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Updated November 2019
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Protein Info
Short Name:
SYNE2
Full Name:
Nesprin-2
Alias:
DKFZP434H2235; KIAA1011; Nesprin-2 gamma; NUA; NUANCE; NUANCE protein; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein; Spectrin repeat containing, nuclear envelope 2; Synaptic nuclear envelope protein 2; Syne-2
Type:
Adapter/scaffold protein
Mass (Da):
796442
Number AA:
6885
UniProt ID:
Q8WXH0
International Prot ID:
IPI00239405
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
G
I
D
D
L
H
I
S
L
Q
A
E
Q
E
D
Site 2
T32
L
Q
A
E
Q
E
D
T
Q
K
K
A
F
T
C
Site 3
T49
N
S
Q
L
A
R
H
T
S
P
S
V
I
S
D
Site 4
S50
S
Q
L
A
R
H
T
S
P
S
V
I
S
D
L
Site 5
S52
L
A
R
H
T
S
P
S
V
I
S
D
L
F
T
Site 6
T59
S
V
I
S
D
L
F
T
D
I
K
K
G
H
V
Site 7
S75
L
D
L
L
E
V
L
S
G
Q
Q
L
P
R
D
Site 8
T87
P
R
D
K
G
S
N
T
F
Q
C
R
I
N
I
Site 9
S145
E
K
L
A
Q
T
L
S
C
N
Y
N
Q
P
S
Site 10
Y148
A
Q
T
L
S
C
N
Y
N
Q
P
S
L
D
D
Site 11
S152
S
C
N
Y
N
Q
P
S
L
D
D
V
S
V
V
Site 12
S157
Q
P
S
L
D
D
V
S
V
V
D
S
S
P
A
Site 13
S161
D
D
V
S
V
V
D
S
S
P
A
S
S
P
P
Site 14
S162
D
V
S
V
V
D
S
S
P
A
S
S
P
P
A
Site 15
S165
V
V
D
S
S
P
A
S
S
P
P
A
K
K
C
Site 16
S166
V
D
S
S
P
A
S
S
P
P
A
K
K
C
S
Site 17
S182
V
Q
A
R
W
Q
M
S
A
R
K
A
L
L
L
Site 18
Y198
A
Q
E
Q
C
A
T
Y
E
S
V
N
V
T
D
Site 19
T204
T
Y
E
S
V
N
V
T
D
F
K
S
S
W
R
Site 20
S232
P
D
L
I
D
M
K
S
V
K
H
R
S
N
K
Site 21
S273
V
V
D
P
D
E
K
S
I
M
T
Y
V
A
Q
Site 22
Y277
D
E
K
S
I
M
T
Y
V
A
Q
F
L
Q
Y
Site 23
S285
V
A
Q
F
L
Q
Y
S
K
D
A
P
G
T
G
Site 24
T307
K
D
A
M
G
W
L
T
L
Q
K
E
K
L
Q
Site 25
S320
L
Q
K
L
L
K
D
S
E
N
D
T
Y
F
K
Site 26
T324
L
K
D
S
E
N
D
T
Y
F
K
K
Y
N
S
Site 27
Y325
K
D
S
E
N
D
T
Y
F
K
K
Y
N
S
L
Site 28
Y329
N
D
T
Y
F
K
K
Y
N
S
L
L
S
F
M
Site 29
S331
T
Y
F
K
K
Y
N
S
L
L
S
F
M
E
S
Site 30
S334
K
K
Y
N
S
L
L
S
F
M
E
S
F
N
E
Site 31
S338
S
L
L
S
F
M
E
S
F
N
E
E
K
K
S
Site 32
S345
S
F
N
E
E
K
K
S
F
L
D
V
L
S
I
Site 33
S351
K
S
F
L
D
V
L
S
I
K
R
D
L
D
E
Site 34
Y386
A
W
K
I
K
L
N
Y
A
L
P
P
P
L
H
Site 35
S411
E
L
M
D
E
D
L
S
A
S
Q
D
H
S
Q
Site 36
S413
M
D
E
D
L
S
A
S
Q
D
H
S
Q
A
V
Site 37
S417
L
S
A
S
Q
D
H
S
Q
A
V
T
L
I
Q
Site 38
T421
Q
D
H
S
Q
A
V
T
L
I
Q
E
K
M
T
Site 39
S432
E
K
M
T
L
F
K
S
L
M
D
R
F
E
H
Site 40
T446
H
H
S
N
I
L
L
T
F
E
N
K
D
E
N
Site 41
S500
G
L
V
D
E
V
K
S
K
L
D
I
W
N
I
Site 42
Y509
L
D
I
W
N
I
K
Y
G
S
R
E
S
V
E
Site 43
S514
I
K
Y
G
S
R
E
S
V
E
L
L
L
E
D
Site 44
T537
E
F
L
A
R
L
D
T
S
F
Q
K
C
G
E
Site 45
S538
F
L
A
R
L
D
T
S
F
Q
K
C
G
E
I
Site 46
Y546
F
Q
K
C
G
E
I
Y
K
N
L
A
G
E
C
Site 47
Y570
V
K
S
D
V
C
M
Y
R
K
N
I
Y
N
V
Site 48
Y575
C
M
Y
R
K
N
I
Y
N
V
K
S
T
L
Q
Site 49
S579
K
N
I
Y
N
V
K
S
T
L
Q
K
V
L
A
Site 50
S646
S
N
D
V
V
G
S
S
I
S
K
E
L
R
R
Site 51
S663
K
R
W
R
K
L
V
S
K
T
Q
L
E
M
N
Site 52
T682
I
K
K
Q
D
Q
P
T
F
D
N
S
G
N
I
Site 53
S691
D
N
S
G
N
I
L
S
K
E
E
K
A
T
V
Site 54
T697
L
S
K
E
E
K
A
T
V
E
F
S
T
D
M
Site 55
S701
E
K
A
T
V
E
F
S
T
D
M
S
V
E
L
Site 56
S705
V
E
F
S
T
D
M
S
V
E
L
P
E
N
Y
Site 57
S755
I
W
E
A
E
A
K
S
V
L
D
Q
D
D
V
Site 58
T764
L
D
Q
D
D
V
D
T
S
M
E
E
S
L
K
Site 59
S765
D
Q
D
D
V
D
T
S
M
E
E
S
L
K
H
Site 60
S769
V
D
T
S
M
E
E
S
L
K
H
L
I
A
K
Site 61
S799
Q
M
D
I
Q
N
I
S
S
Q
E
S
F
Q
H
Site 62
S800
M
D
I
Q
N
I
S
S
Q
E
S
F
Q
H
V
Site 63
S803
Q
N
I
S
S
Q
E
S
F
Q
H
V
L
T
T
Site 64
S841
L
K
N
L
T
D
V
S
P
D
L
D
I
R
L
Site 65
S853
I
R
L
K
M
E
E
S
Q
K
E
L
E
S
Y
Site 66
Y860
S
Q
K
E
L
E
S
Y
M
M
R
A
Q
Q
L
Site 67
S873
Q
L
L
G
Q
R
E
S
P
G
E
L
I
S
K
Site 68
S879
E
S
P
G
E
L
I
S
K
H
K
E
A
L
I
Site 69
S888
H
K
E
A
L
I
I
S
N
T
K
S
L
A
K
Site 70
Y896
N
T
K
S
L
A
K
Y
L
K
A
V
E
E
L
Site 71
S914
V
T
E
D
I
K
M
S
L
E
E
K
S
R
D
Site 72
S919
K
M
S
L
E
E
K
S
R
D
V
C
A
K
W
Site 73
S928
D
V
C
A
K
W
E
S
L
H
H
E
L
S
L
Site 74
S934
E
S
L
H
H
E
L
S
L
Y
V
Q
Q
L
K
Site 75
Y936
L
H
H
E
L
S
L
Y
V
Q
Q
L
K
I
D
Site 76
S950
D
I
E
K
G
K
L
S
D
N
I
L
K
L
E
Site 77
T972
K
L
I
R
R
G
R
T
K
G
L
I
K
E
H
Site 78
Y990
F
S
E
E
G
C
L
Y
Q
L
N
H
H
M
E
Site 79
S1008
E
L
C
E
E
L
P
S
Q
K
S
Q
Q
E
V
Site 80
S1011
E
E
L
P
S
Q
K
S
Q
Q
E
V
K
R
L
Site 81
Y1022
V
K
R
L
L
K
D
Y
E
Q
K
I
E
R
L
Site 82
S1034
E
R
L
L
K
C
A
S
E
I
H
M
T
L
Q
Site 83
T1055
S
K
N
E
G
T
I
T
T
S
E
N
R
G
G
Site 84
S1057
N
E
G
T
I
T
T
S
E
N
R
G
G
D
P
Site 85
S1066
N
R
G
G
D
P
H
S
E
A
P
F
A
K
S
Site 86
S1073
S
E
A
P
F
A
K
S
D
N
Q
P
S
T
E
Site 87
T1086
T
E
K
A
M
E
P
T
M
K
F
S
L
A
S
Site 88
S1102
L
R
P
L
Q
E
E
S
I
M
E
K
D
Y
S
Site 89
Y1108
E
S
I
M
E
K
D
Y
S
A
S
I
N
S
L
Site 90
S1109
S
I
M
E
K
D
Y
S
A
S
I
N
S
L
L
Site 91
S1111
M
E
K
D
Y
S
A
S
I
N
S
L
L
E
R
Site 92
T1121
S
L
L
E
R
Y
D
T
Y
R
D
I
L
E
H
Site 93
Y1122
L
L
E
R
Y
D
T
Y
R
D
I
L
E
H
H
Site 94
T1138
Q
N
N
K
F
R
I
T
S
D
F
S
S
E
E
Site 95
S1139
N
N
K
F
R
I
T
S
D
F
S
S
E
E
D
Site 96
S1143
R
I
T
S
D
F
S
S
E
E
D
R
S
S
S
Site 97
S1148
F
S
S
E
E
D
R
S
S
S
C
L
Q
A
K
Site 98
S1149
S
S
E
E
D
R
S
S
S
C
L
Q
A
K
L
Site 99
S1150
S
E
E
D
R
S
S
S
C
L
Q
A
K
L
T
Site 100
T1198
F
V
I
K
E
R
D
T
L
K
E
R
E
R
E
Site 101
T1209
R
E
R
E
L
Q
M
T
L
N
T
R
M
E
S
Site 102
S1216
T
L
N
T
R
M
E
S
L
E
T
A
L
R
L
Site 103
Y1258
L
I
D
A
D
R
I
Y
Q
H
L
R
N
I
Q
Site 104
S1267
H
L
R
N
I
Q
D
S
I
A
K
Q
I
E
I
Site 105
Y1304
M
Q
N
I
I
L
K
Y
K
T
Q
F
E
G
M
Site 106
S1331
A
L
E
D
F
L
A
S
L
R
T
A
K
L
S
Site 107
S1338
S
L
R
T
A
K
L
S
A
E
P
V
T
D
L
Site 108
S1346
A
E
P
V
T
D
L
S
A
S
D
T
Q
V
A
Site 109
T1350
T
D
L
S
A
S
D
T
Q
V
A
Q
E
N
T
Site 110
T1359
V
A
Q
E
N
T
L
T
V
K
N
K
E
G
E
Site 111
S1387
C
L
K
M
L
D
M
S
F
K
D
A
E
R
G
Site 112
T1397
D
A
E
R
G
D
D
T
S
C
E
N
L
L
D
Site 113
S1398
A
E
R
G
D
D
T
S
C
E
N
L
L
D
A
Site 114
S1407
E
N
L
L
D
A
F
S
I
K
L
S
E
T
H
Site 115
S1411
D
A
F
S
I
K
L
S
E
T
H
G
Y
G
V
Site 116
Y1416
K
L
S
E
T
H
G
Y
G
V
Q
E
E
F
T
Site 117
S1448
K
N
I
Q
D
V
Q
S
Q
I
S
K
I
G
L
Site 118
T1459
K
I
G
L
K
D
P
T
V
P
A
V
K
H
R
Site 119
S1469
A
V
K
H
R
K
K
S
L
I
R
L
D
K
V
Site 120
Y1480
L
D
K
V
L
D
E
Y
E
E
E
K
R
H
L
Site 121
S1493
H
L
Q
E
M
A
N
S
L
P
H
F
K
D
G
Site 122
T1504
F
K
D
G
R
E
K
T
V
N
Q
Q
C
Q
N
Site 123
S1545
K
Q
Y
Q
N
F
K
S
I
L
T
T
L
I
Q
Site 124
T1549
N
F
K
S
I
L
T
T
L
I
Q
K
E
E
S
Site 125
S1559
Q
K
E
E
S
V
I
S
L
Q
A
S
Y
M
G
Site 126
S1563
S
V
I
S
L
Q
A
S
Y
M
G
K
E
N
L
Site 127
Y1604
V
C
K
N
L
Q
F
Y
L
N
K
M
K
T
F
Site 128
T1610
F
Y
L
N
K
M
K
T
F
E
E
P
P
F
E
Site 129
Y1637
I
N
E
K
T
E
D
Y
Y
E
N
L
G
R
A
Site 130
Y1638
N
E
K
T
E
D
Y
Y
E
N
L
G
R
A
L
Site 131
T1693
L
Q
V
H
E
Q
K
T
S
E
F
S
R
R
V
Site 132
T1735
E
H
V
Q
K
C
L
T
G
E
S
N
C
H
A
Site 133
S1738
Q
K
C
L
T
G
E
S
N
C
H
A
L
S
G
Site 134
S1744
E
S
N
C
H
A
L
S
G
S
T
A
E
L
R
Site 135
T1759
E
D
L
D
Q
A
K
T
Q
I
G
M
T
E
S
Site 136
S1772
E
S
L
L
K
A
L
S
P
S
D
S
L
E
I
Site 137
S1776
K
A
L
S
P
S
D
S
L
E
I
F
T
K
L
Site 138
S1796
Q
I
L
Q
Q
K
H
S
M
I
L
L
E
N
Q
Site 139
T1808
E
N
Q
I
G
C
L
T
P
E
L
S
E
L
K
Site 140
S1812
G
C
L
T
P
E
L
S
E
L
K
K
Q
Y
E
Site 141
Y1818
L
S
E
L
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E
S
V
I
S
V
Q
K
L
Site 445
S5204
Q
K
P
E
S
V
I
S
V
Q
K
L
L
L
D
Site 446
S5232
A
L
D
E
L
K
Q
S
Y
L
T
L
E
S
G
Site 447
Y5233
L
D
E
L
K
Q
S
Y
L
T
L
E
S
G
A
Site 448
S5249
P
L
L
E
D
T
A
S
R
I
D
E
L
F
Q
Site 449
S5259
D
E
L
F
Q
K
R
S
S
V
L
T
Q
V
N
Site 450
S5260
E
L
F
Q
K
R
S
S
V
L
T
Q
V
N
Q
Site 451
T5263
Q
K
R
S
S
V
L
T
Q
V
N
Q
L
K
T
Site 452
T5270
T
Q
V
N
Q
L
K
T
S
M
Q
S
V
L
Q
Site 453
Y5282
V
L
Q
E
W
K
I
Y
D
Q
L
Y
D
E
V
Site 454
Y5286
W
K
I
Y
D
Q
L
Y
D
E
V
N
M
M
T
Site 455
T5293
Y
D
E
V
N
M
M
T
I
R
F
W
Y
C
M
Site 456
S5309
H
S
K
P
V
V
L
S
L
E
T
L
R
C
Q
Site 457
S5322
C
Q
V
E
N
L
Q
S
L
Q
D
E
A
E
S
Site 458
S5330
L
Q
D
E
A
E
S
S
E
G
S
W
E
K
L
Site 459
S5333
E
A
E
S
S
E
G
S
W
E
K
L
Q
E
V
Site 460
S5382
D
Q
L
Q
K
A
Q
S
L
L
Q
L
W
K
A
Site 461
S5391
L
Q
L
W
K
A
Y
S
N
A
H
G
E
A
A
Site 462
T5442
L
Q
H
D
V
Q
K
T
K
E
A
F
L
Q
N
Site 463
S5497
N
E
F
E
F
V
L
S
Q
F
K
D
F
G
V
Site 464
S5533
Q
E
K
E
N
P
D
S
F
L
N
H
V
L
A
Site 465
S5555
I
E
H
L
N
E
V
S
L
K
L
P
L
S
D
Site 466
T5567
L
S
D
V
A
V
K
T
L
Q
N
M
N
R
Q
Site 467
T5579
N
R
Q
W
I
R
A
T
A
T
A
L
E
R
C
Site 468
Y5600
G
L
N
E
K
F
L
Y
C
C
E
K
W
I
Q
Site 469
T5633
E
L
L
E
Q
Q
K
T
Y
K
M
L
E
A
E
Site 470
S5642
K
M
L
E
A
E
V
S
I
N
Q
T
I
A
D
Site 471
Y5651
N
Q
T
I
A
D
S
Y
V
T
Q
S
L
Q
L
Site 472
S5655
A
D
S
Y
V
T
Q
S
L
Q
L
L
D
T
T
Site 473
T5661
Q
S
L
Q
L
L
D
T
T
E
I
E
N
R
P
Site 474
T5672
E
N
R
P
E
F
I
T
E
F
S
K
L
T
D
Site 475
T5678
I
T
E
F
S
K
L
T
D
R
W
Q
N
A
V
Site 476
T5706
V
R
Q
W
Q
D
F
T
T
S
V
E
N
L
F
Site 477
T5707
R
Q
W
Q
D
F
T
T
S
V
E
N
L
F
R
Site 478
T5717
E
N
L
F
R
F
L
T
D
T
S
H
L
L
S
Site 479
T5719
L
F
R
F
L
T
D
T
S
H
L
L
S
A
V
Site 480
S5724
T
D
T
S
H
L
L
S
A
V
K
G
Q
E
R
Site 481
S5733
V
K
G
Q
E
R
F
S
L
Y
Q
T
R
S
L
Site 482
Y5735
G
Q
E
R
F
S
L
Y
Q
T
R
S
L
I
H
Site 483
T5737
E
R
F
S
L
Y
Q
T
R
S
L
I
H
E
L
Site 484
S5739
F
S
L
Y
Q
T
R
S
L
I
H
E
L
K
N
Site 485
T5756
I
H
F
Q
R
R
R
T
T
C
A
L
T
L
E
Site 486
T5757
H
F
Q
R
R
R
T
T
C
A
L
T
L
E
A
Site 487
T5761
R
R
T
T
C
A
L
T
L
E
A
G
E
K
L
Site 488
T5771
A
G
E
K
L
L
L
T
T
D
L
K
T
K
E
Site 489
T5776
L
L
T
T
D
L
K
T
K
E
S
V
G
R
R
Site 490
S5779
T
D
L
K
T
K
E
S
V
G
R
R
I
S
Q
Site 491
S5785
E
S
V
G
R
R
I
S
Q
L
Q
D
S
W
K
Site 492
S5790
R
I
S
Q
L
Q
D
S
W
K
D
M
E
P
Q
Site 493
T5811
Q
F
Q
S
T
V
E
T
W
D
Q
C
E
K
K
Site 494
S5824
K
K
I
K
E
L
K
S
R
L
Q
V
L
K
A
Site 495
S5833
L
Q
V
L
K
A
Q
S
E
D
P
L
P
E
L
Site 496
S5857
L
I
K
E
L
E
Q
S
L
A
S
W
T
Q
N
Site 497
T5876
Q
T
M
K
A
D
L
T
R
H
V
L
V
E
D
Site 498
T5918
E
I
E
D
R
L
N
T
W
V
V
F
N
E
K
Site 499
S5987
L
I
K
A
S
N
K
S
R
A
A
E
I
D
D
Site 500
T6020
R
V
K
K
L
K
E
T
F
A
F
I
Q
Q
L
Site 501
S6032
Q
Q
L
D
K
N
M
S
N
L
R
T
W
L
A
Site 502
T6036
K
N
M
S
N
L
R
T
W
L
A
R
I
E
S
Site 503
S6043
T
W
L
A
R
I
E
S
E
L
S
K
P
V
V
Site 504
S6046
A
R
I
E
S
E
L
S
K
P
V
V
Y
D
V
Site 505
S6077
Q
R
D
I
E
Q
H
S
A
G
V
E
S
V
F
Site 506
S6094
C
D
V
L
L
H
D
S
D
A
C
A
N
E
T
Site 507
T6101
S
D
A
C
A
N
E
T
E
C
D
S
I
Q
Q
Site 508
T6109
E
C
D
S
I
Q
Q
T
T
R
S
L
D
R
R
Site 509
S6112
S
I
Q
Q
T
T
R
S
L
D
R
R
W
R
N
Site 510
Y6145
W
Q
K
F
L
D
D
Y
S
R
F
E
D
W
L
Site 511
S6146
Q
K
F
L
D
D
Y
S
R
F
E
D
W
L
K
Site 512
S6154
R
F
E
D
W
L
K
S
A
E
R
T
A
A
C
Site 513
T6158
W
L
K
S
A
E
R
T
A
A
C
P
N
S
S
Site 514
S6164
R
T
A
A
C
P
N
S
S
E
V
L
Y
T
S
Site 515
S6165
T
A
A
C
P
N
S
S
E
V
L
Y
T
S
A
Site 516
Y6169
P
N
S
S
E
V
L
Y
T
S
A
K
E
E
L
Site 517
T6170
N
S
S
E
V
L
Y
T
S
A
K
E
E
L
K
Site 518
S6171
S
S
E
V
L
Y
T
S
A
K
E
E
L
K
R
Site 519
T6191
R
Q
I
H
E
R
L
T
Q
L
E
L
I
N
K
Site 520
Y6200
L
E
L
I
N
K
Q
Y
R
R
L
A
R
E
N
Site 521
T6211
A
R
E
N
R
T
D
T
A
S
R
L
K
Q
M
Site 522
S6213
E
N
R
T
D
T
A
S
R
L
K
Q
M
V
H
Site 523
T6234
D
N
L
Q
R
R
V
T
A
V
L
R
R
L
R
Site 524
T6244
L
R
R
L
R
H
F
T
N
Q
R
E
E
F
E
Site 525
T6253
Q
R
E
E
F
E
G
T
R
E
S
I
L
V
W
Site 526
S6256
E
F
E
G
T
R
E
S
I
L
V
W
L
T
E
Site 527
S6277
N
V
E
H
F
S
E
S
D
A
D
D
K
M
R
Site 528
T6294
N
G
F
Q
Q
E
I
T
L
N
T
N
K
I
D
Site 529
S6314
G
E
Q
L
I
Q
K
S
E
P
L
D
A
V
L
Site 530
Y6332
E
L
E
E
L
H
R
Y
C
Q
E
V
F
G
R
Site 531
S6341
Q
E
V
F
G
R
V
S
R
F
H
R
R
L
T
Site 532
T6348
S
R
F
H
R
R
L
T
S
C
T
P
G
L
E
Site 533
S6349
R
F
H
R
R
L
T
S
C
T
P
G
L
E
D
Site 534
T6351
H
R
R
L
T
S
C
T
P
G
L
E
D
E
K
Site 535
S6361
L
E
D
E
K
E
A
S
E
N
E
T
D
M
E
Site 536
T6365
K
E
A
S
E
N
E
T
D
M
E
D
P
R
E
Site 537
S6377
P
R
E
I
Q
T
D
S
W
R
K
R
G
E
S
Site 538
S6384
S
W
R
K
R
G
E
S
E
E
P
S
S
P
Q
Site 539
S6388
R
G
E
S
E
E
P
S
S
P
Q
S
L
C
H
Site 540
S6389
G
E
S
E
E
P
S
S
P
Q
S
L
C
H
L
Site 541
S6392
E
E
P
S
S
P
Q
S
L
C
H
L
V
A
P
Site 542
S6404
V
A
P
G
H
E
R
S
G
C
E
T
P
V
S
Site 543
T6408
H
E
R
S
G
C
E
T
P
V
S
V
D
S
I
Site 544
S6411
S
G
C
E
T
P
V
S
V
D
S
I
P
L
E
Site 545
S6414
E
T
P
V
S
V
D
S
I
P
L
E
W
D
H
Site 546
T6422
I
P
L
E
W
D
H
T
G
D
V
G
G
S
S
Site 547
S6430
G
D
V
G
G
S
S
S
H
E
E
D
E
E
G
Site 548
Y6439
E
E
D
E
E
G
P
Y
Y
S
A
L
S
G
K
Site 549
Y6440
E
D
E
E
G
P
Y
Y
S
A
L
S
G
K
S
Site 550
S6444
G
P
Y
Y
S
A
L
S
G
K
S
I
S
D
G
Site 551
S6447
Y
S
A
L
S
G
K
S
I
S
D
G
H
S
W
Site 552
S6449
A
L
S
G
K
S
I
S
D
G
H
S
W
H
V
Site 553
S6453
K
S
I
S
D
G
H
S
W
H
V
P
D
S
P
Site 554
S6459
H
S
W
H
V
P
D
S
P
S
C
P
E
H
H
Site 555
Y6467
P
S
C
P
E
H
H
Y
K
Q
M
E
G
D
R
Site 556
S6483
V
P
P
V
P
P
A
S
S
T
P
Y
K
P
P
Site 557
S6484
P
P
V
P
P
A
S
S
T
P
Y
K
P
P
Y
Site 558
T6485
P
V
P
P
A
S
S
T
P
Y
K
P
P
Y
G
Site 559
Y6487
P
P
A
S
S
T
P
Y
K
P
P
Y
G
K
L
Site 560
Y6491
S
T
P
Y
K
P
P
Y
G
K
L
L
L
P
P
Site 561
T6500
K
L
L
L
P
P
G
T
D
G
G
K
E
G
P
Site 562
T6525
D
G
G
L
A
G
I
T
E
Q
Q
S
G
A
F
Site 563
S6558
Q
N
L
Q
Q
L
N
S
D
I
S
A
I
T
T
Site 564
T6565
S
D
I
S
A
I
T
T
W
L
K
K
T
E
A
Site 565
S6584
L
K
M
A
K
P
P
S
D
I
Q
E
I
E
L
Site 566
S6616
L
V
V
S
V
N
V
S
S
K
E
F
L
Q
T
Site 567
T6623
S
S
K
E
F
L
Q
T
E
S
P
E
S
T
E
Site 568
S6625
K
E
F
L
Q
T
E
S
P
E
S
T
E
L
Q
Site 569
S6628
L
Q
T
E
S
P
E
S
T
E
L
Q
S
R
L
Site 570
T6629
Q
T
E
S
P
E
S
T
E
L
Q
S
R
L
R
Site 571
S6639
Q
S
R
L
R
Q
L
S
L
L
W
E
A
A
Q
Site 572
S6651
A
A
Q
G
A
V
D
S
W
R
G
G
L
R
Q
Site 573
S6679
N
L
L
L
W
L
A
S
A
K
N
R
R
Q
K
Site 574
S6761
K
Q
L
R
E
Q
V
S
Q
D
L
M
A
L
Q
Site 575
T6770
D
L
M
A
L
Q
G
T
Q
N
P
A
S
P
L
Site 576
S6775
Q
G
T
Q
N
P
A
S
P
L
P
S
F
D
E
Site 577
S6779
N
P
A
S
P
L
P
S
F
D
E
V
D
S
G
Site 578
S6785
P
S
F
D
E
V
D
S
G
D
Q
P
P
A
T
Site 579
T6792
S
G
D
Q
P
P
A
T
S
V
P
A
P
R
A
Site 580
S6793
G
D
Q
P
P
A
T
S
V
P
A
P
R
A
K
Site 581
T6808
Q
F
R
A
V
R
T
T
E
G
E
E
E
T
E
Site 582
S6816
E
G
E
E
E
T
E
S
R
V
P
G
S
T
R
Site 583
S6821
T
E
S
R
V
P
G
S
T
R
P
Q
R
S
F
Site 584
T6822
E
S
R
V
P
G
S
T
R
P
Q
R
S
F
L
Site 585
S6827
G
S
T
R
P
Q
R
S
F
L
S
R
V
V
R
Site 586
S6830
R
P
Q
R
S
F
L
S
R
V
V
R
A
A
L
Site 587
S6856
L
A
C
L
L
P
S
S
E
E
D
Y
S
C
T
Site 588
Y6860
L
P
S
S
E
E
D
Y
S
C
T
Q
A
N
N
Site 589
S6861
P
S
S
E
E
D
Y
S
C
T
Q
A
N
N
F
Site 590
Y6873
N
N
F
A
R
S
F
Y
P
M
L
R
Y
T
N
Site 591
Y6878
S
F
Y
P
M
L
R
Y
T
N
G
P
P
P
T
Site 592
T6879
F
Y
P
M
L
R
Y
T
N
G
P
P
P
T
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation