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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RIN2
Full Name:
Ras and Rab interactor 2
Alias:
RAB5 interacting protein 2; RAS association (RalGDS/AF-6) domain containing protein JC265; Ras association domain family 4; Ras inhibitor JC265; Ras interaction/interference protein 2; RASSF4
Type:
Guanine nucleotide exchange factor, Rab
Mass (Da):
100163
Number AA:
895
UniProt ID:
Q8WYP3
International Prot ID:
IPI00103752
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0017112
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0007264
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
R
G
L
D
K
R
G
S
F
F
K
L
I
D
T
Site 2
T38
L
K
Q
E
M
V
R
T
D
V
N
L
E
N
G
Site 3
T51
N
G
L
E
P
A
E
T
H
S
M
V
R
H
K
Site 4
Y62
V
R
H
K
D
G
G
Y
S
E
E
E
D
V
K
Site 5
S63
R
H
K
D
G
G
Y
S
E
E
E
D
V
K
T
Site 6
T70
S
E
E
E
D
V
K
T
C
A
R
D
S
G
Y
Site 7
S75
V
K
T
C
A
R
D
S
G
Y
D
S
L
S
N
Site 8
Y77
T
C
A
R
D
S
G
Y
D
S
L
S
N
R
L
Site 9
S79
A
R
D
S
G
Y
D
S
L
S
N
R
L
S
I
Site 10
S81
D
S
G
Y
D
S
L
S
N
R
L
S
I
L
D
Site 11
S85
D
S
L
S
N
R
L
S
I
L
D
R
L
L
H
Site 12
S101
H
P
I
W
L
Q
L
S
L
S
E
E
E
A
A
Site 13
S133
K
M
Q
K
K
V
L
S
L
R
L
P
C
E
F
Site 14
S152
K
E
F
A
I
K
E
S
T
Y
T
F
S
L
E
Site 15
T153
E
F
A
I
K
E
S
T
Y
T
F
S
L
E
G
Site 16
T155
A
I
K
E
S
T
Y
T
F
S
L
E
G
S
G
Site 17
S157
K
E
S
T
Y
T
F
S
L
E
G
S
G
I
S
Site 18
S193
L
K
L
P
Y
A
I
S
T
A
K
S
E
A
Q
Site 19
S197
Y
A
I
S
T
A
K
S
E
A
Q
L
E
E
L
Site 20
S214
M
G
L
N
F
W
S
S
P
A
D
S
K
P
P
Site 21
S218
F
W
S
S
P
A
D
S
K
P
P
N
L
P
P
Site 22
S231
P
P
P
H
R
P
L
S
S
D
G
V
C
P
A
Site 23
S232
P
P
H
R
P
L
S
S
D
G
V
C
P
A
S
Site 24
T254
N
G
V
H
S
I
K
T
R
T
P
S
E
L
E
Site 25
T256
V
H
S
I
K
T
R
T
P
S
E
L
E
C
S
Site 26
S258
S
I
K
T
R
T
P
S
E
L
E
C
S
Q
T
Site 27
S263
T
P
S
E
L
E
C
S
Q
T
N
G
A
L
C
Site 28
T265
S
E
L
E
C
S
Q
T
N
G
A
L
C
F
I
Site 29
S285
K
V
H
S
Q
D
L
S
G
G
L
K
R
P
S
Site 30
S292
S
G
G
L
K
R
P
S
T
R
T
P
N
A
N
Site 31
T293
G
G
L
K
R
P
S
T
R
T
P
N
A
N
G
Site 32
T295
L
K
R
P
S
T
R
T
P
N
A
N
G
T
E
Site 33
T301
R
T
P
N
A
N
G
T
E
R
T
R
S
P
P
Site 34
S306
N
G
T
E
R
T
R
S
P
P
P
R
P
P
P
Site 35
S318
P
P
P
P
A
I
N
S
L
H
T
S
P
R
L
Site 36
S322
A
I
N
S
L
H
T
S
P
R
L
A
R
T
E
Site 37
T330
P
R
L
A
R
T
E
T
Q
T
S
M
P
E
T
Site 38
T332
L
A
R
T
E
T
Q
T
S
M
P
E
T
V
N
Site 39
S333
A
R
T
E
T
Q
T
S
M
P
E
T
V
N
H
Site 40
T337
T
Q
T
S
M
P
E
T
V
N
H
N
K
H
G
Site 41
T354
A
L
P
G
T
K
P
T
P
I
P
P
P
R
L
Site 42
S366
P
R
L
K
K
Q
A
S
F
L
E
A
E
G
G
Site 43
T376
E
A
E
G
G
A
K
T
L
S
G
G
R
P
G
Site 44
S378
E
G
G
A
K
T
L
S
G
G
R
P
G
A
G
Site 45
S395
L
E
L
G
T
A
G
S
P
G
G
A
P
P
E
Site 46
T409
E
A
A
P
G
D
C
T
R
A
P
P
P
S
S
Site 47
S415
C
T
R
A
P
P
P
S
S
E
S
R
P
P
C
Site 48
S416
T
R
A
P
P
P
S
S
E
S
R
P
P
C
H
Site 49
S418
A
P
P
P
S
S
E
S
R
P
P
C
H
G
G
Site 50
S430
H
G
G
R
Q
R
L
S
D
M
S
I
S
T
S
Site 51
S433
R
Q
R
L
S
D
M
S
I
S
T
S
S
S
D
Site 52
S435
R
L
S
D
M
S
I
S
T
S
S
S
D
S
L
Site 53
S437
S
D
M
S
I
S
T
S
S
S
D
S
L
E
F
Site 54
S439
M
S
I
S
T
S
S
S
D
S
L
E
F
D
R
Site 55
S441
I
S
T
S
S
S
D
S
L
E
F
D
R
S
M
Site 56
S447
D
S
L
E
F
D
R
S
M
P
L
F
G
Y
E
Site 57
Y453
R
S
M
P
L
F
G
Y
E
A
D
T
N
S
S
Site 58
T457
L
F
G
Y
E
A
D
T
N
S
S
L
E
D
Y
Site 59
Y464
T
N
S
S
L
E
D
Y
E
G
E
S
D
Q
E
Site 60
T472
E
G
E
S
D
Q
E
T
M
A
P
P
I
K
S
Site 61
S479
T
M
A
P
P
I
K
S
K
K
K
R
S
S
S
Site 62
S484
I
K
S
K
K
K
R
S
S
S
F
V
L
P
K
Site 63
S485
K
S
K
K
K
R
S
S
S
F
V
L
P
K
L
Site 64
S486
S
K
K
K
R
S
S
S
F
V
L
P
K
L
V
Site 65
S495
V
L
P
K
L
V
K
S
Q
L
Q
K
V
S
G
Site 66
S501
K
S
Q
L
Q
K
V
S
G
V
F
S
S
F
M
Site 67
S505
Q
K
V
S
G
V
F
S
S
F
M
T
P
E
K
Site 68
S506
K
V
S
G
V
F
S
S
F
M
T
P
E
K
R
Site 69
T509
G
V
F
S
S
F
M
T
P
E
K
R
M
V
R
Site 70
S522
V
R
R
I
A
E
L
S
R
D
K
C
T
Y
F
Site 71
T527
E
L
S
R
D
K
C
T
Y
F
G
C
L
V
Q
Site 72
Y528
L
S
R
D
K
C
T
Y
F
G
C
L
V
Q
D
Site 73
S538
C
L
V
Q
D
Y
V
S
F
L
Q
E
N
K
E
Site 74
S549
E
N
K
E
C
H
V
S
S
T
D
M
L
Q
T
Site 75
T556
S
S
T
D
M
L
Q
T
I
R
Q
F
M
T
Q
Site 76
Y567
F
M
T
Q
V
K
N
Y
L
S
Q
S
S
E
L
Site 77
S569
T
Q
V
K
N
Y
L
S
Q
S
S
E
L
D
P
Site 78
S571
V
K
N
Y
L
S
Q
S
S
E
L
D
P
P
I
Site 79
S580
E
L
D
P
P
I
E
S
L
I
P
E
D
Q
I
Site 80
Y665
F
M
T
M
Q
K
M
Y
S
P
E
K
K
V
M
Site 81
S666
M
T
M
Q
K
M
Y
S
P
E
K
K
V
M
L
Site 82
T683
R
V
C
K
L
I
Y
T
V
M
E
N
N
S
G
Site 83
Y693
E
N
N
S
G
R
M
Y
G
A
D
D
F
L
P
Site 84
Y737
L
H
G
E
G
G
Y
Y
L
T
S
A
Y
G
A
Site 85
S746
T
S
A
Y
G
A
L
S
L
I
K
N
F
Q
E
Site 86
S761
E
Q
A
A
R
L
L
S
S
E
T
R
D
T
L
Site 87
T767
L
S
S
E
T
R
D
T
L
R
Q
W
H
K
R
Site 88
T776
R
Q
W
H
K
R
R
T
T
N
R
T
I
P
S
Site 89
T777
Q
W
H
K
R
R
T
T
N
R
T
I
P
S
V
Site 90
T780
K
R
R
T
T
N
R
T
I
P
S
V
D
D
F
Site 91
S783
T
T
N
R
T
I
P
S
V
D
D
F
Q
N
Y
Site 92
Y790
S
V
D
D
F
Q
N
Y
L
R
V
A
F
Q
E
Site 93
T806
N
S
G
C
T
G
K
T
L
L
V
R
P
Y
I
Site 94
S835
V
G
D
P
E
E
Y
S
L
F
L
F
V
D
E
Site 95
T843
L
F
L
F
V
D
E
T
W
Q
Q
L
A
E
D
Site 96
Y852
Q
Q
L
A
E
D
T
Y
P
Q
K
I
K
A
E
Site 97
Y873
P
H
I
F
H
F
V
Y
K
R
I
K
N
D
P
Site 98
Y881
K
R
I
K
N
D
P
Y
G
I
I
F
Q
N
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation