PhosphoNET

           
Protein Info 
   
Short Name:  RFFL
Full Name:  E3 ubiquitin-protein ligase rififylin
Alias:  E3 ubiquitin-protein ligase rififylin: RING finger and FYVE-like domain-containing protein 1: FYVE-RING finger protein Sakura: Caspases-8 and -10-associated RING finger protein 2: Caspase regulator CARP2: RING finger protein 189: RING finger protein 34-like: E3 ubiquitin-protein ligase rififylin: RING finger and FYVE-like domain-containing protein 1: FYVE-RING finger protein Sakura: Caspases-8 and -10-associated RING finger protein 2: Caspase regulator CARP2: RING finger protein 189: RING finger protein 34-like; Fring; Hypothetical protein FLJ35793; Rififylin; Ring finger and FYVE-like domain containing 1; RNF189; RNF34L
Type:  Ubiquitin ligase; Vesicle protein; Ubiquitin conjugating system; EC 6.3.2.-; Ligase
Mass (Da):  40514
Number AA:  363
UniProt ID:  Q8WZ73
International Prot ID:  IPI00103867
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0019898     Uniprot OncoNet
Molecular Function:  GO:0016874  GO:0005515  GO:0008270 PhosphoSite+ KinaseNET
Biological Process:  GO:0006915  GO:0019941   Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1Y29QGARMQAYSNPGYSS
Site 2S30GARMQAYSNPGYSSF
Site 3Y34QAYSNPGYSSFPSPT
Site 4S35AYSNPGYSSFPSPTG
Site 5S36YSNPGYSSFPSPTGL
Site 6S39PGYSSFPSPTGLEPS
Site 7S46SPTGLEPSCKSCGAH
Site 8S49GLEPSCKSCGAHFAN
Site 9T62ANTARKQTCLDCKKN
Site 10T94LCQRFRATAFQREEL
Site 11Y112KVKDLRDYLSLHDIS
Site 12S114KDLRDYLSLHDISTE
Site 13S119YLSLHDISTEMCREK
Site 14T120LSLHDISTEMCREKE
Site 15S141LGQQPVISQEDRTRA
Site 16T146VISQEDRTRASTLSP
Site 17S149QEDRTRASTLSPDFP
Site 18T150EDRTRASTLSPDFPE
Site 19S152RTRASTLSPDFPEQQ
Site 20T163PEQQAFLTQPHSSMV
Site 21S167AFLTQPHSSMVPPTS
Site 22S168FLTQPHSSMVPPTSP
Site 23T173HSSMVPPTSPNLPSS
Site 24S174SSMVPPTSPNLPSSS
Site 25S179PTSPNLPSSSAQATS
Site 26S180TSPNLPSSSAQATSV
Site 27S181SPNLPSSSAQATSVP
Site 28T185PSSSAQATSVPPAQV
Site 29S186SSSAQATSVPPAQVQ
Site 30S203QQANGHVSQDQEEPV
Site 31Y211QDQEEPVYLESVARV
Site 32S214EEPVYLESVARVPAE
Site 33T224RVPAEDETQSIDSED
Site 34S226PAEDETQSIDSEDSF
Site 35S229DETQSIDSEDSFVPG
Site 36S232QSIDSEDSFVPGRRA
Site 37S240FVPGRRASLSDLTDL
Site 38S242PGRRASLSDLTDLED
Site 39T245RASLSDLTDLEDIEG
Site 40T254LEDIEGLTVRQLKEI
Site 41Y269LARNFVNYKGCCEKW
Site 42T283WELMERVTRLYKDQK
Site 43Y286MERVTRLYKDQKGLQ
Site 44S297KGLQHLVSGAEDQNG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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