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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LACE1
Full Name:
Lactation elevated protein 1
Alias:
AFG1; ATPase family gene 1; LACE-1; lactation elevated 1; lactation elevated-1
Type:
Unknown function
Mass (Da):
54845
Number AA:
481
UniProt ID:
Q8WV93
International Prot ID:
IPI00166976
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
T
L
R
P
L
A
Q
S
P
L
R
G
R
C
V
Site 2
Y48
G
K
P
F
W
K
A
Y
T
V
Q
T
S
E
S
Site 3
T49
K
P
F
W
K
A
Y
T
V
Q
T
S
E
S
M
Site 4
S55
Y
T
V
Q
T
S
E
S
M
T
P
T
A
T
S
Site 5
T57
V
Q
T
S
E
S
M
T
P
T
A
T
S
E
T
Site 6
T59
T
S
E
S
M
T
P
T
A
T
S
E
T
Y
L
Site 7
S62
S
M
T
P
T
A
T
S
E
T
Y
L
K
A
L
Site 8
Y79
C
H
G
P
L
D
H
Y
D
F
L
I
K
A
H
Site 9
S120
I
E
A
E
G
L
F
S
K
L
F
S
R
S
K
Site 10
S124
G
L
F
S
K
L
F
S
R
S
K
P
P
R
G
Site 11
S126
F
S
K
L
F
S
R
S
K
P
P
R
G
L
Y
Site 12
Y133
S
K
P
P
R
G
L
Y
V
Y
G
D
V
G
T
Site 13
Y135
P
P
R
G
L
Y
V
Y
G
D
V
G
T
G
K
Site 14
T143
G
D
V
G
T
G
K
T
M
V
M
D
M
F
Y
Site 15
Y150
T
M
V
M
D
M
F
Y
A
Y
V
E
M
K
R
Site 16
Y152
V
M
D
M
F
Y
A
Y
V
E
M
K
R
K
K
Site 17
S180
R
I
H
R
L
K
Q
S
L
P
K
R
K
P
G
Site 18
S192
K
P
G
F
M
A
K
S
Y
D
P
I
A
P
I
Site 19
Y252
N
R
P
P
E
D
L
Y
K
N
G
L
Q
R
A
Site 20
S279
C
N
T
V
Q
L
D
S
G
I
D
Y
R
K
R
Site 21
Y283
Q
L
D
S
G
I
D
Y
R
K
R
E
L
P
A
Site 22
Y295
L
P
A
A
G
K
L
Y
Y
L
T
S
E
A
D
Site 23
Y296
P
A
A
G
K
L
Y
Y
L
T
S
E
A
D
V
Site 24
S299
G
K
L
Y
Y
L
T
S
E
A
D
V
E
A
V
Site 25
T322
A
Q
K
Q
N
D
L
T
R
P
R
I
L
K
V
Site 26
T342
R
L
N
K
A
C
G
T
V
A
D
C
T
F
E
Site 27
T347
C
G
T
V
A
D
C
T
F
E
E
L
C
E
R
Site 28
S359
C
E
R
P
L
G
A
S
D
Y
L
E
L
S
K
Site 29
Y361
R
P
L
G
A
S
D
Y
L
E
L
S
K
N
F
Site 30
S365
A
S
D
Y
L
E
L
S
K
N
F
D
T
I
F
Site 31
T370
E
L
S
K
N
F
D
T
I
F
L
R
N
I
P
Site 32
T392
T
Q
G
R
R
F
I
T
L
I
D
N
F
Y
D
Site 33
S414
S
A
S
T
P
I
S
S
L
F
L
H
Q
H
H
Site 34
S423
F
L
H
Q
H
H
D
S
E
L
E
Q
S
R
I
Site 35
S428
H
D
S
E
L
E
Q
S
R
I
L
M
D
D
L
Site 36
S438
L
M
D
D
L
G
L
S
Q
D
S
A
E
G
L
Site 37
S441
D
L
G
L
S
Q
D
S
A
E
G
L
S
M
F
Site 38
S462
F
A
F
Q
R
T
I
S
R
L
T
E
M
Q
T
Site 39
T465
Q
R
T
I
S
R
L
T
E
M
Q
T
E
Q
Y
Site 40
Y472
T
E
M
Q
T
E
Q
Y
W
N
E
G
D
R
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation