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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NEU4
Full Name:
Sialidase-4
Alias:
mgc102757; mgc18222; neu4; neur4; sialidase 4
Type:
Hydrolase; Lipid Metabolism - sphingolipid; Glycan Metabolism - other glycan degradation; EC 3.2.1.18
Mass (Da):
51572
Number AA:
484
UniProt ID:
Q8WWR8
International Prot ID:
IPI00643172
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0043202
GO:0019866
Uniprot
OncoNet
Molecular Function:
GO:0004308
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
G
V
P
R
T
P
S
R
T
V
L
F
Site 2
S8
M
G
V
P
R
T
P
S
R
T
V
L
F
E
R
Site 3
T10
V
P
R
T
P
S
R
T
V
L
F
E
R
E
R
Site 4
T18
V
L
F
E
R
E
R
T
G
L
T
Y
R
V
P
Site 5
T21
E
R
E
R
T
G
L
T
Y
R
V
P
S
L
L
Site 6
Y22
R
E
R
T
G
L
T
Y
R
V
P
S
L
L
P
Site 7
S45
A
F
V
E
Q
R
L
S
P
D
D
S
H
A
H
Site 8
S49
Q
R
L
S
P
D
D
S
H
A
H
R
L
V
L
Site 9
T60
R
L
V
L
R
R
G
T
L
A
G
G
S
V
R
Site 10
S65
R
G
T
L
A
G
G
S
V
R
W
G
A
L
H
Site 11
S84
A
A
L
A
E
H
R
S
M
N
P
C
P
V
H
Site 12
S135
A
S
R
D
A
G
L
S
W
G
S
A
R
D
L
Site 13
S138
D
A
G
L
S
W
G
S
A
R
D
L
T
E
E
Site 14
T143
W
G
S
A
R
D
L
T
E
E
A
I
G
G
A
Site 15
Y177
G
R
L
L
V
P
A
Y
T
Y
R
V
D
R
R
Site 16
T178
R
L
L
V
P
A
Y
T
Y
R
V
D
R
R
E
Site 17
T193
C
F
G
K
I
C
R
T
S
P
H
S
F
A
F
Site 18
S194
F
G
K
I
C
R
T
S
P
H
S
F
A
F
Y
Site 19
S197
I
C
R
T
S
P
H
S
F
A
F
Y
S
D
D
Site 20
Y201
S
P
H
S
F
A
F
Y
S
D
D
H
G
R
T
Site 21
S202
P
H
S
F
A
F
Y
S
D
D
H
G
R
T
W
Site 22
S235
V
D
G
G
Q
A
G
S
F
L
Y
C
N
A
R
Site 23
Y238
G
Q
A
G
S
F
L
Y
C
N
A
R
S
P
L
Site 24
S243
F
L
Y
C
N
A
R
S
P
L
G
S
R
V
Q
Site 25
S247
N
A
R
S
P
L
G
S
R
V
Q
A
L
S
T
Site 26
S253
G
S
R
V
Q
A
L
S
T
D
E
G
T
S
F
Site 27
T254
S
R
V
Q
A
L
S
T
D
E
G
T
S
F
L
Site 28
S259
L
S
T
D
E
G
T
S
F
L
P
A
E
R
V
Site 29
S268
L
P
A
E
R
V
A
S
L
P
E
T
A
W
G
Site 30
T272
R
V
A
S
L
P
E
T
A
W
G
C
Q
G
S
Site 31
S295
P
N
R
P
R
D
D
S
W
S
V
G
P
G
S
Site 32
S297
R
P
R
D
D
S
W
S
V
G
P
G
S
P
L
Site 33
S302
S
W
S
V
G
P
G
S
P
L
Q
P
P
L
L
Site 34
S335
Q
V
P
G
G
P
F
S
R
L
Q
P
R
G
D
Site 35
S354
P
G
P
R
P
G
V
S
G
D
V
G
S
W
T
Site 36
S374
P
F
A
A
P
P
Q
S
P
T
W
L
L
Y
S
Site 37
T376
A
A
P
P
Q
S
P
T
W
L
L
Y
S
H
P
Site 38
Y380
Q
S
P
T
W
L
L
Y
S
H
P
V
G
R
R
Site 39
S381
S
P
T
W
L
L
Y
S
H
P
V
G
R
R
A
Site 40
S397
L
H
M
G
I
R
L
S
Q
S
P
L
D
P
R
Site 41
S399
M
G
I
R
L
S
Q
S
P
L
D
P
R
S
W
Site 42
S405
Q
S
P
L
D
P
R
S
W
T
E
P
W
V
I
Site 43
T407
P
L
D
P
R
S
W
T
E
P
W
V
I
Y
E
Site 44
Y413
W
T
E
P
W
V
I
Y
E
G
P
S
G
Y
S
Site 45
S420
Y
E
G
P
S
G
Y
S
D
L
A
S
I
G
P
Site 46
S424
S
G
Y
S
D
L
A
S
I
G
P
A
P
E
G
Site 47
S441
V
F
A
C
L
Y
E
S
G
A
R
T
S
Y
D
Site 48
T445
L
Y
E
S
G
A
R
T
S
Y
D
E
I
S
F
Site 49
S446
Y
E
S
G
A
R
T
S
Y
D
E
I
S
F
C
Site 50
Y447
E
S
G
A
R
T
S
Y
D
E
I
S
F
C
T
Site 51
S451
R
T
S
Y
D
E
I
S
F
C
T
F
S
L
R
Site 52
S467
V
L
E
N
V
P
A
S
P
K
P
P
N
L
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation