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Updated November 2019
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Protein Info
Short Name:
AUTS2
Full Name:
Autism susceptibility gene 2 protein
Alias:
autism susceptibility 2; autism susceptibility candidate 2; FBRSL2; KIAA0442
Type:
Unknown function
Mass (Da):
138982
Number AA:
1259
UniProt ID:
Q8WXX7
International Prot ID:
IPI00103655
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
G
L
R
K
K
R
R
S
R
S
Q
R
D
R
E
Site 2
S18
R
K
K
R
R
S
R
S
Q
R
D
R
E
R
R
Site 3
S26
Q
R
D
R
E
R
R
S
R
G
G
L
G
A
G
Site 4
T43
G
G
G
G
A
G
R
T
R
A
L
S
L
A
S
Site 5
S47
A
G
R
T
R
A
L
S
L
A
S
S
S
G
S
Site 6
S50
T
R
A
L
S
L
A
S
S
S
G
S
D
K
E
Site 7
S51
R
A
L
S
L
A
S
S
S
G
S
D
K
E
D
Site 8
S52
A
L
S
L
A
S
S
S
G
S
D
K
E
D
N
Site 9
S54
S
L
A
S
S
S
G
S
D
K
E
D
N
G
K
Site 10
S64
E
D
N
G
K
P
P
S
S
A
P
S
R
P
R
Site 11
S65
D
N
G
K
P
P
S
S
A
P
S
R
P
R
P
Site 12
S68
K
P
P
S
S
A
P
S
R
P
R
P
P
R
R
Site 13
S80
P
R
R
K
R
R
E
S
T
S
A
E
E
D
I
Site 14
T81
R
R
K
R
R
E
S
T
S
A
E
E
D
I
I
Site 15
S82
R
K
R
R
E
S
T
S
A
E
E
D
I
I
D
Site 16
T119
E
R
V
E
K
R
Q
T
P
L
T
K
K
K
R
Site 17
T122
E
K
R
Q
T
P
L
T
K
K
K
R
E
A
L
Site 18
T130
K
K
K
R
E
A
L
T
N
G
L
S
F
H
S
Site 19
S134
E
A
L
T
N
G
L
S
F
H
S
K
K
S
R
Site 20
S137
T
N
G
L
S
F
H
S
K
K
S
R
L
S
H
Site 21
S140
L
S
F
H
S
K
K
S
R
L
S
H
P
H
H
Site 22
S143
H
S
K
K
S
R
L
S
H
P
H
H
Y
S
S
Site 23
Y148
R
L
S
H
P
H
H
Y
S
S
D
R
E
N
D
Site 24
S149
L
S
H
P
H
H
Y
S
S
D
R
E
N
D
R
Site 25
S150
S
H
P
H
H
Y
S
S
D
R
E
N
D
R
N
Site 26
S181
Q
L
K
P
G
Q
N
S
C
R
D
S
D
S
E
Site 27
S185
G
Q
N
S
C
R
D
S
D
S
E
S
A
S
G
Site 28
S187
N
S
C
R
D
S
D
S
E
S
A
S
G
E
S
Site 29
S189
C
R
D
S
D
S
E
S
A
S
G
E
S
K
G
Site 30
S191
D
S
D
S
E
S
A
S
G
E
S
K
G
F
H
Site 31
S200
E
S
K
G
F
H
R
S
S
S
R
E
R
L
S
Site 32
S201
S
K
G
F
H
R
S
S
S
R
E
R
L
S
D
Site 33
S202
K
G
F
H
R
S
S
S
R
E
R
L
S
D
S
Site 34
S207
S
S
S
R
E
R
L
S
D
S
S
A
P
S
S
Site 35
S209
S
R
E
R
L
S
D
S
S
A
P
S
S
L
G
Site 36
S210
R
E
R
L
S
D
S
S
A
P
S
S
L
G
T
Site 37
S213
L
S
D
S
S
A
P
S
S
L
G
T
G
Y
F
Site 38
S214
S
D
S
S
A
P
S
S
L
G
T
G
Y
F
C
Site 39
T217
S
A
P
S
S
L
G
T
G
Y
F
C
D
S
D
Site 40
Y219
P
S
S
L
G
T
G
Y
F
C
D
S
D
S
D
Site 41
S223
G
T
G
Y
F
C
D
S
D
S
D
Q
E
E
K
Site 42
S225
G
Y
F
C
D
S
D
S
D
Q
E
E
K
A
S
Site 43
S232
S
D
Q
E
E
K
A
S
D
A
S
S
E
K
L
Site 44
S236
E
K
A
S
D
A
S
S
E
K
L
F
N
T
V
Site 45
T242
S
S
E
K
L
F
N
T
V
I
V
N
K
D
P
Site 46
S261
G
T
L
P
E
H
D
S
Q
D
A
G
P
I
V
Site 47
S277
K
I
S
G
L
E
R
S
Q
E
K
S
Q
D
C
Site 48
S281
L
E
R
S
Q
E
K
S
Q
D
C
C
K
E
P
Site 49
S319
E
P
Q
L
R
A
P
S
P
D
P
D
L
V
Q
Site 50
S338
P
P
Q
P
P
P
L
S
T
Q
P
P
Q
G
P
Site 51
T339
P
Q
P
P
P
L
S
T
Q
P
P
Q
G
P
P
Site 52
S366
Q
R
P
P
R
P
Q
S
P
T
Q
L
L
H
Q
Site 53
T368
P
P
R
P
Q
S
P
T
Q
L
L
H
Q
N
L
Site 54
S383
P
P
V
Q
A
H
P
S
A
Q
S
L
S
Q
P
Site 55
S386
Q
A
H
P
S
A
Q
S
L
S
Q
P
L
S
A
Site 56
S388
H
P
S
A
Q
S
L
S
Q
P
L
S
A
Y
N
Site 57
S392
Q
S
L
S
Q
P
L
S
A
Y
N
S
S
S
L
Site 58
Y394
L
S
Q
P
L
S
A
Y
N
S
S
S
L
S
L
Site 59
S396
Q
P
L
S
A
Y
N
S
S
S
L
S
L
N
S
Site 60
S397
P
L
S
A
Y
N
S
S
S
L
S
L
N
S
L
Site 61
S398
L
S
A
Y
N
S
S
S
L
S
L
N
S
L
S
Site 62
S400
A
Y
N
S
S
S
L
S
L
N
S
L
S
S
S
Site 63
S403
S
S
S
L
S
L
N
S
L
S
S
S
R
S
S
Site 64
S405
S
L
S
L
N
S
L
S
S
S
R
S
S
T
P
Site 65
S406
L
S
L
N
S
L
S
S
S
R
S
S
T
P
A
Site 66
S407
S
L
N
S
L
S
S
S
R
S
S
T
P
A
K
Site 67
S409
N
S
L
S
S
S
R
S
S
T
P
A
K
T
Q
Site 68
S410
S
L
S
S
S
R
S
S
T
P
A
K
T
Q
P
Site 69
T411
L
S
S
S
R
S
S
T
P
A
K
T
Q
P
A
Site 70
T415
R
S
S
T
P
A
K
T
Q
P
A
P
P
H
I
Site 71
S423
Q
P
A
P
P
H
I
S
H
H
P
S
A
S
P
Site 72
S427
P
H
I
S
H
H
P
S
A
S
P
F
P
L
S
Site 73
S429
I
S
H
H
P
S
A
S
P
F
P
L
S
L
P
Site 74
S434
S
A
S
P
F
P
L
S
L
P
N
H
S
P
L
Site 75
S439
P
L
S
L
P
N
H
S
P
L
H
S
F
T
P
Site 76
S443
P
N
H
S
P
L
H
S
F
T
P
T
L
Q
P
Site 77
T445
H
S
P
L
H
S
F
T
P
T
L
Q
P
P
A
Site 78
T447
P
L
H
S
F
T
P
T
L
Q
P
P
A
H
S
Site 79
T464
P
N
M
F
A
P
P
T
A
L
P
P
P
P
P
Site 80
S474
P
P
P
P
P
L
T
S
G
S
L
Q
V
A
G
Site 81
S476
P
P
P
L
T
S
G
S
L
Q
V
A
G
H
P
Site 82
T500
I
L
R
Q
E
L
N
T
R
F
L
A
S
Q
S
Site 83
S505
L
N
T
R
F
L
A
S
Q
S
A
D
R
G
A
Site 84
S507
T
R
F
L
A
S
Q
S
A
D
R
G
A
S
L
Site 85
S513
Q
S
A
D
R
G
A
S
L
G
P
P
P
Y
L
Site 86
Y519
A
S
L
G
P
P
P
Y
L
R
T
E
F
H
Q
Site 87
T542
H
Q
H
T
H
Q
H
T
F
T
P
F
P
H
A
Site 88
T544
H
T
H
Q
H
T
F
T
P
F
P
H
A
I
P
Site 89
T558
P
P
T
A
I
M
P
T
P
A
P
P
M
F
D
Site 90
Y567
A
P
P
M
F
D
K
Y
P
T
K
V
D
P
F
Site 91
Y575
P
T
K
V
D
P
F
Y
R
H
S
L
F
H
S
Site 92
S578
V
D
P
F
Y
R
H
S
L
F
H
S
Y
P
P
Site 93
S582
Y
R
H
S
L
F
H
S
Y
P
P
A
V
S
G
Site 94
Y583
R
H
S
L
F
H
S
Y
P
P
A
V
S
G
I
Site 95
S602
P
P
T
G
P
F
G
S
L
Q
G
A
F
Q
P
Site 96
T611
Q
G
A
F
Q
P
K
T
S
N
P
I
D
V
A
Site 97
T623
D
V
A
A
R
P
G
T
V
P
H
T
L
L
Q
Site 98
T627
R
P
G
T
V
P
H
T
L
L
Q
K
D
P
R
Site 99
T636
L
Q
K
D
P
R
L
T
D
P
F
R
P
M
L
Site 100
S688
G
L
K
P
E
F
L
S
R
P
P
G
P
S
L
Site 101
S694
L
S
R
P
P
G
P
S
L
F
G
A
I
H
H
Site 102
S709
P
H
D
L
A
R
P
S
T
L
F
S
A
A
G
Site 103
T710
H
D
L
A
R
P
S
T
L
F
S
A
A
G
A
Site 104
S713
A
R
P
S
T
L
F
S
A
A
G
A
A
H
P
Site 105
T721
A
A
G
A
A
H
P
T
G
T
P
F
G
P
P
Site 106
T723
G
A
A
H
P
T
G
T
P
F
G
P
P
P
H
Site 107
S732
F
G
P
P
P
H
H
S
N
F
L
N
P
A
A
Site 108
S748
L
E
P
F
N
R
P
S
T
F
T
G
L
A
A
Site 109
T749
E
P
F
N
R
P
S
T
F
T
G
L
A
A
V
Site 110
S768
F
G
G
L
G
N
P
S
V
T
P
N
S
M
F
Site 111
T770
G
L
G
N
P
S
V
T
P
N
S
M
F
G
H
Site 112
S773
N
P
S
V
T
P
N
S
M
F
G
H
K
D
G
Site 113
S782
F
G
H
K
D
G
P
S
V
Q
N
F
S
N
P
Site 114
S787
G
P
S
V
Q
N
F
S
N
P
H
E
P
W
N
Site 115
T799
P
W
N
R
L
H
R
T
P
P
S
F
P
T
P
Site 116
S802
R
L
H
R
T
P
P
S
F
P
T
P
P
P
W
Site 117
T805
R
T
P
P
S
F
P
T
P
P
P
W
L
K
P
Site 118
S818
K
P
G
E
L
E
R
S
A
S
A
A
A
H
D
Site 119
S820
G
E
L
E
R
S
A
S
A
A
A
H
D
R
D
Site 120
S835
R
D
V
D
K
R
D
S
S
V
S
K
D
D
K
Site 121
S836
D
V
D
K
R
D
S
S
V
S
K
D
D
K
E
Site 122
S838
D
K
R
D
S
S
V
S
K
D
D
K
E
R
E
Site 123
S846
K
D
D
K
E
R
E
S
V
E
K
R
H
S
S
Site 124
S852
E
S
V
E
K
R
H
S
S
H
P
S
P
A
P
Site 125
S853
S
V
E
K
R
H
S
S
H
P
S
P
A
P
V
Site 126
S856
K
R
H
S
S
H
P
S
P
A
P
V
L
P
V
Site 127
S871
N
A
L
G
H
T
R
S
S
T
E
Q
I
R
A
Site 128
S872
A
L
G
H
T
R
S
S
T
E
Q
I
R
A
H
Site 129
T873
L
G
H
T
R
S
S
T
E
Q
I
R
A
H
L
Site 130
T882
Q
I
R
A
H
L
N
T
E
A
R
E
K
D
K
Site 131
S898
K
E
R
E
R
D
H
S
E
S
R
K
D
L
A
Site 132
S900
R
E
R
D
H
S
E
S
R
K
D
L
A
A
D
Site 133
S941
K
Q
L
A
R
V
P
S
P
Y
V
R
T
P
V
Site 134
T946
V
P
S
P
Y
V
R
T
P
V
V
E
S
A
R
Site 135
S951
V
R
T
P
V
V
E
S
A
R
P
N
S
T
S
Site 136
S956
V
E
S
A
R
P
N
S
T
S
S
R
E
A
E
Site 137
S958
S
A
R
P
N
S
T
S
S
R
E
A
E
P
R
Site 138
S959
A
R
P
N
S
T
S
S
R
E
A
E
P
R
K
Site 139
Y971
P
R
K
G
E
P
A
Y
E
N
P
K
K
S
S
Site 140
T999
L
P
P
E
A
P
Q
T
H
R
A
S
E
P
P
Site 141
S1003
A
P
Q
T
H
R
A
S
E
P
P
P
P
N
S
Site 142
S1010
S
E
P
P
P
P
N
S
S
S
S
V
H
P
G
Site 143
S1011
E
P
P
P
P
N
S
S
S
S
V
H
P
G
P
Site 144
S1012
P
P
P
P
N
S
S
S
S
V
H
P
G
P
L
Site 145
S1013
P
P
P
N
S
S
S
S
V
H
P
G
P
L
A
Site 146
S1036
T
G
I
H
P
M
N
S
I
S
S
L
D
R
T
Site 147
S1038
I
H
P
M
N
S
I
S
S
L
D
R
T
R
M
Site 148
S1039
H
P
M
N
S
I
S
S
L
D
R
T
R
M
M
Site 149
T1043
S
I
S
S
L
D
R
T
R
M
M
T
P
F
M
Site 150
T1047
L
D
R
T
R
M
M
T
P
F
M
G
I
S
P
Site 151
S1053
M
T
P
F
M
G
I
S
P
L
P
G
G
E
R
Site 152
Y1063
P
G
G
E
R
F
P
Y
P
S
F
H
W
D
P
Site 153
Y1079
R
D
P
L
R
D
P
Y
R
E
L
D
I
H
R
Site 154
S1105
N
D
P
L
H
R
L
S
T
P
R
L
Y
E
A
Site 155
T1106
D
P
L
H
R
L
S
T
P
R
L
Y
E
A
D
Site 156
Y1110
R
L
S
T
P
R
L
Y
E
A
D
R
S
F
R
Site 157
S1115
R
L
Y
E
A
D
R
S
F
R
D
R
E
P
H
Site 158
Y1162
L
H
M
L
R
E
D
Y
E
H
T
R
L
H
S
Site 159
S1169
Y
E
H
T
R
L
H
S
V
H
P
A
S
L
D
Site 160
S1174
L
H
S
V
H
P
A
S
L
D
G
H
L
P
H
Site 161
S1183
D
G
H
L
P
H
P
S
L
I
T
P
G
L
P
Site 162
S1191
L
I
T
P
G
L
P
S
M
H
Y
P
R
I
S
Site 163
Y1194
P
G
L
P
S
M
H
Y
P
R
I
S
P
T
A
Site 164
S1198
S
M
H
Y
P
R
I
S
P
T
A
G
N
Q
N
Site 165
T1211
Q
N
G
L
L
N
K
T
P
P
T
A
A
L
S
Site 166
T1214
L
L
N
K
T
P
P
T
A
A
L
S
A
P
P
Site 167
S1233
T
L
G
G
R
P
V
S
P
R
R
T
T
P
L
Site 168
T1237
R
P
V
S
P
R
R
T
T
P
L
S
A
E
I
Site 169
T1238
P
V
S
P
R
R
T
T
P
L
S
A
E
I
R
Site 170
S1241
P
R
R
T
T
P
L
S
A
E
I
R
E
R
P
Site 171
S1250
E
I
R
E
R
P
P
S
H
T
L
K
D
I
E
Site 172
T1252
R
E
R
P
P
S
H
T
L
K
D
I
E
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation