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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HEXDC
Full Name:
Hexosaminidase D
Alias:
Beta-N-acetylhexosaminidase;Beta-hexosaminidase D;Hexosaminidase domain-containing protein;N-acetyl-beta-galactosaminidase
Type:
Mass (Da):
53790
Number AA:
486
UniProt ID:
Q8WVB3
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y45
A
N
G
L
L
I
E
Y
E
D
M
F
P
Y
E
Site 2
Y51
E
Y
E
D
M
F
P
Y
E
G
P
L
R
L
L
Site 3
Y62
L
R
L
L
R
A
K
Y
A
Y
S
P
S
E
I
Site 4
Y64
L
L
R
A
K
Y
A
Y
S
P
S
E
I
K
E
Site 5
S65
L
R
A
K
Y
A
Y
S
P
S
E
I
K
E
I
Site 6
S67
A
K
Y
A
Y
S
P
S
E
I
K
E
I
L
H
Site 7
S110
A
H
L
R
E
V
G
S
F
P
C
T
L
N
P
Site 8
T114
E
V
G
S
F
P
C
T
L
N
P
H
E
A
E
Site 9
Y151
H
I
G
C
D
E
V
Y
Y
L
G
E
G
E
A
Site 10
Y152
I
G
C
D
E
V
Y
Y
L
G
E
G
E
A
S
Site 11
S159
Y
L
G
E
G
E
A
S
R
R
W
L
Q
Q
E
Site 12
T170
L
Q
Q
E
Q
N
S
T
G
K
L
C
L
S
H
Site 13
S191
G
V
K
A
R
R
P
S
V
T
P
L
V
W
D
Site 14
T193
K
A
R
R
P
S
V
T
P
L
V
W
D
D
M
Site 15
S212
P
E
D
Q
L
A
A
S
G
V
P
Q
L
V
E
Site 16
Y225
V
E
P
V
L
W
D
Y
T
A
D
L
D
V
H
Site 17
T226
E
P
V
L
W
D
Y
T
A
D
L
D
V
H
G
Site 18
Y241
K
V
L
L
M
Q
K
Y
R
R
C
G
F
P
Q
Site 19
S262
F
K
G
A
T
G
P
S
Q
A
V
P
P
V
E
Site 20
S284
Q
W
L
Q
V
A
G
S
G
P
T
D
S
L
Q
Site 21
Y301
I
L
T
G
W
Q
R
Y
D
H
Y
S
V
L
C
Site 22
Y304
G
W
Q
R
Y
D
H
Y
S
V
L
C
E
L
L
Site 23
S346
E
N
L
L
G
I
S
S
L
E
K
T
D
P
V
Site 24
T350
G
I
S
S
L
E
K
T
D
P
V
R
E
G
A
Site 25
S359
P
V
R
E
G
A
G
S
F
P
G
S
N
I
L
Site 26
Y389
A
L
L
E
G
N
R
Y
V
T
G
W
F
S
P
Site 27
Y397
V
T
G
W
F
S
P
Y
H
R
Q
R
K
L
I
Site 28
S454
L
E
E
N
V
H
P
S
L
Q
R
L
Q
A
L
Site 29
S469
L
Q
D
L
S
E
V
S
A
P
P
L
P
P
T
Site 30
T476
S
A
P
P
L
P
P
T
S
P
G
R
D
V
A
Site 31
S477
A
P
P
L
P
P
T
S
P
G
R
D
V
A
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation