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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POF1B
Full Name:
Protein POF1B
Alias:
FLJ22792; POF; Premature ovarian failure protein 1B; Premature ovarian failure, 1B
Type:
Actin binding protein
Mass (Da):
68696
Number AA:
595
UniProt ID:
Q8WVV4
International Prot ID:
IPI00103242
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
S
S
Y
W
S
E
T
S
S
S
S
C
Site 2
T9
S
S
S
Y
W
S
E
T
S
S
S
S
C
G
T
Site 3
S10
S
S
Y
W
S
E
T
S
S
S
S
C
G
T
Q
Site 4
S11
S
Y
W
S
E
T
S
S
S
S
C
G
T
Q
Q
Site 5
S12
Y
W
S
E
T
S
S
S
S
C
G
T
Q
Q
L
Site 6
Y49
P
P
E
K
N
V
V
Y
E
R
V
R
T
Y
S
Site 7
T54
V
V
Y
E
R
V
R
T
Y
S
G
P
M
N
K
Site 8
Y55
V
Y
E
R
V
R
T
Y
S
G
P
M
N
K
V
Site 9
S56
Y
E
R
V
R
T
Y
S
G
P
M
N
K
V
V
Site 10
S71
Q
A
L
D
P
F
N
S
R
E
V
L
S
P
L
Site 11
S76
F
N
S
R
E
V
L
S
P
L
K
T
T
S
S
Site 12
T80
E
V
L
S
P
L
K
T
T
S
S
Y
Q
N
L
Site 13
S83
S
P
L
K
T
T
S
S
Y
Q
N
L
V
W
S
Site 14
Y84
P
L
K
T
T
S
S
Y
Q
N
L
V
W
S
D
Site 15
S90
S
Y
Q
N
L
V
W
S
D
H
S
Q
E
L
H
Site 16
S93
N
L
V
W
S
D
H
S
Q
E
L
H
S
P
T
Site 17
S98
D
H
S
Q
E
L
H
S
P
T
L
K
I
S
T
Site 18
T100
S
Q
E
L
H
S
P
T
L
K
I
S
T
C
A
Site 19
S104
H
S
P
T
L
K
I
S
T
C
A
P
S
T
L
Site 20
T105
S
P
T
L
K
I
S
T
C
A
P
S
T
L
H
Site 21
T110
I
S
T
C
A
P
S
T
L
H
I
T
Q
N
T
Site 22
S123
N
T
E
Q
E
L
H
S
P
T
V
K
L
T
T
Site 23
T125
E
Q
E
L
H
S
P
T
V
K
L
T
T
Y
P
Site 24
T129
H
S
P
T
V
K
L
T
T
Y
P
Q
T
T
I
Site 25
Y131
P
T
V
K
L
T
T
Y
P
Q
T
T
I
R
K
Site 26
Y139
P
Q
T
T
I
R
K
Y
V
V
Q
N
P
E
Q
Site 27
S150
N
P
E
Q
E
P
L
S
Q
F
L
R
G
S
H
Site 28
S156
L
S
Q
F
L
R
G
S
H
F
F
P
G
N
N
Site 29
Y166
F
P
G
N
N
V
I
Y
E
K
T
I
R
K
V
Site 30
T169
N
N
V
I
Y
E
K
T
I
R
K
V
E
K
L
Site 31
T178
R
K
V
E
K
L
N
T
D
Q
G
C
H
P
Q
Site 32
S223
I
T
G
N
N
P
I
S
T
H
I
G
N
E
L
Site 33
S233
I
G
N
E
L
C
H
S
G
S
S
Q
I
C
E
Site 34
S235
N
E
L
C
H
S
G
S
S
Q
I
C
E
Q
V
Site 35
Y256
P
E
K
L
D
P
R
Y
F
G
E
L
L
A
D
Site 36
S265
G
E
L
L
A
D
L
S
R
K
N
T
D
L
Y
Site 37
T269
A
D
L
S
R
K
N
T
D
L
Y
H
C
L
L
Site 38
Y272
S
R
K
N
T
D
L
Y
H
C
L
L
E
H
L
Site 39
S291
G
S
K
Q
D
F
E
S
T
D
E
S
E
D
I
Site 40
S295
D
F
E
S
T
D
E
S
E
D
I
E
S
L
I
Site 41
S300
D
E
S
E
D
I
E
S
L
I
P
K
G
L
S
Site 42
S324
I
L
Q
M
R
G
M
S
D
K
S
L
R
L
V
Site 43
S327
M
R
G
M
S
D
K
S
L
R
L
V
L
S
T
Site 44
S333
K
S
L
R
L
V
L
S
T
F
S
N
I
R
E
Site 45
T334
S
L
R
L
V
L
S
T
F
S
N
I
R
E
E
Site 46
S336
R
L
V
L
S
T
F
S
N
I
R
E
E
L
G
Site 47
T350
G
H
L
Q
N
D
M
T
S
L
E
N
D
K
M
Site 48
S351
H
L
Q
N
D
M
T
S
L
E
N
D
K
M
R
Site 49
S364
M
R
L
E
K
D
L
S
F
K
D
T
Q
L
K
Site 50
T368
K
D
L
S
F
K
D
T
Q
L
K
E
Y
E
E
Site 51
S379
E
Y
E
E
L
L
A
S
V
R
A
N
N
H
Q
Site 52
S394
Q
Q
Q
G
L
Q
D
S
S
S
K
C
Q
A
L
Site 53
S396
Q
G
L
Q
D
S
S
S
K
C
Q
A
L
E
E
Site 54
S407
A
L
E
E
N
N
L
S
L
R
H
T
L
S
D
Site 55
T411
N
N
L
S
L
R
H
T
L
S
D
M
E
Y
R
Site 56
S413
L
S
L
R
H
T
L
S
D
M
E
Y
R
L
K
Site 57
Y417
H
T
L
S
D
M
E
Y
R
L
K
E
L
E
Y
Site 58
Y424
Y
R
L
K
E
L
E
Y
C
K
R
N
L
E
Q
Site 59
S441
Q
N
L
R
M
Q
V
S
E
T
C
T
G
P
M
Site 60
T445
M
Q
V
S
E
T
C
T
G
P
M
L
Q
A
K
Site 61
S480
R
E
I
C
R
L
R
S
Q
L
N
Q
Y
H
K
Site 62
Y485
L
R
S
Q
L
N
Q
Y
H
K
D
V
S
K
R
Site 63
S490
N
Q
Y
H
K
D
V
S
K
R
E
G
S
C
S
Site 64
S495
D
V
S
K
R
E
G
S
C
S
D
F
Q
F
K
Site 65
S497
S
K
R
E
G
S
C
S
D
F
Q
F
K
L
H
Site 66
S508
F
K
L
H
E
L
T
S
L
L
E
E
K
D
S
Site 67
S515
S
L
L
E
E
K
D
S
L
I
K
R
Q
S
E
Site 68
S521
D
S
L
I
K
R
Q
S
E
E
L
S
K
L
R
Site 69
S525
K
R
Q
S
E
E
L
S
K
L
R
Q
E
I
Y
Site 70
Y532
S
K
L
R
Q
E
I
Y
S
S
H
N
Q
P
S
Site 71
S533
K
L
R
Q
E
I
Y
S
S
H
N
Q
P
S
T
Site 72
S534
L
R
Q
E
I
Y
S
S
H
N
Q
P
S
T
G
Site 73
S539
Y
S
S
H
N
Q
P
S
T
G
G
R
T
T
I
Site 74
T540
S
S
H
N
Q
P
S
T
G
G
R
T
T
I
T
Site 75
T545
P
S
T
G
G
R
T
T
I
T
T
K
K
Y
R
Site 76
T548
G
G
R
T
T
I
T
T
K
K
Y
R
T
Q
Y
Site 77
Y551
T
T
I
T
T
K
K
Y
R
T
Q
Y
P
I
L
Site 78
T553
I
T
T
K
K
Y
R
T
Q
Y
P
I
L
G
L
Site 79
Y555
T
K
K
Y
R
T
Q
Y
P
I
L
G
L
L
Y
Site 80
Y565
L
G
L
L
Y
D
D
Y
E
Y
I
P
P
G
S
Site 81
Y567
L
L
Y
D
D
Y
E
Y
I
P
P
G
S
E
T
Site 82
S572
Y
E
Y
I
P
P
G
S
E
T
Q
T
I
V
I
Site 83
T576
P
P
G
S
E
T
Q
T
I
V
I
E
K
T
E
Site 84
T582
Q
T
I
V
I
E
K
T
E
D
K
Y
T
C
V
Site 85
Y586
I
E
K
T
E
D
K
Y
T
C
V
S
S
L
G
Site 86
T587
E
K
T
E
D
K
Y
T
C
V
S
S
L
G
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation