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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYO3B
Full Name:
Myosin-IIIb
Alias:
EC 2.7.11.1; MY3B; Myosin 3b
Type:
Protein kinase, Ser/Thr (non-receptor); Actin binding protein; Motor protein; EC 2.7.11.1;
STE
group; STE20 family; NinaC subfamily
Mass (Da):
151804
Number AA:
1341
UniProt ID:
Q8WXR4
International Prot ID:
IPI00337720
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016459
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003779
GO:0003774
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0050896
GO:0007601
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
P
M
M
L
G
L
E
S
L
P
D
P
T
D
T
Site 2
T24
L
E
S
L
P
D
P
T
D
T
W
E
I
I
E
Site 3
T26
S
L
P
D
P
T
D
T
W
E
I
I
E
T
I
Site 4
T32
D
T
W
E
I
I
E
T
I
G
K
G
T
Y
G
Site 5
Y38
E
T
I
G
K
G
T
Y
G
K
V
Y
K
V
T
Site 6
Y42
K
G
T
Y
G
K
V
Y
K
V
T
N
K
R
D
Site 7
T45
Y
G
K
V
Y
K
V
T
N
K
R
D
G
S
L
Site 8
S62
V
K
I
L
D
P
V
S
D
M
D
E
E
I
E
Site 9
T165
K
G
N
N
I
L
L
T
T
E
G
G
V
K
L
Site 10
T182
F
G
V
S
A
Q
L
T
S
T
R
L
R
R
N
Site 11
S183
G
V
S
A
Q
L
T
S
T
R
L
R
R
N
T
Site 12
T190
S
T
R
L
R
R
N
T
S
V
G
T
P
F
W
Site 13
S191
T
R
L
R
R
N
T
S
V
G
T
P
F
W
M
Site 14
T194
R
R
N
T
S
V
G
T
P
F
W
M
A
P
E
Site 15
Y209
V
I
A
C
E
Q
Q
Y
D
S
S
Y
D
A
R
Site 16
Y213
E
Q
Q
Y
D
S
S
Y
D
A
R
C
D
V
W
Site 17
T244
F
D
M
H
P
V
K
T
L
F
K
I
P
R
N
Site 18
T255
I
P
R
N
P
P
P
T
L
L
H
P
E
K
W
Site 19
S283
K
D
F
E
R
R
P
S
V
T
H
L
L
D
H
Site 20
T285
F
E
R
R
P
S
V
T
H
L
L
D
H
P
F
Site 21
T330
T
R
H
E
R
M
H
T
R
R
P
Y
H
V
E
Site 22
Y334
R
M
H
T
R
R
P
Y
H
V
E
D
A
E
K
Site 23
T358
L
E
V
L
D
E
D
T
I
I
H
Q
L
Q
K
Site 24
S390
L
N
P
F
Q
N
L
S
I
Y
S
P
Q
F
S
Site 25
Y392
P
F
Q
N
L
S
I
Y
S
P
Q
F
S
R
L
Site 26
S393
F
Q
N
L
S
I
Y
S
P
Q
F
S
R
L
Y
Site 27
S397
S
I
Y
S
P
Q
F
S
R
L
Y
H
G
V
K
Site 28
Y400
S
P
Q
F
S
R
L
Y
H
G
V
K
R
A
S
Site 29
S407
Y
H
G
V
K
R
A
S
N
P
P
H
I
F
A
Site 30
S435
K
D
Q
C
I
V
I
S
G
E
S
G
S
G
K
Site 31
S440
V
I
S
G
E
S
G
S
G
K
T
E
S
A
H
Site 32
S445
S
G
S
G
K
T
E
S
A
H
L
I
V
Q
H
Site 33
T463
L
G
K
A
N
N
Q
T
L
R
E
K
I
L
Q
Site 34
S489
C
T
A
I
N
D
N
S
S
R
F
G
K
Y
L
Site 35
S490
T
A
I
N
D
N
S
S
R
F
G
K
Y
L
E
Site 36
Y495
N
S
S
R
F
G
K
Y
L
E
M
M
F
T
P
Site 37
Y514
M
G
A
R
I
S
E
Y
L
L
E
K
S
R
V
Site 38
S519
S
E
Y
L
L
E
K
S
R
V
I
K
Q
A
A
Site 39
Y535
E
K
N
F
H
I
F
Y
Y
I
Y
A
G
L
H
Site 40
Y538
F
H
I
F
Y
Y
I
Y
A
G
L
H
H
Q
K
Site 41
S548
L
H
H
Q
K
K
L
S
D
F
R
L
P
E
E
Site 42
Y560
P
E
E
K
P
P
R
Y
I
A
D
E
T
G
R
Site 43
T565
P
R
Y
I
A
D
E
T
G
R
V
M
H
D
I
Site 44
T573
G
R
V
M
H
D
I
T
S
K
E
S
Y
R
R
Site 45
S574
R
V
M
H
D
I
T
S
K
E
S
Y
R
R
Q
Site 46
S577
H
D
I
T
S
K
E
S
Y
R
R
Q
F
E
A
Site 47
Y578
D
I
T
S
K
E
S
Y
R
R
Q
F
E
A
I
Site 48
S601
F
T
D
K
E
V
H
S
V
Y
R
I
L
A
G
Site 49
T626
A
I
S
S
Q
H
Q
T
D
K
S
E
V
P
N
Site 50
S629
S
Q
H
Q
T
D
K
S
E
V
P
N
A
E
A
Site 51
S657
E
L
Q
E
A
L
T
S
H
C
V
V
T
R
G
Site 52
T672
E
T
I
I
R
A
N
T
V
D
R
A
A
D
V
Site 53
T701
W
I
V
N
R
I
N
T
L
L
Q
P
D
E
N
Site 54
Y748
I
A
N
E
Q
I
Q
Y
Y
F
N
Q
H
V
F
Site 55
Y749
A
N
E
Q
I
Q
Y
Y
F
N
Q
H
V
F
A
Site 56
Y762
F
A
L
E
Q
M
E
Y
Q
N
E
G
I
D
A
Site 57
S799
L
A
L
L
D
E
E
S
R
F
P
Q
A
T
D
Site 58
T805
E
S
R
F
P
Q
A
T
D
Q
T
L
V
D
K
Site 59
T808
F
P
Q
A
T
D
Q
T
L
V
D
K
F
E
D
Site 60
Y821
E
D
N
L
R
C
K
Y
F
W
R
P
K
G
V
Site 61
Y843
H
Y
A
G
K
V
L
Y
D
A
S
G
V
L
E
Site 62
S846
G
K
V
L
Y
D
A
S
G
V
L
E
K
N
R
Site 63
T894
A
Q
T
R
A
R
I
T
V
A
S
S
S
L
P
Site 64
S897
R
A
R
I
T
V
A
S
S
S
L
P
P
H
F
Site 65
S905
S
S
L
P
P
H
F
S
A
G
K
A
K
V
D
Site 66
T913
A
G
K
A
K
V
D
T
L
E
V
I
R
H
P
Site 67
T923
V
I
R
H
P
E
E
T
T
N
M
K
R
Q
T
Site 68
T930
T
T
N
M
K
R
Q
T
V
A
S
Y
F
R
Y
Site 69
S933
M
K
R
Q
T
V
A
S
Y
F
R
Y
S
L
M
Site 70
Y934
K
R
Q
T
V
A
S
Y
F
R
Y
S
L
M
D
Site 71
S979
R
V
L
A
Q
L
R
S
T
G
I
L
E
T
V
Site 72
T980
V
L
A
Q
L
R
S
T
G
I
L
E
T
V
S
Site 73
T985
R
S
T
G
I
L
E
T
V
S
I
R
R
Q
G
Site 74
S987
T
G
I
L
E
T
V
S
I
R
R
Q
G
Y
S
Site 75
Y993
V
S
I
R
R
Q
G
Y
S
H
R
I
L
F
E
Site 76
S994
S
I
R
R
Q
G
Y
S
H
R
I
L
F
E
E
Site 77
Y1007
E
E
F
V
K
R
Y
Y
Y
L
A
F
T
A
H
Site 78
Y1008
E
F
V
K
R
Y
Y
Y
L
A
F
T
A
H
Q
Site 79
T1016
L
A
F
T
A
H
Q
T
P
L
A
S
K
E
S
Site 80
Y1047
K
T
K
V
F
L
K
Y
Y
H
V
E
Q
L
N
Site 81
Y1048
T
K
V
F
L
K
Y
Y
H
V
E
Q
L
N
L
Site 82
Y1080
G
W
L
G
A
R
R
Y
N
K
V
R
E
K
R
Site 83
S1096
K
G
A
I
A
I
Q
S
A
W
R
G
Y
D
A
Site 84
Y1101
I
Q
S
A
W
R
G
Y
D
A
R
R
K
F
K
Site 85
S1111
R
R
K
F
K
K
I
S
N
R
R
N
E
S
A
Site 86
S1117
I
S
N
R
R
N
E
S
A
A
H
N
Q
A
G
Site 87
T1126
A
H
N
Q
A
G
D
T
S
N
Q
S
S
G
P
Site 88
S1127
H
N
Q
A
G
D
T
S
N
Q
S
S
G
P
H
Site 89
S1130
A
G
D
T
S
N
Q
S
S
G
P
H
S
P
V
Site 90
S1131
G
D
T
S
N
Q
S
S
G
P
H
S
P
V
A
Site 91
S1135
N
Q
S
S
G
P
H
S
P
V
A
A
G
T
R
Site 92
S1144
V
A
A
G
T
R
G
S
A
E
V
Q
D
C
S
Site 93
S1151
S
A
E
V
Q
D
C
S
E
P
G
D
H
K
V
Site 94
S1162
D
H
K
V
L
R
G
S
V
H
R
R
S
H
S
Site 95
S1167
R
G
S
V
H
R
R
S
H
S
Q
A
E
S
N
Site 96
S1169
S
V
H
R
R
S
H
S
Q
A
E
S
N
N
G
Site 97
S1173
R
S
H
S
Q
A
E
S
N
N
G
R
T
Q
T
Site 98
T1178
A
E
S
N
N
G
R
T
Q
T
S
S
N
S
P
Site 99
T1180
S
N
N
G
R
T
Q
T
S
S
N
S
P
A
V
Site 100
S1182
N
G
R
T
Q
T
S
S
N
S
P
A
V
T
E
Site 101
S1184
R
T
Q
T
S
S
N
S
P
A
V
T
E
K
N
Site 102
T1188
S
S
N
S
P
A
V
T
E
K
N
G
H
S
Q
Site 103
S1194
V
T
E
K
N
G
H
S
Q
A
Q
S
S
P
K
Site 104
S1198
N
G
H
S
Q
A
Q
S
S
P
K
G
C
D
I
Site 105
S1199
G
H
S
Q
A
Q
S
S
P
K
G
C
D
I
F
Site 106
S1214
A
G
H
A
N
K
H
S
V
S
G
T
D
L
L
Site 107
S1216
H
A
N
K
H
S
V
S
G
T
D
L
L
S
S
Site 108
T1218
N
K
H
S
V
S
G
T
D
L
L
S
S
R
I
Site 109
S1236
A
P
D
Q
Q
G
L
S
L
W
G
A
P
Q
K
Site 110
S1246
G
A
P
Q
K
P
G
S
E
N
G
L
A
Q
K
Site 111
T1256
G
L
A
Q
K
H
R
T
P
R
R
R
C
Q
Q
Site 112
S1269
Q
Q
P
K
M
L
S
S
P
E
D
T
M
Y
Y
Site 113
T1273
M
L
S
S
P
E
D
T
M
Y
Y
N
Q
L
N
Site 114
Y1275
S
S
P
E
D
T
M
Y
Y
N
Q
L
N
G
T
Site 115
Y1276
S
P
E
D
T
M
Y
Y
N
Q
L
N
G
T
L
Site 116
S1288
G
T
L
E
Y
Q
G
S
K
R
K
P
R
K
L
Site 117
Y1307
V
L
D
G
E
D
E
Y
Y
K
S
L
S
P
V
Site 118
Y1308
L
D
G
E
D
E
Y
Y
K
S
L
S
P
V
D
Site 119
S1310
G
E
D
E
Y
Y
K
S
L
S
P
V
D
C
I
Site 120
S1312
D
E
Y
Y
K
S
L
S
P
V
D
C
I
P
E
Site 121
S1323
C
I
P
E
E
N
N
S
A
H
P
S
F
F
S
Site 122
S1327
E
N
N
S
A
H
P
S
F
F
S
S
S
S
K
Site 123
S1330
S
A
H
P
S
F
F
S
S
S
S
K
G
D
S
Site 124
S1331
A
H
P
S
F
F
S
S
S
S
K
G
D
S
F
Site 125
S1332
H
P
S
F
F
S
S
S
S
K
G
D
S
F
A
Site 126
S1333
P
S
F
F
S
S
S
S
K
G
D
S
F
A
Q
Site 127
S1337
S
S
S
S
K
G
D
S
F
A
Q
H
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation