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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRPF31
Full Name:
U4/U6 small nuclear ribonucleoprotein Prp31
Alias:
NY-BR-99; Pre-mRNA-processing factor 31; Prp31; PRP31 pre-mRNA processing factor 31; RP11; U4/U6 snRNP 61 kDa
Type:
RNA binding protein
Mass (Da):
55456
Number AA:
499
UniProt ID:
Q8WWY3
International Prot ID:
IPI00292000
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0015030
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0043021
PhosphoSite+
KinaseNET
Biological Process:
GO:0000244
GO:0000375
GO:0000377
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
A
E
E
E
E
G
G
S
Y
G
E
E
E
E
E
Site 2
Y23
E
E
E
E
G
G
S
Y
G
E
E
E
E
E
P
Site 3
S44
E
E
T
Q
L
D
L
S
G
D
S
V
K
T
I
Site 4
S47
Q
L
D
L
S
G
D
S
V
K
T
I
A
K
L
Site 5
S78
I
S
K
Q
A
K
A
S
E
V
M
G
P
V
E
Site 6
Y90
P
V
E
A
A
P
E
Y
R
V
I
V
D
A
N
Site 7
Y118
H
K
F
I
R
D
K
Y
S
K
R
F
P
E
L
Site 8
S119
K
F
I
R
D
K
Y
S
K
R
F
P
E
L
E
Site 9
S127
K
R
F
P
E
L
E
S
L
V
P
N
A
L
D
Site 10
S145
T
V
K
E
L
G
N
S
L
D
K
C
K
N
N
Site 11
S180
T
T
Q
G
Q
Q
L
S
E
E
E
L
E
R
L
Site 12
S200
M
A
L
E
L
N
A
S
K
H
R
I
Y
E
Y
Site 13
Y205
N
A
S
K
H
R
I
Y
E
Y
V
E
S
R
M
Site 14
Y207
S
K
H
R
I
Y
E
Y
V
E
S
R
M
S
F
Site 15
S210
R
I
Y
E
Y
V
E
S
R
M
S
F
I
A
P
Site 16
S213
E
Y
V
E
S
R
M
S
F
I
A
P
N
L
S
Site 17
T258
L
L
G
A
Q
R
K
T
L
S
G
F
S
S
T
Site 18
S260
G
A
Q
R
K
T
L
S
G
F
S
S
T
S
V
Site 19
S263
R
K
T
L
S
G
F
S
S
T
S
V
L
P
H
Site 20
S264
K
T
L
S
G
F
S
S
T
S
V
L
P
H
T
Site 21
S266
L
S
G
F
S
S
T
S
V
L
P
H
T
G
Y
Site 22
T271
S
T
S
V
L
P
H
T
G
Y
I
Y
H
S
D
Site 23
Y273
S
V
L
P
H
T
G
Y
I
Y
H
S
D
I
V
Site 24
Y275
L
P
H
T
G
Y
I
Y
H
S
D
I
V
Q
S
Site 25
S282
Y
H
S
D
I
V
Q
S
L
P
P
D
L
R
R
Site 26
S307
T
L
A
A
R
V
D
S
F
H
E
S
T
E
G
Site 27
S311
R
V
D
S
F
H
E
S
T
E
G
K
V
G
Y
Site 28
Y318
S
T
E
G
K
V
G
Y
E
L
K
D
E
I
E
Site 29
Y359
K
K
R
G
G
R
R
Y
R
K
M
K
E
R
L
Site 30
S379
R
K
Q
A
N
R
M
S
F
G
E
I
E
E
D
Site 31
Y388
G
E
I
E
E
D
A
Y
Q
E
D
L
G
F
S
Site 32
S395
Y
Q
E
D
L
G
F
S
L
G
H
L
G
K
S
Site 33
S402
S
L
G
H
L
G
K
S
G
S
G
R
V
R
Q
Site 34
S404
G
H
L
G
K
S
G
S
G
R
V
R
Q
T
Q
Site 35
T410
G
S
G
R
V
R
Q
T
Q
V
N
E
A
T
K
Site 36
T416
Q
T
Q
V
N
E
A
T
K
A
R
I
S
K
T
Site 37
S421
E
A
T
K
A
R
I
S
K
T
L
Q
R
T
L
Site 38
T423
T
K
A
R
I
S
K
T
L
Q
R
T
L
Q
K
Site 39
T427
I
S
K
T
L
Q
R
T
L
Q
K
Q
S
V
V
Site 40
S432
Q
R
T
L
Q
K
Q
S
V
V
Y
G
G
K
S
Site 41
Y435
L
Q
K
Q
S
V
V
Y
G
G
K
S
T
I
R
Site 42
S439
S
V
V
Y
G
G
K
S
T
I
R
D
R
S
S
Site 43
T440
V
V
Y
G
G
K
S
T
I
R
D
R
S
S
G
Site 44
S445
K
S
T
I
R
D
R
S
S
G
T
A
S
S
V
Site 45
S446
S
T
I
R
D
R
S
S
G
T
A
S
S
V
A
Site 46
T448
I
R
D
R
S
S
G
T
A
S
S
V
A
F
T
Site 47
S450
D
R
S
S
G
T
A
S
S
V
A
F
T
P
L
Site 48
S451
R
S
S
G
T
A
S
S
V
A
F
T
P
L
Q
Site 49
T455
T
A
S
S
V
A
F
T
P
L
Q
G
L
E
I
Site 50
Y479
V
A
E
A
N
Q
K
Y
F
S
S
M
A
E
F
Site 51
S481
E
A
N
Q
K
Y
F
S
S
M
A
E
F
L
K
Site 52
S482
A
N
Q
K
Y
F
S
S
M
A
E
F
L
K
V
Site 53
S494
L
K
V
K
G
E
K
S
G
L
M
S
T
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation