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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCNB3
Full Name:
G2/mitotic-specific cyclin-B3
Alias:
CYCB3; cyclin B3
Type:
Cell cycle regulation
Mass (Da):
157980
Number AA:
UniProt ID:
Q8WWL7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0051301
GO:0007126
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
L
L
P
L
P
P
Q
S
S
K
P
V
P
K
K
Site 2
S10
L
P
L
P
P
Q
S
S
K
P
V
P
K
K
S
Site 3
S17
S
K
P
V
P
K
K
S
Q
S
S
K
I
V
P
Site 4
S19
P
V
P
K
K
S
Q
S
S
K
I
V
P
S
H
Site 5
S20
V
P
K
K
S
Q
S
S
K
I
V
P
S
H
H
Site 6
S25
Q
S
S
K
I
V
P
S
H
H
D
P
S
E
K
Site 7
T39
K
T
G
E
N
C
Q
T
K
I
S
P
S
S
L
Site 8
S42
E
N
C
Q
T
K
I
S
P
S
S
L
Q
E
S
Site 9
S44
C
Q
T
K
I
S
P
S
S
L
Q
E
S
P
S
Site 10
S45
Q
T
K
I
S
P
S
S
L
Q
E
S
P
S
S
Site 11
S49
S
P
S
S
L
Q
E
S
P
S
S
L
Q
G
A
Site 12
S51
S
S
L
Q
E
S
P
S
S
L
Q
G
A
L
K
Site 13
S52
S
L
Q
E
S
P
S
S
L
Q
G
A
L
K
K
Site 14
T67
R
S
A
F
E
D
L
T
N
A
S
Q
C
Q
P
Site 15
S70
F
E
D
L
T
N
A
S
Q
C
Q
P
V
Q
P
Site 16
T97
S
K
K
I
N
R
N
T
H
A
L
G
L
A
K
Site 17
T118
K
W
H
K
L
E
V
T
P
V
V
A
S
T
T
Site 18
S140
K
P
L
I
L
D
I
S
T
T
S
K
T
P
N
Site 19
T141
P
L
I
L
D
I
S
T
T
S
K
T
P
N
T
Site 20
S143
I
L
D
I
S
T
T
S
K
T
P
N
T
E
E
Site 21
T145
D
I
S
T
T
S
K
T
P
N
T
E
E
A
S
Site 22
T148
T
T
S
K
T
P
N
T
E
E
A
S
L
F
R
Site 23
S152
T
P
N
T
E
E
A
S
L
F
R
K
P
L
V
Site 24
T170
E
P
T
I
E
D
E
T
L
I
N
K
S
L
S
Site 25
S175
D
E
T
L
I
N
K
S
L
S
L
K
K
C
S
Site 26
S177
T
L
I
N
K
S
L
S
L
K
K
C
S
N
H
Site 27
S188
C
S
N
H
E
E
V
S
L
L
E
K
L
Q
P
Site 28
S200
L
Q
P
L
Q
E
E
S
D
S
D
D
A
F
V
Site 29
S202
P
L
Q
E
E
S
D
S
D
D
A
F
V
I
E
Site 30
T212
A
F
V
I
E
P
M
T
F
K
K
T
H
K
T
Site 31
T225
K
T
E
E
A
A
I
T
K
K
T
L
S
L
K
Site 32
T228
E
A
A
I
T
K
K
T
L
S
L
K
K
K
M
Site 33
S230
A
I
T
K
K
T
L
S
L
K
K
K
M
C
A
Site 34
S238
L
K
K
K
M
C
A
S
Q
R
K
Q
S
C
Q
Site 35
S243
C
A
S
Q
R
K
Q
S
C
Q
E
E
S
L
A
Site 36
S248
K
Q
S
C
Q
E
E
S
L
A
V
Q
D
V
N
Site 37
S260
D
V
N
M
E
E
D
S
F
F
M
E
S
M
S
Site 38
S265
E
D
S
F
F
M
E
S
M
S
F
K
K
K
P
Site 39
S267
S
F
F
M
E
S
M
S
F
K
K
K
P
K
T
Site 40
T274
S
F
K
K
K
P
K
T
E
E
S
I
P
T
H
Site 41
S277
K
K
P
K
T
E
E
S
I
P
T
H
K
L
S
Site 42
T280
K
T
E
E
S
I
P
T
H
K
L
S
S
L
K
Site 43
S284
S
I
P
T
H
K
L
S
S
L
K
K
K
C
T
Site 44
S285
I
P
T
H
K
L
S
S
L
K
K
K
C
T
I
Site 45
T291
S
S
L
K
K
K
C
T
I
Y
G
K
I
C
H
Site 46
Y293
L
K
K
K
C
T
I
Y
G
K
I
C
H
F
R
Site 47
S315
T
I
C
G
A
M
S
S
I
K
K
P
T
T
E
Site 48
T321
S
S
I
K
K
P
T
T
E
K
E
T
L
F
Q
Site 49
S331
E
T
L
F
Q
E
L
S
V
L
Q
E
K
H
T
Site 50
T339
V
L
Q
E
K
H
T
T
E
H
E
M
S
I
L
Site 51
S344
H
T
T
E
H
E
M
S
I
L
K
K
S
L
A
Site 52
S349
E
M
S
I
L
K
K
S
L
A
L
Q
K
T
N
Site 53
T355
K
S
L
A
L
Q
K
T
N
F
K
E
D
S
L
Site 54
S361
K
T
N
F
K
E
D
S
L
V
K
E
S
L
A
Site 55
S366
E
D
S
L
V
K
E
S
L
A
F
K
K
K
P
Site 56
S374
L
A
F
K
K
K
P
S
T
E
E
A
I
M
M
Site 57
T375
A
F
K
K
K
P
S
T
E
E
A
I
M
M
P
Site 58
T391
I
L
K
E
Q
C
M
T
E
G
K
R
S
R
L
Site 59
S396
C
M
T
E
G
K
R
S
R
L
K
P
L
V
L
Site 60
S412
E
I
T
S
G
E
K
S
L
I
M
K
P
L
S
Site 61
S419
S
L
I
M
K
P
L
S
I
K
E
K
P
S
T
Site 62
S425
L
S
I
K
E
K
P
S
T
E
K
E
S
F
S
Site 63
T426
S
I
K
E
K
P
S
T
E
K
E
S
F
S
Q
Site 64
S430
K
P
S
T
E
K
E
S
F
S
Q
E
P
S
A
Site 65
S432
S
T
E
K
E
S
F
S
Q
E
P
S
A
L
Q
Site 66
S436
E
S
F
S
Q
E
P
S
A
L
Q
K
K
H
T
Site 67
S455
V
S
I
L
K
E
P
S
S
L
L
K
S
P
T
Site 68
S456
S
I
L
K
E
P
S
S
L
L
K
S
P
T
E
Site 69
S460
E
P
S
S
L
L
K
S
P
T
E
E
S
P
F
Site 70
T462
S
S
L
L
K
S
P
T
E
E
S
P
F
D
E
Site 71
S465
L
K
S
P
T
E
E
S
P
F
D
E
A
L
A
Site 72
T485
T
I
E
E
A
P
P
T
K
K
P
L
I
L
K
Site 73
T497
I
L
K
R
K
H
A
T
Q
G
T
M
S
H
L
Site 74
S502
H
A
T
Q
G
T
M
S
H
L
K
K
P
L
I
Site 75
T512
K
K
P
L
I
L
Q
T
T
S
G
E
K
S
L
Site 76
S514
P
L
I
L
Q
T
T
S
G
E
K
S
L
I
K
Site 77
S518
Q
T
T
S
G
E
K
S
L
I
K
E
P
L
P
Site 78
S532
P
F
K
E
E
K
V
S
L
K
K
K
C
T
T
Site 79
T539
S
L
K
K
K
C
T
T
Q
E
M
M
S
I
C
Site 80
S569
S
F
F
M
E
P
M
S
F
R
K
N
P
T
T
Site 81
T576
S
F
R
K
N
P
T
T
E
E
T
V
L
T
K
Site 82
T579
K
N
P
T
T
E
E
T
V
L
T
K
T
S
L
Site 83
T582
T
T
E
E
T
V
L
T
K
T
S
L
S
L
Q
Site 84
S585
E
T
V
L
T
K
T
S
L
S
L
Q
E
K
K
Site 85
T594
S
L
Q
E
K
K
I
T
Q
G
K
M
S
H
L
Site 86
S599
K
I
T
Q
G
K
M
S
H
L
K
K
P
L
V
Site 87
S612
L
V
L
Q
K
I
T
S
E
E
E
S
F
Y
K
Site 88
S616
K
I
T
S
E
E
E
S
F
Y
K
K
L
L
P
Site 89
Y618
T
S
E
E
E
S
F
Y
K
K
L
L
P
F
K
Site 90
S628
L
L
P
F
K
M
K
S
T
T
E
E
K
F
L
Site 91
T630
P
F
K
M
K
S
T
T
E
E
K
F
L
S
Q
Site 92
S636
T
T
E
E
K
F
L
S
Q
E
P
S
A
L
K
Site 93
S640
K
F
L
S
Q
E
P
S
A
L
K
E
K
H
T
Site 94
T648
A
L
K
E
K
H
T
T
L
Q
E
V
S
L
S
Site 95
S653
H
T
T
L
Q
E
V
S
L
S
K
E
S
L
A
Site 96
S655
T
L
Q
E
V
S
L
S
K
E
S
L
A
I
Q
Site 97
T667
A
I
Q
E
K
A
T
T
E
E
E
F
S
Q
E
Site 98
S672
A
T
T
E
E
E
F
S
Q
E
L
F
S
L
H
Site 99
T683
F
S
L
H
V
K
H
T
N
K
S
G
S
L
F
Site 100
S706
K
T
D
A
E
E
D
S
L
K
N
L
L
A
L
Site 101
S717
L
L
A
L
Q
E
K
S
T
M
E
E
E
S
L
Site 102
S723
K
S
T
M
E
E
E
S
L
I
N
K
L
L
A
Site 103
S748
T
N
I
Q
T
Q
L
S
L
K
K
K
S
T
S
Site 104
S753
Q
L
S
L
K
K
K
S
T
S
H
G
K
V
F
Site 105
Y788
Q
P
L
A
L
E
G
Y
P
S
I
A
E
G
E
Site 106
S838
L
A
L
Q
E
E
P
S
T
E
K
E
A
V
L
Site 107
T839
A
L
Q
E
E
P
S
T
E
K
E
A
V
L
K
Site 108
S849
E
A
V
L
K
E
P
S
V
D
T
E
A
H
F
Site 109
S867
L
A
L
Q
E
K
P
S
I
E
Q
E
A
L
F
Site 110
S878
E
A
L
F
K
R
H
S
A
L
W
E
K
P
S
Site 111
S885
S
A
L
W
E
K
P
S
T
E
K
E
T
I
F
Site 112
T886
A
L
W
E
K
P
S
T
E
K
E
T
I
F
K
Site 113
T939
A
L
N
E
K
P
T
T
G
K
E
L
S
F
K
Site 114
S944
P
T
T
G
K
E
L
S
F
K
E
P
L
A
L
Site 115
S954
E
P
L
A
L
Q
E
S
P
T
Y
K
E
D
T
Site 116
Y957
A
L
Q
E
S
P
T
Y
K
E
D
T
F
L
K
Site 117
T961
S
P
T
Y
K
E
D
T
F
L
K
T
L
L
V
Site 118
S978
V
G
T
S
P
N
V
S
S
T
A
P
E
S
I
Site 119
S979
G
T
S
P
N
V
S
S
T
A
P
E
S
I
T
Site 120
T980
T
S
P
N
V
S
S
T
A
P
E
S
I
T
S
Site 121
S984
V
S
S
T
A
P
E
S
I
T
S
K
S
S
I
Site 122
T986
S
T
A
P
E
S
I
T
S
K
S
S
I
A
T
Site 123
S987
T
A
P
E
S
I
T
S
K
S
S
I
A
T
M
Site 124
S989
P
E
S
I
T
S
K
S
S
I
A
T
M
T
S
Site 125
S990
E
S
I
T
S
K
S
S
I
A
T
M
T
S
V
Site 126
T993
T
S
K
S
S
I
A
T
M
T
S
V
G
K
S
Site 127
T995
K
S
S
I
A
T
M
T
S
V
G
K
S
G
T
Site 128
S996
S
S
I
A
T
M
T
S
V
G
K
S
G
T
I
Site 129
S1000
T
M
T
S
V
G
K
S
G
T
I
N
E
A
F
Site 130
T1002
T
S
V
G
K
S
G
T
I
N
E
A
F
L
F
Site 131
T1014
F
L
F
E
D
M
I
T
L
N
E
K
P
T
T
Site 132
T1021
T
L
N
E
K
P
T
T
G
K
E
L
S
F
K
Site 133
S1036
E
P
L
A
L
Q
E
S
P
T
C
K
E
D
T
Site 134
T1043
S
P
T
C
K
E
D
T
F
L
E
T
F
L
I
Site 135
S1056
L
I
P
Q
I
G
T
S
P
Y
V
F
S
T
T
Site 136
Y1058
P
Q
I
G
T
S
P
Y
V
F
S
T
T
P
E
Site 137
S1061
G
T
S
P
Y
V
F
S
T
T
P
E
S
I
T
Site 138
T1062
T
S
P
Y
V
F
S
T
T
P
E
S
I
T
E
Site 139
T1063
S
P
Y
V
F
S
T
T
P
E
S
I
T
E
K
Site 140
S1066
V
F
S
T
T
P
E
S
I
T
E
K
S
S
I
Site 141
S1071
P
E
S
I
T
E
K
S
S
I
A
T
M
T
S
Site 142
S1072
E
S
I
T
E
K
S
S
I
A
T
M
T
S
V
Site 143
T1075
T
E
K
S
S
I
A
T
M
T
S
V
G
K
S
Site 144
T1077
K
S
S
I
A
T
M
T
S
V
G
K
S
R
T
Site 145
S1078
S
S
I
A
T
M
T
S
V
G
K
S
R
T
T
Site 146
S1082
T
M
T
S
V
G
K
S
R
T
T
T
E
S
S
Site 147
T1084
T
S
V
G
K
S
R
T
T
T
E
S
S
A
C
Site 148
T1085
S
V
G
K
S
R
T
T
T
E
S
S
A
C
E
Site 149
T1086
V
G
K
S
R
T
T
T
E
S
S
A
C
E
S
Site 150
S1088
K
S
R
T
T
T
E
S
S
A
C
E
S
A
S
Site 151
S1089
S
R
T
T
T
E
S
S
A
C
E
S
A
S
D
Site 152
S1093
T
E
S
S
A
C
E
S
A
S
D
K
P
V
S
Site 153
S1095
S
S
A
C
E
S
A
S
D
K
P
V
S
P
Q
Site 154
S1100
S
A
S
D
K
P
V
S
P
Q
A
K
G
T
P
Site 155
T1106
V
S
P
Q
A
K
G
T
P
K
E
I
T
P
R
Site 156
T1111
K
G
T
P
K
E
I
T
P
R
E
D
I
D
E
Site 157
S1120
R
E
D
I
D
E
D
S
S
D
P
S
F
N
P
Site 158
S1121
E
D
I
D
E
D
S
S
D
P
S
F
N
P
M
Site 159
S1124
D
E
D
S
S
D
P
S
F
N
P
M
Y
A
K
Site 160
Y1129
D
P
S
F
N
P
M
Y
A
K
E
I
F
S
Y
Site 161
Y1136
Y
A
K
E
I
F
S
Y
M
K
E
R
E
E
Q
Site 162
Y1149
E
Q
F
I
L
T
D
Y
M
N
R
Q
I
E
I
Site 163
T1157
M
N
R
Q
I
E
I
T
S
D
M
R
A
I
L
Site 164
S1174
W
L
V
E
V
Q
V
S
F
E
M
T
H
E
T
Site 165
T1178
V
Q
V
S
F
E
M
T
H
E
T
L
Y
L
A
Site 166
S1222
A
K
F
E
E
H
N
S
P
R
V
D
D
F
V
Site 167
Y1230
P
R
V
D
D
F
V
Y
I
C
D
D
N
Y
Q
Site 168
Y1236
V
Y
I
C
D
D
N
Y
Q
R
S
E
V
L
S
Site 169
S1239
C
D
D
N
Y
Q
R
S
E
V
L
S
M
E
I
Site 170
S1243
Y
Q
R
S
E
V
L
S
M
E
I
N
I
L
N
Site 171
T1280
H
T
N
M
K
T
L
T
L
S
R
Y
I
C
E
Site 172
Y1284
K
T
L
T
L
S
R
Y
I
C
E
M
T
L
Q
Site 173
Y1293
C
E
M
T
L
Q
E
Y
H
Y
V
Q
E
K
A
Site 174
Y1295
M
T
L
Q
E
Y
H
Y
V
Q
E
K
A
S
K
Site 175
Y1319
L
Y
M
K
K
L
G
Y
W
V
P
F
L
E
H
Site 176
S1331
L
E
H
Y
S
G
Y
S
I
S
E
L
H
P
L
Site 177
S1333
H
Y
S
G
Y
S
I
S
E
L
H
P
L
V
R
Site 178
T1347
R
Q
L
N
K
L
L
T
F
S
S
Y
D
S
L
Site 179
S1349
L
N
K
L
L
T
F
S
S
Y
D
S
L
K
A
Site 180
S1350
N
K
L
L
T
F
S
S
Y
D
S
L
K
A
V
Site 181
S1353
L
T
F
S
S
Y
D
S
L
K
A
V
Y
Y
K
Site 182
Y1358
Y
D
S
L
K
A
V
Y
Y
K
Y
S
H
P
V
Site 183
Y1359
D
S
L
K
A
V
Y
Y
K
Y
S
H
P
V
F
Site 184
Y1361
L
K
A
V
Y
Y
K
Y
S
H
P
V
F
F
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation