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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JPH3
Full Name:
Junctophilin-3
Alias:
CAGL237; HDL2; JP3; JP-3; Junctophilin type 3; TNRC22
Type:
Plasma membrane, Endoplasmic reticulum, Endoplasmic reticulum membrane, Integral membrane proein
Mass (Da):
81469
Number AA:
748
UniProt ID:
Q8WXH2
International Prot ID:
IPI00166646
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0016021
GO:0014701
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0060402
GO:0060314
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y39
G
P
K
G
Q
G
E
Y
T
G
S
W
S
H
G
Site 2
T40
P
K
G
Q
G
E
Y
T
G
S
W
S
H
G
F
Site 3
S42
G
Q
G
E
Y
T
G
S
W
S
H
G
F
E
V
Site 4
S44
G
E
Y
T
G
S
W
S
H
G
F
E
V
L
G
Site 5
Y53
G
F
E
V
L
G
V
Y
T
W
P
S
G
N
T
Site 6
Y61
T
W
P
S
G
N
T
Y
Q
G
T
W
A
Q
G
Site 7
T64
S
G
N
T
Y
Q
G
T
W
A
Q
G
K
R
H
Site 8
Y83
E
S
K
G
K
W
V
Y
K
G
E
W
T
H
G
Site 9
Y95
T
H
G
F
K
G
R
Y
G
V
R
E
C
A
G
Site 10
Y107
C
A
G
N
G
A
K
Y
E
G
T
W
S
N
G
Site 11
T110
N
G
A
K
Y
E
G
T
W
S
N
G
L
Q
D
Site 12
Y119
S
N
G
L
Q
D
G
Y
G
T
E
T
Y
S
D
Site 13
T123
Q
D
G
Y
G
T
E
T
Y
S
D
G
G
T
Y
Site 14
Y124
D
G
Y
G
T
E
T
Y
S
D
G
G
T
Y
Q
Site 15
S125
G
Y
G
T
E
T
Y
S
D
G
G
T
Y
Q
G
Site 16
T129
E
T
Y
S
D
G
G
T
Y
Q
G
Q
W
V
G
Site 17
Y142
V
G
G
M
R
Q
G
Y
G
V
R
Q
S
V
P
Site 18
S147
Q
G
Y
G
V
R
Q
S
V
P
Y
G
M
A
A
Site 19
S158
G
M
A
A
V
I
R
S
P
L
R
T
S
I
N
Site 20
T162
V
I
R
S
P
L
R
T
S
I
N
S
L
R
S
Site 21
S163
I
R
S
P
L
R
T
S
I
N
S
L
R
S
E
Site 22
S166
P
L
R
T
S
I
N
S
L
R
S
E
H
T
N
Site 23
S182
T
A
L
H
P
D
A
S
P
A
V
A
G
S
P
Site 24
S204
V
L
V
A
H
S
D
S
E
I
L
K
S
K
K
Site 25
S209
S
D
S
E
I
L
K
S
K
K
K
G
L
F
R
Site 26
S218
K
K
G
L
F
R
R
S
L
L
S
G
L
K
L
Site 27
S221
L
F
R
R
S
L
L
S
G
L
K
L
R
K
S
Site 28
S228
S
G
L
K
L
R
K
S
E
S
K
S
S
L
A
Site 29
S230
L
K
L
R
K
S
E
S
K
S
S
L
A
S
Q
Site 30
S232
L
R
K
S
E
S
K
S
S
L
A
S
Q
R
S
Site 31
S233
R
K
S
E
S
K
S
S
L
A
S
Q
R
S
K
Site 32
S236
E
S
K
S
S
L
A
S
Q
R
S
K
Q
S
S
Site 33
S239
S
S
L
A
S
Q
R
S
K
Q
S
S
F
R
S
Site 34
S242
A
S
Q
R
S
K
Q
S
S
F
R
S
E
A
G
Site 35
S243
S
Q
R
S
K
Q
S
S
F
R
S
E
A
G
M
Site 36
S246
S
K
Q
S
S
F
R
S
E
A
G
M
S
T
V
Site 37
S251
F
R
S
E
A
G
M
S
T
V
S
S
T
A
S
Site 38
T252
R
S
E
A
G
M
S
T
V
S
S
T
A
S
D
Site 39
S254
E
A
G
M
S
T
V
S
S
T
A
S
D
I
H
Site 40
S255
A
G
M
S
T
V
S
S
T
A
S
D
I
H
S
Site 41
S258
S
T
V
S
S
T
A
S
D
I
H
S
T
I
S
Site 42
S262
S
T
A
S
D
I
H
S
T
I
S
L
G
E
A
Site 43
S265
S
D
I
H
S
T
I
S
L
G
E
A
E
A
E
Site 44
Y288
D
A
T
T
T
E
T
Y
V
G
E
W
K
N
D
Site 45
S298
E
W
K
N
D
K
R
S
G
F
G
V
S
Q
R
Site 46
S303
K
R
S
G
F
G
V
S
Q
R
S
D
G
L
K
Site 47
S306
G
F
G
V
S
Q
R
S
D
G
L
K
Y
E
G
Site 48
Y323
A
S
N
R
R
H
G
Y
G
C
M
T
F
P
D
Site 49
T327
R
H
G
Y
G
C
M
T
F
P
D
G
T
K
E
Site 50
T332
C
M
T
F
P
D
G
T
K
E
E
G
K
Y
K
Site 51
Y338
G
T
K
E
E
G
K
Y
K
Q
N
I
L
V
G
Site 52
S357
N
L
I
P
L
R
A
S
K
I
R
E
K
V
D
Site 53
T375
E
A
A
E
R
A
A
T
I
A
K
Q
K
A
E
Site 54
S386
Q
K
A
E
I
A
A
S
R
T
S
H
S
R
A
Site 55
S389
E
I
A
A
S
R
T
S
H
S
R
A
K
A
E
Site 56
T400
A
K
A
E
A
A
L
T
A
A
Q
K
A
Q
E
Site 57
T415
E
A
R
I
A
R
I
T
A
K
E
F
S
P
S
Site 58
S420
R
I
T
A
K
E
F
S
P
S
F
Q
H
R
E
Site 59
S422
T
A
K
E
F
S
P
S
F
Q
H
R
E
N
G
Site 60
Y432
H
R
E
N
G
L
E
Y
Q
R
P
K
R
Q
T
Site 61
T439
Y
Q
R
P
K
R
Q
T
S
C
D
D
I
E
V
Site 62
S440
Q
R
P
K
R
Q
T
S
C
D
D
I
E
V
L
Site 63
T449
D
D
I
E
V
L
S
T
G
T
P
L
Q
Q
E
Site 64
T451
I
E
V
L
S
T
G
T
P
L
Q
Q
E
S
P
Site 65
S457
G
T
P
L
Q
Q
E
S
P
E
L
Y
R
K
G
Site 66
T465
P
E
L
Y
R
K
G
T
T
P
S
D
L
T
P
Site 67
T466
E
L
Y
R
K
G
T
T
P
S
D
L
T
P
D
Site 68
T471
G
T
T
P
S
D
L
T
P
D
D
S
P
L
Q
Site 69
S475
S
D
L
T
P
D
D
S
P
L
Q
S
F
P
T
Site 70
S479
P
D
D
S
P
L
Q
S
F
P
T
S
P
A
A
Site 71
S483
P
L
Q
S
F
P
T
S
P
A
A
T
P
P
P
Site 72
T487
F
P
T
S
P
A
A
T
P
P
P
A
P
A
A
Site 73
S502
R
N
K
V
A
H
F
S
R
Q
V
S
V
D
E
Site 74
S506
A
H
F
S
R
Q
V
S
V
D
E
E
R
G
G
Site 75
S530
A
G
D
C
A
R
S
S
W
G
E
E
Q
A
G
Site 76
S544
G
G
S
R
G
V
R
S
G
A
L
R
G
G
L
Site 77
S561
D
D
F
R
T
R
G
S
G
R
K
Q
P
G
N
Site 78
T576
P
K
P
R
E
R
R
T
E
S
P
P
V
F
T
Site 79
S578
P
R
E
R
R
T
E
S
P
P
V
F
T
W
T
Site 80
S591
W
T
S
H
H
R
A
S
N
H
S
P
G
G
S
Site 81
S594
H
H
R
A
S
N
H
S
P
G
G
S
R
L
L
Site 82
S598
S
N
H
S
P
G
G
S
R
L
L
E
L
Q
E
Site 83
S609
E
L
Q
E
E
K
L
S
N
Y
R
M
E
M
K
Site 84
Y611
Q
E
E
K
L
S
N
Y
R
M
E
M
K
P
L
Site 85
T623
K
P
L
L
R
M
E
T
H
P
Q
K
R
R
Y
Site 86
Y630
T
H
P
Q
K
R
R
Y
S
K
G
G
A
C
R
Site 87
S631
H
P
Q
K
R
R
Y
S
K
G
G
A
C
R
G
Site 88
S657
F
G
V
Q
R
L
R
S
K
A
Q
N
K
E
N
Site 89
S669
K
E
N
F
R
P
A
S
S
A
E
P
A
V
Q
Site 90
T696
R
L
L
R
W
D
L
T
F
S
P
P
Q
K
S
Site 91
S698
L
R
W
D
L
T
F
S
P
P
Q
K
S
L
P
Site 92
S703
T
F
S
P
P
Q
K
S
L
P
V
A
L
E
S
Site 93
S710
S
L
P
V
A
L
E
S
D
E
E
N
G
D
E
Site 94
S720
E
N
G
D
E
L
K
S
S
T
G
S
A
P
I
Site 95
S721
N
G
D
E
L
K
S
S
T
G
S
A
P
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation