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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LEO1
Full Name:
RNA polymerase-associated protein LEO1
Alias:
Leo1, Paf1/RNA polymerase II complex component,; RDL; Replicative senescence downregulated leo1-like protein; Replicative senescence down-regulated leo1-like protein
Type:
Transcription regulation protein
Mass (Da):
75404
Number AA:
666
UniProt ID:
Q8WVC0
International Prot ID:
IPI00103090
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016593
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0033523
GO:0010390
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
D
M
E
D
L
F
G
S
D
A
D
S
E
A
E
Site 2
S14
L
F
G
S
D
A
D
S
E
A
E
R
K
D
S
Site 3
S21
S
E
A
E
R
K
D
S
D
S
G
S
D
S
D
Site 4
S23
A
E
R
K
D
S
D
S
G
S
D
S
D
S
D
Site 5
S25
R
K
D
S
D
S
G
S
D
S
D
S
D
Q
E
Site 6
S27
D
S
D
S
G
S
D
S
D
S
D
Q
E
N
A
Site 7
S29
D
S
G
S
D
S
D
S
D
Q
E
N
A
A
S
Site 8
S36
S
D
Q
E
N
A
A
S
G
S
N
A
S
G
S
Site 9
S38
Q
E
N
A
A
S
G
S
N
A
S
G
S
E
S
Site 10
S41
A
A
S
G
S
N
A
S
G
S
E
S
D
Q
D
Site 11
S43
S
G
S
N
A
S
G
S
E
S
D
Q
D
E
R
Site 12
S45
S
N
A
S
G
S
E
S
D
Q
D
E
R
G
D
Site 13
S53
D
Q
D
E
R
G
D
S
G
Q
P
S
N
K
E
Site 14
S57
R
G
D
S
G
Q
P
S
N
K
E
L
F
G
D
Site 15
S66
K
E
L
F
G
D
D
S
E
D
E
G
A
S
H
Site 16
S72
D
S
E
D
E
G
A
S
H
H
S
G
S
D
N
Site 17
S75
D
E
G
A
S
H
H
S
G
S
D
N
H
S
E
Site 18
S77
G
A
S
H
H
S
G
S
D
N
H
S
E
R
S
Site 19
S81
H
S
G
S
D
N
H
S
E
R
S
D
N
R
S
Site 20
S84
S
D
N
H
S
E
R
S
D
N
R
S
E
A
S
Site 21
S88
S
E
R
S
D
N
R
S
E
A
S
E
R
S
D
Site 22
S91
S
D
N
R
S
E
A
S
E
R
S
D
H
E
D
Site 23
S102
D
H
E
D
N
D
P
S
D
V
D
Q
H
S
G
Site 24
S108
P
S
D
V
D
Q
H
S
G
S
E
A
P
N
D
Site 25
S110
D
V
D
Q
H
S
G
S
E
A
P
N
D
D
E
Site 26
S123
D
E
D
E
G
H
R
S
D
G
G
S
H
H
S
Site 27
S127
G
H
R
S
D
G
G
S
H
H
S
E
A
E
G
Site 28
S130
S
D
G
G
S
H
H
S
E
A
E
G
S
E
K
Site 29
S135
H
H
S
E
A
E
G
S
E
K
A
H
S
D
D
Site 30
S140
E
G
S
E
K
A
H
S
D
D
E
K
W
G
R
Site 31
S151
K
W
G
R
E
D
K
S
D
Q
S
D
D
E
K
Site 32
S154
R
E
D
K
S
D
Q
S
D
D
E
K
I
Q
N
Site 33
S162
D
D
E
K
I
Q
N
S
D
D
E
E
R
A
Q
Site 34
S171
D
E
E
R
A
Q
G
S
D
E
D
K
L
Q
N
Site 35
S179
D
E
D
K
L
Q
N
S
D
D
D
E
K
M
Q
Site 36
T188
D
D
E
K
M
Q
N
T
D
D
E
E
R
P
Q
Site 37
S197
D
E
E
R
P
Q
L
S
D
D
E
R
Q
Q
L
Site 38
S205
D
D
E
R
Q
Q
L
S
E
E
E
K
A
N
S
Site 39
S212
S
E
E
E
K
A
N
S
D
D
E
R
P
V
A
Site 40
S220
D
D
E
R
P
V
A
S
D
N
D
D
E
K
Q
Site 41
S229
N
D
D
E
K
Q
N
S
D
D
E
E
Q
P
Q
Site 42
S238
D
E
E
Q
P
Q
L
S
D
E
E
K
M
Q
N
Site 43
S246
D
E
E
K
M
Q
N
S
D
D
E
R
P
Q
A
Site 44
S254
D
D
E
R
P
Q
A
S
D
E
E
H
R
H
S
Site 45
S261
S
D
E
E
H
R
H
S
D
D
E
E
E
Q
D
Site 46
S271
E
E
E
Q
D
H
K
S
E
S
A
R
G
S
D
Site 47
S273
E
Q
D
H
K
S
E
S
A
R
G
S
D
S
E
Site 48
S277
K
S
E
S
A
R
G
S
D
S
E
D
E
V
L
Site 49
S279
E
S
A
R
G
S
D
S
E
D
E
V
L
R
M
Site 50
S294
K
R
K
N
A
I
A
S
D
S
E
A
D
S
D
Site 51
S296
K
N
A
I
A
S
D
S
E
A
D
S
D
T
E
Site 52
S300
A
S
D
S
E
A
D
S
D
T
E
V
P
K
D
Site 53
T302
D
S
E
A
D
S
D
T
E
V
P
K
D
N
S
Site 54
S309
T
E
V
P
K
D
N
S
G
T
M
D
L
F
G
Site 55
T311
V
P
K
D
N
S
G
T
M
D
L
F
G
G
A
Site 56
S322
F
G
G
A
D
D
I
S
S
G
S
D
G
E
D
Site 57
S323
G
G
A
D
D
I
S
S
G
S
D
G
E
D
K
Site 58
T333
D
G
E
D
K
P
P
T
P
G
Q
P
V
D
E
Site 59
T356
E
E
E
P
I
P
E
T
R
I
E
V
E
I
P
Site 60
Y374
T
D
L
G
N
D
L
Y
F
V
K
L
P
N
F
Site 61
S383
V
K
L
P
N
F
L
S
V
E
P
R
P
F
D
Site 62
Y393
P
R
P
F
D
P
Q
Y
Y
E
D
E
F
E
D
Site 63
Y394
R
P
F
D
P
Q
Y
Y
E
D
E
F
E
D
E
Site 64
T419
L
K
L
K
V
E
N
T
I
R
W
R
I
R
R
Site 65
S436
E
G
N
E
I
K
E
S
N
A
R
I
V
K
W
Site 66
S444
N
A
R
I
V
K
W
S
D
G
S
M
S
L
H
Site 67
S447
I
V
K
W
S
D
G
S
M
S
L
H
L
G
N
Site 68
S449
K
W
S
D
G
S
M
S
L
H
L
G
N
E
V
Site 69
Y460
G
N
E
V
F
D
V
Y
K
A
P
L
Q
G
D
Site 70
T487
Q
G
Q
A
V
F
K
T
K
L
T
F
R
P
H
Site 71
T490
A
V
F
K
T
K
L
T
F
R
P
H
S
T
D
Site 72
S495
K
L
T
F
R
P
H
S
T
D
S
A
T
H
R
Site 73
S498
F
R
P
H
S
T
D
S
A
T
H
R
K
M
T
Site 74
T500
P
H
S
T
D
S
A
T
H
R
K
M
T
L
S
Site 75
T505
S
A
T
H
R
K
M
T
L
S
L
A
D
R
C
Site 76
S507
T
H
R
K
M
T
L
S
L
A
D
R
C
S
K
Site 77
S513
L
S
L
A
D
R
C
S
K
T
Q
K
I
R
I
Site 78
T515
L
A
D
R
C
S
K
T
Q
K
I
R
I
L
P
Site 79
T533
R
D
P
E
C
Q
R
T
E
M
I
K
K
E
E
Site 80
S546
E
E
E
R
L
R
A
S
I
R
R
E
S
Q
Q
Site 81
S551
R
A
S
I
R
R
E
S
Q
Q
R
R
M
R
E
Site 82
S566
K
Q
H
Q
R
G
L
S
A
S
Y
L
E
P
D
Site 83
S568
H
Q
R
G
L
S
A
S
Y
L
E
P
D
R
Y
Site 84
Y569
Q
R
G
L
S
A
S
Y
L
E
P
D
R
Y
D
Site 85
Y575
S
Y
L
E
P
D
R
Y
D
E
E
E
E
G
E
Site 86
S584
E
E
E
E
G
E
E
S
I
S
L
A
A
I
K
Site 87
S586
E
E
G
E
E
S
I
S
L
A
A
I
K
N
R
Site 88
Y606
R
E
E
R
A
R
I
Y
S
S
D
S
D
E
G
Site 89
S607
E
E
R
A
R
I
Y
S
S
D
S
D
E
G
S
Site 90
S608
E
R
A
R
I
Y
S
S
D
S
D
E
G
S
E
Site 91
S610
A
R
I
Y
S
S
D
S
D
E
G
S
E
E
D
Site 92
S614
S
S
D
S
D
E
G
S
E
E
D
K
A
Q
R
Site 93
T629
L
L
K
A
K
K
L
T
S
D
E
E
G
E
P
Site 94
S630
L
K
A
K
K
L
T
S
D
E
E
G
E
P
S
Site 95
S637
S
D
E
E
G
E
P
S
G
K
R
K
A
E
D
Site 96
Y655
A
N
K
K
H
K
K
Y
V
I
S
D
E
E
E
Site 97
S658
K
H
K
K
Y
V
I
S
D
E
E
E
E
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation