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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRUNE2
Full Name:
Protein prune homolog 2
Alias:
BNIP2 motif-containing molecule at the C-terminal region 1
Type:
Mass (Da):
33610
Number AA:
296
UniProt ID:
Q8WUY3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
F
L
Q
R
A
K
S
K
L
N
R
S
K
R
Site 2
S15
A
K
S
K
L
N
R
S
K
R
L
E
K
V
H
Site 3
S34
P
K
S
C
D
L
D
S
L
I
S
T
F
T
Y
Site 4
T64
P
V
L
N
I
P
R
T
E
F
N
Y
F
T
E
Site 5
Y68
I
P
R
T
E
F
N
Y
F
T
E
T
R
F
I
Site 6
T70
R
T
E
F
N
Y
F
T
E
T
R
F
I
L
E
Site 7
S104
L
N
D
E
G
K
L
S
I
T
L
V
G
S
S
Site 8
S110
L
S
I
T
L
V
G
S
S
V
L
A
S
E
D
Site 9
S115
V
G
S
S
V
L
A
S
E
D
K
T
L
E
S
Site 10
S122
S
E
D
K
T
L
E
S
A
V
V
K
V
I
N
Site 11
S134
V
I
N
P
V
E
Q
S
D
A
N
V
E
F
R
Site 12
S143
A
N
V
E
F
R
E
S
S
S
S
L
V
L
K
Site 13
S146
E
F
R
E
S
S
S
S
L
V
L
K
E
I
L
Site 14
T178
S
I
L
F
K
W
M
T
M
E
S
E
K
I
S
Site 15
S185
T
M
E
S
E
K
I
S
E
K
Q
E
E
I
L
Site 16
S217
E
F
V
Q
R
Q
D
S
P
R
D
N
S
E
R
Site 17
S218
V
L
Q
E
T
Q
F
S
A
Q
G
L
S
I
E
Site 18
T227
Q
G
L
S
I
E
Q
T
M
L
K
D
L
K
E
Site 19
T261
S
R
I
E
P
K
G
T
W
L
V
N
R
D
A
Site 20
S271
V
N
R
D
A
F
Q
S
R
N
S
G
S
K
C
Site 21
S274
D
A
F
Q
S
R
N
S
G
S
K
C
M
P
G
Site 22
S276
F
Q
S
R
N
S
G
S
K
C
M
P
G
T
T
Site 23
T288
G
T
T
V
L
Q
C
T
L
R
S
L
Q
R
G
Site 24
S291
V
L
Q
C
T
L
R
S
L
Q
R
G
K
_
_
Site 25
S340
S
S
I
D
R
R
A
S
D
S
V
F
Q
P
K
Site 26
S389
Q
N
L
P
M
E
K
S
P
L
P
N
T
S
P
Site 27
T903
H
S
A
N
V
K
D
T
H
S
P
D
A
P
A
Site 28
S905
A
N
V
K
D
T
H
S
P
D
A
P
A
A
S
Site 29
Y1379
D
P
K
S
E
N
I
Y
D
Y
L
D
S
S
E
Site 30
Y1381
K
S
E
N
I
Y
D
Y
L
D
S
S
E
P
A
Site 31
S1444
G
D
V
A
W
Q
I
S
P
K
A
S
F
P
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation