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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BLNK
Full Name:
B-cell linker protein
Alias:
B-cell adapter containing a SH2 domain protein;B-cell adapter containing a Src homology 2 domain protein;Cytoplasmic adapter protein;Src homology 2 domain-containing leukocyte protein of 65 kDa
Type:
Adapter/scaffold protein
Mass (Da):
50466
Number AA:
456
UniProt ID:
Q8WV28
International Prot ID:
IPI00002434
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005070
GO:0005068
PhosphoSite+
KinaseNET
Biological Process:
GO:0030183
GO:0006959
GO:0006954
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
D
K
L
N
K
I
T
V
P
A
S
Q
K
L
Site 2
S12
N
K
I
T
V
P
A
S
Q
K
L
R
Q
L
Q
Site 3
S46
L
K
V
K
A
P
P
S
V
P
R
R
D
Y
A
Site 4
Y52
P
S
V
P
R
R
D
Y
A
S
E
S
P
A
D
Site 5
S54
V
P
R
R
D
Y
A
S
E
S
P
A
D
E
E
Site 6
S56
R
R
D
Y
A
S
E
S
P
A
D
E
E
E
Q
Site 7
S65
A
D
E
E
E
Q
W
S
D
D
F
D
S
D
Y
Site 8
S70
Q
W
S
D
D
F
D
S
D
Y
E
N
P
D
E
Site 9
Y72
S
D
D
F
D
S
D
Y
E
N
P
D
E
H
S
Site 10
S81
N
P
D
E
H
S
D
S
E
M
Y
V
M
P
A
Site 11
Y84
E
H
S
D
S
E
M
Y
V
M
P
A
E
E
N
Site 12
S95
A
E
E
N
A
D
D
S
Y
E
P
P
P
V
E
Site 13
Y96
E
E
N
A
D
D
S
Y
E
P
P
P
V
E
Q
Site 14
Y119
L
P
F
A
R
G
E
Y
I
D
N
R
S
S
Q
Site 15
S124
G
E
Y
I
D
N
R
S
S
Q
R
H
S
P
P
Site 16
S125
E
Y
I
D
N
R
S
S
Q
R
H
S
P
P
F
Site 17
S129
N
R
S
S
Q
R
H
S
P
P
F
S
K
T
L
Site 18
S133
Q
R
H
S
P
P
F
S
K
T
L
P
S
K
P
Site 19
T135
H
S
P
P
F
S
K
T
L
P
S
K
P
S
W
Site 20
S138
P
F
S
K
T
L
P
S
K
P
S
W
P
S
E
Site 21
S141
K
T
L
P
S
K
P
S
W
P
S
E
K
A
R
Site 22
S144
P
S
K
P
S
W
P
S
E
K
A
R
L
T
S
Site 23
T150
P
S
E
K
A
R
L
T
S
T
L
P
A
L
T
Site 24
S151
S
E
K
A
R
L
T
S
T
L
P
A
L
T
A
Site 25
T152
E
K
A
R
L
T
S
T
L
P
A
L
T
A
L
Site 26
Y178
L
L
E
D
E
A
D
Y
V
V
P
V
E
D
N
Site 27
Y189
V
E
D
N
D
E
N
Y
I
H
P
T
E
S
S
Site 28
T193
D
E
N
Y
I
H
P
T
E
S
S
S
P
P
P
Site 29
S195
N
Y
I
H
P
T
E
S
S
S
P
P
P
E
K
Site 30
S197
I
H
P
T
E
S
S
S
P
P
P
E
K
A
P
Site 31
S209
K
A
P
M
V
N
R
S
T
K
P
N
S
S
T
Site 32
T210
A
P
M
V
N
R
S
T
K
P
N
S
S
T
P
Site 33
S214
N
R
S
T
K
P
N
S
S
T
P
A
S
P
P
Site 34
S215
R
S
T
K
P
N
S
S
T
P
A
S
P
P
G
Site 35
T216
S
T
K
P
N
S
S
T
P
A
S
P
P
G
T
Site 36
S219
P
N
S
S
T
P
A
S
P
P
G
T
A
S
G
Site 37
T223
T
P
A
S
P
P
G
T
A
S
G
R
N
S
G
Site 38
S225
A
S
P
P
G
T
A
S
G
R
N
S
G
A
W
Site 39
S229
G
T
A
S
G
R
N
S
G
A
W
E
T
K
S
Site 40
T234
R
N
S
G
A
W
E
T
K
S
P
P
P
A
A
Site 41
S236
S
G
A
W
E
T
K
S
P
P
P
A
A
P
S
Site 42
S243
S
P
P
P
A
A
P
S
P
L
P
R
A
G
K
Site 43
T254
R
A
G
K
K
P
T
T
P
L
K
T
T
P
V
Site 44
T258
K
P
T
T
P
L
K
T
T
P
V
A
S
Q
Q
Site 45
T259
P
T
T
P
L
K
T
T
P
V
A
S
Q
Q
N
Site 46
S263
L
K
T
T
P
V
A
S
Q
Q
N
A
S
S
V
Site 47
S269
A
S
Q
Q
N
A
S
S
V
C
E
E
K
P
I
Site 48
S284
P
A
E
R
H
R
G
S
S
H
R
Q
E
A
V
Site 49
S285
A
E
R
H
R
G
S
S
H
R
Q
E
A
V
Q
Site 50
S293
H
R
Q
E
A
V
Q
S
P
V
F
P
P
A
Q
Site 51
T314
P
I
P
L
P
R
F
T
E
G
G
N
P
T
V
Site 52
T320
F
T
E
G
G
N
P
T
V
D
G
P
L
P
S
Site 53
S327
T
V
D
G
P
L
P
S
F
S
S
N
S
T
I
Site 54
S329
D
G
P
L
P
S
F
S
S
N
S
T
I
S
E
Site 55
S330
G
P
L
P
S
F
S
S
N
S
T
I
S
E
Q
Site 56
S332
L
P
S
F
S
S
N
S
T
I
S
E
Q
E
A
Site 57
T333
P
S
F
S
S
N
S
T
I
S
E
Q
E
A
G
Site 58
Y347
G
V
L
C
K
P
W
Y
A
G
A
C
D
R
K
Site 59
S355
A
G
A
C
D
R
K
S
A
E
E
A
L
H
R
Site 60
S368
H
R
S
N
K
D
G
S
F
L
I
R
K
S
S
Site 61
S374
G
S
F
L
I
R
K
S
S
G
H
D
S
K
Q
Site 62
S375
S
F
L
I
R
K
S
S
G
H
D
S
K
Q
P
Site 63
S379
R
K
S
S
G
H
D
S
K
Q
P
Y
T
L
V
Site 64
Y383
G
H
D
S
K
Q
P
Y
T
L
V
V
F
F
N
Site 65
T384
H
D
S
K
Q
P
Y
T
L
V
V
F
F
N
K
Site 66
T404
P
V
R
F
I
E
A
T
K
Q
Y
A
L
G
R
Site 67
Y418
R
K
K
N
G
E
E
Y
F
G
S
V
A
E
I
Site 68
S421
N
G
E
E
Y
F
G
S
V
A
E
I
I
R
N
Site 69
S432
I
I
R
N
H
Q
H
S
P
L
V
L
I
D
S
Site 70
S439
S
P
L
V
L
I
D
S
Q
N
N
T
K
D
S
Site 71
T443
L
I
D
S
Q
N
N
T
K
D
S
T
R
L
K
Site 72
S446
S
Q
N
N
T
K
D
S
T
R
L
K
Y
A
V
Site 73
Y451
K
D
S
T
R
L
K
Y
A
V
K
V
S
_
_
Site 74
S456
L
K
Y
A
V
K
V
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation