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Updated November 2019
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Protein Info
Short Name:
ATXN2L
Full Name:
Ataxin-2-like protein
Alias:
A2D; A2D-C; A2lp; Ataxin 2-like; Ataxin-2 domain protein; Ataxin-2 related domain protein; ATX2L
Type:
Membrane protein, peripheral
Mass (Da):
113374
Number AA:
1075
UniProt ID:
Q8WWM7
International Prot ID:
IPI00456363
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
Q
P
L
Q
Q
P
S
Q
P
Q
Q
P
P
P
Site 2
T31
A
R
R
P
P
G
G
T
S
P
P
N
G
G
L
Site 3
S32
R
R
P
P
G
G
T
S
P
P
N
G
G
L
P
Site 4
T44
G
L
P
G
P
L
A
T
S
A
A
P
P
G
P
Site 5
S45
L
P
G
P
L
A
T
S
A
A
P
P
G
P
P
Site 6
S56
P
G
P
P
A
A
A
S
P
C
L
G
P
V
A
Site 7
S67
G
P
V
A
A
A
G
S
G
L
R
R
G
A
E
Site 8
S98
P
G
A
A
A
I
G
S
A
R
G
Q
S
T
G
Site 9
S103
I
G
S
A
R
G
Q
S
T
G
K
G
P
P
Q
Site 10
S111
T
G
K
G
P
P
Q
S
P
V
F
E
G
V
Y
Site 11
Y118
S
P
V
F
E
G
V
Y
N
N
S
R
M
L
H
Site 12
S121
F
E
G
V
Y
N
N
S
R
M
L
H
F
L
T
Site 13
T128
S
R
M
L
H
F
L
T
A
V
V
G
S
T
C
Site 14
T134
L
T
A
V
V
G
S
T
C
D
V
K
V
K
N
Site 15
Y145
K
V
K
N
G
T
T
Y
E
G
I
F
K
T
L
Site 16
T151
T
Y
E
G
I
F
K
T
L
S
S
K
F
E
L
Site 17
S168
D
A
V
H
R
K
A
S
E
P
A
G
G
P
R
Site 18
T182
R
R
E
D
I
V
D
T
M
V
F
K
P
S
D
Site 19
Y202
F
R
N
V
D
F
N
Y
A
T
K
D
K
F
T
Site 20
S211
T
K
D
K
F
T
D
S
A
I
A
M
N
S
K
Site 21
S236
Q
R
W
E
G
G
D
S
N
S
D
D
Y
D
L
Site 22
S238
W
E
G
G
D
S
N
S
D
D
Y
D
L
E
S
Site 23
Y241
G
D
S
N
S
D
D
Y
D
L
E
S
D
M
S
Site 24
S245
S
D
D
Y
D
L
E
S
D
M
S
N
G
W
D
Site 25
S248
Y
D
L
E
S
D
M
S
N
G
W
D
P
N
E
Site 26
Y264
F
K
F
N
E
E
N
Y
G
V
K
T
T
Y
D
Site 27
T268
E
E
N
Y
G
V
K
T
T
Y
D
S
S
L
S
Site 28
T269
E
N
Y
G
V
K
T
T
Y
D
S
S
L
S
S
Site 29
Y270
N
Y
G
V
K
T
T
Y
D
S
S
L
S
S
Y
Site 30
S272
G
V
K
T
T
Y
D
S
S
L
S
S
Y
T
V
Site 31
S273
V
K
T
T
Y
D
S
S
L
S
S
Y
T
V
P
Site 32
S275
T
T
Y
D
S
S
L
S
S
Y
T
V
P
L
E
Site 33
S276
T
Y
D
S
S
L
S
S
Y
T
V
P
L
E
K
Site 34
Y277
Y
D
S
S
L
S
S
Y
T
V
P
L
E
K
D
Site 35
T278
D
S
S
L
S
S
Y
T
V
P
L
E
K
D
N
Site 36
S286
V
P
L
E
K
D
N
S
E
E
F
R
Q
R
E
Site 37
S305
Q
L
A
R
E
I
E
S
S
P
Q
Y
R
L
R
Site 38
S306
L
A
R
E
I
E
S
S
P
Q
Y
R
L
R
I
Site 39
Y309
E
I
E
S
S
P
Q
Y
R
L
R
I
A
M
E
Site 40
S328
R
T
E
E
E
K
H
S
A
V
Q
R
Q
G
S
Site 41
S335
S
A
V
Q
R
Q
G
S
G
R
E
S
P
S
L
Site 42
S339
R
Q
G
S
G
R
E
S
P
S
L
A
S
R
E
Site 43
S341
G
S
G
R
E
S
P
S
L
A
S
R
E
G
K
Site 44
S344
R
E
S
P
S
L
A
S
R
E
G
K
Y
I
P
Site 45
Y349
L
A
S
R
E
G
K
Y
I
P
L
P
Q
R
V
Site 46
S367
P
R
G
G
V
R
C
S
S
S
R
G
G
R
P
Site 47
S368
R
G
G
V
R
C
S
S
S
R
G
G
R
P
G
Site 48
S369
G
G
V
R
C
S
S
S
R
G
G
R
P
G
L
Site 49
S377
R
G
G
R
P
G
L
S
S
L
P
P
R
G
P
Site 50
S378
G
G
R
P
G
L
S
S
L
P
P
R
G
P
H
Site 51
S390
G
P
H
H
L
D
N
S
S
P
G
P
G
S
E
Site 52
S391
P
H
H
L
D
N
S
S
P
G
P
G
S
E
A
Site 53
S396
N
S
S
P
G
P
G
S
E
A
R
G
I
N
G
Site 54
S406
R
G
I
N
G
G
P
S
R
M
S
P
K
A
Q
Site 55
S409
N
G
G
P
S
R
M
S
P
K
A
Q
R
P
L
Site 56
T421
R
P
L
R
G
A
K
T
L
S
S
P
S
N
R
Site 57
S423
L
R
G
A
K
T
L
S
S
P
S
N
R
P
S
Site 58
S424
R
G
A
K
T
L
S
S
P
S
N
R
P
S
G
Site 59
S426
A
K
T
L
S
S
P
S
N
R
P
S
G
E
T
Site 60
S430
S
S
P
S
N
R
P
S
G
E
T
S
V
P
P
Site 61
T433
S
N
R
P
S
G
E
T
S
V
P
P
P
P
A
Site 62
S434
N
R
P
S
G
E
T
S
V
P
P
P
P
A
V
Site 63
Y445
P
P
A
V
G
R
M
Y
P
P
R
S
P
K
S
Site 64
S449
G
R
M
Y
P
P
R
S
P
K
S
A
A
P
A
Site 65
S452
Y
P
P
R
S
P
K
S
A
A
P
A
P
I
S
Site 66
S459
S
A
A
P
A
P
I
S
A
S
C
P
E
P
P
Site 67
S469
C
P
E
P
P
I
G
S
A
V
P
T
S
S
A
Site 68
T481
S
S
A
S
I
P
V
T
S
S
V
S
D
P
G
Site 69
S491
V
S
D
P
G
V
G
S
I
S
P
A
S
P
K
Site 70
S493
D
P
G
V
G
S
I
S
P
A
S
P
K
I
S
Site 71
S496
V
G
S
I
S
P
A
S
P
K
I
S
L
A
P
Site 72
S500
S
P
A
S
P
K
I
S
L
A
P
T
D
V
K
Site 73
T504
P
K
I
S
L
A
P
T
D
V
K
E
L
S
T
Site 74
S510
P
T
D
V
K
E
L
S
T
K
E
P
G
R
T
Site 75
T511
T
D
V
K
E
L
S
T
K
E
P
G
R
T
L
Site 76
T517
S
T
K
E
P
G
R
T
L
E
P
Q
E
L
A
Site 77
S557
A
Q
F
K
L
Q
P
S
S
S
P
E
N
S
L
Site 78
S558
Q
F
K
L
Q
P
S
S
S
P
E
N
S
L
D
Site 79
S559
F
K
L
Q
P
S
S
S
P
E
N
S
L
D
P
Site 80
S563
P
S
S
S
P
E
N
S
L
D
P
F
P
P
R
Site 81
T588
K
E
V
D
G
L
L
T
S
E
P
M
G
S
P
Site 82
S589
E
V
D
G
L
L
T
S
E
P
M
G
S
P
V
Site 83
S594
L
T
S
E
P
M
G
S
P
V
S
S
K
T
E
Site 84
S597
E
P
M
G
S
P
V
S
S
K
T
E
S
V
S
Site 85
S598
P
M
G
S
P
V
S
S
K
T
E
S
V
S
D
Site 86
T600
G
S
P
V
S
S
K
T
E
S
V
S
D
K
E
Site 87
S602
P
V
S
S
K
T
E
S
V
S
D
K
E
D
K
Site 88
S604
S
S
K
T
E
S
V
S
D
K
E
D
K
P
P
Site 89
S615
D
K
P
P
L
A
P
S
G
G
T
E
G
P
E
Site 90
T618
P
L
A
P
S
G
G
T
E
G
P
E
Q
P
P
Site 91
S630
Q
P
P
P
P
C
P
S
Q
T
G
S
P
P
V
Site 92
T632
P
P
P
C
P
S
Q
T
G
S
P
P
V
G
L
Site 93
S634
P
C
P
S
Q
T
G
S
P
P
V
G
L
I
K
Site 94
S674
N
P
T
K
P
L
L
S
V
N
K
S
T
S
T
Site 95
S678
P
L
L
S
V
N
K
S
T
S
T
P
T
S
P
Site 96
T679
L
L
S
V
N
K
S
T
S
T
P
T
S
P
G
Site 97
S680
L
S
V
N
K
S
T
S
T
P
T
S
P
G
P
Site 98
T681
S
V
N
K
S
T
S
T
P
T
S
P
G
P
R
Site 99
T683
N
K
S
T
S
T
P
T
S
P
G
P
R
T
H
Site 100
S684
K
S
T
S
T
P
T
S
P
G
P
R
T
H
S
Site 101
T689
P
T
S
P
G
P
R
T
H
S
T
P
S
I
P
Site 102
S691
S
P
G
P
R
T
H
S
T
P
S
I
P
V
L
Site 103
T692
P
G
P
R
T
H
S
T
P
S
I
P
V
L
T
Site 104
S694
P
R
T
H
S
T
P
S
I
P
V
L
T
A
G
Site 105
S703
P
V
L
T
A
G
Q
S
G
L
Y
S
P
Q
Y
Site 106
Y706
T
A
G
Q
S
G
L
Y
S
P
Q
Y
I
S
Y
Site 107
S707
A
G
Q
S
G
L
Y
S
P
Q
Y
I
S
Y
I
Site 108
Y710
S
G
L
Y
S
P
Q
Y
I
S
Y
I
P
Q
I
Site 109
Y713
Y
S
P
Q
Y
I
S
Y
I
P
Q
I
H
M
G
Site 110
Y729
A
V
Q
A
P
Q
M
Y
P
Y
P
V
S
N
S
Site 111
Y731
Q
A
P
Q
M
Y
P
Y
P
V
S
N
S
V
P
Site 112
S734
Q
M
Y
P
Y
P
V
S
N
S
V
P
G
Q
Q
Site 113
S736
Y
P
Y
P
V
S
N
S
V
P
G
Q
Q
G
K
Site 114
Y744
V
P
G
Q
Q
G
K
Y
R
G
A
K
G
S
L
Site 115
S750
K
Y
R
G
A
K
G
S
L
P
P
Q
R
S
D
Site 116
S756
G
S
L
P
P
Q
R
S
D
Q
H
Q
P
A
S
Site 117
S763
S
D
Q
H
Q
P
A
S
A
P
P
M
M
Q
A
Site 118
Y784
P
L
V
A
A
T
P
Y
S
S
Y
I
P
Y
N
Site 119
S785
L
V
A
A
T
P
Y
S
S
Y
I
P
Y
N
P
Site 120
Y790
P
Y
S
S
Y
I
P
Y
N
P
Q
Q
F
P
G
Site 121
T826
Q
S
N
P
R
M
L
T
S
G
S
H
P
Q
A
Site 122
S827
S
N
P
R
M
L
T
S
G
S
H
P
Q
A
I
Site 123
S829
P
R
M
L
T
S
G
S
H
P
Q
A
I
V
S
Site 124
S836
S
H
P
Q
A
I
V
S
S
S
T
P
Q
Y
P
Site 125
S838
P
Q
A
I
V
S
S
S
T
P
Q
Y
P
S
A
Site 126
T839
Q
A
I
V
S
S
S
T
P
Q
Y
P
S
A
E
Site 127
Y842
V
S
S
S
T
P
Q
Y
P
S
A
E
Q
P
T
Site 128
S844
S
S
T
P
Q
Y
P
S
A
E
Q
P
T
P
Q
Site 129
T849
Y
P
S
A
E
Q
P
T
P
Q
A
L
Y
A
T
Site 130
Y854
Q
P
T
P
Q
A
L
Y
A
T
V
H
Q
S
Y
Site 131
T856
T
P
Q
A
L
Y
A
T
V
H
Q
S
Y
P
H
Site 132
Y861
Y
A
T
V
H
Q
S
Y
P
H
H
A
T
Q
L
Site 133
T877
A
H
Q
P
Q
P
A
T
T
P
T
G
S
Q
P
Site 134
T878
H
Q
P
Q
P
A
T
T
P
T
G
S
Q
P
Q
Site 135
S882
P
A
T
T
P
T
G
S
Q
P
Q
S
Q
H
A
Site 136
S886
P
T
G
S
Q
P
Q
S
Q
H
A
A
P
S
P
Site 137
S892
Q
S
Q
H
A
A
P
S
P
V
Q
H
Q
A
G
Site 138
Y914
G
Q
P
Q
Q
N
L
Y
H
P
G
A
L
T
G
Site 139
T920
L
Y
H
P
G
A
L
T
G
T
P
P
S
L
P
Site 140
T922
H
P
G
A
L
T
G
T
P
P
S
L
P
P
G
Site 141
S925
A
L
T
G
T
P
P
S
L
P
P
G
P
S
A
Site 142
S931
P
S
L
P
P
G
P
S
A
Q
S
P
Q
S
S
Site 143
S934
P
P
G
P
S
A
Q
S
P
Q
S
S
F
P
Q
Site 144
S937
P
S
A
Q
S
P
Q
S
S
F
P
Q
P
A
A
Site 145
S938
S
A
Q
S
P
Q
S
S
F
P
Q
P
A
A
V
Site 146
T973
A
H
V
Q
T
G
I
T
A
A
P
P
P
H
P
Site 147
S996
M
L
L
H
P
P
Q
S
H
G
G
P
P
Q
G
Site 148
S1014
Q
S
G
V
P
A
L
S
A
S
T
P
S
P
Y
Site 149
S1016
G
V
P
A
L
S
A
S
T
P
S
P
Y
P
Y
Site 150
S1019
A
L
S
A
S
T
P
S
P
Y
P
Y
I
G
H
Site 151
Y1021
S
A
S
T
P
S
P
Y
P
Y
I
G
H
P
Q
Site 152
Y1023
S
T
P
S
P
Y
P
Y
I
G
H
P
Q
G
E
Site 153
S1050
D
D
R
I
R
E
F
S
L
A
G
G
I
W
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation