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Updated November 2019
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Protein Info
Short Name:
CNKSR2
Full Name:
Connector enhancer of kinase suppressor of ras 2
Alias:
CNK homolog protein 2
Type:
Mass (Da):
117535
Number AA:
1032
UniProt ID:
Q8WXI2
International Prot ID:
IPI00435208
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0019898
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0009966
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
M
E
P
V
S
K
W
S
P
S
Q
V
V
D
W
Site 2
S14
P
V
S
K
W
S
P
S
Q
V
V
D
W
M
K
Site 3
Y30
L
D
D
C
L
Q
Q
Y
I
K
N
F
E
R
E
Site 4
T48
G
D
Q
L
L
R
I
T
H
Q
E
L
E
D
L
Site 5
T87
L
E
T
E
N
L
K
T
L
S
H
K
L
N
A
Site 6
S89
T
E
N
L
K
T
L
S
H
K
L
N
A
S
A
Site 7
T104
K
N
L
Q
N
F
I
T
G
R
R
R
S
G
H
Site 8
S109
F
I
T
G
R
R
R
S
G
H
Y
D
G
R
T
Site 9
Y112
G
R
R
R
S
G
H
Y
D
G
R
T
S
R
K
Site 10
T116
S
G
H
Y
D
G
R
T
S
R
K
L
P
N
D
Site 11
S117
G
H
Y
D
G
R
T
S
R
K
L
P
N
D
F
Site 12
T151
R
S
P
F
A
A
V
T
D
Y
S
V
T
R
N
Site 13
Y153
P
F
A
A
V
T
D
Y
S
V
T
R
N
N
V
Site 14
T176
T
I
V
Q
Q
D
C
T
V
Y
E
T
E
N
K
Site 15
S208
L
S
S
D
P
L
V
S
Q
S
A
H
L
E
V
Site 16
Y230
P
S
E
G
L
G
M
Y
I
K
S
T
Y
D
G
Site 17
Y235
G
M
Y
I
K
S
T
Y
D
G
L
H
V
I
T
Site 18
T244
G
L
H
V
I
T
G
T
T
E
N
S
P
A
D
Site 19
S248
I
T
G
T
T
E
N
S
P
A
D
R
C
K
K
Site 20
S287
N
A
L
R
E
D
P
S
G
V
I
L
T
L
K
Site 21
T292
D
P
S
G
V
I
L
T
L
K
K
R
P
Q
S
Site 22
S299
T
L
K
K
R
P
Q
S
M
L
T
S
A
P
A
Site 23
T302
K
R
P
Q
S
M
L
T
S
A
P
A
L
L
K
Site 24
S303
R
P
Q
S
M
L
T
S
A
P
A
L
L
K
N
Site 25
S325
L
Q
P
L
I
P
R
S
P
T
S
S
V
A
T
Site 26
T327
P
L
I
P
R
S
P
T
S
S
V
A
T
P
S
Site 27
S328
L
I
P
R
S
P
T
S
S
V
A
T
P
S
S
Site 28
S329
I
P
R
S
P
T
S
S
V
A
T
P
S
S
T
Site 29
T332
S
P
T
S
S
V
A
T
P
S
S
T
I
S
T
Site 30
S334
T
S
S
V
A
T
P
S
S
T
I
S
T
P
T
Site 31
S335
S
S
V
A
T
P
S
S
T
I
S
T
P
T
K
Site 32
T336
S
V
A
T
P
S
S
T
I
S
T
P
T
K
R
Site 33
S338
A
T
P
S
S
T
I
S
T
P
T
K
R
D
S
Site 34
T339
T
P
S
S
T
I
S
T
P
T
K
R
D
S
S
Site 35
T341
S
S
T
I
S
T
P
T
K
R
D
S
S
A
L
Site 36
S345
S
T
P
T
K
R
D
S
S
A
L
Q
D
L
Y
Site 37
S346
T
P
T
K
R
D
S
S
A
L
Q
D
L
Y
I
Site 38
Y352
S
S
A
L
Q
D
L
Y
I
P
P
P
P
A
E
Site 39
Y361
P
P
P
P
A
E
P
Y
I
P
R
D
E
K
G
Site 40
S388
G
K
P
V
H
K
G
S
E
S
P
N
S
F
L
Site 41
S390
P
V
H
K
G
S
E
S
P
N
S
F
L
D
Q
Site 42
S393
K
G
S
E
S
P
N
S
F
L
D
Q
E
Y
R
Site 43
Y399
N
S
F
L
D
Q
E
Y
R
K
R
F
N
I
V
Site 44
Y413
V
E
E
D
T
V
L
Y
C
Y
E
Y
E
K
G
Site 45
Y415
E
D
T
V
L
Y
C
Y
E
Y
E
K
G
R
S
Site 46
Y417
T
V
L
Y
C
Y
E
Y
E
K
G
R
S
S
S
Site 47
S423
E
Y
E
K
G
R
S
S
S
Q
G
R
R
E
S
Site 48
S424
Y
E
K
G
R
S
S
S
Q
G
R
R
E
S
T
Site 49
S430
S
S
Q
G
R
R
E
S
T
P
T
Y
G
K
L
Site 50
T431
S
Q
G
R
R
E
S
T
P
T
Y
G
K
L
R
Site 51
T433
G
R
R
E
S
T
P
T
Y
G
K
L
R
P
I
Site 52
Y434
R
R
E
S
T
P
T
Y
G
K
L
R
P
I
S
Site 53
S441
Y
G
K
L
R
P
I
S
M
P
V
E
Y
N
W
Site 54
Y446
P
I
S
M
P
V
E
Y
N
W
V
G
D
Y
E
Site 55
Y452
E
Y
N
W
V
G
D
Y
E
D
P
N
K
M
K
Site 56
S462
P
N
K
M
K
R
D
S
R
R
E
N
S
L
L
Site 57
S467
R
D
S
R
R
E
N
S
L
L
R
Y
M
S
N
Site 58
Y471
R
E
N
S
L
L
R
Y
M
S
N
E
K
I
A
Site 59
S473
N
S
L
L
R
Y
M
S
N
E
K
I
A
Q
E
Site 60
Y482
E
K
I
A
Q
E
E
Y
M
F
Q
R
N
S
K
Site 61
S488
E
Y
M
F
Q
R
N
S
K
K
D
T
G
K
K
Site 62
T492
Q
R
N
S
K
K
D
T
G
K
K
S
K
K
K
Site 63
S496
K
K
D
T
G
K
K
S
K
K
K
G
D
K
S
Site 64
S503
S
K
K
K
G
D
K
S
N
S
P
T
H
Y
S
Site 65
S505
K
K
G
D
K
S
N
S
P
T
H
Y
S
L
L
Site 66
T507
G
D
K
S
N
S
P
T
H
Y
S
L
L
P
S
Site 67
S510
S
N
S
P
T
H
Y
S
L
L
P
S
L
Q
M
Site 68
S514
T
H
Y
S
L
L
P
S
L
Q
M
D
A
L
R
Site 69
T527
L
R
Q
D
I
M
G
T
P
V
P
E
T
T
L
Site 70
Y535
P
V
P
E
T
T
L
Y
H
T
F
Q
Q
S
S
Site 71
T537
P
E
T
T
L
Y
H
T
F
Q
Q
S
S
L
Q
Site 72
S542
Y
H
T
F
Q
Q
S
S
L
Q
H
K
S
K
K
Site 73
S547
Q
S
S
L
Q
H
K
S
K
K
K
N
K
G
P
Site 74
S559
K
G
P
I
A
G
K
S
K
R
R
I
S
C
K
Site 75
S564
G
K
S
K
R
R
I
S
C
K
D
L
G
R
G
Site 76
Y586
K
K
K
D
A
K
S
Y
F
S
Q
K
W
K
K
Site 77
Y594
F
S
Q
K
W
K
K
Y
W
F
V
L
K
D
A
Site 78
Y604
V
L
K
D
A
S
L
Y
W
Y
I
N
E
E
D
Site 79
Y606
K
D
A
S
L
Y
W
Y
I
N
E
E
D
E
K
Site 80
S619
E
K
A
E
G
F
I
S
L
P
E
F
K
I
D
Site 81
S629
E
F
K
I
D
R
A
S
E
C
R
K
K
Y
A
Site 82
Y635
A
S
E
C
R
K
K
Y
A
F
K
A
C
H
P
Site 83
Y648
H
P
K
I
K
S
F
Y
F
A
A
E
H
L
D
Site 84
T668
L
N
R
I
N
M
L
T
A
G
Y
A
E
R
E
Site 85
Y671
I
N
M
L
T
A
G
Y
A
E
R
E
R
I
K
Site 86
Y683
R
I
K
Q
E
Q
D
Y
W
S
E
S
D
K
E
Site 87
S685
K
Q
E
Q
D
Y
W
S
E
S
D
K
E
E
A
Site 88
S687
E
Q
D
Y
W
S
E
S
D
K
E
E
A
D
T
Site 89
T694
S
D
K
E
E
A
D
T
P
S
T
P
K
Q
D
Site 90
S696
K
E
E
A
D
T
P
S
T
P
K
Q
D
S
P
Site 91
T697
E
E
A
D
T
P
S
T
P
K
Q
D
S
P
P
Site 92
S702
P
S
T
P
K
Q
D
S
P
P
P
P
Y
D
T
Site 93
Y707
Q
D
S
P
P
P
P
Y
D
T
Y
P
R
P
P
Site 94
T709
S
P
P
P
P
Y
D
T
Y
P
R
P
P
S
M
Site 95
Y710
P
P
P
P
Y
D
T
Y
P
R
P
P
S
M
S
Site 96
S715
D
T
Y
P
R
P
P
S
M
S
C
A
S
P
Y
Site 97
S717
Y
P
R
P
P
S
M
S
C
A
S
P
Y
V
E
Site 98
S720
P
P
S
M
S
C
A
S
P
Y
V
E
A
K
H
Site 99
Y722
S
M
S
C
A
S
P
Y
V
E
A
K
H
S
R
Site 100
S728
P
Y
V
E
A
K
H
S
R
L
S
S
T
E
T
Site 101
S731
E
A
K
H
S
R
L
S
S
T
E
T
S
Q
S
Site 102
S732
A
K
H
S
R
L
S
S
T
E
T
S
Q
S
Q
Site 103
T733
K
H
S
R
L
S
S
T
E
T
S
Q
S
Q
S
Site 104
T735
S
R
L
S
S
T
E
T
S
Q
S
Q
S
S
H
Site 105
S736
R
L
S
S
T
E
T
S
Q
S
Q
S
S
H
E
Site 106
S738
S
S
T
E
T
S
Q
S
Q
S
S
H
E
E
F
Site 107
S740
T
E
T
S
Q
S
Q
S
S
H
E
E
F
R
Q
Site 108
S741
E
T
S
Q
S
Q
S
S
H
E
E
F
R
Q
E
Site 109
S752
F
R
Q
E
V
T
G
S
S
A
V
S
P
I
R
Site 110
S753
R
Q
E
V
T
G
S
S
A
V
S
P
I
R
K
Site 111
S756
V
T
G
S
S
A
V
S
P
I
R
K
T
A
S
Site 112
T761
A
V
S
P
I
R
K
T
A
S
Q
R
R
S
W
Site 113
S763
S
P
I
R
K
T
A
S
Q
R
R
S
W
Q
D
Site 114
S767
K
T
A
S
Q
R
R
S
W
Q
D
L
I
E
T
Site 115
T774
S
W
Q
D
L
I
E
T
P
L
T
S
S
G
L
Site 116
T786
S
G
L
H
Y
L
Q
T
L
P
L
E
D
S
V
Site 117
S792
Q
T
L
P
L
E
D
S
V
F
S
D
S
A
A
Site 118
S795
P
L
E
D
S
V
F
S
D
S
A
A
I
S
P
Site 119
S797
E
D
S
V
F
S
D
S
A
A
I
S
P
E
H
Site 120
S801
F
S
D
S
A
A
I
S
P
E
H
R
R
Q
S
Site 121
S808
S
P
E
H
R
R
Q
S
T
L
P
T
Q
K
C
Site 122
T809
P
E
H
R
R
Q
S
T
L
P
T
Q
K
C
H
Site 123
T812
R
R
Q
S
T
L
P
T
Q
K
C
H
L
Q
D
Site 124
Y821
K
C
H
L
Q
D
H
Y
G
P
Y
P
L
A
E
Site 125
Y824
L
Q
D
H
Y
G
P
Y
P
L
A
E
S
E
R
Site 126
S829
G
P
Y
P
L
A
E
S
E
R
M
Q
V
L
N
Site 127
S844
G
N
G
G
K
P
R
S
F
T
L
P
R
D
S
Site 128
T846
G
G
K
P
R
S
F
T
L
P
R
D
S
G
F
Site 129
S898
G
E
N
I
G
E
K
S
E
S
R
E
E
K
L
Site 130
S900
N
I
G
E
K
S
E
S
R
E
E
K
L
G
D
Site 131
S908
R
E
E
K
L
G
D
S
L
Q
D
L
Y
R
A
Site 132
Y913
G
D
S
L
Q
D
L
Y
R
A
L
E
Q
A
S
Site 133
S920
Y
R
A
L
E
Q
A
S
L
S
P
L
G
E
H
Site 134
S922
A
L
E
Q
A
S
L
S
P
L
G
E
H
R
I
Site 135
S930
P
L
G
E
H
R
I
S
T
K
M
E
Y
K
L
Site 136
T931
L
G
E
H
R
I
S
T
K
M
E
Y
K
L
S
Site 137
Y935
R
I
S
T
K
M
E
Y
K
L
S
F
I
K
R
Site 138
S960
H
R
L
R
I
L
K
S
T
L
K
A
R
E
G
Site 139
T961
R
L
R
I
L
K
S
T
L
K
A
R
E
G
E
Site 140
T982
V
L
D
N
P
D
L
T
S
K
E
F
Q
Q
W
Site 141
S983
L
D
N
P
D
L
T
S
K
E
F
Q
Q
W
K
Site 142
Y993
F
Q
Q
W
K
Q
M
Y
L
D
L
F
L
D
I
Site 143
S1006
D
I
C
Q
N
T
T
S
N
D
P
L
S
I
S
Site 144
S1011
T
T
S
N
D
P
L
S
I
S
S
E
V
D
V
Site 145
T1020
S
S
E
V
D
V
I
T
S
S
L
A
H
T
H
Site 146
S1022
E
V
D
V
I
T
S
S
L
A
H
T
H
S
Y
Site 147
T1026
I
T
S
S
L
A
H
T
H
S
Y
I
E
T
H
Site 148
S1028
S
S
L
A
H
T
H
S
Y
I
E
T
H
V
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation