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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IPCEF1
Full Name:
Interactor protein for cytohesin exchange factors 1
Alias:
Phosphoinositide-binding protein PIP3-E
Type:
Mass (Da):
48993
Number AA:
437
UniProt ID:
Q8WWN9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
R
Q
K
P
R
R
K
T
Q
G
F
L
T
M
S
Site 2
T28
R
K
T
Q
G
F
L
T
M
S
R
R
R
I
S
Site 3
S30
T
Q
G
F
L
T
M
S
R
R
R
I
S
C
K
Site 4
S35
T
M
S
R
R
R
I
S
C
K
D
L
G
H
A
Site 5
Y49
A
D
C
Q
G
W
L
Y
K
K
K
E
K
G
S
Site 6
S56
Y
K
K
K
E
K
G
S
F
L
S
N
K
W
K
Site 7
Y75
I
L
K
G
S
S
L
Y
W
Y
S
N
Q
M
A
Site 8
Y77
K
G
S
S
L
Y
W
Y
S
N
Q
M
A
E
K
Site 9
T95
F
V
N
L
P
D
F
T
V
E
R
A
S
E
C
Site 10
S100
D
F
T
V
E
R
A
S
E
C
K
K
K
H
A
Site 11
T117
I
S
H
P
Q
I
K
T
F
Y
F
A
A
E
N
Site 12
Y119
H
P
Q
I
K
T
F
Y
F
A
A
E
N
V
Q
Site 13
S137
V
W
L
N
K
L
G
S
A
V
I
H
Q
E
S
Site 14
S144
S
A
V
I
H
Q
E
S
T
T
K
D
E
E
C
Site 15
S153
T
K
D
E
E
C
Y
S
E
S
E
Q
E
D
P
Site 16
S155
D
E
E
C
Y
S
E
S
E
Q
E
D
P
E
I
Site 17
T166
D
P
E
I
A
A
E
T
P
P
P
P
H
A
S
Site 18
S173
T
P
P
P
P
H
A
S
Q
T
Q
S
L
T
A
Site 19
S177
P
H
A
S
Q
T
Q
S
L
T
A
Q
Q
A
S
Site 20
T179
A
S
Q
T
Q
S
L
T
A
Q
Q
A
S
S
S
Site 21
S184
S
L
T
A
Q
Q
A
S
S
S
S
P
S
L
S
Site 22
S185
L
T
A
Q
Q
A
S
S
S
S
P
S
L
S
G
Site 23
S186
T
A
Q
Q
A
S
S
S
S
P
S
L
S
G
T
Site 24
S187
A
Q
Q
A
S
S
S
S
P
S
L
S
G
T
S
Site 25
S189
Q
A
S
S
S
S
P
S
L
S
G
T
S
Y
S
Site 26
S191
S
S
S
S
P
S
L
S
G
T
S
Y
S
F
S
Site 27
T193
S
S
P
S
L
S
G
T
S
Y
S
F
S
S
L
Site 28
S194
S
P
S
L
S
G
T
S
Y
S
F
S
S
L
E
Site 29
Y195
P
S
L
S
G
T
S
Y
S
F
S
S
L
E
N
Site 30
S196
S
L
S
G
T
S
Y
S
F
S
S
L
E
N
T
Site 31
S198
S
G
T
S
Y
S
F
S
S
L
E
N
T
V
K
Site 32
S199
G
T
S
Y
S
F
S
S
L
E
N
T
V
K
T
Site 33
T203
S
F
S
S
L
E
N
T
V
K
T
P
S
S
F
Site 34
T206
S
L
E
N
T
V
K
T
P
S
S
F
P
S
S
Site 35
S208
E
N
T
V
K
T
P
S
S
F
P
S
S
L
S
Site 36
S209
N
T
V
K
T
P
S
S
F
P
S
S
L
S
K
Site 37
S212
K
T
P
S
S
F
P
S
S
L
S
K
E
R
Q
Site 38
S213
T
P
S
S
F
P
S
S
L
S
K
E
R
Q
S
Site 39
S215
S
S
F
P
S
S
L
S
K
E
R
Q
S
L
P
Site 40
S220
S
L
S
K
E
R
Q
S
L
P
D
T
V
N
S
Site 41
T224
E
R
Q
S
L
P
D
T
V
N
S
L
S
A
A
Site 42
S227
S
L
P
D
T
V
N
S
L
S
A
A
E
D
E
Site 43
S229
P
D
T
V
N
S
L
S
A
A
E
D
E
G
Q
Site 44
T239
E
D
E
G
Q
P
I
T
F
A
V
Q
V
H
S
Site 45
S250
Q
V
H
S
P
V
P
S
E
A
G
I
H
K
A
Site 46
S261
I
H
K
A
L
E
N
S
F
V
T
S
E
S
G
Site 47
S265
L
E
N
S
F
V
T
S
E
S
G
F
L
N
S
Site 48
S272
S
E
S
G
F
L
N
S
L
S
S
D
D
T
S
Site 49
S274
S
G
F
L
N
S
L
S
S
D
D
T
S
S
L
Site 50
S275
G
F
L
N
S
L
S
S
D
D
T
S
S
L
S
Site 51
T278
N
S
L
S
S
D
D
T
S
S
L
S
S
N
H
Site 52
S279
S
L
S
S
D
D
T
S
S
L
S
S
N
H
D
Site 53
S280
L
S
S
D
D
T
S
S
L
S
S
N
H
D
H
Site 54
S282
S
D
D
T
S
S
L
S
S
N
H
D
H
L
T
Site 55
S283
D
D
T
S
S
L
S
S
N
H
D
H
L
T
V
Site 56
T289
S
S
N
H
D
H
L
T
V
P
D
K
P
A
G
Site 57
S308
D
K
E
E
T
K
V
S
E
D
D
E
M
E
K
Site 58
Y317
D
D
E
M
E
K
L
Y
K
S
L
E
Q
A
S
Site 59
S319
E
M
E
K
L
Y
K
S
L
E
Q
A
S
L
S
Site 60
S324
Y
K
S
L
E
Q
A
S
L
S
P
L
G
D
R
Site 61
S326
S
L
E
Q
A
S
L
S
P
L
G
D
R
R
P
Site 62
S334
P
L
G
D
R
R
P
S
T
K
K
E
L
R
K
Site 63
T335
L
G
D
R
R
P
S
T
K
K
E
L
R
K
S
Site 64
S342
T
K
K
E
L
R
K
S
F
V
K
R
C
K
N
Site 65
S351
V
K
R
C
K
N
P
S
I
N
E
K
L
H
K
Site 66
T361
E
K
L
H
K
I
R
T
L
N
S
T
L
K
C
Site 67
T365
K
I
R
T
L
N
S
T
L
K
C
K
E
H
D
Site 68
T386
L
L
D
D
P
K
L
T
A
R
K
Y
R
E
W
Site 69
Y390
P
K
L
T
A
R
K
Y
R
E
W
K
V
M
N
Site 70
Y405
T
L
L
I
Q
D
I
Y
Q
Q
Q
R
A
S
P
Site 71
S411
I
Y
Q
Q
Q
R
A
S
P
A
P
D
D
T
D
Site 72
T417
A
S
P
A
P
D
D
T
D
D
T
P
Q
E
L
Site 73
T420
A
P
D
D
T
D
D
T
P
Q
E
L
K
K
S
Site 74
S427
T
P
Q
E
L
K
K
S
P
S
S
P
S
V
E
Site 75
S429
Q
E
L
K
K
S
P
S
S
P
S
V
E
N
S
Site 76
S430
E
L
K
K
S
P
S
S
P
S
V
E
N
S
I
Site 77
S432
K
K
S
P
S
S
P
S
V
E
N
S
I
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation