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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIAA1199
Full Name:
Protein KIAA1199
Alias:
CCSP1; Colon cancer secreted protein 1; IR2155535; K1199; TMEM2L; Transmembrane protein 2-like
Type:
Tumor suppressor
Mass (Da):
153000
Number AA:
UniProt ID:
Q8WUJ3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S40
A
A
G
C
P
D
Q
S
P
E
L
Q
P
W
N
Site 2
S74
T
S
S
A
T
V
Y
S
I
H
I
S
E
G
G
Site 3
Y137
E
G
I
Q
P
D
P
Y
Y
G
L
K
Y
I
G
Site 4
Y138
G
I
Q
P
D
P
Y
Y
G
L
K
Y
I
G
V
Site 5
Y142
D
P
Y
Y
G
L
K
Y
I
G
V
G
K
G
G
Site 6
T162
G
Q
K
K
L
S
W
T
F
L
N
K
T
L
H
Site 7
T167
S
W
T
F
L
N
K
T
L
H
P
G
G
M
A
Site 8
Y178
G
G
M
A
E
G
G
Y
F
F
E
R
S
W
G
Site 9
S198
V
H
V
I
D
P
K
S
G
T
V
I
H
S
D
Site 10
T200
V
I
D
P
K
S
G
T
V
I
H
S
D
R
F
Site 11
S204
K
S
G
T
V
I
H
S
D
R
F
D
T
Y
R
Site 12
T209
I
H
S
D
R
F
D
T
Y
R
S
K
K
E
S
Site 13
Y210
H
S
D
R
F
D
T
Y
R
S
K
K
E
S
E
Site 14
S212
D
R
F
D
T
Y
R
S
K
K
E
S
E
R
L
Site 15
S216
T
Y
R
S
K
K
E
S
E
R
L
V
Q
Y
L
Site 16
Y222
E
S
E
R
L
V
Q
Y
L
N
A
V
P
D
G
Site 17
S233
V
P
D
G
R
I
L
S
V
A
V
N
D
E
G
Site 18
S241
V
A
V
N
D
E
G
S
R
N
L
D
D
M
A
Site 19
T253
D
M
A
R
K
A
M
T
K
L
G
S
K
H
F
Site 20
S257
K
A
M
T
K
L
G
S
K
H
F
L
H
L
G
Site 21
S270
L
G
F
R
H
P
W
S
F
L
T
V
K
G
N
Site 22
T273
R
H
P
W
S
F
L
T
V
K
G
N
P
S
S
Site 23
S279
L
T
V
K
G
N
P
S
S
S
V
E
D
H
I
Site 24
S280
T
V
K
G
N
P
S
S
S
V
E
D
H
I
E
Site 25
S281
V
K
G
N
P
S
S
S
V
E
D
H
I
E
Y
Site 26
Y288
S
V
E
D
H
I
E
Y
H
G
H
R
G
S
A
Site 27
S294
E
Y
H
G
H
R
G
S
A
A
A
R
V
F
K
Site 28
Y310
F
Q
T
E
H
G
E
Y
F
N
V
S
L
S
S
Site 29
S314
H
G
E
Y
F
N
V
S
L
S
S
E
W
V
Q
Site 30
S316
E
Y
F
N
V
S
L
S
S
E
W
V
Q
D
V
Site 31
S335
W
F
D
H
D
K
V
S
Q
T
K
G
G
E
K
Site 32
S344
T
K
G
G
E
K
I
S
D
L
W
K
A
H
P
Site 33
S372
T
M
D
G
V
N
L
S
T
E
V
V
Y
K
K
Site 34
Y383
V
Y
K
K
G
Q
D
Y
R
F
A
C
Y
D
R
Site 35
Y388
Q
D
Y
R
F
A
C
Y
D
R
G
R
A
C
R
Site 36
S396
D
R
G
R
A
C
R
S
Y
R
V
R
F
L
C
Site 37
Y397
R
G
R
A
C
R
S
Y
R
V
R
F
L
C
G
Site 38
T412
K
P
V
R
P
K
L
T
V
T
I
D
T
N
V
Site 39
S421
T
I
D
T
N
V
N
S
T
I
L
N
L
E
D
Site 40
T438
Q
S
W
K
P
G
D
T
L
V
I
A
S
T
D
Site 41
S443
G
D
T
L
V
I
A
S
T
D
Y
S
M
Y
Q
Site 42
Y446
L
V
I
A
S
T
D
Y
S
M
Y
Q
A
E
E
Site 43
S447
V
I
A
S
T
D
Y
S
M
Y
Q
A
E
E
F
Site 44
Y475
K
V
A
G
K
P
M
Y
L
H
I
G
E
E
I
Site 45
Y555
G
Q
Q
L
V
G
Q
Y
P
I
H
F
H
L
A
Site 46
Y571
D
V
D
E
R
G
G
Y
D
P
P
T
Y
I
R
Site 47
T575
R
G
G
Y
D
P
P
T
Y
I
R
D
L
S
I
Site 48
Y576
G
G
Y
D
P
P
T
Y
I
R
D
L
S
I
H
Site 49
S581
P
T
Y
I
R
D
L
S
I
H
H
T
F
S
R
Site 50
T585
R
D
L
S
I
H
H
T
F
S
R
C
V
T
V
Site 51
T591
H
T
F
S
R
C
V
T
V
H
G
S
N
G
L
Site 52
T624
D
G
P
E
E
R
N
T
F
D
H
C
L
G
L
Site 53
T637
G
L
L
V
K
S
G
T
L
L
P
S
D
R
D
Site 54
S641
K
S
G
T
L
L
P
S
D
R
D
S
K
M
C
Site 55
S645
L
L
P
S
D
R
D
S
K
M
C
K
M
I
T
Site 56
Y656
K
M
I
T
E
D
S
Y
P
G
Y
I
P
K
P
Site 57
Y659
T
E
D
S
Y
P
G
Y
I
P
K
P
R
Q
D
Site 58
S707
H
H
V
P
T
G
P
S
V
G
M
Y
S
P
G
Site 59
Y711
T
G
P
S
V
G
M
Y
S
P
G
Y
S
E
H
Site 60
S712
G
P
S
V
G
M
Y
S
P
G
Y
S
E
H
I
Site 61
Y715
V
G
M
Y
S
P
G
Y
S
E
H
I
P
L
G
Site 62
S716
G
M
Y
S
P
G
Y
S
E
H
I
P
L
G
K
Site 63
Y725
H
I
P
L
G
K
F
Y
N
N
R
A
H
S
N
Site 64
Y733
N
N
R
A
H
S
N
Y
R
A
G
M
I
I
D
Site 65
T745
I
I
D
N
G
V
K
T
T
E
A
S
A
K
D
Site 66
S758
K
D
K
R
P
F
L
S
I
I
S
A
R
Y
S
Site 67
S761
R
P
F
L
S
I
I
S
A
R
Y
S
P
H
Q
Site 68
S765
S
I
I
S
A
R
Y
S
P
H
Q
D
A
D
P
Site 69
Y787
I
I
R
H
F
I
A
Y
K
N
Q
D
H
G
A
Site 70
T822
L
T
L
A
S
G
G
T
F
P
Y
D
D
G
S
Site 71
Y825
A
S
G
G
T
F
P
Y
D
D
G
S
K
Q
E
Site 72
S829
T
F
P
Y
D
D
G
S
K
Q
E
I
K
N
S
Site 73
S836
S
K
Q
E
I
K
N
S
L
F
V
G
E
S
G
Site 74
S863
G
P
G
G
L
D
H
S
G
R
T
L
P
I
G
Site 75
Y881
P
I
R
G
I
Q
L
Y
D
G
P
I
N
I
Q
Site 76
S904
A
L
E
G
R
H
T
S
A
L
A
F
R
L
N
Site 77
T955
L
D
M
D
G
D
K
T
S
V
F
H
D
V
D
Site 78
S956
D
M
D
G
D
K
T
S
V
F
H
D
V
D
G
Site 79
S964
V
F
H
D
V
D
G
S
V
S
E
Y
P
G
S
Site 80
S966
H
D
V
D
G
S
V
S
E
Y
P
G
S
Y
L
Site 81
Y968
V
D
G
S
V
S
E
Y
P
G
S
Y
L
T
K
Site 82
S971
S
V
S
E
Y
P
G
S
Y
L
T
K
N
D
N
Site 83
Y1005
S
G
C
Y
A
Q
M
Y
I
Q
A
Y
K
T
S
Site 84
S1025
I
I
K
N
D
F
P
S
H
P
L
Y
L
E
G
Site 85
Y1029
D
F
P
S
H
P
L
Y
L
E
G
A
L
T
R
Site 86
T1035
L
Y
L
E
G
A
L
T
R
S
T
H
Y
Q
Q
Site 87
S1037
L
E
G
A
L
T
R
S
T
H
Y
Q
Q
Y
Q
Site 88
T1038
E
G
A
L
T
R
S
T
H
Y
Q
Q
Y
Q
P
Site 89
Y1043
R
S
T
H
Y
Q
Q
Y
Q
P
V
V
T
L
Q
Site 90
S1091
Y
P
R
G
T
T
F
S
I
L
S
D
V
H
N
Site 91
S1105
N
R
L
L
K
Q
T
S
K
T
G
V
F
V
R
Site 92
S1122
Q
M
D
K
V
E
Q
S
Y
P
G
R
S
H
Y
Site 93
Y1123
M
D
K
V
E
Q
S
Y
P
G
R
S
H
Y
Y
Site 94
Y1129
S
Y
P
G
R
S
H
Y
Y
W
D
E
D
S
G
Site 95
Y1130
Y
P
G
R
S
H
Y
Y
W
D
E
D
S
G
L
Site 96
S1175
I
P
K
N
A
G
V
S
D
C
T
A
T
A
Y
Site 97
T1178
N
A
G
V
S
D
C
T
A
T
A
Y
P
K
F
Site 98
Y1182
S
D
C
T
A
T
A
Y
P
K
F
T
E
R
A
Site 99
S1202
M
P
K
K
L
F
G
S
Q
L
K
T
K
D
H
Site 100
T1206
L
F
G
S
Q
L
K
T
K
D
H
F
L
E
V
Site 101
S1218
L
E
V
K
M
E
S
S
K
Q
H
F
F
H
L
Site 102
Y1231
H
L
W
N
D
F
A
Y
I
E
V
D
G
K
K
Site 103
Y1239
I
E
V
D
G
K
K
Y
P
S
S
E
D
G
I
Site 104
S1241
V
D
G
K
K
Y
P
S
S
E
D
G
I
Q
V
Site 105
S1242
D
G
K
K
Y
P
S
S
E
D
G
I
Q
V
V
Site 106
S1260
G
N
Q
G
R
V
V
S
H
T
S
F
R
N
S
Site 107
T1262
Q
G
R
V
V
S
H
T
S
F
R
N
S
I
L
Site 108
S1263
G
R
V
V
S
H
T
S
F
R
N
S
I
L
Q
Site 109
S1267
S
H
T
S
F
R
N
S
I
L
Q
G
I
P
W
Site 110
Y1297
L
M
A
S
K
G
R
Y
V
S
R
G
P
W
T
Site 111
S1299
A
S
K
G
R
Y
V
S
R
G
P
W
T
R
V
Site 112
T1337
S
F
R
P
I
W
V
T
L
D
T
E
D
H
K
Site 113
T1340
P
I
W
V
T
L
D
T
E
D
H
K
A
K
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation