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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ADAMTS14
Full Name:
A disintegrin and metalloproteinase with thrombospondin motifs 14
Alias:
ADAM metallopeptidase with thrombospondin type 1 motif, 14; ADAM-TS 14; ADAM-TS14; ATS14; EC 3.4.24.-
Type:
EC 3.4.24.-; Protease
Mass (Da):
133872
Number AA:
1223
UniProt ID:
Q8WXS8
International Prot ID:
IPI00103606
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005578
Uniprot
OncoNet
Molecular Function:
GO:0004222
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0030574
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
C
A
A
A
G
S
R
T
P
E
L
H
L
S
G
Site 2
S32
R
T
P
E
L
H
L
S
G
K
L
S
D
Y
G
Site 3
Y38
L
S
G
K
L
S
D
Y
G
V
T
V
P
C
S
Site 4
T41
K
L
S
D
Y
G
V
T
V
P
C
S
T
D
F
Site 5
S45
Y
G
V
T
V
P
C
S
T
D
F
R
G
R
F
Site 6
S54
D
F
R
G
R
F
L
S
H
V
V
S
G
P
A
Site 7
T72
A
G
S
M
V
V
D
T
P
P
T
L
P
R
H
Site 8
T75
M
V
V
D
T
P
P
T
L
P
R
H
S
S
H
Site 9
S80
P
P
T
L
P
R
H
S
S
H
L
R
V
A
R
Site 10
S81
P
T
L
P
R
H
S
S
H
L
R
V
A
R
S
Site 11
S88
S
H
L
R
V
A
R
S
P
L
H
P
G
G
T
Site 12
T95
S
P
L
H
P
G
G
T
L
W
P
G
R
V
G
Site 13
S105
P
G
R
V
G
R
H
S
L
Y
F
N
V
T
V
Site 14
T111
H
S
L
Y
F
N
V
T
V
F
G
K
E
L
H
Site 15
S132
R
R
L
V
V
P
G
S
S
V
E
W
Q
E
D
Site 16
Y154
P
L
R
Q
E
C
V
Y
T
G
G
V
T
G
M
Site 17
T155
L
R
Q
E
C
V
Y
T
G
G
V
T
G
M
P
Site 18
S182
A
G
L
I
R
T
D
S
T
D
F
F
I
E
P
Site 19
S200
G
Q
Q
E
K
E
A
S
G
R
T
H
V
V
Y
Site 20
Y207
S
G
R
T
H
V
V
Y
R
R
E
A
V
Q
Q
Site 21
T247
V
G
D
Q
L
G
D
T
E
R
K
R
R
H
A
Site 22
S258
R
R
H
A
K
P
G
S
Y
S
I
E
V
L
L
Site 23
Y283
G
K
E
H
V
Q
N
Y
V
L
T
L
M
N
I
Site 24
Y295
M
N
I
V
D
E
I
Y
H
D
E
S
L
G
V
Site 25
S321
V
G
Y
R
Q
S
L
S
L
I
E
R
G
N
P
Site 26
S331
E
R
G
N
P
S
R
S
L
E
Q
V
C
R
W
Site 27
Y369
Q
D
F
G
P
S
G
Y
A
P
V
T
G
M
C
Site 28
T373
P
S
G
Y
A
P
V
T
G
M
C
H
P
L
R
Site 29
T419
G
N
G
C
A
D
E
T
S
L
G
S
V
M
A
Site 30
S420
N
G
C
A
D
E
T
S
L
G
S
V
M
A
P
Site 31
S442
R
F
H
W
S
R
C
S
K
L
E
L
S
R
Y
Site 32
S447
R
C
S
K
L
E
L
S
R
Y
L
P
S
Y
D
Site 33
Y449
S
K
L
E
L
S
R
Y
L
P
S
Y
D
C
L
Site 34
S452
E
L
S
R
Y
L
P
S
Y
D
C
L
L
D
D
Site 35
Y453
L
S
R
Y
L
P
S
Y
D
C
L
L
D
D
P
Site 36
Y476
P
E
L
P
G
I
N
Y
S
M
D
E
Q
C
R
Site 37
Y490
R
F
D
F
G
S
G
Y
Q
T
C
L
A
F
R
Site 38
T498
Q
T
C
L
A
F
R
T
F
E
P
C
K
Q
L
Site 39
Y514
C
S
H
P
D
N
P
Y
F
C
K
T
K
K
G
Site 40
T518
D
N
P
Y
F
C
K
T
K
K
G
P
P
L
D
Site 41
T527
K
G
P
P
L
D
G
T
E
C
A
P
G
K
W
Site 42
Y549
W
K
S
P
E
Q
T
Y
G
Q
D
G
G
W
S
Site 43
S563
S
S
W
T
K
F
G
S
C
S
R
S
C
G
G
Site 44
S565
W
T
K
F
G
S
C
S
R
S
C
G
G
G
V
Site 45
S567
K
F
G
S
C
S
R
S
C
G
G
G
V
R
S
Site 46
S574
S
C
G
G
G
V
R
S
R
S
R
S
C
N
N
Site 47
S576
G
G
G
V
R
S
R
S
R
S
C
N
N
P
S
Site 48
S578
G
V
R
S
R
S
R
S
C
N
N
P
S
P
A
Site 49
S583
S
R
S
C
N
N
P
S
P
A
Y
G
G
R
P
Site 50
Y598
C
L
G
P
M
F
E
Y
Q
V
C
N
S
E
E
Site 51
T609
N
S
E
E
C
P
G
T
Y
E
D
F
R
A
Q
Site 52
Y624
Q
C
A
K
R
N
S
Y
Y
V
H
Q
N
A
K
Site 53
Y625
C
A
K
R
N
S
Y
Y
V
H
Q
N
A
K
H
Site 54
Y637
A
K
H
S
W
V
P
Y
E
P
D
D
D
A
Q
Site 55
S672
V
H
D
G
T
R
C
S
Y
R
D
P
Y
S
V
Site 56
Y673
H
D
G
T
R
C
S
Y
R
D
P
Y
S
V
C
Site 57
Y677
R
C
S
Y
R
D
P
Y
S
V
C
A
R
G
E
Site 58
S696
G
C
D
K
E
V
G
S
M
K
A
D
D
K
C
Site 59
T715
G
D
N
S
H
C
R
T
V
K
G
T
L
G
K
Site 60
T719
H
C
R
T
V
K
G
T
L
G
K
A
S
K
Q
Site 61
S750
Q
I
E
A
L
E
K
S
P
H
R
I
V
V
K
Site 62
S763
V
K
N
Q
V
T
G
S
F
I
L
N
P
K
G
Site 63
S775
P
K
G
K
E
A
T
S
R
T
F
T
A
M
G
Site 64
T777
G
K
E
A
T
S
R
T
F
T
A
M
G
L
E
Site 65
T779
E
A
T
S
R
T
F
T
A
M
G
L
E
W
E
Site 66
S795
A
V
E
D
A
K
E
S
L
K
T
S
G
P
L
Site 67
T798
D
A
K
E
S
L
K
T
S
G
P
L
P
E
A
Site 68
S799
A
K
E
S
L
K
T
S
G
P
L
P
E
A
I
Site 69
T814
A
I
L
A
L
P
P
T
E
G
G
P
R
S
S
Site 70
S820
P
T
E
G
G
P
R
S
S
L
A
Y
K
Y
V
Site 71
S821
T
E
G
G
P
R
S
S
L
A
Y
K
Y
V
I
Site 72
Y824
G
P
R
S
S
L
A
Y
K
Y
V
I
H
E
D
Site 73
Y826
R
S
S
L
A
Y
K
Y
V
I
H
E
D
L
L
Site 74
T848
V
L
L
E
E
M
D
T
Y
E
W
A
L
K
S
Site 75
Y849
L
L
E
E
M
D
T
Y
E
W
A
L
K
S
W
Site 76
Y872
G
G
I
Q
F
T
K
Y
G
C
R
R
R
R
D
Site 77
S922
E
W
G
A
C
S
R
S
C
G
K
L
G
V
Q
Site 78
S940
I
Q
C
L
L
P
L
S
N
G
T
H
K
V
M
Site 79
T997
Q
R
Q
V
V
C
R
T
N
A
N
S
L
G
H
Site 80
S1001
V
C
R
T
N
A
N
S
L
G
H
C
E
G
D
Site 81
T1012
C
E
G
D
R
P
D
T
V
Q
V
C
S
L
P
Site 82
T1029
G
G
N
H
Q
N
S
T
V
R
A
D
V
W
E
Site 83
T1039
A
D
V
W
E
L
G
T
P
E
G
Q
W
V
P
Site 84
S1048
E
G
Q
W
V
P
Q
S
E
P
L
H
P
I
N
Site 85
S1059
H
P
I
N
K
I
S
S
T
E
P
C
T
G
D
Site 86
T1060
P
I
N
K
I
S
S
T
E
P
C
T
G
D
R
Site 87
T1064
I
S
S
T
E
P
C
T
G
D
R
S
V
F
C
Site 88
Y1079
Q
M
E
V
L
D
R
Y
C
S
I
P
G
Y
H
Site 89
S1081
E
V
L
D
R
Y
C
S
I
P
G
Y
H
R
L
Site 90
Y1085
R
Y
C
S
I
P
G
Y
H
R
L
C
C
V
S
Site 91
T1109
P
G
P
D
P
G
P
T
S
L
P
P
F
S
T
Site 92
S1110
G
P
D
P
G
P
T
S
L
P
P
F
S
T
P
Site 93
S1115
P
T
S
L
P
P
F
S
T
P
G
S
P
L
P
Site 94
T1116
T
S
L
P
P
F
S
T
P
G
S
P
L
P
G
Site 95
S1119
P
P
F
S
T
P
G
S
P
L
P
G
P
Q
D
Site 96
S1140
P
P
G
K
P
T
G
S
E
D
H
Q
H
G
R
Site 97
T1149
D
H
Q
H
G
R
A
T
Q
L
P
G
A
L
D
Site 98
T1157
Q
L
P
G
A
L
D
T
S
S
P
G
T
Q
H
Site 99
S1158
L
P
G
A
L
D
T
S
S
P
G
T
Q
H
P
Site 100
S1159
P
G
A
L
D
T
S
S
P
G
T
Q
H
P
F
Site 101
T1162
L
D
T
S
S
P
G
T
Q
H
P
F
A
P
E
Site 102
T1170
Q
H
P
F
A
P
E
T
P
I
P
G
A
S
W
Site 103
S1176
E
T
P
I
P
G
A
S
W
S
I
S
P
T
T
Site 104
S1178
P
I
P
G
A
S
W
S
I
S
P
T
T
P
G
Site 105
S1180
P
G
A
S
W
S
I
S
P
T
T
P
G
G
L
Site 106
T1182
A
S
W
S
I
S
P
T
T
P
G
G
L
P
W
Site 107
T1183
S
W
S
I
S
P
T
T
P
G
G
L
P
W
G
Site 108
T1192
G
G
L
P
W
G
W
T
Q
T
P
T
P
V
P
Site 109
T1194
L
P
W
G
W
T
Q
T
P
T
P
V
P
E
D
Site 110
T1196
W
G
W
T
Q
T
P
T
P
V
P
E
D
K
G
Site 111
T1214
E
D
L
R
H
P
G
T
S
L
P
A
A
S
P
Site 112
S1215
D
L
R
H
P
G
T
S
L
P
A
A
S
P
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation