V
S
T
F
Q
E
F
E
S
Site 11
T60
V
K
A
K
R
V
S
T
F
Q
E
F
E
S
N
Site 12
S69
Q
E
F
E
S
N
T
S
D
A
W
D
A
G
E
Site 13
S106
N
R
V
L
R
N
H
S
Q
R
Q
G
R
P
T
Site 14
T113
S
Q
R
Q
G
R
P
T
L
Q
E
G
P
G
L
Site 15
S132
R
P
E
A
E
P
P
S
P
P
S
G
D
L
R
Site 16
S135
A
E
P
P
S
P
P
S
G
D
L
R
L
V
K
Site 17
S143
G
D
L
R
L
V
K
S
V
S
E
S
H
T
S
Site 18
S145
L
R
L
V
K
S
V
S
E
S
H
T
S
C
P
Site 19
S147
L
V
K
S
V
S
E
S
H
T
S
C
P
A
E
Site 20
T149
K
S
V
S
E
S
H
T
S
C
P
A
E
S
A
Site 21
S150
S
V
S
E
S
H
T
S
C
P
A
E
S
A
S
Site 22
S157
S
C
P
A
E
S
A
S
D
A
A
P
L
Q
R
Site 23
S165
D
A
A
P
L
Q
R
S
Q
S
L
P
H
S
A
Site 24
S167
A
P
L
Q
R
S
Q
S
L
P
H
S
A
T
V
Site 25
S171
R
S
Q
S
L
P
H
S
A
T
V
T
L
G
G
Site 26
T173
Q
S
L
P
H
S
A
T
V
T
L
G
G
T
S
Site 27
T175
L
P
H
S
A
T
V
T
L
G
G
T
S
D
P
Site 28
T179
A
T
V
T
L
G
G
T
S
D
P
S
T
L
S
Site 29
S180
T
V
T
L
G
G
T
S
D
P
S
T
L
S
S
Site 30
S183
L
G
G
T
S
D
P
S
T
L
S
S
S
A
L
Site 31
T184
G
G
T
S
D
P
S
T
L
S
S
S
A
L
S
Site 32
S186
T
S
D
P
S
T
L
S
S
S
A
L
S
E
R
Site 33
S187
S
D
P
S
T
L
S
S
S
A
L
S
E
R
E
Site 34
S188
D
P
S
T
L
S
S
S
A
L
S
E
R
E
A
Site 35
S191
T
L
S
S
S
A
L
S
E
R
E
A
S
R
L
Site 36
S196
A
L
S
E
R
E
A
S
R
L
D
K
F
K
Q
Site 37
T210
Q
L
L
A
G
P
N
T
D
L
E
E
L
R
R
Site 38
S219
L
E
E
L
R
R
L
S
W
S
G
I
P
K
P
Site 39
S221
E
L
R
R
L
S
W
S
G
I
P
K
P
V
R
Site 40
T231
P
K
P
V
R
P
M
T
W
K
L
L
S
G
Y
Site 41
T249
N
V
D
R
R
P
A
T
L
Q
R
K
Q
K
E
Site 42
Y257
L
Q
R
K
Q
K
E
Y
F
A
F
I
E
H
Y
Site 43
Y265
F
A
F
I
E
H
Y
Y
D
S
R
N
D
E
V
Site 44
Y277
D
E
V
H
Q
D
T
Y
R
Q
I
H
I
D
I
Site 45
S288
H
I
D
I
P
R
M
S
P
E
A
L
I
L
Q
Site 46
Y318
I
R
H
P
A
S
G
Y
V
Q
G
I
N
D
L
Site 47
Y378
L
D
G
I
Q
D
N
Y
T
F
A
Q
P
G
I
Site 48
T379
D
G
I
Q
D
N
Y
T
F
A
Q
P
G
I
Q
Site 49
S397
K
M
L
E
E
L
V
S
R
I
D
E
Q
V
H
Site 50
Y414
L
D
Q
H
E
V
R
Y
L
Q
F
A
F
R
W
Site 51
T435
R
E
V
P
L
R
C
T
I
R
L
W
D
T
Y
Site 52
T441
C
T
I
R
L
W
D
T
Y
Q
S
E
P
D
G
Site 53
Y442
T
I
R
L
W
D
T
Y
Q
S
E
P
D
G
F
Site 54
S444
R
L
W
D
T
Y
Q
S
E
P
D
G
F
S
H
Site 55
S495
H
W
D
D
E
D
I
S
L
L
L
A
E
A
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation