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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGR8
Full Name:
Relaxin receptor 2
Alias:
GPR106; G-protein coupled receptor affecting testicular descent; GREAT; INSL3R; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin/insulin-like family peptide receptor 2; RXFP2; RXFPR2
Type:
Receptor, GPCR; Membrane protein, integral
Mass (Da):
86453
Number AA:
754
UniProt ID:
Q8WXD0
International Prot ID:
IPI00103510
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
D
F
A
L
T
Q
G
S
M
I
T
P
S
C
Q
Site 2
T42
L
T
Q
G
S
M
I
T
P
S
C
Q
K
G
Y
Site 3
Y49
T
P
S
C
Q
K
G
Y
F
P
C
G
N
L
T
Site 4
T88
G
D
T
S
G
W
A
T
I
F
G
T
V
H
G
Site 5
S99
T
V
H
G
N
A
N
S
V
A
L
T
Q
E
C
Site 6
T103
N
A
N
S
V
A
L
T
Q
E
C
F
L
K
Q
Site 7
T140
P
M
I
S
N
N
V
T
L
L
S
L
K
K
N
Site 8
S143
S
N
N
V
T
L
L
S
L
K
K
N
K
I
H
Site 9
S151
L
K
K
N
K
I
H
S
L
P
D
K
V
F
I
Site 10
Y160
P
D
K
V
F
I
K
Y
T
K
L
K
K
I
F
Site 11
T199
L
N
H
N
C
I
T
T
L
R
P
G
I
F
K
Site 12
S225
D
N
P
I
T
R
I
S
Q
R
L
F
T
G
L
Site 13
Y244
F
L
S
M
V
N
N
Y
L
E
A
L
P
K
Q
Site 14
Y271
L
E
G
N
R
I
K
Y
L
T
N
S
T
F
L
Site 15
T273
G
N
R
I
K
Y
L
T
N
S
T
F
L
S
C
Site 16
S275
R
I
K
Y
L
T
N
S
T
F
L
S
C
D
S
Site 17
S302
F
V
P
E
K
T
F
S
S
L
K
N
L
G
E
Site 18
S313
N
L
G
E
L
D
L
S
S
N
T
I
T
E
L
Site 19
S314
L
G
E
L
D
L
S
S
N
T
I
T
E
L
S
Site 20
T318
D
L
S
S
N
T
I
T
E
L
S
P
H
L
F
Site 21
S321
S
N
T
I
T
E
L
S
P
H
L
F
K
D
L
Site 22
Y343
L
S
S
N
P
L
M
Y
L
H
K
N
Q
F
E
Site 23
S351
L
H
K
N
Q
F
E
S
L
K
Q
L
Q
S
L
Site 24
S357
E
S
L
K
Q
L
Q
S
L
D
L
E
R
I
E
Site 25
Y383
M
K
N
L
S
H
I
Y
F
K
N
F
R
Y
C
Site 26
T448
S
F
I
K
A
E
N
T
T
H
A
M
S
I
K
Site 27
Y478
V
G
I
F
D
I
K
Y
R
G
Q
Y
Q
K
Y
Site 28
Y482
D
I
K
Y
R
G
Q
Y
Q
K
Y
A
L
L
W
Site 29
Y485
Y
R
G
Q
Y
Q
K
Y
A
L
L
W
M
E
S
Site 30
Y562
I
P
F
W
N
K
D
Y
F
G
N
F
Y
G
K
Site 31
Y567
K
D
Y
F
G
N
F
Y
G
K
N
G
V
C
F
Site 32
Y577
N
G
V
C
F
P
L
Y
Y
D
Q
T
E
D
I
Site 33
Y578
G
V
C
F
P
L
Y
Y
D
Q
T
E
D
I
G
Site 34
T581
F
P
L
Y
Y
D
Q
T
E
D
I
G
S
K
G
Site 35
S586
D
Q
T
E
D
I
G
S
K
G
Y
S
L
G
I
Site 36
S713
L
H
K
H
Q
R
K
S
I
F
K
I
K
K
K
Site 37
S723
K
I
K
K
K
S
L
S
T
S
I
V
W
I
E
Site 38
S725
K
K
K
S
L
S
T
S
I
V
W
I
E
D
S
Site 39
S748
N
K
I
T
L
G
D
S
I
M
K
P
V
S
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation