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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CASKIN2
Full Name:
Caskin-2
Alias:
ANKS5B; CASK interacting protein 2; Cask-interacting protein 2; CSKI2; FLJ21609; Hypothetical protein KIAA1139; KIAA1139
Type:
Unknown function
Mass (Da):
126711
Number AA:
1202
UniProt ID:
Q8WXE0
International Prot ID:
IPI00103516
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0044424
GO:0044464
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T31
A
K
V
K
A
T
K
T
K
L
L
G
S
T
K
Site 2
S36
T
K
T
K
L
L
G
S
T
K
R
L
N
V
N
Site 3
Y44
T
K
R
L
N
V
N
Y
Q
D
A
D
G
F
S
Site 4
T74
L
L
L
E
A
Q
A
T
V
D
I
K
D
S
N
Site 5
Y88
N
G
M
R
P
L
H
Y
A
A
W
Q
G
R
L
Site 6
T150
L
V
N
K
A
K
K
T
P
L
D
L
A
C
E
Site 7
Y189
K
D
P
C
D
P
N
Y
T
T
P
L
H
L
A
Site 8
T191
P
C
D
P
N
Y
T
T
P
L
H
L
A
A
K
Site 9
T219
G
I
E
I
N
R
Q
T
K
T
G
T
A
L
H
Site 10
Y231
A
L
H
E
A
A
L
Y
G
K
T
E
V
V
R
Site 11
T252
V
D
V
N
I
R
N
T
Y
N
Q
T
A
L
D
Site 12
Y253
D
V
N
I
R
N
T
Y
N
Q
T
A
L
D
I
Site 13
S267
I
V
N
Q
F
T
T
S
Q
A
S
R
E
I
K
Site 14
S281
K
Q
L
L
R
E
A
S
G
I
L
K
V
R
A
Site 15
T310
V
R
A
G
D
V
I
T
V
L
E
Q
H
P
D
Site 16
S327
W
K
G
H
I
H
E
S
Q
R
G
T
D
R
I
Site 17
T331
I
H
E
S
Q
R
G
T
D
R
I
G
Y
F
P
Site 18
Y336
R
G
T
D
R
I
G
Y
F
P
P
G
I
V
E
Site 19
S358
I
P
A
A
R
L
P
S
A
P
T
P
L
R
P
Site 20
T361
A
R
L
P
S
A
P
T
P
L
R
P
G
F
S
Site 21
S368
T
P
L
R
P
G
F
S
R
T
P
Q
P
P
A
Site 22
T370
L
R
P
G
F
S
R
T
P
Q
P
P
A
E
E
Site 23
T383
E
E
P
P
H
P
L
T
Y
S
Q
L
P
R
V
Site 24
Y384
E
P
P
H
P
L
T
Y
S
Q
L
P
R
V
G
Site 25
S385
P
P
H
P
L
T
Y
S
Q
L
P
R
V
G
L
Site 26
S393
Q
L
P
R
V
G
L
S
P
D
S
P
A
G
D
Site 27
S396
R
V
G
L
S
P
D
S
P
A
G
D
R
N
S
Site 28
S403
S
P
A
G
D
R
N
S
V
G
S
E
G
S
V
Site 29
S406
G
D
R
N
S
V
G
S
E
G
S
V
G
S
I
Site 30
S409
N
S
V
G
S
E
G
S
V
G
S
I
R
S
A
Site 31
S412
G
S
E
G
S
V
G
S
I
R
S
A
G
S
G
Site 32
S415
G
S
V
G
S
I
R
S
A
G
S
G
Q
S
S
Site 33
S418
G
S
I
R
S
A
G
S
G
Q
S
S
E
G
T
Site 34
S422
S
A
G
S
G
Q
S
S
E
G
T
N
G
H
G
Site 35
T425
S
G
Q
S
S
E
G
T
N
G
H
G
P
G
L
Site 36
S456
L
P
G
L
H
P
P
S
L
A
D
N
L
S
H
Site 37
S462
P
S
L
A
D
N
L
S
H
R
P
L
A
N
C
Site 38
S471
R
P
L
A
N
C
R
S
G
E
Q
I
F
T
Q
Site 39
T477
R
S
G
E
Q
I
F
T
Q
D
V
R
P
E
Q
Site 40
Y506
S
E
F
Q
L
E
G
Y
T
A
H
F
L
Q
A
Site 41
Y515
A
H
F
L
Q
A
G
Y
D
V
P
T
I
S
R
Site 42
T519
Q
A
G
Y
D
V
P
T
I
S
R
M
T
P
E
Site 43
T529
R
M
T
P
E
D
L
T
A
I
G
V
T
K
P
Site 44
S544
G
H
R
K
K
I
A
S
E
I
A
Q
L
S
I
Site 45
Y575
C
A
L
G
L
P
Q
Y
H
K
Q
L
V
S
S
Site 46
S582
Y
H
K
Q
L
V
S
S
G
Y
D
S
M
G
L
Site 47
T659
E
N
G
E
G
P
A
T
A
G
P
R
L
L
T
Site 48
T666
T
A
G
P
R
L
L
T
F
Q
G
S
E
L
S
Site 49
S673
T
F
Q
G
S
E
L
S
P
E
L
Q
A
A
M
Site 50
S695
L
P
L
P
P
A
R
S
P
S
Q
E
S
I
G
Site 51
S697
L
P
P
A
R
S
P
S
Q
E
S
I
G
A
R
Site 52
S700
A
R
S
P
S
Q
E
S
I
G
A
R
S
R
G
Site 53
S705
Q
E
S
I
G
A
R
S
R
G
S
G
H
S
Q
Site 54
S708
I
G
A
R
S
R
G
S
G
H
S
Q
E
Q
P
Site 55
S711
R
S
R
G
S
G
H
S
Q
E
Q
P
A
P
Q
Site 56
S720
E
Q
P
A
P
Q
P
S
G
G
D
P
S
P
P
Site 57
S725
Q
P
S
G
G
D
P
S
P
P
Q
E
R
N
L
Site 58
T736
E
R
N
L
P
E
G
T
E
R
P
P
K
L
C
Site 59
S744
E
R
P
P
K
L
C
S
S
L
P
G
Q
G
P
Site 60
S745
R
P
P
K
L
C
S
S
L
P
G
Q
G
P
P
Site 61
Y754
P
G
Q
G
P
P
P
Y
V
F
M
Y
P
Q
G
Site 62
Y758
P
P
P
Y
V
F
M
Y
P
Q
G
S
P
S
S
Site 63
S762
V
F
M
Y
P
Q
G
S
P
S
S
P
A
P
G
Site 64
S764
M
Y
P
Q
G
S
P
S
S
P
A
P
G
P
P
Site 65
S765
Y
P
Q
G
S
P
S
S
P
A
P
G
P
P
P
Site 66
S779
P
G
A
P
W
A
F
S
Y
L
A
G
P
P
A
Site 67
T787
Y
L
A
G
P
P
A
T
P
P
D
P
P
R
P
Site 68
S798
P
P
R
P
K
R
R
S
H
S
L
S
R
P
G
Site 69
S800
R
P
K
R
R
S
H
S
L
S
R
P
G
P
T
Site 70
S802
K
R
R
S
H
S
L
S
R
P
G
P
T
E
G
Site 71
S821
E
A
E
G
P
V
G
S
T
L
G
S
Y
A
T
Site 72
S825
P
V
G
S
T
L
G
S
Y
A
T
L
T
R
R
Site 73
T828
S
T
L
G
S
Y
A
T
L
T
R
R
P
G
R
Site 74
T830
L
G
S
Y
A
T
L
T
R
R
P
G
R
S
A
Site 75
S836
L
T
R
R
P
G
R
S
A
L
V
R
T
S
P
Site 76
S842
R
S
A
L
V
R
T
S
P
S
V
T
P
T
P
Site 77
S844
A
L
V
R
T
S
P
S
V
T
P
T
P
A
R
Site 78
T846
V
R
T
S
P
S
V
T
P
T
P
A
R
G
T
Site 79
T848
T
S
P
S
V
T
P
T
P
A
R
G
T
P
R
Site 80
T853
T
P
T
P
A
R
G
T
P
R
S
Q
S
F
A
Site 81
S856
P
A
R
G
T
P
R
S
Q
S
F
A
L
R
A
Site 82
S858
R
G
T
P
R
S
Q
S
F
A
L
R
A
R
R
Site 83
S877
P
P
P
P
K
R
L
S
S
V
S
G
P
S
P
Site 84
S878
P
P
P
K
R
L
S
S
V
S
G
P
S
P
E
Site 85
S880
P
K
R
L
S
S
V
S
G
P
S
P
E
P
P
Site 86
S883
L
S
S
V
S
G
P
S
P
E
P
P
P
L
D
Site 87
S892
E
P
P
P
L
D
G
S
P
G
P
K
E
G
A
Site 88
T900
P
G
P
K
E
G
A
T
G
P
R
R
R
T
L
Site 89
T906
A
T
G
P
R
R
R
T
L
S
E
P
A
G
P
Site 90
S908
G
P
R
R
R
T
L
S
E
P
A
G
P
S
E
Site 91
S914
L
S
E
P
A
G
P
S
E
P
P
G
P
P
A
Site 92
S927
P
A
P
A
G
P
A
S
D
T
E
E
E
E
P
Site 93
T929
P
A
G
P
A
S
D
T
E
E
E
E
P
G
P
Site 94
T939
E
E
P
G
P
E
G
T
P
P
S
R
G
S
S
Site 95
S942
G
P
E
G
T
P
P
S
R
G
S
S
G
E
G
Site 96
S945
G
T
P
P
S
R
G
S
S
G
E
G
L
P
F
Site 97
S946
T
P
P
S
R
G
S
S
G
E
G
L
P
F
A
Site 98
T959
F
A
E
E
G
N
L
T
I
K
Q
R
P
K
P
Site 99
T974
A
G
P
P
P
R
E
T
P
V
P
P
G
L
D
Site 100
T985
P
G
L
D
F
N
L
T
E
S
D
T
V
K
R
Site 101
S987
L
D
F
N
L
T
E
S
D
T
V
K
R
R
P
Site 102
T989
F
N
L
T
E
S
D
T
V
K
R
R
P
K
C
Site 103
T1004
R
E
R
E
P
L
Q
T
A
L
L
A
F
G
V
Site 104
S1024
G
P
A
A
P
L
P
S
P
T
P
G
E
S
P
Site 105
T1026
A
A
P
L
P
S
P
T
P
G
E
S
P
P
A
Site 106
S1030
P
S
P
T
P
G
E
S
P
P
A
S
S
L
P
Site 107
S1034
P
G
E
S
P
P
A
S
S
L
P
Q
P
E
P
Site 108
S1035
G
E
S
P
P
A
S
S
L
P
Q
P
E
P
S
Site 109
S1042
S
L
P
Q
P
E
P
S
S
L
P
A
Q
G
V
Site 110
S1043
L
P
Q
P
E
P
S
S
L
P
A
Q
G
V
P
Site 111
S1073
C
P
G
P
G
L
E
S
S
A
A
S
R
W
N
Site 112
S1074
P
G
P
G
L
E
S
S
A
A
S
R
W
N
G
Site 113
S1077
G
L
E
S
S
A
A
S
R
W
N
G
E
T
E
Site 114
T1083
A
S
R
W
N
G
E
T
E
P
P
A
A
P
A
Site 115
S1135
V
P
P
P
R
P
E
S
T
G
T
V
G
P
G
Site 116
T1136
P
P
P
R
P
E
S
T
G
T
V
G
P
G
Q
Site 117
T1138
P
R
P
E
S
T
G
T
V
G
P
G
Q
A
Q
Site 118
S1152
Q
Q
R
L
E
Q
T
S
S
S
L
A
A
A
L
Site 119
S1153
Q
R
L
E
Q
T
S
S
S
L
A
A
A
L
R
Site 120
S1154
R
L
E
Q
T
S
S
S
L
A
A
A
L
R
A
Site 121
S1165
A
L
R
A
A
E
K
S
I
G
T
K
E
Q
E
Site 122
T1174
G
T
K
E
Q
E
G
T
P
S
A
S
T
K
H
Site 123
S1176
K
E
Q
E
G
T
P
S
A
S
T
K
H
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation