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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPM1E
Full Name:
Protein phosphatase 1E
Alias:
Ca(2+)/calmodulin-dependent protein kinase phosphatase N;CaMKP-nucleus;Partner of PIX 1;Partner of PIX-alpha
Type:
Mass (Da):
85242
Number AA:
766
UniProt ID:
Q8WY54
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
G
C
I
P
E
E
K
T
Y
R
R
F
L
E
L
Site 2
Y11
C
I
P
E
E
K
T
Y
R
R
F
L
E
L
F
Site 3
S47
E
P
E
P
E
P
E
S
E
P
E
P
E
P
E
Site 4
S64
E
A
E
A
A
E
A
S
V
E
E
P
G
E
E
Site 5
T74
E
P
G
E
E
A
A
T
V
A
A
T
E
E
G
Site 6
T106
E
E
E
E
G
A
A
T
A
A
A
A
P
G
H
Site 7
S114
A
A
A
A
P
G
H
S
A
V
P
P
P
P
P
Site 8
S134
P
P
L
P
R
P
L
S
E
R
I
T
P
R
P
Site 9
T138
R
P
L
S
E
R
I
T
P
R
P
L
S
E
R
Site 10
S143
R
I
T
P
R
P
L
S
E
R
I
T
R
E
E
Site 11
T147
R
P
L
S
E
R
I
T
R
E
E
V
E
G
E
Site 12
S155
R
E
E
V
E
G
E
S
L
D
L
C
L
Q
Q
Site 13
Y164
D
L
C
L
Q
Q
L
Y
K
Y
N
C
P
S
F
Site 14
S181
A
A
L
A
R
A
T
S
D
E
V
L
Q
S
D
Site 15
S187
T
S
D
E
V
L
Q
S
D
L
S
A
H
Y
I
Site 16
S190
E
V
L
Q
S
D
L
S
A
H
Y
I
P
K
E
Site 17
T201
I
P
K
E
T
D
G
T
E
G
T
V
E
I
E
Site 18
T204
E
T
D
G
T
E
G
T
V
E
I
E
T
V
K
Site 19
T209
E
G
T
V
E
I
E
T
V
K
L
A
R
S
V
Site 20
S215
E
T
V
K
L
A
R
S
V
F
S
K
L
H
E
Site 21
Y240
L
R
R
R
P
Q
L
Y
Y
E
T
S
I
H
A
Site 22
Y241
R
R
R
P
Q
L
Y
Y
E
T
S
I
H
A
I
Site 23
Y279
E
D
Q
E
E
Q
A
Y
F
A
V
F
D
G
H
Site 24
T324
L
C
R
A
F
R
V
T
D
E
R
F
V
Q
K
Site 25
S336
V
Q
K
A
A
R
E
S
L
R
C
G
T
T
G
Site 26
S409
W
R
V
N
G
S
L
S
V
S
R
A
I
G
D
Site 27
S411
V
N
G
S
L
S
V
S
R
A
I
G
D
A
E
Site 28
Y422
G
D
A
E
H
K
P
Y
I
C
G
D
A
D
S
Site 29
S431
C
G
D
A
D
S
A
S
T
V
L
D
G
T
E
Site 30
Y449
I
L
A
C
D
G
F
Y
D
T
V
N
P
D
E
Site 31
T451
A
C
D
G
F
Y
D
T
V
N
P
D
E
A
V
Site 32
S473
K
E
N
N
G
D
S
S
M
V
A
H
K
L
V
Site 33
S482
V
A
H
K
L
V
A
S
A
R
D
A
G
S
S
Site 34
S489
S
A
R
D
A
G
S
S
D
N
I
T
V
I
V
Site 35
T515
V
S
E
E
S
D
W
T
E
N
S
F
Q
G
G
Site 36
S518
E
S
D
W
T
E
N
S
F
Q
G
G
Q
E
D
Site 37
Y553
S
A
P
A
D
L
G
Y
D
G
R
V
D
S
F
Site 38
S559
G
Y
D
G
R
V
D
S
F
T
D
R
T
S
L
Site 39
T561
D
G
R
V
D
S
F
T
D
R
T
S
L
S
P
Site 40
T564
V
D
S
F
T
D
R
T
S
L
S
P
G
S
Q
Site 41
S565
D
S
F
T
D
R
T
S
L
S
P
G
S
Q
I
Site 42
S567
F
T
D
R
T
S
L
S
P
G
S
Q
I
N
V
Site 43
S570
R
T
S
L
S
P
G
S
Q
I
N
V
L
E
D
Site 44
Y580
N
V
L
E
D
P
G
Y
L
D
L
T
Q
I
E
Site 45
T584
D
P
G
Y
L
D
L
T
Q
I
E
A
S
K
P
Site 46
S589
D
L
T
Q
I
E
A
S
K
P
H
S
A
Q
F
Site 47
S623
E
L
M
M
E
K
K
S
V
Q
S
S
L
P
E
Site 48
S626
M
E
K
K
S
V
Q
S
S
L
P
E
W
S
G
Site 49
S627
E
K
K
S
V
Q
S
S
L
P
E
W
S
G
A
Site 50
S632
Q
S
S
L
P
E
W
S
G
A
G
E
F
P
T
Site 51
T639
S
G
A
G
E
F
P
T
A
F
N
L
G
S
T
Site 52
Y651
G
S
T
G
E
Q
I
Y
R
M
Q
S
L
S
P
Site 53
S655
E
Q
I
Y
R
M
Q
S
L
S
P
V
C
S
G
Site 54
S661
Q
S
L
S
P
V
C
S
G
L
E
N
E
Q
F
Site 55
S670
L
E
N
E
Q
F
K
S
P
G
N
R
V
S
R
Site 56
S676
K
S
P
G
N
R
V
S
R
L
S
H
L
R
H
Site 57
S679
G
N
R
V
S
R
L
S
H
L
R
H
H
Y
S
Site 58
Y685
L
S
H
L
R
H
H
Y
S
K
K
W
H
R
F
Site 59
S700
R
F
N
P
K
F
Y
S
F
L
S
A
Q
E
P
Site 60
S703
P
K
F
Y
S
F
L
S
A
Q
E
P
S
H
K
Site 61
T713
E
P
S
H
K
I
G
T
S
L
S
S
L
T
G
Site 62
S714
P
S
H
K
I
G
T
S
L
S
S
L
T
G
S
Site 63
S716
H
K
I
G
T
S
L
S
S
L
T
G
S
G
K
Site 64
S717
K
I
G
T
S
L
S
S
L
T
G
S
G
K
R
Site 65
T719
G
T
S
L
S
S
L
T
G
S
G
K
R
N
R
Site 66
S721
S
L
S
S
L
T
G
S
G
K
R
N
R
I
R
Site 67
S729
G
K
R
N
R
I
R
S
S
L
P
W
R
Q
N
Site 68
S730
K
R
N
R
I
R
S
S
L
P
W
R
Q
N
S
Site 69
S737
S
L
P
W
R
Q
N
S
W
K
G
Y
S
E
N
Site 70
Y741
R
Q
N
S
W
K
G
Y
S
E
N
M
R
K
L
Site 71
T751
N
M
R
K
L
R
K
T
H
D
I
P
C
P
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation