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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NUP133
Full Name:
Nuclear pore complex protein Nup133
Alias:
133 kDa nucleoporin; FLJ10814; NU133; nuclear pore complex protein Nup133; nucleoporin 133kDa; Nucleoporin Nup133
Type:
Transport protein, facilitator
Mass (Da):
128979
Number AA:
1156
UniProt ID:
Q8WUM0
International Prot ID:
IPI00291200
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000776
GO:0000777
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005215
GO:0005487
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006405
GO:0006406
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
F
P
A
A
P
S
P
R
T
P
G
T
G
Site 2
T10
P
A
A
P
S
P
R
T
P
G
T
G
S
R
R
Site 3
T13
P
S
P
R
T
P
G
T
G
S
R
R
G
P
L
Site 4
S15
P
R
T
P
G
T
G
S
R
R
G
P
L
A
G
Site 5
S27
L
A
G
L
G
P
G
S
T
P
R
T
A
S
R
Site 6
T28
A
G
L
G
P
G
S
T
P
R
T
A
S
R
K
Site 7
T31
G
P
G
S
T
P
R
T
A
S
R
K
G
L
P
Site 8
S33
G
S
T
P
R
T
A
S
R
K
G
L
P
L
G
Site 9
S41
R
K
G
L
P
L
G
S
A
V
S
S
P
V
L
Site 10
S44
L
P
L
G
S
A
V
S
S
P
V
L
F
S
P
Site 11
S45
P
L
G
S
A
V
S
S
P
V
L
F
S
P
V
Site 12
S50
V
S
S
P
V
L
F
S
P
V
G
R
R
S
S
Site 13
S56
F
S
P
V
G
R
R
S
S
L
S
S
R
G
T
Site 14
S57
S
P
V
G
R
R
S
S
L
S
S
R
G
T
P
Site 15
S59
V
G
R
R
S
S
L
S
S
R
G
T
P
T
R
Site 16
S60
G
R
R
S
S
L
S
S
R
G
T
P
T
R
M
Site 17
T63
S
S
L
S
S
R
G
T
P
T
R
M
F
P
H
Site 18
S72
T
R
M
F
P
H
H
S
I
T
E
S
V
N
Y
Site 19
T74
M
F
P
H
H
S
I
T
E
S
V
N
Y
D
V
Site 20
S76
P
H
H
S
I
T
E
S
V
N
Y
D
V
K
T
Site 21
Y79
S
I
T
E
S
V
N
Y
D
V
K
T
F
G
S
Site 22
T83
S
V
N
Y
D
V
K
T
F
G
S
S
L
P
V
Site 23
T106
A
E
V
D
D
Q
L
T
I
N
I
D
E
G
G
Site 24
S131
I
I
W
K
I
A
L
S
P
I
T
K
L
S
V
Site 25
T134
K
I
A
L
S
P
I
T
K
L
S
V
C
K
E
Site 26
S147
K
E
L
Q
L
P
P
S
D
F
H
W
S
A
D
Site 27
S159
S
A
D
L
V
A
L
S
Y
S
S
P
S
G
E
Site 28
Y160
A
D
L
V
A
L
S
Y
S
S
P
S
G
E
A
Site 29
S161
D
L
V
A
L
S
Y
S
S
P
S
G
E
A
H
Site 30
S162
L
V
A
L
S
Y
S
S
P
S
G
E
A
H
S
Site 31
S164
A
L
S
Y
S
S
P
S
G
E
A
H
S
T
Q
Site 32
S183
M
V
A
T
R
E
G
S
I
R
Y
W
P
S
L
Site 33
S189
G
S
I
R
Y
W
P
S
L
A
G
E
D
T
Y
Site 34
T195
P
S
L
A
G
E
D
T
Y
T
E
A
F
V
D
Site 35
Y196
S
L
A
G
E
D
T
Y
T
E
A
F
V
D
S
Site 36
T197
L
A
G
E
D
T
Y
T
E
A
F
V
D
S
G
Site 37
S203
Y
T
E
A
F
V
D
S
G
G
D
K
T
Y
S
Site 38
T208
V
D
S
G
G
D
K
T
Y
S
F
L
T
A
V
Site 39
Y209
D
S
G
G
D
K
T
Y
S
F
L
T
A
V
Q
Site 40
S210
S
G
G
D
K
T
Y
S
F
L
T
A
V
Q
G
Site 41
T213
D
K
T
Y
S
F
L
T
A
V
Q
G
G
S
F
Site 42
S224
G
G
S
F
I
L
S
S
S
G
S
Q
L
I
R
Site 43
S236
L
I
R
L
I
P
E
S
S
G
K
I
H
Q
H
Site 44
S237
I
R
L
I
P
E
S
S
G
K
I
H
Q
H
I
Site 45
S253
P
Q
G
Q
G
M
L
S
G
I
G
R
K
V
S
Site 46
S260
S
G
I
G
R
K
V
S
S
L
F
G
I
L
S
Site 47
S261
G
I
G
R
K
V
S
S
L
F
G
I
L
S
P
Site 48
S267
S
S
L
F
G
I
L
S
P
S
S
D
L
T
L
Site 49
S275
P
S
S
D
L
T
L
S
S
V
L
W
D
R
E
Site 50
S276
S
S
D
L
T
L
S
S
V
L
W
D
R
E
R
Site 51
S284
V
L
W
D
R
E
R
S
S
F
Y
S
L
T
S
Site 52
S285
L
W
D
R
E
R
S
S
F
Y
S
L
T
S
S
Site 53
S288
R
E
R
S
S
F
Y
S
L
T
S
S
N
I
S
Site 54
T290
R
S
S
F
Y
S
L
T
S
S
N
I
S
K
W
Site 55
S291
S
S
F
Y
S
L
T
S
S
N
I
S
K
W
E
Site 56
S292
S
F
Y
S
L
T
S
S
N
I
S
K
W
E
L
Site 57
S295
S
L
T
S
S
N
I
S
K
W
E
L
D
D
S
Site 58
S302
S
K
W
E
L
D
D
S
S
E
K
H
A
Y
S
Site 59
Y308
D
S
S
E
K
H
A
Y
S
W
D
I
N
R
A
Site 60
T321
R
A
L
K
E
N
I
T
D
A
I
W
G
S
E
Site 61
Y331
I
W
G
S
E
S
N
Y
E
A
I
K
E
G
V
Site 62
Y342
K
E
G
V
N
I
R
Y
L
D
L
K
Q
N
C
Site 63
S383
E
D
N
G
C
Q
M
S
D
A
V
T
V
E
V
Site 64
T387
C
Q
M
S
D
A
V
T
V
E
V
T
Q
Y
N
Site 65
Y393
V
T
V
E
V
T
Q
Y
N
P
P
F
Q
S
E
Site 66
Y418
N
F
S
N
Q
T
A
Y
L
Y
N
E
S
A
V
Site 67
Y420
S
N
Q
T
A
Y
L
Y
N
E
S
A
V
Y
V
Site 68
S436
S
T
G
T
G
K
F
S
L
P
Q
E
K
I
V
Site 69
S450
V
F
N
A
Q
G
D
S
V
L
G
A
G
A
C
Site 70
S472
S
R
N
S
G
L
V
S
I
T
S
R
E
N
V
Site 71
S480
I
T
S
R
E
N
V
S
I
L
A
E
D
L
E
Site 72
S489
L
A
E
D
L
E
G
S
L
A
S
S
V
A
G
Site 73
S492
D
L
E
G
S
L
A
S
S
V
A
G
P
N
S
Site 74
S493
L
E
G
S
L
A
S
S
V
A
G
P
N
S
E
Site 75
S499
S
S
V
A
G
P
N
S
E
S
M
I
F
E
T
Site 76
S501
V
A
G
P
N
S
E
S
M
I
F
E
T
T
T
Site 77
T512
E
T
T
T
K
N
E
T
I
A
Q
E
D
K
I
Site 78
Y529
L
K
A
A
F
L
Q
Y
C
R
K
D
L
G
H
Site 79
S546
M
V
V
D
E
L
F
S
S
H
S
D
L
D
S
Site 80
S547
V
V
D
E
L
F
S
S
H
S
D
L
D
S
D
Site 81
S549
D
E
L
F
S
S
H
S
D
L
D
S
D
S
E
Site 82
S553
S
S
H
S
D
L
D
S
D
S
E
L
D
R
A
Site 83
S555
H
S
D
L
D
S
D
S
E
L
D
R
A
V
T
Site 84
Y572
S
V
D
L
M
D
D
Y
P
A
S
D
P
R
W
Site 85
S575
L
M
D
D
Y
P
A
S
D
P
R
W
A
E
S
Site 86
S582
S
D
P
R
W
A
E
S
V
P
E
E
A
P
G
Site 87
S658
I
V
L
K
N
H
H
S
R
L
S
D
L
V
N
Site 88
S661
K
N
H
H
S
R
L
S
D
L
V
N
T
A
I
Site 89
Y677
I
A
L
N
K
R
E
Y
E
I
P
S
N
L
T
Site 90
T684
Y
E
I
P
S
N
L
T
P
A
D
V
F
F
R
Site 91
S718
L
R
D
A
P
M
D
S
I
E
W
A
E
V
V
Site 92
S748
H
Y
R
Q
N
R
N
S
L
Y
R
R
E
E
S
Site 93
Y750
R
Q
N
R
N
S
L
Y
R
R
E
E
S
L
E
Site 94
S755
S
L
Y
R
R
E
E
S
L
E
K
E
P
E
Y
Site 95
Y762
S
L
E
K
E
P
E
Y
V
P
W
T
A
T
S
Site 96
T766
E
P
E
Y
V
P
W
T
A
T
S
G
P
G
G
Site 97
T768
E
Y
V
P
W
T
A
T
S
G
P
G
G
I
R
Site 98
T776
S
G
P
G
G
I
R
T
V
I
I
R
Q
H
E
Site 99
S818
C
F
L
D
G
Y
V
S
Q
L
K
S
V
D
K
Site 100
S822
G
Y
V
S
Q
L
K
S
V
D
K
S
S
N
R
Site 101
S826
Q
L
K
S
V
D
K
S
S
N
R
E
R
Y
D
Site 102
S827
L
K
S
V
D
K
S
S
N
R
E
R
Y
D
N
Site 103
Y832
K
S
S
N
R
E
R
Y
D
N
L
E
M
E
Y
Site 104
S844
M
E
Y
L
Q
K
R
S
D
L
L
S
P
L
L
Site 105
S848
Q
K
R
S
D
L
L
S
P
L
L
S
L
G
Q
Site 106
T890
S
R
L
Q
R
Y
M
T
Q
F
A
D
Q
N
F
Site 107
Y905
S
D
F
L
F
R
W
Y
L
E
K
G
K
R
G
Site 108
S916
G
K
R
G
K
L
L
S
Q
P
I
S
Q
H
G
Site 109
S920
K
L
L
S
Q
P
I
S
Q
H
G
Q
L
A
N
Site 110
S943
S
W
L
H
E
I
N
S
Q
E
L
E
K
A
H
Site 111
Y963
L
A
N
M
E
T
R
Y
F
A
K
K
K
T
L
Site 112
T969
R
Y
F
A
K
K
K
T
L
L
G
L
S
K
L
Site 113
S984
A
A
L
A
S
D
F
S
E
D
M
L
Q
E
K
Site 114
T1007
R
F
L
L
H
Q
E
T
L
P
E
Q
L
L
A
Site 115
Y1035
A
P
Q
L
I
G
L
Y
I
C
E
E
N
R
R
Site 116
Y1046
E
N
R
R
A
N
E
Y
D
F
K
K
A
L
D
Site 117
Y1057
K
A
L
D
L
L
E
Y
I
D
E
E
E
D
I
Site 118
S1084
A
L
Q
R
D
N
W
S
S
S
D
G
K
D
D
Site 119
S1085
L
Q
R
D
N
W
S
S
S
D
G
K
D
D
P
Site 120
S1086
Q
R
D
N
W
S
S
S
D
G
K
D
D
P
I
Site 121
S1116
L
K
D
G
I
Q
L
S
E
Y
L
P
E
V
K
Site 122
Y1118
D
G
I
Q
L
S
E
Y
L
P
E
V
K
D
L
Site 123
S1133
L
Q
A
D
Q
L
G
S
L
K
S
N
P
Y
F
Site 124
S1136
D
Q
L
G
S
L
K
S
N
P
Y
F
E
F
V
Site 125
Y1139
G
S
L
K
S
N
P
Y
F
E
F
V
L
K
A
Site 126
Y1148
E
F
V
L
K
A
N
Y
E
Y
Y
V
Q
G
Q
Site 127
Y1150
V
L
K
A
N
Y
E
Y
Y
V
Q
G
Q
I
_
Site 128
Y1151
L
K
A
N
Y
E
Y
Y
V
Q
G
Q
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation