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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KLHL6
Full Name:
Kelch-like protein 6
Alias:
FLJ00029; kelch-like 6; kelch-like protein KLHL6
Type:
Mass (Da):
70360
Number AA:
UniProt ID:
Q8WZ60
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S19
M
G
D
V
V
E
K
S
L
E
G
P
L
A
P
Site 2
S27
L
E
G
P
L
A
P
S
T
D
E
P
S
Q
K
Site 3
T28
E
G
P
L
A
P
S
T
D
E
P
S
Q
K
T
Site 4
S32
A
P
S
T
D
E
P
S
Q
K
T
G
D
L
V
Site 5
S55
K
F
D
D
A
G
L
S
L
I
L
Q
N
G
L
Site 6
T64
I
L
Q
N
G
L
E
T
L
R
M
E
N
A
L
Site 7
Y109
C
N
D
L
K
E
K
Y
E
K
R
I
I
I
K
Site 8
T122
I
K
G
V
D
A
E
T
M
H
T
L
L
D
Y
Site 9
T125
V
D
A
E
T
M
H
T
L
L
D
Y
T
Y
T
Site 10
Y129
T
M
H
T
L
L
D
Y
T
Y
T
S
K
A
L
Site 11
Y131
H
T
L
L
D
Y
T
Y
T
S
K
A
L
I
T
Site 12
T183
G
I
L
R
L
A
D
T
H
S
L
D
S
L
K
Site 13
S185
L
R
L
A
D
T
H
S
L
D
S
L
K
K
Q
Site 14
S188
A
D
T
H
S
L
D
S
L
K
K
Q
V
Q
S
Site 15
S224
T
L
H
H
I
L
K
S
D
D
L
Y
V
T
E
Site 16
Y228
I
L
K
S
D
D
L
Y
V
T
E
E
A
Q
V
Site 17
S248
S
W
V
R
H
K
P
S
E
R
L
C
L
L
P
Site 18
Y297
L
L
Q
E
A
R
M
Y
H
L
S
G
N
E
I
Site 19
S300
E
A
R
M
Y
H
L
S
G
N
E
I
I
S
E
Site 20
S306
L
S
G
N
E
I
I
S
E
R
T
K
P
R
M
Site 21
S346
C
L
D
P
L
R
R
S
R
L
E
V
A
K
L
Site 22
T356
E
V
A
K
L
P
L
T
E
H
E
L
E
S
E
Site 23
Y380
V
T
L
K
N
E
V
Y
I
S
G
G
K
E
T
Site 24
S382
L
K
N
E
V
Y
I
S
G
G
K
E
T
Q
H
Site 25
Y406
N
K
W
I
Q
I
E
Y
L
N
I
G
R
W
R
Site 26
Y424
V
V
L
G
G
K
V
Y
V
I
G
G
F
D
G
Site 27
T464
H
V
S
S
F
A
A
T
S
H
K
K
K
L
Y
Site 28
S465
V
S
S
F
A
A
T
S
H
K
K
K
L
Y
V
Site 29
Y471
T
S
H
K
K
K
L
Y
V
I
G
G
G
P
N
Site 30
T486
G
K
L
A
T
D
K
T
Q
C
Y
D
P
S
T
Site 31
Y489
A
T
D
K
T
Q
C
Y
D
P
S
T
N
K
W
Site 32
T493
T
Q
C
Y
D
P
S
T
N
K
W
S
L
K
A
Site 33
Y529
G
G
A
M
R
A
L
Y
A
Y
S
P
L
E
D
Site 34
Y531
A
M
R
A
L
Y
A
Y
S
P
L
E
D
S
W
Site 35
S532
M
R
A
L
Y
A
Y
S
P
L
E
D
S
W
C
Site 36
S550
Q
L
S
H
E
R
A
S
C
G
I
A
P
C
N
Site 37
Y561
A
P
C
N
N
R
L
Y
I
T
G
G
R
D
E
Site 38
T575
E
K
N
E
V
I
A
T
V
L
C
W
D
P
E
Site 39
S601
R
G
V
S
H
H
G
S
V
T
I
R
K
S
Y
Site 40
T603
V
S
H
H
G
S
V
T
I
R
K
S
Y
T
H
Site 41
S607
G
S
V
T
I
R
K
S
Y
T
H
I
R
R
I
Site 42
Y608
S
V
T
I
R
K
S
Y
T
H
I
R
R
I
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation