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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYLIP
Full Name:
E3 ubiquitin-protein ligase MYLIP
Alias:
Inducible degrader of the LDL-receptor;Myosin regulatory light chain interacting protein
Type:
Mass (Da):
49910
Number AA:
445
UniProt ID:
Q8WY64
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S49
F
G
L
Q
F
T
G
S
K
G
E
S
L
W
L
Site 2
S53
F
T
G
S
K
G
E
S
L
W
L
N
L
R
N
Site 3
S63
L
N
L
R
N
R
I
S
Q
Q
M
D
G
L
A
Site 4
Y131
A
Q
T
K
F
G
D
Y
N
Q
N
T
A
K
Y
Site 5
Y138
Y
N
Q
N
T
A
K
Y
N
Y
E
E
L
C
A
Site 6
T166
K
H
K
E
L
E
G
T
S
Q
A
S
A
E
Y
Site 7
S191
N
Y
G
I
E
W
H
S
V
R
D
S
E
G
Q
Site 8
S195
E
W
H
S
V
R
D
S
E
G
Q
K
L
L
I
Site 9
S210
G
V
G
P
E
G
I
S
I
C
K
D
D
F
S
Site 10
S217
S
I
C
K
D
D
F
S
P
I
N
R
I
A
Y
Site 11
Y238
T
Q
S
G
K
N
V
Y
L
T
V
T
K
E
S
Site 12
T240
S
G
K
N
V
Y
L
T
V
T
K
E
S
G
N
Site 13
T269
S
G
L
Y
R
A
I
T
E
T
H
A
F
Y
R
Site 14
S282
Y
R
C
D
T
V
T
S
A
V
M
M
Q
Y
S
Site 15
Y288
T
S
A
V
M
M
Q
Y
S
R
D
L
K
G
H
Site 16
S289
S
A
V
M
M
Q
Y
S
R
D
L
K
G
H
L
Site 17
Y311
N
I
N
L
G
K
K
Y
V
F
D
I
K
R
T
Site 18
T318
Y
V
F
D
I
K
R
T
S
K
E
V
Y
D
H
Site 19
S319
V
F
D
I
K
R
T
S
K
E
V
Y
D
H
A
Site 20
Y323
K
R
T
S
K
E
V
Y
D
H
A
R
R
A
L
Site 21
Y331
D
H
A
R
R
A
L
Y
N
A
G
V
V
D
L
Site 22
S340
A
G
V
V
D
L
V
S
R
N
N
Q
S
P
S
Site 23
S345
L
V
S
R
N
N
Q
S
P
S
H
S
P
L
K
Site 24
S347
S
R
N
N
Q
S
P
S
H
S
P
L
K
S
S
Site 25
S349
N
N
Q
S
P
S
H
S
P
L
K
S
S
E
S
Site 26
S353
P
S
H
S
P
L
K
S
S
E
S
S
M
N
C
Site 27
S354
S
H
S
P
L
K
S
S
E
S
S
M
N
C
S
Site 28
S356
S
P
L
K
S
S
E
S
S
M
N
C
S
S
C
Site 29
S357
P
L
K
S
S
E
S
S
M
N
C
S
S
C
E
Site 30
S361
S
E
S
S
M
N
C
S
S
C
E
G
L
S
C
Site 31
S362
E
S
S
M
N
C
S
S
C
E
G
L
S
C
Q
Site 32
S367
C
S
S
C
E
G
L
S
C
Q
Q
T
R
V
L
Site 33
T371
E
G
L
S
C
Q
Q
T
R
V
L
Q
E
K
L
Site 34
S417
S
C
A
A
Q
L
Q
S
C
P
V
C
R
S
R
Site 35
Y432
V
E
H
V
Q
H
V
Y
L
P
T
H
T
S
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation