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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HPSE2
Full Name:
Heparanase-2
Alias:
Type:
Mass (Da):
66596
Number AA:
592
UniProt ID:
Q8WWQ2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
F
P
E
A
M
P
S
S
N
S
R
P
P
A
Site 2
S14
F
P
E
A
M
P
S
S
N
S
R
P
P
A
C
Site 3
S16
E
A
M
P
S
S
N
S
R
P
P
A
C
L
A
Site 4
S38
L
L
L
H
L
S
L
S
S
Q
A
G
D
R
R
Site 5
S80
T
V
N
E
N
F
L
S
L
Q
L
D
P
S
I
Site 6
T120
L
R
F
G
G
K
R
T
D
F
L
Q
F
Q
N
Site 7
S134
N
L
R
N
P
A
K
S
R
G
G
P
G
P
D
Site 8
Y142
R
G
G
P
G
P
D
Y
Y
L
K
N
Y
E
D
Site 9
Y143
G
G
P
G
P
D
Y
Y
L
K
N
Y
E
D
D
Site 10
Y147
P
D
Y
Y
L
K
N
Y
E
D
D
I
V
R
S
Site 11
S194
V
L
L
K
E
Q
F
S
N
T
Y
S
N
L
I
Site 12
S198
E
Q
F
S
N
T
Y
S
N
L
I
L
T
A
R
Site 13
T203
T
Y
S
N
L
I
L
T
A
R
S
L
D
K
L
Site 14
Y211
A
R
S
L
D
K
L
Y
N
F
A
D
C
S
G
Site 15
S235
L
R
R
N
P
N
N
S
W
N
S
S
S
A
L
Site 16
S238
N
P
N
N
S
W
N
S
S
S
A
L
S
L
L
Site 17
S239
P
N
N
S
W
N
S
S
S
A
L
S
L
L
K
Site 18
S240
N
N
S
W
N
S
S
S
A
L
S
L
L
K
Y
Site 19
S243
W
N
S
S
S
A
L
S
L
L
K
Y
S
A
S
Site 20
Y247
S
A
L
S
L
L
K
Y
S
A
S
K
K
Y
N
Site 21
S248
A
L
S
L
L
K
Y
S
A
S
K
K
Y
N
I
Site 22
S250
S
L
L
K
Y
S
A
S
K
K
Y
N
I
S
W
Site 23
Y266
L
G
N
E
P
N
N
Y
R
T
M
H
G
R
A
Site 24
S277
H
G
R
A
V
N
G
S
Q
L
G
K
D
Y
I
Site 25
Y283
G
S
Q
L
G
K
D
Y
I
Q
L
K
S
L
L
Site 26
S288
K
D
Y
I
Q
L
K
S
L
L
Q
P
I
R
I
Site 27
S297
L
Q
P
I
R
I
Y
S
R
A
S
L
Y
G
P
Site 28
S300
I
R
I
Y
S
R
A
S
L
Y
G
P
N
I
G
Site 29
Y302
I
Y
S
R
A
S
L
Y
G
P
N
I
G
R
P
Site 30
T351
K
V
M
D
F
L
K
T
R
L
L
D
T
L
S
Site 31
T356
L
K
T
R
L
L
D
T
L
S
D
Q
I
R
K
Site 32
S358
T
R
L
L
D
T
L
S
D
Q
I
R
K
I
Q
Site 33
T370
K
I
Q
K
V
V
N
T
Y
T
P
G
K
K
I
Site 34
T372
Q
K
V
V
N
T
Y
T
P
G
K
K
I
W
L
Site 35
T390
V
T
T
S
A
G
G
T
N
N
L
S
D
S
Y
Site 36
S394
A
G
G
T
N
N
L
S
D
S
Y
A
A
G
F
Site 37
S396
G
T
N
N
L
S
D
S
Y
A
A
G
F
L
W
Site 38
Y428
H
S
F
F
D
H
G
Y
N
H
L
V
D
Q
N
Site 39
Y442
N
F
N
P
L
P
D
Y
W
L
S
L
L
Y
K
Site 40
Y448
D
Y
W
L
S
L
L
Y
K
R
L
I
G
P
K
Site 41
Y481
I
R
D
K
L
R
I
Y
A
H
C
T
N
H
H
Site 42
Y492
T
N
H
H
N
H
N
Y
V
R
G
S
I
T
L
Site 43
T516
K
K
I
K
L
A
G
T
L
R
D
K
L
V
H
Site 44
Y525
R
D
K
L
V
H
Q
Y
L
L
Q
P
Y
G
Q
Site 45
S537
Y
G
Q
E
G
L
K
S
K
S
V
Q
L
N
G
Site 46
S539
Q
E
G
L
K
S
K
S
V
Q
L
N
G
Q
P
Site 47
T554
L
V
M
V
D
D
G
T
L
P
E
L
K
P
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation