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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MADD
Full Name:
MAP kinase-activating death domain protein
Alias:
DENN; Differentially expressed in normal and neoplastic cells; Insulinoma glucagonoma clone 20; Insulinoma-glucagonoma clone 20; KIAA0358; MAP-kinase activating death domain; Rab3 GDP/GTP exchange factor; RAB3GEP
Type:
Adaptor/scaffold
Mass (Da):
183303
Number AA:
1647
UniProt ID:
Q8WXG6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016021
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0017112
GO:0005123
GO:0030295
PhosphoSite+
KinaseNET
Biological Process:
GO:0000187
GO:0006915
GO:0007166
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
I
V
G
A
R
H
P
S
S
D
S
V
A
Q
T
Site 2
S25
V
G
A
R
H
P
S
S
D
S
V
A
Q
T
P
Site 3
S27
A
R
H
P
S
S
D
S
V
A
Q
T
P
E
L
Site 4
T31
S
S
D
S
V
A
Q
T
P
E
L
L
R
R
Y
Site 5
Y38
T
P
E
L
L
R
R
Y
P
L
E
D
H
T
E
Site 6
T44
R
Y
P
L
E
D
H
T
E
F
P
L
P
P
D
Site 7
S63
C
Q
P
E
G
C
L
S
V
R
Q
R
R
M
S
Site 8
S70
S
V
R
Q
R
R
M
S
L
R
D
D
T
S
F
Site 9
T75
R
M
S
L
R
D
D
T
S
F
V
F
T
L
T
Site 10
S76
M
S
L
R
D
D
T
S
F
V
F
T
L
T
D
Site 11
T80
D
D
T
S
F
V
F
T
L
T
D
K
D
T
G
Site 12
T86
F
T
L
T
D
K
D
T
G
V
T
R
Y
G
I
Site 13
Y98
Y
G
I
C
V
N
F
Y
R
S
F
Q
K
R
I
Site 14
S106
R
S
F
Q
K
R
I
S
K
E
K
G
E
G
G
Site 15
S116
K
G
E
G
G
A
G
S
R
G
K
E
G
T
H
Site 16
T122
G
S
R
G
K
E
G
T
H
A
T
C
A
S
E
Site 17
S128
G
T
H
A
T
C
A
S
E
E
G
G
T
E
S
Site 18
T133
C
A
S
E
E
G
G
T
E
S
S
E
S
G
S
Site 19
S135
S
E
E
G
G
T
E
S
S
E
S
G
S
S
L
Site 20
S136
E
E
G
G
T
E
S
S
E
S
G
S
S
L
Q
Site 21
S138
G
G
T
E
S
S
E
S
G
S
S
L
Q
P
L
Site 22
S140
T
E
S
S
E
S
G
S
S
L
Q
P
L
S
A
Site 23
S141
E
S
S
E
S
G
S
S
L
Q
P
L
S
A
D
Site 24
S146
G
S
S
L
Q
P
L
S
A
D
S
T
P
D
V
Site 25
S149
L
Q
P
L
S
A
D
S
T
P
D
V
N
Q
S
Site 26
T150
Q
P
L
S
A
D
S
T
P
D
V
N
Q
S
P
Site 27
S156
S
T
P
D
V
N
Q
S
P
R
G
K
R
R
A
Site 28
S167
K
R
R
A
K
A
G
S
R
S
R
N
S
T
L
Site 29
S169
R
A
K
A
G
S
R
S
R
N
S
T
L
T
S
Site 30
S172
A
G
S
R
S
R
N
S
T
L
T
S
L
C
V
Site 31
T173
G
S
R
S
R
N
S
T
L
T
S
L
C
V
L
Site 32
T175
R
S
R
N
S
T
L
T
S
L
C
V
L
S
H
Site 33
S176
S
R
N
S
T
L
T
S
L
C
V
L
S
H
Y
Site 34
Y194
S
T
F
R
E
C
L
Y
T
L
K
R
L
V
D
Site 35
S204
K
R
L
V
D
C
C
S
E
R
L
L
G
K
K
Site 36
S230
M
W
R
I
F
T
G
S
L
L
V
E
E
K
S
Site 37
Y252
R
E
I
E
A
W
I
Y
R
L
L
R
S
P
V
Site 38
S257
W
I
Y
R
L
L
R
S
P
V
P
V
S
G
Q
Site 39
S262
L
R
S
P
V
P
V
S
G
Q
K
R
V
D
I
Site 40
T281
Q
E
L
Q
P
A
L
T
F
A
L
P
D
P
S
Site 41
T291
L
P
D
P
S
R
F
T
L
V
D
F
P
L
H
Site 42
S421
P
I
L
P
E
P
E
S
L
E
L
K
K
H
L
Site 43
S434
H
L
K
Q
A
L
A
S
M
S
L
N
T
Q
P
Site 44
S462
P
L
L
L
G
R
P
S
N
D
L
Q
S
T
P
Site 45
S467
R
P
S
N
D
L
Q
S
T
P
S
T
E
F
N
Site 46
T468
P
S
N
D
L
Q
S
T
P
S
T
E
F
N
P
Site 47
S470
N
D
L
Q
S
T
P
S
T
E
F
N
P
L
I
Site 48
T471
D
L
Q
S
T
P
S
T
E
F
N
P
L
I
Y
Site 49
T512
G
F
Q
M
H
T
R
T
L
R
L
F
P
R
P
Site 50
S531
Q
A
G
S
F
L
A
S
R
P
R
Q
T
P
F
Site 51
T536
L
A
S
R
P
R
Q
T
P
F
A
E
K
L
A
Site 52
Y550
A
R
T
Q
A
V
E
Y
F
G
E
W
I
L
N
Site 53
Y583
I
G
D
K
P
K
W
Y
A
H
Q
L
Q
P
I
Site 54
Y592
H
Q
L
Q
P
I
H
Y
R
V
Y
D
S
N
S
Site 55
Y595
Q
P
I
H
Y
R
V
Y
D
S
N
S
Q
L
A
Site 56
S597
I
H
Y
R
V
Y
D
S
N
S
Q
L
A
E
A
Site 57
S599
Y
R
V
Y
D
S
N
S
Q
L
A
E
A
L
S
Site 58
S606
S
Q
L
A
E
A
L
S
V
P
P
E
R
D
S
Site 59
S613
S
V
P
P
E
R
D
S
D
S
E
P
T
D
D
Site 60
S615
P
P
E
R
D
S
D
S
E
P
T
D
D
S
G
Site 61
S621
D
S
E
P
T
D
D
S
G
S
D
S
M
D
Y
Site 62
S623
E
P
T
D
D
S
G
S
D
S
M
D
Y
D
D
Site 63
S625
T
D
D
S
G
S
D
S
M
D
Y
D
D
S
S
Site 64
Y628
S
G
S
D
S
M
D
Y
D
D
S
S
S
S
Y
Site 65
S631
D
S
M
D
Y
D
D
S
S
S
S
Y
S
S
L
Site 66
S632
S
M
D
Y
D
D
S
S
S
S
Y
S
S
L
G
Site 67
S633
M
D
Y
D
D
S
S
S
S
Y
S
S
L
G
D
Site 68
S634
D
Y
D
D
S
S
S
S
Y
S
S
L
G
D
F
Site 69
Y635
Y
D
D
S
S
S
S
Y
S
S
L
G
D
F
V
Site 70
S636
D
D
S
S
S
S
Y
S
S
L
G
D
F
V
S
Site 71
S637
D
S
S
S
S
Y
S
S
L
G
D
F
V
S
E
Site 72
T654
K
C
D
I
N
G
D
T
P
N
V
D
P
L
T
Site 73
T661
T
P
N
V
D
P
L
T
H
A
A
L
G
D
A
Site 74
S669
H
A
A
L
G
D
A
S
E
V
E
I
D
E
L
Site 75
S689
A
E
E
P
G
P
D
S
E
N
S
Q
E
N
P
Site 76
S692
P
G
P
D
S
E
N
S
Q
E
N
P
P
L
R
Site 77
S700
Q
E
N
P
P
L
R
S
S
S
S
T
T
A
S
Site 78
S701
E
N
P
P
L
R
S
S
S
S
T
T
A
S
S
Site 79
S702
N
P
P
L
R
S
S
S
S
T
T
A
S
S
S
Site 80
S703
P
P
L
R
S
S
S
S
T
T
A
S
S
S
P
Site 81
T704
P
L
R
S
S
S
S
T
T
A
S
S
S
P
S
Site 82
T705
L
R
S
S
S
S
T
T
A
S
S
S
P
S
T
Site 83
S707
S
S
S
S
T
T
A
S
S
S
P
S
T
V
I
Site 84
S708
S
S
S
T
T
A
S
S
S
P
S
T
V
I
H
Site 85
S709
S
S
T
T
A
S
S
S
P
S
T
V
I
H
G
Site 86
S711
T
T
A
S
S
S
P
S
T
V
I
H
G
A
N
Site 87
T712
T
A
S
S
S
P
S
T
V
I
H
G
A
N
S
Site 88
S724
A
N
S
E
P
A
D
S
T
E
M
D
D
K
A
Site 89
S741
G
V
S
K
P
L
P
S
V
P
P
S
I
G
K
Site 90
S745
P
L
P
S
V
P
P
S
I
G
K
S
N
V
D
Site 91
S749
V
P
P
S
I
G
K
S
N
V
D
R
R
Q
A
Site 92
S762
Q
A
E
I
G
E
G
S
V
R
R
R
I
Y
D
Site 93
Y768
G
S
V
R
R
R
I
Y
D
N
P
Y
F
E
P
Site 94
Y772
R
R
I
Y
D
N
P
Y
F
E
P
Q
Y
G
F
Site 95
Y777
N
P
Y
F
E
P
Q
Y
G
F
P
P
E
E
D
Site 96
S791
D
E
D
E
Q
G
E
S
Y
T
P
R
F
S
Q
Site 97
Y792
E
D
E
Q
G
E
S
Y
T
P
R
F
S
Q
H
Site 98
T793
D
E
Q
G
E
S
Y
T
P
R
F
S
Q
H
V
Site 99
S797
E
S
Y
T
P
R
F
S
Q
H
V
S
G
N
R
Site 100
S801
P
R
F
S
Q
H
V
S
G
N
R
A
Q
K
L
Site 101
S813
Q
K
L
L
R
P
N
S
L
R
L
A
S
D
S
Site 102
S818
P
N
S
L
R
L
A
S
D
S
D
A
E
S
D
Site 103
S820
S
L
R
L
A
S
D
S
D
A
E
S
D
S
R
Site 104
S824
A
S
D
S
D
A
E
S
D
S
R
A
S
S
P
Site 105
S826
D
S
D
A
E
S
D
S
R
A
S
S
P
N
S
Site 106
S829
A
E
S
D
S
R
A
S
S
P
N
S
T
V
S
Site 107
S830
E
S
D
S
R
A
S
S
P
N
S
T
V
S
N
Site 108
S833
S
R
A
S
S
P
N
S
T
V
S
N
T
S
T
Site 109
T834
R
A
S
S
P
N
S
T
V
S
N
T
S
T
E
Site 110
S836
S
S
P
N
S
T
V
S
N
T
S
T
E
G
F
Site 111
S839
N
S
T
V
S
N
T
S
T
E
G
F
G
G
I
Site 112
T840
S
T
V
S
N
T
S
T
E
G
F
G
G
I
M
Site 113
S848
E
G
F
G
G
I
M
S
F
A
S
S
L
Y
R
Site 114
S851
G
G
I
M
S
F
A
S
S
L
Y
R
N
H
S
Site 115
S852
G
I
M
S
F
A
S
S
L
Y
R
N
H
S
T
Site 116
Y854
M
S
F
A
S
S
L
Y
R
N
H
S
T
S
F
Site 117
S858
S
S
L
Y
R
N
H
S
T
S
F
S
L
S
N
Site 118
T859
S
L
Y
R
N
H
S
T
S
F
S
L
S
N
L
Site 119
S860
L
Y
R
N
H
S
T
S
F
S
L
S
N
L
T
Site 120
S862
R
N
H
S
T
S
F
S
L
S
N
L
T
L
P
Site 121
S864
H
S
T
S
F
S
L
S
N
L
T
L
P
T
K
Site 122
T867
S
F
S
L
S
N
L
T
L
P
T
K
G
A
R
Site 123
T878
K
G
A
R
E
K
A
T
P
F
P
S
L
K
V
Site 124
S882
E
K
A
T
P
F
P
S
L
K
V
F
G
L
N
Site 125
T896
N
T
L
M
E
I
V
T
E
A
G
P
G
S
G
Site 126
S915
R
A
L
V
D
Q
K
S
S
V
I
K
H
S
P
Site 127
S921
K
S
S
V
I
K
H
S
P
T
V
K
R
E
P
Site 128
T923
S
V
I
K
H
S
P
T
V
K
R
E
P
P
S
Site 129
S930
T
V
K
R
E
P
P
S
P
Q
G
R
S
S
N
Site 130
S935
P
P
S
P
Q
G
R
S
S
N
S
S
E
N
Q
Site 131
S936
P
S
P
Q
G
R
S
S
N
S
S
E
N
Q
Q
Site 132
S938
P
Q
G
R
S
S
N
S
S
E
N
Q
Q
F
L
Site 133
S939
Q
G
R
S
S
N
S
S
E
N
Q
Q
F
L
K
Site 134
S972
K
V
R
R
L
L
E
S
E
Q
L
R
V
F
V
Site 135
T1046
G
L
L
E
I
A
Q
T
H
Y
Y
S
K
E
P
Site 136
Y1048
L
E
I
A
Q
T
H
Y
Y
S
K
E
P
D
K
Site 137
S1059
E
P
D
K
R
K
R
S
P
T
E
S
V
N
T
Site 138
T1061
D
K
R
K
R
S
P
T
E
S
V
N
T
P
V
Site 139
S1063
R
K
R
S
P
T
E
S
V
N
T
P
V
G
K
Site 140
T1066
S
P
T
E
S
V
N
T
P
V
G
K
D
P
G
Site 141
S1097
Q
L
G
P
R
A
P
S
A
T
G
K
G
P
K
Site 142
T1099
G
P
R
A
P
S
A
T
G
K
G
P
K
E
L
Site 143
T1108
K
G
P
K
E
L
D
T
R
S
L
K
E
E
N
Site 144
S1110
P
K
E
L
D
T
R
S
L
K
E
E
N
F
I
Site 145
S1157
G
E
T
E
E
K
K
S
Q
I
S
A
D
S
G
Site 146
S1160
E
E
K
K
S
Q
I
S
A
D
S
G
V
S
L
Site 147
S1163
K
S
Q
I
S
A
D
S
G
V
S
L
T
S
S
Site 148
S1166
I
S
A
D
S
G
V
S
L
T
S
S
S
Q
R
Site 149
T1168
A
D
S
G
V
S
L
T
S
S
S
Q
R
T
D
Site 150
S1170
S
G
V
S
L
T
S
S
S
Q
R
T
D
Q
D
Site 151
S1171
G
V
S
L
T
S
S
S
Q
R
T
D
Q
D
S
Site 152
T1174
L
T
S
S
S
Q
R
T
D
Q
D
S
V
I
G
Site 153
S1178
S
Q
R
T
D
Q
D
S
V
I
G
V
S
P
A
Site 154
S1183
Q
D
S
V
I
G
V
S
P
A
V
M
I
R
S
Site 155
S1190
S
P
A
V
M
I
R
S
S
S
Q
D
S
E
V
Site 156
S1191
P
A
V
M
I
R
S
S
S
Q
D
S
E
V
S
Site 157
S1192
A
V
M
I
R
S
S
S
Q
D
S
E
V
S
T
Site 158
S1195
I
R
S
S
S
Q
D
S
E
V
S
T
V
V
S
Site 159
S1198
S
S
Q
D
S
E
V
S
T
V
V
S
N
S
S
Site 160
T1199
S
Q
D
S
E
V
S
T
V
V
S
N
S
S
G
Site 161
S1202
S
E
V
S
T
V
V
S
N
S
S
G
E
T
L
Site 162
T1208
V
S
N
S
S
G
E
T
L
G
A
D
S
D
L
Site 163
S1213
G
E
T
L
G
A
D
S
D
L
S
S
N
A
G
Site 164
S1216
L
G
A
D
S
D
L
S
S
N
A
G
D
G
P
Site 165
S1217
G
A
D
S
D
L
S
S
N
A
G
D
G
P
G
Site 166
S1228
D
G
P
G
G
E
G
S
V
H
L
A
S
S
R
Site 167
S1233
E
G
S
V
H
L
A
S
S
R
G
T
L
S
D
Site 168
S1234
G
S
V
H
L
A
S
S
R
G
T
L
S
D
S
Site 169
T1237
H
L
A
S
S
R
G
T
L
S
D
S
E
I
E
Site 170
S1239
A
S
S
R
G
T
L
S
D
S
E
I
E
T
N
Site 171
S1241
S
R
G
T
L
S
D
S
E
I
E
T
N
S
A
Site 172
T1245
L
S
D
S
E
I
E
T
N
S
A
T
S
T
I
Site 173
S1247
D
S
E
I
E
T
N
S
A
T
S
T
I
F
G
Site 174
T1251
E
T
N
S
A
T
S
T
I
F
G
K
A
H
S
Site 175
S1258
T
I
F
G
K
A
H
S
L
K
P
S
I
K
E
Site 176
S1262
K
A
H
S
L
K
P
S
I
K
E
K
L
A
G
Site 177
S1270
I
K
E
K
L
A
G
S
P
I
R
T
S
E
D
Site 178
T1274
L
A
G
S
P
I
R
T
S
E
D
V
S
Q
R
Site 179
S1275
A
G
S
P
I
R
T
S
E
D
V
S
Q
R
V
Site 180
S1279
I
R
T
S
E
D
V
S
Q
R
V
Y
L
Y
E
Site 181
Y1283
E
D
V
S
Q
R
V
Y
L
Y
E
G
L
L
G
Site 182
Y1285
V
S
Q
R
V
Y
L
Y
E
G
L
L
G
R
D
Site 183
S1295
L
L
G
R
D
K
G
S
M
W
D
Q
L
E
D
Site 184
T1307
L
E
D
A
A
M
E
T
F
S
I
S
K
E
R
Site 185
S1309
D
A
A
M
E
T
F
S
I
S
K
E
R
S
T
Site 186
S1311
A
M
E
T
F
S
I
S
K
E
R
S
T
L
W
Site 187
S1315
F
S
I
S
K
E
R
S
T
L
W
D
Q
M
Q
Site 188
T1316
S
I
S
K
E
R
S
T
L
W
D
Q
M
Q
F
Site 189
Y1352
P
Q
E
M
I
D
R
Y
L
S
L
G
E
H
D
Site 190
S1354
E
M
I
D
R
Y
L
S
L
G
E
H
D
R
K
Site 191
T1373
D
E
D
R
L
L
A
T
L
L
H
N
L
I
S
Site 192
Y1381
L
L
H
N
L
I
S
Y
M
L
L
M
K
V
N
Site 193
S1429
N
L
N
G
R
D
L
S
I
W
S
S
G
S
R
Site 194
S1432
G
R
D
L
S
I
W
S
S
G
S
R
H
M
K
Site 195
S1433
R
D
L
S
I
W
S
S
G
S
R
H
M
K
K
Site 196
T1442
S
R
H
M
K
K
Q
T
F
V
V
H
A
G
T
Site 197
Y1475
R
S
N
I
G
T
V
Y
E
R
W
W
Y
E
K
Site 198
Y1488
E
K
L
I
N
M
T
Y
C
P
K
T
K
V
L
Site 199
S1503
C
L
W
R
R
N
G
S
E
T
Q
L
N
K
F
Site 200
T1505
W
R
R
N
G
S
E
T
Q
L
N
K
F
Y
T
Site 201
Y1519
T
K
K
C
R
E
L
Y
Y
C
V
K
D
S
M
Site 202
Y1520
K
K
C
R
E
L
Y
Y
C
V
K
D
S
M
E
Site 203
S1525
L
Y
Y
C
V
K
D
S
M
E
R
A
A
A
R
Site 204
S1535
R
A
A
A
R
Q
Q
S
I
K
P
G
P
E
L
Site 205
T1553
F
P
V
Q
D
L
K
T
G
E
G
G
L
L
Q
Site 206
Y1609
K
E
V
V
S
H
K
Y
K
T
P
M
A
H
E
Site 207
T1611
V
V
S
H
K
Y
K
T
P
M
A
H
E
I
C
Site 208
T1640
S
S
E
E
D
L
R
T
P
P
R
P
V
S
S
Site 209
S1647
T
P
P
R
P
V
S
S
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation